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What happens when this treatment fails and what other treatments are available besides chemotherapy or radiation

🎯 Key points for quick navigation: 00:00 *🧬 Introduction to Prostate Cancer Immunotherapy* - Discussion of commonality and challenges of prostate cancer. - Introduction to immune cells that can hinder or help in fighting cancer. 02:15 *🛡️ Approaches in Immunotherapy for Prostate Cancer* - Presenting two classes of immunotherapy: stimulating existing killer cells versus reprogramming them. - Various treatment examples, including checkpoints, cytokine therapies, and vaccines like sipuleucel-T (Provenge). 06:43 *🚀 FDA-approved Treatments and Mechanisms* - Explanation of FDA-approved treatment sipuleucel-T and its application. - Differentiation between sipuleucel-T and other approaches in clinical trials, such as CAR T cells and bispecific antibodies. 11:04 *🔍 Challenges of Checkpoint Therapies in Prostate Cancer* - Factors casting off the efficacy of checkpoint blockade in prostate cancer treatment. - Tackling multiple suppressive mechanisms with new combined treatment approaches. 14:57 *🧪 Ongoing Clinical Trials and Future Directions* - Ongoing trials for both watchful waiting and aggressive cases. - Insight into day-to-day patient involvement in trials and potential trial outcomes. 20:21 *👥 Eligibility and Factors for Immunotherapy Trials* - Understanding criteria and age considerations for participating in immunotherapy trials. - Immunosenescence and its impact on immunotherapy outcomes and future research directions. 25:06 *⚖️ Hormone Therapy and Immunotherapy Compatibility* - Discussion on continuation of standard hormone treatments alongside immunotherapy. - Examples of additional treatment combinations in prostate cancer therapy. 27:10 *🧬 Combination Therapy Approaches* - Combining immunotherapy with hormonal therapy for prostate cancer, - Blocking androgens to enhance immune responses, - Coordinating treatments to improve outcomes. 28:16 *⚠️ Side Effects of Immunotherapies* - Minor side effects with Sipuleucel-T, - Checkpoint inhibitors can cause immune-related toxicities, - CAR T cells and bi-specifics involve cytokine release syndrome, requiring careful management. 30:34 *🔍 Monitoring Treatment Responses* - Patients may feel better without tumor shrinkage, - Cancer can be held in check without progression, - Different outcomes are assessed in clinical trials. 32:25 *🗣️ Guidance for Patients and Caregivers* - Understanding the aggressiveness of prostate cancer, - Tailoring treatments based on cancer behavior, - Importance of understanding and discussing various treatment options with physicians. Made with HARPA AI

Endro problems, have to take cortisol, but cancer free .

My side effect was low cortisol levels, I am on cortisol medication. Small price to pay.

Mi tio murio por culpa de la inmunoterapia, al mes de habersela puesto con el primer tratamiento!

Thank you so much for this ❤

y donde lo hacen

Thank you for trying this and paving the way for the rest of us!

@7:34 checkpoint blockers

@6:34

@6:05

P53?

Excelente médico

Thank you, doctor!

Porfavor denme información de como yegar a esta terapia po qie mi mama esta enferma en etapa terminal😢

Husband diagnosed with stage 4 sarcomatoid carcinoma of skin metastasis to left lung had 1st session of Libtayo immunotherapy.

Es buena la inmunoterapia para el carcinoma uroterial papilar

Very nice 👍.

Jesucristo dijo no lo que uno come o alimenta, hace daño o impuro el cuero, sino lo que sale de la boca, uno se va a la letrina pero lo otro se queda en el Alma, el cáncer es uno mismo matándose o tus propias células matandote, quiere decir que tiene que haber una terapia espiritual y psíquica, lenguistica que cada enfermo de cáncer tiene que sanar el Alma, sanar no lo que come o la medicina metódicamente ingeridas, sino aprender a perdonar, aprender a sumir la culpa y a perdonarse a si mismo, aprender a sanar su relación con Dios y pedir perdón a Dios, y pedir perdón a los que haya dañado, ofendido o defraudado, y perdonar a todo, no tener enemigos y aprender a amar y ayudar y dar su tiempo a los que no tienen oportunidades, y vas a ver cómo el cáncer no solo desacelerar, sino empieza a recobrar la salud y el sistema inmunológico y le cambio el rostro de amargura, tristeza, depresivo y empieza un rostro de verdadera felicidad no una forzada o inventada sino una que fluya desde adentro como ríos de agua viva..

May please have your opinion on the role of prebiotics in preventing cancer.

I was diagnosed with stage 4 melanoma 2 weeks ago. my immunotherapy starts on Monday. Thank you for your story.

Wonderful presentation and explained this complex topic so well. Thank you, Dr Chen and Dr Brodsky!

Por chismosos como ustedes hay mucha gente que pierde la vida por una enfermedad tan delicada como el cáncer y acuden a porquerías sin ningun sustento científico, las venden como producto milagro!!! Pero quien la promociona no es ningun médico , entonces como le vas a dar un producto de dudosa procedencia a un enfermo, ridículos charlatanes.

