9 жыл бұрын
9 жыл бұрын
Пікірлер
@Hezlrap0 3 ай бұрын
ANANIZI BACINIZI S.KYM OKEY Mİ BU NE LAN BÖYLE!!!!
@Zolien10 3 ай бұрын
Thank you!
@tianalee7497 7 ай бұрын
Thank you for making learning fun and describing it in a comprehensive way
@logainmod6515 8 ай бұрын
Legendary work 🔥❤️❤️❤️❤️❤️❤️
@MG-oi2zy 8 ай бұрын
Great video!
@cad0420alice 8 ай бұрын
This is the first KZbin video I encountered that is harder to understand than a professor’s lecture 😢
@jugalparikh2906 Жыл бұрын
Holy hell its amazing
@dist321 Жыл бұрын
This is awesome!
@jonathantruelshansen5284 Жыл бұрын
Finally a clear and straight to the point video. Good work, and thank you
@rifqimuwaffaqssahab1501 Жыл бұрын
Thanks for make a great animation video. Thats make this topic is more clear for me
@rinosimic856 Жыл бұрын
Sensational
@vanathyvimal8637 Жыл бұрын
I ve understood . ..but still needs clarity can anybody suggest me a book which explains this topic better.....
@laylaakramawi8218 Жыл бұрын
I thought off bipolar cells keep cell depolarized
@sdapathfindersdaily3224 2 жыл бұрын
Plz break it down further..I'm lost😲
@missroyal9029 2 жыл бұрын
Brillant So easy to learn
@LanNguyen-iu3oe 2 жыл бұрын
excellent video!
@DebayanRaha 2 жыл бұрын
Thank you sir
@alanzajac5592 2 жыл бұрын
One thing the video missed out is that the neurotransmitter used from the presynaptic membrane of the cones to the postsynaptic membrane of the bipolar cells is GABA. GABA is an inhibitory neurotransmitter, hence the less of it being produced the more the bipolar cell will be activated. So when a cone receives light and hyperpolarises (as mentioned in the video) it will decrease the amount of GABA released (as the cone cell cannot propagate the signal to the presynaptic membrane) and hence the bipolar cell will be less inhibited and will fire more. The opposite is true for when there is no light input, the cone cell will be depolarised so an action potential can propagate meaning more GABA will be released by the cell and so more inhibition will occur on the postsynaptic bipolar cell.
@vishnumohan2363 Жыл бұрын
not true, glutamate is always released. On centre has mGlur6 and off centre has Ampa or Kainate
@mattaku9430 Жыл бұрын
Yeah, that Hc behaviour description is really weird. When cells are depolarises HC releases GABA, which in turn inhibits CaV channels preventing Ca2 from flowing in, so that PR achieves resting state. When cell is hyperpolarised it’s releases less GABA, which in turn disinhibits CaV channel, so those black surrounding will depolarise. It’s a self stabilising loop with negative and positive feedback
@digitalradiostationshow9332 3 жыл бұрын
Super
@Haraenul 3 жыл бұрын
Why tho
@AwesomeBrotherChun 3 жыл бұрын
much better than textbook or some online lectures
@edwina7895 3 жыл бұрын
Thank you for this. I finally understand it!
@stavshmueli6932 3 жыл бұрын
Fantastic explanation about the concept of the receptive field of the RGC - I'd just want to add something in case some people had the same question as I did whilst watching this video: Both photoreceptor cells of the retina (Rods and Cones) utilise ONLY glutamate as a neurotransmitter - which evokes the question: How is it possible that an ON CENTER bipolar cell even exists, because glutamate is EXCITATORY and somehow the ON CENTER bipolar cell reverses the sign of the ON CENTER cone cell, so how such an arrangement possible? So apparently it is because in the retina we have a special type of glutamate receptor which is actually INHIBITORY, and the ON CENTER bipolar cells have these kind of inhibitory glutamate receptors on their synapses - therefore when the ON CENTER cone cell is going to release glutamate on the ON CENTER bipolar cell it is actually going to be an INHIBITORY "message", NOT an excitatory message, which totally goes against the conventional "glutamate is an excitatory neurotransmitter idea" - apparently for this type of arrangement in the retina glutamate can actually act as an inhibitory neurotransmitter because of these specialized INHIBITORY glutamate receptors.
