Been completely mystified by the teaching I've had on this & you've really cleared it up, thank you :)

The Controlled Substances Act liberalized our drug laws and made them more humane. Prior to that we had the Boggs Act of 1952. Before Nixon, a first offense marijuana possession carried a minimum sentence of 2-10 years with a fine of up to $20,000. CSA also allowed for the first time states to write their own drug policies under the Uniform Controlled Substances Act leaving federal law up to interpretation. This led up to 11 states during the 1970s to decriminalize marijuana including a handful of red states. Nixon's CSA also created the Methadone Maintenance Program which built the first Methadone clinics across the country. Democrats in Congress funded and pushed for the publication of the Martinson Report in 1975. This showed that the rehabilitative model was putting too much power into the hands of judges. The consequence of not enforcing drug laws in only certain cases was an environment that opened the door for racial profiling. It was argued that whites were getting far less severe drug sentences in America’s courts than black Americans. Ted Kennedy was opposed to the CSA because he as an uber-liberal, in essence, did not believe in the rehabilitative model of drug sentencing and voted to bring back mandatory minimums in the Sentencing Reform Act of 1984 which received bipartisan support. It is unfortunate that from 1980 to 1987, federal support for drug and alcohol treatment services dropped by more than 40 percent under Ronald Reagan, which was the entire point of the original Controlled Substances Act. States have now returned to the rehabilitative model of sentencing and the country has gone 180 degrees again. The history often gets confused as the laws have changed so many times. Thanks for listening to my short speech.

The sound issues are extremely problematic! I can't focus on the content at all and kept checking my phone for notifications. It's using up all my focus and energy!

This is amazing, thank you so much for this!!!

Ritalin doesn't cause pupil dilation...why??

Thank you so much!!

Some good information

wonderful work

I know this series is older but it just helped me study for my Physio Psych Final in a little under 4 days. Thank you for finally making physiology understandable!!

Drugs kill person that use and start with the brain

Good video

Those are illegal but doctors prescribed to people

Some good information

Drug will kill person

Good information but the audio is not that good drug don’t make you crazy like to be danger to others drug to tell you go in the car and hit the wall come on be real

Sort your audio out bro 😂bloody hell man

thank you so much can I download the ppt?

Better volume.., thanks 1:47

Volume sucks 2:05

Loving all of these lectures!

What he had for himself!!

I nearly died last night in hospital from not a huge amount of speed. I've done it for years and never had a bad reaction. Now I've damaged my heart and they said I very nearly had a heart attack. They said if I had any more I could've very possibly died. I'm 21. Please be careful guys you don't realise how easy it is until it happens to you.

Great talk: please, please re-record without cough or edit it out and repost!

Please

Great talk but: Please, please consider re-recording when you don’t have a cough. It’s phenomenally distracting. Maybe you could edit out the coughing and repost

The opponent process theory is wrong. You say that the afterimage of red is green, and for green it's red. But that's not true. The afterimage of red is cyan, and for green it's magenta. This proves this and some other assumptions of the opponent process theory wrong.

Imagine themat u can control someone's sexual behavior remotley

A homie died huffing Freon. Inhalants are no joke

watching this for part of my learning at #CDICcollege 2024 #addictionsandcommunitysupport

Superb lecture

Where can we find the PowerPoint slides? I want to see the pdf outside of KZbin and analyze it

