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Both healthy cells and cancer cells rely on oxidative phosphorylation (OxPhos) for survival and growth. Studies have shown that cancer cells derive around 50% of their energy from OxPhos.

Once approved, this vaccine can be made available globally.

Thank you for your comment

Anixa Biosciences is focusing on Triple Negative Breast Cancer but feel free to reach out to them for more info.

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Except Seyfried apparently is not aware that cancer cells not only use glucose and fructose as fuel sources, but also ketones, lactate, fatty acids and various amino acids. Since many of these are produced by the body, it is impossible to starve cancer cells. Furthermore, in addition to ketones being a fuel source for cancer cells, numerous studies have also shown that ketones promote cancer cell metastases by activating hyaluronidase and proteolytic enzymes needed for natural cancer metastases.

@@hveragerthi9642 Interesting, thank you. Can you share the research papers for my readings. Thank you.

@@andyc7747 What makes you think he is right? Because you are a gullible idiot who believes any KZbin video you see instead of doing some real research? I have been working in medicine and researching cancer over 45 years. Unlike Seyfried, I don't just make up bullshit, I do the research.

@@hveragerthi9642 thank you for this information. Can you point me to the studies so I can read more about this?

Seyfried is wrong again. All cancers are genetic as there are changes to the genetic code of the cells. They have never been proven to be hereditary though, which is not the same thing. Seyfried also needs to do some basic research on cancer such as cancer fuels. Cancer cells not only use glucose and fructose as fuel sources, but also ketones, lactate, fatty acids and various amino acids. Since many of these are produced by the body, it is impossible to starve cancer cells. Furthermore, in addition to ketones being a fuel source for cancer cells, numerous studies have also shown that ketones promote cancer cell metastases by activating hyaluronidase and proteolytic enzymes needed for natural cancer metastases.

This vaccine is currently in clinical trial for women who have had TNBC (Triple Negative Breast Cancer). For invasive lobular carcinoma (ILC), you may check with Anixa Biosciences.

@TargetCancer mine started as ER+ lobular cell and devolved to triple negative (lobular cell). It seems they're not mutually exclusive

The Anixa Biosciences vaccine is currently in Phase 1 of clinical trials. Stay updated on the latest developments by visiting their website.

A clinical trial was made with women who have had TNBC (Triple Negative Breast Cancer) with positive results.

What are the options for monitoring it then? A lot of women have mammograms and never get breast cancer. Wear a neck shield, also with dental xrays, to protect your thyroid

Many thanks for your comment! Have a great day ahead!

Cancer cells not only use glucose and fructose as fuel sources, but also ketones, lactate, fatty acids and various amino acids. Since many of these are produced by the body, it is impossible to starve cancer cells. Furthermore, in addition to ketones being a fuel source for cancer cells, numerous studies have also shown that ketones promote cancer cell metastases by activating hyaluronidase and proteolytic enzymes needed for natural cancer metastases. Ketones and lactate “fuel” tumor growth and metastasis www.ncbi.nlm.nih.gov/pmc/articles/PMC3047616/ "Ketones are a “super-fuel” for mitochondria, producing more energy than lactate and simultaneously decreasing oxygen consumption.15-17" "So, just as ketones are a “super-fuel” under conditions of ischemia in the heart and in the brain, they could fulfill a similar function during tumorigenesis, as the hypoxic tumor exceeds its blood supply. Stromal ketone production could obviate the need for tumor angiogenesis. Once ketones are produced and released from stromal cells, they could then be re-utilized by epithelial cancer cells, where they could directly enter the TCA cycle, just like lactate. In this sense, ketones are a more powerful mitochondrial fuel, as compared with lactate." "Similarly, acute fasting in rodent animal models is also sufficient to dramatically increase tumor growth.22 Both of these experimental conditions (diabetes and fasting/starvation) are known to be highly ketogenic and, thus, are consistent with our current hypothesis that ketone production fuels tumor growth. Finally, given our current findings that ketones increase tumor growth, cancer patients and their dieticians may want to re-consider the use of a “ketogenic diet” as a form of anti-cancer therapy." Ketone body utilization drives tumor growth and metastasis www.ncbi.nlm.nih.gov/pmc/articles/PMC3507492/ "Thus, the tumor stroma may serve as a reservoir for ketone body production, while cancer cells upregulate the enzymes required for ketone body re-utilization, driving oxidative mitochondrial metabolism (OXPHOS) in epithelial cancer cells (Fig. 9). To prevent this form of “two-compartment tumor metabolism,” ketone inhibitors should be designed to halt ketone body production in cancer-associated fibroblasts and ketone body re-utilization in epithelial cancer cells. This simple strategy could effectively starve cancer cells to death by “cutting off their fuel supply.” Finally, it is worth noting that ketogenic fibroblasts were more prone to a loss of stromal Cav-1 expression. In breast cancer patients, a loss of stromal Cav-1 expression is associated with increased tumor recurrence, metastasis, drug resistance and overall poor clinical outcome.10-13 Thus, stromal Cav-1 could be used as a biomarker to select patients that would be more likely to benefit from therapy with ketone inhibitors, allowing biomarker-based treatment stratification and personalized cancer therapy." Ketone bodies and two-compartment tumor metabolism www.ncbi.nlm.nih.gov/pmc/articles/PMC3507491/ "We have previously suggested that ketone body metabolism is critical for tumor progression and metastasis. Here, using a co-culture system employing human breast cancer cells (MCF7) and hTERT-immortalized fibroblasts, we provide new evidence to directly support this hypothesis. More specifically, we show that the enzymes required for ketone body production are highly upregulated within cancer-associated fibroblasts. This appears to be mechanistically controlled by the stromal expression of caveolin-1 (Cav-1) and/or serum starvation. In addition, treatment with ketone bodies (such as 3-hydroxy-butyrate, and/or butanediol) is sufficient to drive mitochondrial biogenesis in human breast cancer cells. This observation was also validated by unbiased proteomic analysis. Interestingly, an MCT1 inhibitor was sufficient to block the onset of mitochondrial biogenesis in human breast cancer cells, suggesting a possible avenue for anticancer therapy. Finally, using human breast cancer tumor samples, we directly confirmed that the enzymes associated with ketone body production (HMGCS2, HMGCL and BDH1) were preferentially expressed in the tumor stroma. Conversely, enzymes associated with ketone re-utilization (ACAT1) and mitochondrial biogenesis (HSP60) were selectively associated with the epithelial tumor cell compartment. Our current findings are consistent with the "two-compartment tumor metabolism" model. Furthermore, they suggest that we should target ketone body metabolism as a new area for drug discovery, for the prevention and treatment of human cancers."

After a Google search, we found that chemothermia.com/ is a place in Turkey where Dr. Berkarda has cooperated with Dr. Seyfried on a research paper. However, we are unable to confirm this information. Please do your due diligence. Wishing you all the best.

Glad it was helpful!