ADVICE FOR PEOPLE WITH THE SYNDROME AND THEIR COMPANIONS!!!! IMPORTANT !!!!! In my experience, hospitals take pretty bad care of people with this syndrome. Having experienced it twice in hardcore version, once 11 days of vomiting, and once 3 weeks of severe nausea and pain with controlled vomiting, I have SOME VERY IMPORTANT ADVICE to help you get out of it as quickly as possible and limit vomiting: 1) Of course you need a GOOD HOT SHOWER. If possible, remove the night mode from the water heater to have hot water permanently, otherwise go to someone who has a good water heater, otherwise go to the hospital and make sure you have a room with a shower and hot enough water, with a good flow. Personally, at the worst of the crisis, I used 2000 to 3000L of water per day. Fortunately I have an instantaneous gas water heater so I didn't have a limit on the amount of hot water available, and my water comes from a source so I didn't have to pay for it. You have to be ready to pay a few euros to pay for your hot water and survive... 2) Baths also work but make it more difficult to manage body temperature, they can be enough in the light phases but showers will help you more surely at the worst of the crisis (one to two weeks each time for me). It is interesting to pass the water jet successively over several parts of the body: neck, head, stomach, legs, feet, arms, neck... 3) When you are not in the shower, OVERHEAT YOURSELF AS MUCH AS POSSIBLE: multiple sweaters, scarf, hat, slippers, heater, blanket, HOT WATER BOTTLE in short the whole lot, THE HOTTEST, THE BETTER. Personally, I spent a week with three sweaters, two pants, and a hat, sometimes even in the sun, in the middle of a 40° heatwave and it was necessary: ​​it stops the nausea from coming back too quickly, HEAT IS REALLY THE KEY TO GETTING OUT OF THIS...!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! 4) TO BE ABLE TO DRINK WITHOUT VOMITING and compensate for the sweating due to the heat that you need, only drink HOT WATER, because cold water triggers nausea and vomiting very quickly. It can be interesting to put a spoonful of sugar in each glass of hot water, to keep a little energy when you can no longer eat. 5) Eat what you can, slowly, when you can eat without vomiting. Personally, I managed to eat some fruit juices then fruit first, hot soup can be good too. This state, spent several days without eating, created irresistible cravings for certain foods when I started to feel a little better, I believe it is important to respect these desires of the body which will inform you of what you need. For sure, avoid coke, it restarted vomiting very quickly! 6) DO NOT FORCE YOURSELF TO VOMIT, to avoid entering a vicious circle, damaging the esophagus, and increasing the feeling of nausea. Only vomit when it comes on its own. DO NOT HESITATE TO DRINK HOT WATER BEFORE VOMITING TO AVOID VOMITING ONLY MARBLE. 7) TRY TO HAVE SOMEONE TRUSTED AND PATIENT, STOIC, AND NOT TOO SENSITIVE BY YOUR SIDE, to help you stock up, watch over you, and get you what you might need. Reassure this person by telling them that it will pass but that it may take a long time, and if they encourage you to go to the hospital, choose consciously but know that some hospitals will prevent you from having unlimited access to showers and hot water to drink, and thereby increase your nausea and vomiting. They have no treatment for this, apart from the ability to hydrate you, and to get you high. 8) Of course I AM NOT A DOCTOR and I am only giving my opinion based on my experience and I can in no way replace medical advice. 9) It seems to me that the hospital becomes interesting if you can no longer drink at all without vomiting, in which case an IV will be useful to avoid dehydration. 10) The state of discomfort due to nausea leads the hospital staff to consider you as mentally ill and so they will try to get you high as much as possible to calm you down. It has the advantage of allowing you to sleep (personally I had not slept for 1 week before the hospital), but it will not necessarily change much for the nausea. In addition, the hospital refused me showers, extra blankets, hot water... in short, almost everything I needed... Refuse the liquid Tertian, prefer it in tablet form if they want to destroy you..., the liquid hurts the stomach and restarts vomiting. If you have to go to the hospital despite everything because you vomit too much or you are dehydrated, try to have a relative bring you a kettle in secret so you can drink hot liquid instead of cold water, come with multiple blankets, clothes, hat, scarf, slippers, HOT WATER BOTTLE to be able to warm yourself better than what is offered to you. Try to hide your nervousness from the caregivers if you can to avoid them knocking you out too much, which would prevent you from taking the showers you need. Personally, I spent 10 days in the hospital during my first attack, with uninterrupted vomiting, and burning of the esophagus, I could not even drink a single drop of water, I left the hospital sick on the 10th day when I understood that only hot showers would cure me while they limited my access to a single shower taking me for a mental patient, I managed to cure myself by going to my family who let me shower and warm myself up to the point, cured in 24 hours. During the second crisis, I went to the hospital after a week, because my water source was drying up in the middle of a heatwave, I left the hospital sick on the 4th day when they transferred me to the addiction department in a room with a shower that was not hot, with a push button to press every 20 seconds, and very little flow. I finally returned to treat myself at home by reusing multiple times the same water captured in my bathtub, transferred to tanks, then reheated multiple times... The use of cpasaicine relieves a little but it is really not a miracle solution, at best a little support to help you warm up even more. 11) Stop smoking cannabis. Personally, I had vaped after my first hospitalization 13 years ago and it had not triggered the syndrome again. At the time I did not know that it was linked to cannabis. During my second crisis last summer I stopped because I don't want to relive a crisis of such intensity, nor make my family and myself suffer this worry, it was far too horrible. I also understood that a certain number of situations of pseudo indigestion of certain foods, were in fact micro crises that I did not suspect were linked to the consumption of cannabis, but which in fact resulted from it, also, quitting smoking can help you improve your digestive capacities in general. 12) Good luck, it will be better soon! "Quitting drugs is the easiest, after, on the other hand, there is life...." (Ken Loach)

What is the reference

Excellent presentation thank you

Chimeric receptors are very clever, but pretending that one type of T cell can be the silver bullet, it is a fraude.

CRS therapy 11:41 stage 4 17:02

please share the ppt if you dont mind

Hi just wanna ask. Is gentamicin has better outcome as synergy?

I am a PharmD student and aspiring clinical pharmacist. I found this very nice and informative presentation. I am also working on GCA presentation and case study. For my educational purpose, Can I get a copy of this presentation? It will be very helpful for me to understand more about GCA. Waiting for your reply. Thank you!

Very nice presentation, well done !

Very interesting! And what a professional disseminating all of this information.

You are doing a great job thanks a lot

Great presentation, Madeline Volk... not sure if your a fib guidelines reference is available to outside professionals (like me), if so would love a link.

7:00 AFFIRM trial (9:15 bottom line of AFFIRM) 9:49 EAST-AFNET trial (12:50 bottom line and limitations) 13:30 Rate vs Rhythm clinical decision making tool 14:30 Rate control. RACE trial. 15:35 Bottom line of RACE 15:59 Rate control agents 16:52 Digoxin 19:45 Knowledge check (answer is actually B) 22:00 Rhythm control 23:10 CAST trial 26:00 Choice of agents for rhythm control 30:40 Prevention of thromboembolism 31:00 CHADS2VASC and HASBLED