Dr Efrati’s “bullshit” statement regarding all other HBOT Chambers is totally irresponsible and misleading for people that truly need this therapy! Instead of saying bullshit, The doctor should have explained what to look for in a safe and effective HBOT chamber and facility, instead of discrediting all others that are not his! So disappointed and shocked!

I love this webinar series! By any chance, is there any aging seminar, PhD course, or online course from NUS that can be taken from external people (students, PhDs, postdocs)? Thank you and keep up the good work!

On Lithium it would have been good to so mouse study with doses comparable to humans who seemed to show life extension from elevated Li in water. Also, would have been good to state the human equivalent Li used in mouse studies. This is always an oversight.

If burning fat is good for ageing, it will try to avoid doing so.I rather do things that are good against ageing.😄

lol "dinitrophenol"? are you serious lol

Pof Luc 😂😂

How much percentage of their diet is meat? Do they eat a higher fat diet with fatty meat or a lower fat diet with lean meat? Can someone answer this dang question, I’ve posted this everywhere. Thank you 🙏

I gleaned helpful information from your talk. Thank you.

One way to deal with it is draw blood monthly and just use it for prp for whatever you want- like hair growth boosting or skin improvement. By doing this draw every month, you will rid of some accumulated iron.

Can one use standard blood panels markers like hsCRP, ferritin, transferrin, etc to infer iron dysregulation? For example, is ferritin a useful marker of tissue accumulation and should we be looking to keep it towards low end of reference range?

Prof Leeuwenburgh presented his research area very clearly and interesting. I enjoyed very much the Q and A section of this talk!

Any datas on aging of hemochromatosis people? What would we expect, based on epidemiologic studies, for hemochromatosis patient with normal ferritin(~60-70ng/mL) moderately high Iron (>180ug/dL) and moderately high transferrin saturation (>50%)?

re: Parkinson's patients with normal iron levels but with very low ferritin, would there be any benefit to introduce iron supplementation.

👏🏻👏🏻👏🏻

I want that hearing aid in my ear my name is keyen

I want that

"Medicine is a lot tougher than you think" - when the long working hours is a result of system flaw but not medicine itself. Why can doctors only accept this flaw but no improvement in the system has been made over the years?

Wanted to watch this content but could not understand most of the presenters .. especially the first so lost interest ..l I seem to recall the last time I tried to watch your content it was the same story

Well done, Weiming! Super proud of you and your forward looking approach to your profession.

Diet, exercise and continuous learning are still fundamental.

hi Doctor, my son is 5-year-old he was Lossing hearing both side of ear at the age of 3. peels helping me if you have any way.

*promo sm* ☹️

58:55 so 'Muscle Madness' lists this video title as '99 years old crossfit athlete', but a commenter (Jibbie49) gave the correct info: "Lauren Bruzzone 75 is 5'5" and 114#. She received a PhD in Mathematics from NYU in 1973 and an MBA, She has a JD from Pace University."

Thanks so much for your great webinar, NUS Medicine. Please consider having a researcher from Baylor working on GlyNAC (glycine + N-Acetylcysteine) supplementation, the rate limiting amino acids for intracellular glutathione synthesis. There is compelling animal model research (24% mean lifespan increase for male and female mice: www.ncbi.nlm.nih.gov/pmc/articles/pmid/35268089/). And there are a series of studies that consistently find functional, cognitive and metabolic improvements in human subjects (e.g. pubmed.ncbi.nlm.nih.gov/35975308/). The studies compare young and old-aged individuals, showing clear deficits in the older samples at baseline. Then, in as little as 2 weeks of supplementation with GlyNAC, improvement in the old-aged subjects can be detected, with further improvement after several months of supplementation, and many measures approaching youthful levels. GlyNAC is safe, inexpensive, readily available, and appears to effectively stabilize many of the hallmarks of aging in older adults. The Baylor work seems a natural fit for a webinar.

