Amazing video! You successed to make me understand isotype switching which my textbook failed haha
@dimitrilyubarski7152 Жыл бұрын
Good video 👌
@avishvj Жыл бұрын
the body is wild
@Seenshadow Жыл бұрын
Summary/Transcribed: a. Initiated when C1 recognises a microbial surface directly or binds to antibodies already bound to a pathogen. b. Binding causes cross proteolysis and activation of C1r and C1s proteases -> Activated C1 c. Activated C1s cleaves C4 into C4a (acts as anaphylatoxin*) and C4b which covalently attaches to the surface of the pathogen. d. C2 coenzyme binds to C2b and is then cleaved by activated C1 releasing C2a, creating Protease C4bC2b** = C3 convertase e. C3 binds to C3 convertase and is then cleaved by it as well releasing another anaphylatoxin C3a while C3b binds covalently to Pathogen surface and associate with C4bC2b forming C4bC2bC3b = C3/C5 convertase f. Many molecules of C3 can be cleaved by C3/C5 convertase releasing many molecules of C3a and C3b (binds to surface of pathogen inducing phagocytosis). g. C3/C5 convertase also cleaves and activates C5 releasing C5a (potent anaphylatoxin and most important chemoattractant) and C5b which then acts to form the initiation of formation of the membrane attack complex (MAC). h. C5b (not membrane associated) assembles with C6 and C7 (membrane associated) and insert themselves in bacterial membrane i. C8 binds to C5bC6C7 complex and inserts as well into cell membrane forming C5bC6C7C8 complex j. Complex catalyses assembly of many C9 molecules creating cylindrical pore k. Pore disrupts cell balances and kills cell. *Play a role in inflammation, chemotaxis, and the activation of immune cells. **New nomenclature.
@-BhadoriyaMohitSinghN2 жыл бұрын
Best video on KZbin for Immunosupressent concept 👌 👏 🙌
@sambarnett54132 жыл бұрын
Thanks for helping me pass MICRB410!
@elmatrababdelmottalib34872 жыл бұрын
thanks
@azidei42 жыл бұрын
MIGUEL ÚTERO LENDÁRIO🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥 ESSE ÚTERO É FOGO, PARECE O DA MINHA PRIMA🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥
@adamgamelover85112 жыл бұрын
so what happens after the signalisation ?
@OficialThiagoVieira2 жыл бұрын
Bem ilustrativo
@dabratory98012 жыл бұрын
what genes do it activate what happens to the T cell
@sousouyes56772 жыл бұрын
Thank you very much
@tandeyi60802 жыл бұрын
Abcisic acid
@milagrosferreyra34822 жыл бұрын
Tienen esto video en español?
@gabrielamaciel67882 жыл бұрын
Vídeo incrível, didática excelente. Facilita muito a compreensão desse tema que não é trivial. Obrigada
@svithmkk20752 жыл бұрын
why did i apply to this major
@garrendavis94972 жыл бұрын
So much better than a lot of the other videos on this topic. I wish this was top recommended when I first searched vdj recombination.
@somibenam92803 жыл бұрын
amazing 😮😮😮😮😮
@legesseeshetu82653 жыл бұрын
Thank you
@reportrakantroll37553 жыл бұрын
no habla ingles
@Seenshadow Жыл бұрын
Hablo un pocito espanol
@Imunologiatododia3 жыл бұрын
Awesome
@simonesalvati57853 жыл бұрын
Nice video. just a thing: Ca++ doesn't come from external membrane but from IP3R in endoplasmatic reticulum;
@arsildarouiche8923 жыл бұрын
perfect, simple explanation thanks
@angelaperschau64383 жыл бұрын
Great video, this cleared up my questions in A&P. THANK YOU
@leonardoruggeri91543 жыл бұрын
Clear, simple complete. Thanks
@cristinamichaels33243 жыл бұрын
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@hafizfayyaz73623 жыл бұрын
owesome!!
@camerynboggio-shean42623 жыл бұрын
thank you so much, that made everything so clear
@sumaira39964 жыл бұрын
😍😍😍
@YouGenom4 жыл бұрын
Where is the video from?
@PhuongHoang-qc9hj4 жыл бұрын
Sir, can you share me all videos of "Janeway's Immunologybiology" book ? Thanks so much !
@Hizabrelshara4 жыл бұрын
There is no God but Allah
@mustafaal-ghezi17573 жыл бұрын
what does that have to do with TCR signaling?
@Manuzoka19963 жыл бұрын
@@mustafaal-ghezi1757 The religion of "peace", I mean, war and death.
@osamaaldweik2 жыл бұрын
@@mustafaal-ghezi1757 god created you and TCR signaling.
@Isla-bn3wk4 жыл бұрын
I finally understand thank God
@christopherchen69374 жыл бұрын
Very very helpful, thanks!!!
@DrivingABC4 жыл бұрын
Well explained! great job!
@sophieszedlacsek93434 жыл бұрын
Amazing Video! The animation is super helpful for understanding this fundamental immunology mechanism!
@ambar92324 жыл бұрын
Where is 6.2
@ambar92324 жыл бұрын
Where is 6.2 video
@Almindor4 жыл бұрын
You could say that his was a PYCARD maneuver :D
@lucilaalvarez40955 жыл бұрын
Ohhh my God thank u! Lol now I understand better 🙏
@knzay5 жыл бұрын
thank you queen!
@esan120au5 жыл бұрын
Best video on youtube for this topic. thanks
@act_pvt5 жыл бұрын
Thanks for d video.. this helped me a lot
@goksuavar48095 жыл бұрын
00:58 Better war scene than The War of Winterfell.