Thank you for a fantastic presentation! I look forward to reading your website and following your videos. Do you have a link to the study on DHEA extending the life of mice? I was always of two minds with DHEA - it seems to have many benefits and be high in youth, but also stimulates IGF-1 which seems very negative for aging, especially cancer. Thanks again
@jmitteld9 сағат бұрын
Thank you for the correction, Kleffbois -- I misspoke about DHEA in mice. "DHEA is essentially a human molecule." I recommend this article for a review of the benefits and risks of DHEA: link.springer.com/article/10.1007/s40265-014-0259-8 "In the elderly, DHEA exerts an immunomodulatory action, increasing the number of monocytes, T cells expressing T-cell receptor gamma/delta (TCRγδ) and natural killer (NK) cells. It improves physical and psychological well-being, muscle strength and bone density, and reduces body fat and age-related skin atrophy stimulating procollagen/sebum production."
@noobkiller100Күн бұрын
Very interesting
@chaelcanterbury87872 күн бұрын
Great video, keep it up. I prefer reading the detailed blog entries instead, but once in a while it's refreshing to get an umbrella "digest" that covers the state of the situation in a form of a more casual presentation.
@davidkatz28972 күн бұрын
Thank you for the video!
@carinaekstrom12 күн бұрын
I don't believe number 2 at all. The community is not served by individuals selfdestructing. If it was about balance it would be better to not be so fertile. No, it's just a fight against entropy. Nature would like to keep us alive forever if it could. It's doing its best. But humans can renovate a lot of things that nature can't, without creating any harmful side effects.
@jmitteldКүн бұрын
Hey Carina -- no fair telling me "I don't believe..." before you even listen to the video. If statement #2 was obvious, or if it followed easily from known evolutionary principles, why would anyone need this video? So yes, it's surprising, but please hear the evidence before you put out an opinion that it must be wrong.
@carinaekstrom1Күн бұрын
@@jmitteld I like the part about Mrna. For the main subject I see no evidence, nothing that can't be explained by normal wear and tear. What would the individual parts know about population regulation anyway, or why even want it? One man can have hundreds of offspring, and that would only be a positive for the species (as long as incest was avoided). Probably saved us from extinction a few times as well. Denis Noble also opposes the selfish gene theory, but does not have a population regulation idea attached to it. The fertility period in healthy humans is also being prolonged, as we live longer, healthier lives. Nature doesn't have to worry about depending on inbuilt systems to make us die, there's enough environmental causes of death. No one will ever be completely indestructable, but I'm sure we will find ways to stay young and healthy for as long as we are alive, and I agree that we should focus on systems that control major aging processes. I just don't agree on your reasoning why these systems exist. To me the systems´ functions are about where to prioritise a limited source of energy and repair. Anything systemic is usually more energy efficient.
@jmitteldКүн бұрын
@@carinaekstrom1 Have you listened to any of the evidence? How do you explain DAF2 and AGE1 and P66shc? How do you think about hormesis? Are semelparous organisms an exception? Why does epigenetic change consistently turn on self-destructive proteins like FSH and TGF beta late in life?
@carinaekstrom1Күн бұрын
@@jmitteld I listened to the video. Some things I have not heard about before, but the way you explain away the things I have heard about tells me that the rest is probably the same, which is nothing there. There were several things I wanted to comment on, including epigenetics and hormesis. But there's no space or sense in going into details about all this. I could see that you didn't want to consider other possibilities. An overview of evolution in general tells me that the Idea does not hold water.
@bob-ss4wx2 күн бұрын
Excellent presentation looking at the picture of aging. Hope you are faring well after your accident.
@jmitteld2 күн бұрын
For those who don't know me, I was hit by a speeding SUV in a head-on collision with my bicycle 3 years ago. The probability of survival in this case is nil. Miraculously, there was no damage to my brain, my spine, or any internal organs. I benefited from excellent surgeons, who saved my life and rebuilt my legs. In the interim, my body has performed miracles of its own. I'm swimming, hiking, and bicycling on a vigorous schedule. Today, I ran a 5K road race, a benefit for my neighborhood elementary school. I'm VERY SLOW, but grateful that I can run.
@joshlocher71Күн бұрын
@@jmitteld hi my name is josh what is this rejuvenation technology that is almost ready for human trials i am eager to know is it a pill a cream or injection what is it
@jmitteldКүн бұрын
@@joshlocher71 It's in the last few minutes of the video. I've also blogged about it here: joshmitteldorf.scienceblog.com/2024/05/27/robust-rejuvenation-with-exosomes/
@germainclaude65853 күн бұрын
thank you
@notlikely4468 Жыл бұрын
No.... Arousal and anxiety are not the same thing One of the great benefits of organized sport is that it teaches you to manage anxiety When you are in those starter blocks or called to the start line You are aroused On edge....but the consequences of failing to manage that arousal Allowing it to become anxiety Is....really nothing....a race lost But you learn Anxiety is dysfunctional The neurotic responses to relieve anxiety are dysfunctional Fibromyalgia Crohn's Lupus You can't control the stress in your life But you can manage it...control your reaction to that stress
@sebastianaguiarbrunemeier91922 жыл бұрын
Great idea!
@lifespanextensionresearch85182 жыл бұрын
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@sebastianaguiarbrunemeier91922 жыл бұрын
Nice presentation
@williamdias34563 жыл бұрын
Thanks for all your work and dedication , hope you recover completely soon .
@DrWhom3 жыл бұрын
You are nuts, Josh. Get a life.
@ortcloud993 жыл бұрын
survival of the fittest flushes out the weak genes, but you still need a short life cycle so you can have frequent new generations because evolution occurs at each new generation so you have flexibility to adapt to environmental changes quicker.
@MrStarchild30013 жыл бұрын
Excellent!
@leonniceday68074 жыл бұрын
Thank you! (just please try a more neutral voice tone next time; this one sounded sad to me)
@leonniceday68074 жыл бұрын
thank you
@laura-youtube14538 жыл бұрын
Very interesting....it reminds me of Leonard Hayflick (read the book many years ago) where he explains that cells have a limited number of replication cycles. The life of our cells comes to an end (except on those where the telomerase is active). So yes, it makes sense that, like in the case of a cell, certain genes are limiting our living time. I do have hope we can manipulate that in the future. Haven't read your book yet, but for sure I will. Thanks.
@arthurandrostylez26306 жыл бұрын
Even if telomerase (+reverse transcriptase) were active on regular cells, there is no 100% possibility that the genetic code would not break and create cancer cells. In other words: lenghting the telomeres does not mean the cell will divide successfully because of telomere lengthening. Who knows what kind of damage the DNA has already taken.
@DrWhom3 жыл бұрын
@@arthurandrostylez2630 Nonsense. The germ line is immortal. Somatic lines could be too, but they aren't, thank God.
@jmitteld8 жыл бұрын
Blog: JoshMitteldorf.ScienceBlog.com Read the preface of the book: scienceblog.com/484749/preface-cracking-aging-code-josh-mitteldorf-dorion-sagan/ Buy the book: amazon.com/Cracking-Aging-Code-Science-Old---/dp/1250061709