This is very exciting. What an incredible facility!

I tell about medical shcool indonesia more good than yours ya.

👏👏👏

A simple google search showed me that Nika here isn’t a biologist or medical doctor but has a marketing degree. Now, if you have a full scientific team behind you as you say, why not let them convey the knowledge and progress they surely understand better than you do? Maybe it’s because its not about the science first after all? :) Furthermore, this all sounds dandy, but where is the actual published and replicated data? You talk about preclinical trials but don’t show a single figure or number that’s been peer-reviewed, published, or cited. And yet, you still have the face to sell your products as food. How are the products being personalized for a plethora of possible and complex diseases? Who are the scientists and experts behind this research and personalization? On your website you list 7 supplements. Are these your whole portfolio that are used to target every individuals’ unique needs? Also, as prof. Maier brought up, can a picture of a tongue even be used a model for microbiome assessment? This and many more questions are not even addressed here. They haven’t even scratched the surface. There is nothing of substance here, just lots of fancy sounding yet empty words spoken to get you to buy their unstandardized and untested product.

In the presentation "Ageing clocks based on accumulating stochastic variation" by David Meyer, the key points and conclusions are: 1. Aging clocks, developed around 10 years ago, use biological data like methylation to accurately predict chronological age. Meyer et al. previously built a transcriptomic-based aging clock in C. elegans that could predict both chronological and biological age. Their clock found enrichment of systemic pathways like signal peptides, immune response, neuropeptides, and channel transporter activities (Meyer et al, 2023). 2. There is debate on whether aging is programmed or driven by stochastic processes. Evidence for a program includes enrichment of developmental pathways in aging clocks and arguments that methylation clocks may control aging (de Magalhães, 2023; Horvath, 2023). Evidence for stochasticity includes many redundant chronological aging clocks throughout the genome, increased transcriptional noise with age, the role of stochastic DNA damage, and single-cell methylation data showing most CpG sites behave stochastically with age (Gladyshev et al, 2023). 3. To determine how much stochastic processes alone could explain aging clocks, Meyer simulated data starting from a ground state and adding random normal noise at each time step, with values constrained within biologically meaningful limits (e.g. 0-100% methylation). Surprisingly, this constrained random walk model produced data that enabled building a clock to accurately predict the number of random walk steps, analogous to age. 4. Next, they simulated single-cell methylation data, starting from a young human methylome ground state. Methylation state (0 or 1) was determined stochastically at each CpG site and time step based on a maintenance probability parameter. Bulk simulated data was generated by averaging single-cell values at each time step. Strikingly, existing first and second generation human aging clocks, like Horvath's clock, PhenoAge, GrimAge, and even a 3-CpG clock, showed strong correlation with the simulated "age" from this purely stochastic process. 5. Furthermore, clocks trained on the simulated stochastic walk methylation data could predict chronological age in actual human data with high accuracy (r>0.8 across 15,000 samples). The stochastic clocks also recapitulated biological age differences, e.g. predicting shorter-lived species to age faster in the Mammalian Methylation Consortium data (Lu et al, 2023). They captured known longevity interventions in mice and the rejuvenating effect of cellular reprogramming. 6. Similar results were found for transcriptomic data in C. elegans. Clocks trained on simulated data, generated by adding random normal noise to a young transcriptome, could predict both chronological and biological age in real worm data. Even BioAge, a worm clock that performs median normalization to reduce noise, still correlated with purely stochastic simulated age. 7. In conclusion, Meyer et al. demonstrate that stochastic variation accumulation, constrained within biologically reasonable limits, is sufficient to explain the performance of many existing epigenetic and transcriptomic aging clocks. Clocks trained on simulated stochastic data recapitulate both chronological and biological age predictions in real human and worm data, suggesting stochastic processes play a key role in aging. 8. For future work to build optimal aging clocks, Meyer recommends: - Longitudinal data to capture the pace of aging and individual differences - Diversity in data across populations and genders - Combining data modalities (methylome, transcriptome, proteome, metabolome, etc.) - Modeling nonlinear patterns - Predicting mortality, time-to-death, or frailty rather than just chronological age - Including non-omic biomarkers like facial age - Extensive validation with lifestyle and longevity interventions - Prioritizing human data but leveraging animal models for pre-clinical screening 9. Meyer speculates that improving maintenance to minimize the accumulation of stochastic "errors" is likely the best we can do to slow aging, since perfect maintenance is infeasible. Reversing aging may be possible to some extent with epigenetic reprogramming, but careful tuning will be needed.

