we interested to start oyster farm but we ask you to assistant

10:27 : cone snails practice combinatorial chemistry, they use multiple drugs at the same time to immobilize the prey. 10:50: related species have related families of peptides that hit the same molecular targets in the prey ; for example they have the same types of peptides that stop muscles from contracting. 11:15 : But each cone snail species has a completely unique venom ; they work on the same receptors but they are slightly if not quite different. 12:05 : it is estimated that each cone snail produces 150 to 200 different active constituents in its venom. And with 700 different known species, we think there is at least 200K different active peptides to be uncharacterized. 13:00 : their behaviour coevolves with their venom. Some species have a much less powerful venom but have a very strong tooth... they don't even wait for the venom to kick in but try to pull the fish into its mouth. Another species) has a powerful venom that works almost instantaneously, and its tooth is completely different and so is the way it approches its prey, you can see confidence in the snail almost. 13:50 : (their behaviour is an indicator of the potency of their venom), especially the way they react to being handled by humans. (which) is a very very good indicator of whether or not they are dangerous. 14:40 : there are many different strategies for venom. A lot of snails attack the red blood cells and tha actual circlatory system of the prey. It coagulates the blood. Others like spiders target the nervous system, like all snails do. Bees tend to target broad acting cells peptides and make the cells explode, there is a lot of pain, a lot of information at the site and it's localized. Cone snails, from what we've seen so far, show venom constituents of every other venomous animal. They attack the nervous system, cells, and the blood although instead of coagulating the blood they try and digest the blood, they open up the wound more so that the venom can profuse throughout the tissues. 15:50 : cone snails seem extremely highly evolved, with some of the smallest peptides or gene products known in the venom world. For example, spider venoms have about 180 aminoacids per toxin ; the venom of some cone snails have only 20 aminoacids. 17:16 : the cone snail venoms are very characterized, we know a lot of the exact neural toxins and where they act. So we know the receptor. And most of these receptors are on the nerves or on part of the nerves. 17:40 : a lot of the late-stage cancer phenotypes seem to express these same receptors, except they're in the body. 18:08 : cancer cells express these receptors that are only found in the brain 18:50 : Conotoxin MVIIA, that comes from Conus magus venum, is the first and (so far only) FDA-approved drug that comes from a marine ressource. It's synthesized, thanks to the chemistry being very simple. 23:30 : we don't know how many species there are. The more we look, the more we find. In Guam we know of about 85 species (at the time of interview, 2016 ?). 24:35 : Conus textile and admiral (C. ammiralis) like to dig through rubble, often find them 2 or 3 m down into a rubble pile, they like to move quite a bit up and down in the strata. 26:55 : most of the threat for cone snails comes from the shell trade. 27:05 : there is no known antivenom because each species has a unique venom so you can't really make an antivenom for cone snails. 27:40 : some details on the trump/tube/siphon/folded flap, 28:54 on the eyes 29:48 : 3 or 4 glands inside the body are hooked up to the proboscis and the tube, so I hypothesized that they also produce other venom components that we haven't even discovered before. One of the glands we've looked at, the salivary gland, also has unique venom components. 30:23 : Jon-Paul Bingham (uni of Hawai) works on breeding them in captivity 31:08 : in some species, offsprings hatch and directly crawl out of the shell. Others have planctonic stages and most of them have planctonic stages that vary anywhere from 2 to 6 or 8 weeks. 32:04 : one of the ideas (of venom uses) is for sports medicine, in the case of bone breaks : the venom could be used to paralyse the broken member for a couple of weeks to prevent secondary damages to the tissues near the broken bone, which are caused by movements of the muscles near the break ; this would noticeably reduce the time needed for healing the break. 33:20 : there are things in bee venom that makes cells explode. Bee venom, as well as cone snail venom, are started to be worked out for hand sanitizers, also as topical anesthetics and antibiotics because broad spectrum things that make cells explode can be used to sterilize.

Captivating- especially the part about the mosquitoes

What a diverse array of projects!

"you watch them very carefully if you pick them up" says someone who wants to see his darwin award coming.

😮😮😮

This was a fun episode to make! Thanks to all the scientists!

It was amazing to work with this talented group of Scientists on Hadal Profiler cruise!

Much love and respect to the University of Manoa and all that are working on this project 🤙

Not all big 🐟 are female. That's why you must ask the fish for its gender first? 😅😂 Remember! Eat the ones that are running away 😅😂😂 Much Alofa's.

Maikaʻi nui!! Hoihoi nō hoʻi.

🙌

Uncle Wally ito got very useful information! Spot on

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In our place in Albay Gulf, in Philippines we inject the crown of thorn with vinegar and we continue doing it to control the infestations.