@Fossilized-cryptid 2 жыл бұрын
Yes, a little background in one of the teams that was heavily involved in recognizing metabotropic g protein coupled receptor on the synaptic cleft of the teledendron of the peripheral process of the bipolar cell, this GLUM6R in the prescene of GLU will activate the g protein which as of this time it is unknown the cascade effect that eventually ends up blocking the same receptor and preventing cations from flowing into the cell, when there is low amounts of GLU (when the photoreceptor is hyperpolarized) the G protein won't be stimulated and so the receptor will open and allow depolarization to occur (although it's technically not depolarization beacuse all retina cells except Müller and Ganglion cells are so small, photoreceptors 2-3 mircons in diameter, that there is no need for action potentials, only changes in electrotonic voltage will be sufficient to exocytose the neurotransmitters on their respective teledendrons) thus effectively creating a sign reversing synapse
@kanayanfantv 3 жыл бұрын
GREAT! I have lots of ideas. You guys are great! Hugs from Brazil! I bought the 9th edition recently...
@nikotakai8796 Жыл бұрын
There is no 9th edition?
@ryanthaiable 3 жыл бұрын
this shit dont make sense
@janeelizabxth 3 жыл бұрын
This was SO clear thank you so much!!!
@ganeshbhandari1942 3 жыл бұрын
Very well explained, many thanks
@learningdoctors3211 3 жыл бұрын
good explaining
@tabalaplayerajitkumarbhat6389 3 жыл бұрын
Thank you so so so much Mam 🥺
@drr.k.zenith8821 4 жыл бұрын
Well explained...good job.
@ruffie5847 4 жыл бұрын
Thanks! This video is much better than the interpretation presented by my teacher in university LOL
@shiyinchen145 4 жыл бұрын
my ears & eyes:yeah now I understand my brain: no you don't
@anilslands 4 жыл бұрын
skim böyle nöronu
@letmedream111 4 жыл бұрын
This was GREAT. Thank you very much. The thorough example was so useful.
@jobellecastro6444 4 жыл бұрын
This was so helpful thank you!!
@amannagar726 4 жыл бұрын
Sir is there any answer for what is time and how it induces life to evolve even an organism to get older, I have an answer but it needs a thorough explanation via research wait for few years I will provide it i.e. The theory of everything.
@nicolasgiaconia8051 4 жыл бұрын
Check out Stephen Wolfram's channel, he just published his 50 years of research on the final theory of physics. I'd say it's pretty dope and seems convincing to me
@emmamifsud9169 4 жыл бұрын
after 2 hours or more of reading notes and books i gave up. I watched this video and managed to understand it, thank you so much
@rinosimic856 Жыл бұрын
All freaking day..... but there s light in the end amazing
@Brad3627 4 жыл бұрын
kzbin.info/aero/PLFk30doHyX-dkFzKERdsuH5L_iRf4ibev V helpful video
@dararojas7 4 жыл бұрын
OMG now my PhD is safe!
@casperix3741 4 жыл бұрын
Lucky you, I'm just trying to get through a minor
@ellentran1303 4 жыл бұрын
wow i get it thank mam
@nhanquang8884 4 жыл бұрын
on off on off on off OMG :(((
@jordanbullock5795 4 жыл бұрын
I swear i get everything else having to do with light transmition accept for this
@ayushichoudhary192 5 жыл бұрын
👌🏻👌🏻👌🏻
@esserste85se 5 жыл бұрын
Thank u sooooo much I finally got it 🥳
@Nitishkumar-ip5rp 5 жыл бұрын
nicely explained
@ninteski 5 жыл бұрын
Best explanation of this topic in the internet
@elisesalas2106 5 жыл бұрын
Thank you so much this saved me
@Koomer79 5 жыл бұрын
soooo counterintuitive but great explanation
@MissFredRay 5 жыл бұрын
Really great job! It's clear, simple and well put. I was desperate, I didn't understand it, but thanks to you now I do. 👏
@JankProducties 5 жыл бұрын
Even with a great explanation like this, this shit is still complicated as hell!
@DogeFrom2014 5 жыл бұрын
You're right, this is getting into some highly technical and abstract concepts, and without a good analogy the average college student won't probably get this.
@peaceya100 3 жыл бұрын
@@DogeFrom2014 I m that average student you referring to! You knw what's playing in my head rii now... WHY GOD WHY GOD do I GOTTA SUFFER- KENDRICK lol