Fascinating! AI gets a bad wrap, but there are so many synergies to be gained through this. I’d prefer AI to review my MRIs instead of a Dr which in my experience can be discretionary.

Everything must be anxiety with women. This stereotype is why women are misdiagnosed and dismissed.

Very interesting!

Btw it hasn't been easy

Hi from nyc. Ppms 35+ yrs. I am 75+f. What do you do? Nothing can be done. Had few mri( maybe 3 total) never had lp. Use a rollator, still drive. Ted my case in mild to moderate category. But major bladder, walking difficulties. Rarely see neurology, last one said, see you in a year.

As a data scientist myself - I think you may need two techniques for each issue 1) lesions 2) atrophy. I think for the lesions a model could be trained on image recognition using a YOLOv5 setup. Lesions are classified and identified. Overlapping the found regions between time series would give you an idea of as to whether new places appear. For brain atrophy I think an image segmentation technique may be useful. Each "slice" of the brain could be segmented into "white matter" and the outer skull. Finding the volume or area of white matter with the image and subtracting that from the area of the skull would give an idea of the area within that space. A cumulative addition of all slices and a normalization step may give you an idea of the % volume. Comparing vertical / horizontal slices would improve the accuracy. Normalization step may be required as I have noticed some images from the scans aren't exported in the same format so we need a relative % measurement. Comparing these in time series may give an idea of volume changes. It has always bugged me as to why this isn't done as standard with MS. All of this has given me some ideas xD I may have to look into it myself and play around with my own scans :) Very interesting topic and video thank you! :D

For me WAY B4 an uncomfortable lumbar puncture & a neurology diagnosis; my best friend's mother a nurse at the time delivered those very words "IT COULD BE MS!" as did my 1st Neurologist & I was devastated as I'd heard nothing good about such a diagnosis. As the late Richard Pryor called it MORE 💩 that's EXACTLY what it is. So after returning to complete my degree carrying my 2nd son I did what I ALWAYS dreamed of doing, to DJ which paid for me to play abroad with my husband carrying my record bag experiencing Warsaw Poland briefly, invited to return but I declined due to MS progression to chronic! 🫣🫠

That could be my story! From initial symptoms, to diagnosis, to the rate of progression. I hate that I can relate so well.

Dos swollen blood vessels in Brain come to MS.

AI can be a great tool for data analysis and scans are data. This will hopefully speed up analysis, highlighting areas for a neuro-radiologist to focus on. As patients, we still need human interaction.

What exercises are you doing for your knees?

Looking forward to seeing what happens!

YES. STEM CELLS ARE WHAT I NEEED.! VIVIEN GRAY!

Good luck

You tease!

Here for the journey. 👍

Good going and the best of luck. I'm a big Iron Maiden can and their former drummer suffered from MS. God Bless and keep that attitude up!

Brilliant. Knee health and strength in those muscles is essential to staying on your feet and walking. I miss being able to walk. I wish I'd looked harder for an exercise form I liked. Enjoy. I hope you get the dopamine rush.

Stay healthy, life is beautiful ❤

The sound is perfect now!!🤗

Thanks for this incredibly interesting video! I'm consuming all the aHSCT content I can find as I've just been approved by the MDT for aHSCT treatment. My Relapsing/Remitting MS is aggressive enough that I have failed only two years after Lemtrada(Campath) treatment. It was a bit of a slap in the face to find out I'd no longer be suitable for Lemtrada treatment, but I am also excited and scared in equal measure about having the HSCT. On a sidenote, my partner and I are probably going to vlog the experience in a warts-n-all fashion, so anyone in a similar position can get an idea of what the process is like in late 2024. I think it would be nice to get a fix on how impactful it is (or isn't) for a partner.

Thank you for the video Dominic, very inspirational and I wish I had known about you when I was diagnosed 7 years ago because I would have started on a stronger medication.

How much like it get i liked com and vid?

You never interview ugly people.

So did this end up working?

❤ Great

What a bunch of crap, there’ve been saying this same stuff for years and still no cure, we’re all screwed

I started using a cane for my mysterious chronic joint pain and it’s helped a lot, but i’m still struggling in a lot of ways. I’ve been thinking about a wheelchair for very bad days, but i still have that lingering “oh it’s not bad enough for that, I don’t need it” guilt

Thanks

Old tweaker

Thanks for your upload. Only problem is when you seek out a different doctor then you're accused of Doctor shopping. Even though technically that's what it is, your viewed in a very poor light such as a drug seeking individual and looking for a doctor who will prescribe anything that a patient suggests that could help. My trust in the medical field is that an all-time low because the government keeps them from prescribing the things that patients with a diagnosis absolutely do need but are forced suffer it's the government. And Trust me, the way a majority of the medical field has been treating patients who are not drug addicts as if they are and can simply exercise, or practice mindfulness all of those things that yes do work, to some degree and are healthy practices to compliment the medications that some people really need for quality of life. I feel as if doctor knows best attitude will continue to be the narrative. Please understand that I am not saying all doctors are like that but in recent times, they are a rare find. I am in the US. Your accent tells me you might be in Europe. I know the Healthcare System is better there than here. Ty. Blessings.

In 2008 when I was diagnosed at 28 years of age, I was offered Capaxone, and you know what, I said NO thank you, but I’ll stick to a healthy diet, exercise, and low carbs and it worked. But then in 2021, I had a massive relapse and I have never been the same 😔😪… damn MS, managed to catch up with me in the end 😂😂😂

How are you feeling now 2 years on being on Kesimpta? Any joint pain? Thank you

Is it safe to take with an SSRI

How you feel after you recommended are they helo you for pain in the pelvis too

Another helpful video - thank you 🙂👍 Who’s that explaining?