You mentioned that In regards to Suboxone the buprenorphine is responsible for controlling the withdrawal symptom, while the naloxone is responsible for suboxone's blocking effects. This is not accurate, the buprenorphine is responsible for all of the effects in Suboxone, and the naloxone is basically inert. The reason for this is because buprenorphine has a far greater binding affinity at the opioid receptors compared to naloxone. Because of this none of the naloxone is able to reach the receptors as they are already saturated by the buprenorphine. So it is buprenorphine and buprenorphine alone that is responsible for the blocking effects of suboxone and why Subutex and other mono formula versions are still effective. It's also a big misconception that the naloxone contained in the Suboxone will throw users into precipitated withdrawal or have blocking effects if they were to try and abuse suboxone via injecting or insufflation. This too is inaccurate and for the exact same reason, buprenorphine simply has far too high of a binding affinity for naloxone to push past it especially in the dose ratios contained inside Suboxone. In 99% of cases the effects of Suboxone and subutex are exactly the same no matter what the route of administration is. These misconceptions were started when Suboxone was released as they used the naloxone and these "myths" regarding it to make their product stand out from the rest helping it get faster approval from the FDA. While at the same time utilizing it as a marketing strategy to both medical providers and patients, setting suboxone aside from the rest of the bupe medications this boosting their sales. In reality the naloxone provides no benefits whatsoever to the medication. It is important for this misconception to be clarified especially amongst medical professionals because there are times that Subutex can be a much better form of treatment. For example naloxone Even when it is not active at the opioid receptors can still cause negative side effects to some people who are allergic or don't tolerate it well, like a migraines for example that is one very common side effect of Suboxone and it is due to the naloxone it contains. Also Subutex tends to be a much cheaper alternative which is beneficial for many people suffering from OUD. Yet many doctors are unwilling to prescribe it due to this very common misconception started by the creators of Suboxone. this is one of many misconceptions surrounding addiction in general, and one that definitely needs to be clarified and corrected because many people are negatively impacted due to the ignorance of their providers.

Is there a chance someone could expand on how vasoconstriction contributes to debilitating physiological effects in MethA use?

very informative. thank you!

I have some questions about the csa.

I know this lecture playlist is old, but some of my better memories during 2020 were listening to these, so I hope Paul keeps this set uploaded.

i love u

I just found this channel and im very thankful!!

I'm "going" twice 😁 bc I'm listening further, as I write and I WANT to again say THANK YOU IMMENSELY for this!!! What your explaining this second half is exactly the kind of information I was looking for but doubted I'd get. I thought it'd be too difficult to put into words since it's abstract. AWESOME and PRICELESS information here!!!

Yes, very interesting and PUZZLING indeed. Pretty difficult to fully understand from their perspective. My poor kitty is actually experiencing this after a stroke. So I thank you VERY much for sharing your education with us.... especially since it's not at all straightforward in understanding. This is great in helping us understand their world a bit better so we can hopefully assist them better.

I want some

Some of this is bogus, nobody puts mushrooms on their pizza, bevause the ovens heat will degrade the sensitive tryptamine molecules. And it's also not a lipophilic compound it's soluble in water and ethanol. More stable in ethanol solution though. In fact there is a procedure called "lemon-tek" where people soak the mushrooms in a tiny bit of lemon juice, to acidify and extract the psilocybin and psilocin as well as partially convert the psilocybin to psilocin, and causes a faster onset and overall more compressed pharmacokinetics. Cooking with lipids is for THC! I don't mean to barge in and start being professor over here, but this is my niche, and my BS meter went crazy. I don't blame you tho just your source. My sister got a minor in addiction and recovery studies at A&M and their curriculum had a lot of straight up misinformation that seemed straight out of the Reagan Era. I study pharmacology, so we often got into fights about things like thisb 😂

Your information about the potency of cannabis is extremely outdated. 99% of the available cannabis that isn't brick weed is gonna be at LEAST 10% at MINIMUM and often 12-15% or even 20%. Some strains can be as high as 25% THC. In this day and age (and even 4 years ago) it would be a challenge to find cannabis that low potency. Also Your slide said indica has more thc than sativa but this is not true. They can both have wildly different contents.

Airplane bottles are usually 50mL rather than 2oz or 1oz.

@13:45-14:00 you put Antabuse in the substitute category. Antabuse is not an alcohol substitute nor is it even psychoactive. It inhibits Acetaldehyde dehydrogenase, causing a buildup of Acetaldehyde which is extremely unpleasant, and is supposed to cause aversion to alcohol. Can be dangerous though. Either way it's not a substitute! Acamprosate however is somewhat closer to a substitute in that it has effect on GABA and NMDA like alcohol and therefore works with the same receptors.

This was a great watch on ketamine! 🤣

Sometime older is better

If cannabis was a gateway drug as many many many of our politicians have spouted for years, I would be dead.

thank you so much for this playlist✨

👍