Very nice research, I guess this puts to sleep the idea of programmed aging.

We're all selfish we want to eat whatever we want to eat drink whatever we want to drink smoke whatever we want to smoke whatever it takes we're not strong and dedicated to keep our mind-body and spirit To the best of our ability Many people wanna have their cake and eat it too Brian Johnson knows exactly what he's talking about it's just that of course it can't benefit society cause society is so selfish to self indulgence

Doe a favor...let go of your hate for Brian johnson...see he will live longer then anyone and quite possibly 4 ever...and your pist...because you don't have the dedication that he does

I really need you guys to talk about osteoporosis and whether anti-aging medicine is working on finding a solution that is different t from the actual drugs which are not ideal

I need that si stance but in my bones!

If a Dr finds this disturbing, maybe it’s time to change careers

this demographic analysis needs to be shared with financial planners and governments

Too many topics. Not focused.

Walking eight kilometers (five miles) per week will keep you healthy. It is thought that fast moving blood kills cancer so walking fast, or walking uphill to increase blood flow for part of the walk would be more beneficial.

Ambient air under pressure is a treatment as efficient, as shown with the Quebec studies (Pierre Marois): the two groups had 30% improvement, Lancet had to correct its first article about the results, there was no placebo used, as soon as you put more pressure on air, you have a therapeutic effect. Hypoxic tents, yes that's right is not a treatment like HBOT or Mild hyperbaric oxygen therapy.

I hope the next trial is done comparing Mediterranean diet and Keto diet .

@45 min: Comment on data not being charted. I noticed that a long time ago. Makes no sense for a clinician to not have trend data immediately available (in visual not just tabular form) during each visit. Especially helpful, for patient and Phyician, to see if there are negative trends within the reference ranges. Another big problem is that standard blood panel results do not have optimum values or ranges so that the average person is fooled into thinking they are OK.

last time i went to polyclinic a dr said maybe you got selective hearing ??!! like wth you didn’t do a single test and just assume that i didn’t want to listen to my parents nag? now i’m in my late 20s and still have problems with my right ear even with irrigation done a few times, but am scared to be made fun of again

What would you say the best major is to start a career in cancer research? Biochemistry and genetics? Would a computer science degree major be better than genetics? For drug discovery machine learning/ AI etc?

The first 7 minutes were meant to decrease MY longevity 😅

WEF??

Could the reason that other species don’t go through menopause be that they have a shorter lifespan in general?

I love the fact that things are moving faster and faster! Here just 2 years ago saying we won't have it anytime soon and now we're 10-15 years away with the now trajectory of how things are done. and for me I don't know if I want to live super long or forever not really that interested in that but if I can have the current lifespan or live to 85-90 looking and feeling 25-30 (skin muscles mood libido everything at a young level) then I'd more than happy!

She lost me at the N=1 description of her own symptoms. This is unusual for an NUS medical speaker where data and evidence usually come first.

Thank you for plowing through all the background noises. Very interesting talk. Definitely see the interaction between our various microbiomes and feeling status. I have noticed that in myself especially since becoming strictly Whole Foods and restricting saturated fats. I’ve added algae based Omega 3’s, wheat germ to my supplement regime.

1961 - aging is expected to occur. When you get older you start to feel/think differently