Best of luck - I hope it works

My previous comment disappeared. I took the 50%. Betted on DMF when the other choice was a 50% chance of thyroid issues with Lemtrada. So far the gamble has paid off. But if I could switch to Cladribine I would.

I hate that people are put off DMF by the side effects. The very manageable side effects.

I took the 50% (DMF). Vs Lemtrada which had a 50% chance of acquiring a new condition (thyroid issues). So far the gamble has paid off. But if I could switch to Cladribine I would.

The first time I had Covid they sent Paxlovid via a courier on the same day (5pm, no point sending it earlier as I had to wait until dinner to take it anyway). The second time I had to walk 45 minutes to the only pharmacy in the borough that stocked it. And 45 minutes back.

Way too many commercials on this video.

Thank you for this advise. Glad that you're feeling better.

Wish you a speedy recovery! My first covid did a number on me, triggered horrible worsening that I never recovered from. Took my EDSS from 1 to 4 within 2 years. No one in the medical system took me seriously, nor the fact that I had been using Ocrevus for 4 years at the time. Only when my fever went to 40 deegres C, I was given some antibiotics. As for my second covid, I went straight to pulmologist and did chest x-ray. Paid for it of course in private practice, because I have no faith anymore in Bosnian health care system (not after massive failure with my first covid treatment anyway). Paxlovid is not available in Bosnia, but you can get it in Croatia for a nice price of 980 euro. I've just googled it. I hope that you will get well and that covid will not give you any worsenings... Take care

Are this new discoveries planning to repair old damages/lesions ? or only acute one :'(

Found it! Thanks Dom. I'm preparing to onboatd to Mavenclad after several years of Mayzent (with no complaints)

Fantastic information THANK YOU! I hope your much better soon !! unfortunately I had Covid in April not long after my infusion. 😣 I felt so ill, thought my head was going to explode but didn’t think about covid until I had a rash appear all over my legs, 🙄 probably because I hadn’t really been anywhere, but family then did say you probably picked it up in the hospital. I didn’t know about antivirals & seemed to be over the worst of it by the time I took the test & the rash had appeared, but it’s not something I wish to have again!! Any signs and I’ll definitely be phoning, I wish there was something easier in place though - the last thing you feel like doing when so ill is phoning your MS nurse, GP, 111 , pharmacist… it’s crazy but hopefully things will get easier for us? Best wishes 🫂

Thank you !! I'm sooo scared and obsessed about avoiding people wearing covid masks and cleaning my hands. I've been wondering with this antiviral was that efficient. Well thank you this is a good news. And bad to hear that you had to be thaaat patient and that insistant ! ( I live in France, it would have been way easier ) Take care

I'm not sure your experience is things working very well! I've had Covid twice now. Both times I called 111. The first time I had a callback very quickly from my hospital trust's Covid Medical Unit and by 5PM on the day after the evening I tested positive the courier delivered the drugs. That was in November 2022. Then I tested positive again in December 2023. I was all dressed ready to run to work but I had a slightly scratchy throat so thought I had better test first. I was shocked to see a very faint second line (so faint it didn't even show up in a photo, but it was undeniably there). I called 111 again around 8AM. Again I had a call back from a clinician really quickly and was prescribed Paxlovid with no issues. She also told me to take manuka honey, I told her as a New Zealander I already had a mug of hot manuka and lemon in my other hand. The difference this time was they said the medicine wasn't coming from the hospital any more and I would have to collect it from the pharmacy. There is only one pharmacy per London borough that dispenses Paxlovid and the one I needed to go to was a 45 minute walk away on the other side of the borough. I am one of the 66% of local residents who do not have a car. There was no way I was going to get on a bus with Covid. But remember I was dressed to run and feeling quite good? My good friend N is an EM consultant and said quite firmly DON'T run Sarah. So I streeeetched out that walk, enjoying my last time outside for the next 5 days. It was a route I use often when I run, through as many parks as possible. I got home and logged in to work around 11am. I still had to wait until evening before taking my first dose. I'm not sure how I feel about this approach. Like I said most people don't have cars. I'm going to assume most people with Covid also don't feel as good as I did that day. So the whole one pharmacy per borough thing makes the antivirals really hard to access, though it was easy and fun for me as I was marathon training at the time. I have no idea how someone with limited mobility would get there and back. Also financially, I live in a very poor area and because Paxlovid is two drugs I had to pay two prescription charges. The pharmacist said if it was sent by the hospital there was no charge but there is a charge when you collect from a pharmacy. So you were lucky your hospital sent the drugs, though I'm surprised you had to wait until the next day, as you need to start it as soon as possible after your symptoms start for it to be effective. I have no idea if my symptoms would have got worse if I hadn't started Paxlovid the same day. I felt fine for my five days' isolation and just a little wheezy when I finally did go for that run. Incidentally, I hugged that doctor friend two weeks ago and she tested positive for Covid in the next few days. She spent a couple of days working from home but was then told to go in to work on what would have been Day 6, despite still testing positive and feeling rough. Sorry this turned into an essay! I hope the Paxlovid is doing the trick and you feel better quickly. It is magic stuff even though it makes everything taste so bad.

o hope u get well soon did anyone sleep then suddenly woke up as if they fell off something i just did body even moves on last second of my sleep im from the kingdom od saidi Arabs had ms since 2004 or 5 not sure im on gilenya