Soy de Colombia y quiero comparir mi experiencia con las inmunoterapias. En 2019 a mi mamá le diagnosticaron cáncer de pulmón cuando ya le había hecho metástasis. Al inicio fue terrible porque las radioterapias y las quimioterapias son muy fuertes, además de que tuvieron que hacerle un injerto de titanio en el femur izquierdo y perdió parte de su movilidad. Más o menos al año le comenzaron su tratamiento con inmunoterapias y me contaba que sentía menos fuerte los efectos secundarios o que simplemente no le daban y que a los pocos días sentía cómo sus fuerzas se iban recuperando, aunque la verdad es que esta enfermedad es un tobogan con muchas subidas y bajadas. Hoy ya llevamos cinco años en este tratamiento y los nodulos que tenía en su cuerpo han desaparecido casi todos (incluso los del cerebro), el cáncer está controlado de momento y hoy precisamente el oncólogo le suspendió las inmunoterapias hasta nueva orden porque consideró que su recuperación va por buen camino. No quiero decir que la inmunoterapia sea la solución para todos los pacientes de cáncer porque sé que cada organismo reaciona de una forma distintan y tampo insinuo que fue algo fácil, más bien ha sido una combinación de especialistas con mucha experiencia que abordaron su caso correctamente, su actitud ante la vida y las adversidades, su experiencia como enfermera de toda la vida y que siguió al pie de la letra todas las indicaciones médicas. Ojalá y la ciencia siga avanazando en este tipo de tratamientos para ayudar a tantas y tantas personas que lo requieren.

Hi what is survival chances of squamous cell carcinoma developed mestastic oral cancer started to affect lungs how can we save from spreading to lungs?

Wonderful testimony 🎉

My stage 4 pancreate cancer with mets to the liver has been brought to No Evidence of Disease using intratumoral immunotherpy, injecting the tumor directly with immunotherapy, inhibators and immune system enhancements. I did this at the Williams Cancer Institute. They also have evidence that using Rebyota helps many people. So you need combinations of therapies.

Actually keytruda can work. I had stage 4 pancreatic cancer with mets to the liver. I did intratumoral immunotherapy at the Williams Cancer Institute. Now I have been cancer free over 16 months and counting. Injecting the tumor with immunotherapy and inhibitors can work and it needs researching. I am happy to talk with anyone and with researchers. No one is funding this because it's a procedure not a drug. No ROI for a procedure. It does require a doctor and an operation room so in the short term it's more expensive than a nurse and a chair. But in the long run would cost less than conventional treatment.

Hola... es seguro utiiizarlo durante quimioterapia?

My ex husband gets hiccups and stinging in his leg varicose leg veins. He is on his first round of immunotherapy/chemo treatment.

Pancreatic cancer?

Can breast cancer her + er/pr treated with immunotherapy?

i was diagnosed with breast melanoma stage 4 last year oct i went thru immunotherapy updevo n ipilimomab but after two doses of ipi i got severe side effects so my doctor stopped ipi n continued updivo good news that my tumour is completely gone..my medicine will continue for two years

Excellent! My late husband was diagnosed in 2000 with non small cell lung cancer and managed to live 21 years with the use of conventional treatment (chemo, surgery, radiation). I had pushed for immunotherapy but our doctors said it was not available to him. I often wonder if I had fought harder for him to get the doctors to agree to immunotherapy what outcome we would have had. He died actually as a result of all of the treatments…they really damaged his body. He was cancer free at death. 😢

I’m 😅😅😅😅😅😅😊😅😅😅😅😅😅😅😅😅

This was a wonderful conversation. I too hope that immunotheraphy will someday soon become the first line of treatment. Thank you for producing and sharing the video.

I think there is an innate immune response much quicker than this adaptive immune response on viruses. Also, the invaded epithelial cells are already damaged, and the burst should be including millions of viruses. Adaptive immune response against viruses like SARS Cov-II are too slow too reactive. Innate immune cells are the only quick helpers against viruses, in my opinion.

🫶👏👏

👍💯💪😀

My son Had a similar journey . Stage 4 terminal cancer in 2018 he was given 2 to 5 years max .A team of extraordinary doctors offered a plan that he is still on . Since then he met a wonderful woman, got married and enjoy life .GOD bless those wonderful researchers .

18:07 18:08 18:45 19:25 19:59

9:21 😢

Jill, you're such a wonderful and passionate leader. Thank you for your life's work.

So how come they are not using this more? The first thing they offer is chemo, this is a shame. Is it stil only in trial phase?

Sean, you've come a long way since that day in 2020 at the StoneWater Golf Club. I'm so proud of the man you've become. I'm so impressed that you're sharing your experience and offering hope to other glioma patients. LuvG

When you say high-grade glioma, do you mean GBM or Something ?

Is Mutiple Myeloma treated with immunotherapy ?

ابلغ لك سلامي الخار داعيا من الله لك الصحة و العافية ولكل افراد اسرتك هنيءا لك