you are most welcome

Thank you!

Such a nice compliment! Thank you and glad to have helped.

Azide anion can form a toxic gas (HN3) if in the presence of acid. Benzyl azide is not azide anion, and it does not pose the HN3 safety risk.

Glad you found it helpful!

Ha, ha, thanks! Glad it was helpful! :)

It depends on the calculation. Some mixed operations end up being limited by the multiplication/division part of the calculation, while others are limited by the addition/subtraction piece. Unfortunately, there isn't one rule you can apply to mixed operations, which is why they are the most difficult for sig figs!

The data in the video are from an application called Spartan. It is not free. There is a package called MOPAC (openmopac.net/) that I believe is free to use, though I have not used it since I was in grad school. At that time, MOPAC calculations were performed on a mainframe. Now any desktop computer can handle the operations.

@@ChemHelpASAP Thank you! ✌

So glad it helped!

So you just have an alkyne and NH3?

@@ogbenchmarks7127 sorry I miss, allylborane react with aldehyde and NH3

@@notl4ch188 This sounds like some old Petasis chemistry - a boron Mannich. The aldehyde and ammonia form an iminium ion, and the iminium ion is attacked by the R-group on the boron.

@@ogbenchmarks7127 it would be better if we went to another messenger and I would show the photo with this reaction

Cause there are two compound have other functional group

Wonderful!! Best of luck to you in your studies.

Resmetirom is approved for NASH, not NAFLD. It might help on NAFLD, but the drug's efficacy was measured on steatohepatitis.

Wonderful! I hope they help.

I am definitely not an expert on docking, but I do know that the most commonly used free molecular database is zinc (zinc.docking.org/). The Zinc database is specifically curated for searching and downloading in a form that can be readily imported into docking software. For full disclosure, I have never imported compounds from the Zinc database. When I have done modeling and docking, I have mostly modified ligands that are already bound in a protein (i.e., modified a PDB cocrystal structure).

Thank you for watching, and I'm glad the video was helpful for you.

poor georgie!

I am sure that somebody has tried to generate the alkyl azide in situ, but I haven't seen it. I am a bit wary of forming different metal-azide salts, which doesn't happen if you pre-form the alkyl azide.

Bare hyggelig

That negative charge is the formal charge on the carbon atom - the carbon atom that bears the lone pair. Keep in mind that the carbon also has a C-H bond (not shown), so the carbon has three bonds (one to the carbon chain, one to oxygen, one to hydrogen) and a lone pair. That gives it a formal charge of -1.