How my beloved Hawai'i used to be smh

Interesting video that I just watched in full. I have been researching all things to do with Sea Urchins since March 2023. Is Stella Swanson aware of this paper? Mass mortality of the invasive alien echinoid Diadema setosum (Echinoidea: Diadematidae) in the Mediterranean Sea. Authors: Rotem Zirler, Lisa-Maria Schmidt, Lachan Roth, Maria Corsini-Foka, Konstantinos Kalaentzis, Gerasimos Kondylatos, Dimitris Mavrouleas, Emmanouil Bardanis, Omri Bronstein Publication Date: 24/5/2023 Journal: Royal Society Open Science Adam Neira World Peace 2050 Founded April 2000 Paris, Jerusalem

Excited to go back next time and see the booths we missed this time around!

19:12 pretty sure she eats more then seaweed.

only problem is the younger palama's that hang out on the beach and surf (badly) are complete assholes.

Well done. Keep up the outreach. Letʻs hope DOH is listening.

Very glad that Nainoa helped get this Wa'a to safe shores during the disaster at Lahaina.

Note: As of 2023, tsunami maps are no longer published in Hawaiʻi phone books. Please see www.honolulu.gov/tsunamievac for current Hawaiʻi tsunami evacuation maps.

Note: As of 2023, tsunami maps are no longer published in Hawaiʻi phone books. Please see www.honolulu.gov/tsunamievac for current Hawaiʻi tsunami evacuation maps.

Note: As of 2023, tsunami maps are no longer published in Hawaiʻi phone books. Please see www.honolulu.gov/tsunamievac for current Hawaiʻi tsunami evacuation maps.

❤❤❤❤❤

👍👍👍

😀 *PromoSM*

Be very thankfull, and don’t forget, that there was a man, who could give navigation without instruments back to the islands of the pacific. He was a true legend from Satawal. We all know who he was. RIP Papa Mao.

Great work!! Thanks for share. Keep going 💪🏿🔥

Is there any videos that show a person how to set up this up step by step in my back yard?

More in philiphines

Beautiful to restore the wetlands. The white man believes the wet lands should be filled in and drained to develop and make money. But true value is food water and fish and fowl. We once lived in harmony with the land. The white man brings his fake money, materialism , greed, dependency and destruction.

Don't built your house on sand. Matthew 7:24-27

Has it launched?

So incredible of your love and care for nature and uour history

I read somewhere, if you bag them up they get stressed and release their eggs as fast as within 10 seconds is that correct?

I don't like how they say Ga'i and Ga 'o...what's that mean

Should’ve put somebody who knows and can translate his native language so that he can give a better education and understand of what he’s doing

good day! Please tell me how you can write to this center?

Hi there, that beach cleaner where can we purchase one of those. I live in PAPUA NEW GUINEA.

Mahalo for your service 🤙

What a gorgeous canoe! The Hawaiian outrigger canoe I think is the most beautiful thing on the water. I helped make a few racing canoes in The Fiberglass Shop at 404 Piikoi back in the 70s. At the time we were making canoes from a mold taken off the Malia. And there's still plenty of those same canoes in Hilo Bay used by Outrigger Canoe clubs where I paddle today

Beautiful American Samoa 🇼🇸 culture .I visited Samoa islands 🏝 about one year. Greetings from beautiful Hawaii islands ⛵️ About 40 years living in Hawaiian islands 🏝

Thanks James Wharram

This is the best explanation I’ve ever seen on this topic. It also explains the escalating erosion further down the coast in front of Kaanapali Beach hotels. Thank you for this.

1 The Gospel of the Kingdom of Heavens always comes from Heaven through an angel while there is another gospel that comes from the abyss through pastoral school for God fills the heart while the devil fills the head. Remember how on April 24, 1993, the sound of his voice came into me and I fell dead. You see? It’s the devil that has instituted pastoral school. For, if I send someone to call my wife who is on a journey to the village, this messenger doesn’t have to receive any instruction from anyone. I am the only one who should tell him what to say to my wife and I know that she will believe him. [Ed: The congregation says, “Amen!”]. [Kc.2v3] 2 Let Satan and his children have pastoral schools, Bible institutes and the Internet, me and my house will stay with the prophetic revelation. [Ed: The congregation says: "Amen!"]. And after pastoral school, seminaries and theological degrees, when those hypocrites, sons of the devil stand in the pulpit, they say: "O God may I decrease and you speak through me." You see? It's a confusion! If you know that you can decrease for God to speak through you, so what did you go and look for in pastoral schools? 3 Pastoral school is nothing but a place where people go and learn techniques of psychological manipulation. You see? They study the reactions and behaviours of people. This is all that is called mysticism. And that's what they hide from people. [Kc.2v1-3] [Kc.57v8]

Stop studying us and go back to the caucus mountains. White people need to stay in their fckn place

2,000.00 per sand bag?? Hey Maui, I have a bridge I'd like to sell you!

I served as Director of the Palau Mariculture Demonstration Center (then Micronesian Mariculture Demonstration Center) in the early 1980s. During that time, my colleague and U. of Hawaii classmate Gerald Heslinga developed the mass rearing technology featured in this video. My job as Director was mostly to sit in the office building you see in the background writing grant proposals to various funding agencies and being ready to jump into dog-and-pony mode whenever the Palauan government decided to drop by with a limousine full of foreign investors. Fun times.