4 ай бұрын
4 ай бұрын
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Пікірлер
@maksudulislamtonu2876 16 күн бұрын
nice
@XIAOHANZHAO-d8w Ай бұрын
Great video, where can I find the simulation code?
@sib-swissinstituteofbioinf4579 Ай бұрын
The material for this lecture is available here: github.com/fmicompbio/adv_scrnaseq_2020/tree/master/rna-velocity
@guowanglin4537 Ай бұрын
Many thanks, great demo. I use Numba for genomic analysis, speed up more than 100 times than pure Python code.
@jawswasnevermyscene4258 2 ай бұрын
Are there any other asap tutorial around , thank you so much for this one
@sib-swissinstituteofbioinf4579 2 ай бұрын
Not for now I am afraid... There was a course organized in early November, which will probably be renewed next year. You can visit this page: www.sib.swiss/training/upcoming-training-courses and even register to receive information about upcoming courses
@fabdoc 2 ай бұрын
We need video on viralflow please
@valeriewood1076 3 ай бұрын
This is an excellent, comprehensive introduction to the use of LLMs in biology.
@aliyazdizadeh 3 ай бұрын
Good resource for biologist to get started on this field 💯
@sib-swissinstituteofbioinf4579 3 ай бұрын
Thanks ! Glad it helps.
@AlgoNudger 3 ай бұрын
Thanks.
@seeker816 4 ай бұрын
Question regarding the mitochondrial gene cut off is not answered
@minjun9900 Ай бұрын
it depends on your data no absolute value can be used for mitochondrial gene expression cut off
@davidgithaiga6993 4 ай бұрын
A little statistic with bayes theorem
@bamh1re318 6 ай бұрын
Great presentation, thanks! How many of the ~5,000 human enzymes have been targeted with clinical medicines? Is Lipinski's 'rule of five' still valid? He claimed there are ~500 enzymes considered "bottleneck" in biologically high impact nodules.
@sib-swissinstituteofbioinf4579 5 ай бұрын
UniProt is probably not the first place to start looking for drug targets, and to obtain such numbers, as this is outside our field of expertise. But there are various resources that are trying to address drug targets and which are worth exploring, although they probably all define targets and druggability slightly differently: - IDG resources (Illuminating the Druggable Genome): They assign 4 different "target development levels" to drug targets: Tclin, Tchem, Tbio or Tdark. Tclin are targets for which an approved drug exists; Tchem are proteins that are not Tclin, but are known to bind small molecules with high potency, etc... (academic.oup.com/nar/article/51/D1/D1405/6851109). The PHAROS interface can be used to query the IDG data, e.g. for Tclin and Tchem pharos.nih.gov/targets?facet=Target%2BDevelopment%2BLevel!Tclin&facet=Target%2BDevelopment%2BLevel!Tchem , and to further filter this for enzymes. - DrugBank allows filtering for targets (e.g.go.drugbank.com/releases/latest#target-sequences) or enzymes. - OpenTargets www.opentargets.org/ - Human Protein Atlas (HPA) www.proteinatlas.org/humanproteome/tissue/druggable UniProtKB has cross-references to PHAROS, DrugBank, OpenTargets and HPA, and you can explore narrowing down the set of human enzymes to those entries with cross-references to one or more of these databases. Please don't hesitate to contact the UniProt helpdesk (www.uniprot.org/contact) with questions about UniProt, or directly write to the providers of the resources listed above. The UniProt team
@pumla5481 6 ай бұрын
These videos have been very helpful, is there a part 3 ?
@hasantarek6521 6 ай бұрын
better quality plz
@zirban6434 7 ай бұрын
how can you do a 50% and a 70% modeling?
@AlgoNudger 9 ай бұрын
Thanks.
@AlgoNudger 9 ай бұрын
Thanks.
@MariiaLomovskaia 9 ай бұрын
Wonderful tool! Thanks a lot for cover up the opportunity!
@StevenNess 10 ай бұрын
super helpful, thank you
@efstratioskirtsios298 10 ай бұрын
Is there any video available on how to go on refining the clustering in more detail?
@patrickjiang402 10 ай бұрын
Thank you for this wonderful talk! It is very insightful on the current advances of physics-informed machine learning techniques in protein-ligand interactions!
@philippkrumm5921 11 ай бұрын
is it possible to upload this in a better quality? Thats the most importand video from the series and its hard to read in 360p
@vicentcaselles4807 Жыл бұрын
How do you get intuitively that the p of genotype error is 0.02?? I don't understand that
@aleserain 4 ай бұрын
it is a binomial distribution formula in which 0.002 is the likelihood.
@MaheshJethalia Жыл бұрын
I am an avid user of SWISS PROT and Homology models. I have used SIB software and loved them. I would have loved to visit or see in person but I trust you guys for doing an amazing job.
@AlgoNudger Жыл бұрын
Thanks.
@AnimeshSharma1977 Жыл бұрын
thanks for sharing this! i see that you are analyzing group specific missing values separately from rest of data, wondering is there is an elegant way without utilizing group information?
@露露宋 Жыл бұрын
I want to get the course material, but the link can't be opened. Could you please update the link?
@amalelfoly5944 Жыл бұрын
I am following using the same steps but local quality estimates figure isnot porvided? what does this mean?
@chrisjmolina Жыл бұрын
Thank you for sharing!
@PraveenIloveBharat Жыл бұрын
Best tutorial video. It will useful for all life science researchers. Thank you SIB.
@wilsonfarrell4774 Жыл бұрын
Promo`SM ☀️
@ruruyang914 Жыл бұрын
When you introduce each method, it will be great and helpful to give a comments or recommendations for each modality.
@AlgoNudger Жыл бұрын
Thanks.
@SlavisaSladojevic Жыл бұрын
👍👍
@saubaral Жыл бұрын
i love this :)😄😄
@Matladi474 Жыл бұрын
I am new to bioinformatics, my question is what if % identity and Query coverage is less but the GMQE and Qmean score is good?, which factors are more important than the other when deciding on a good model? Again what does it mean when your swiss model has no QSQE score?
@life7294 Жыл бұрын
anyone can please tell me the scope of bioinformatics? how can we professionally work in this field?
@IaroslavKorkodinov Жыл бұрын
Where can we access the swiss_census_1880.csv?
@hmzkha01 Жыл бұрын
What are the criterias to get job in SIB
@chitarnjansahu473 Жыл бұрын
I have KYC my account but still my money is not coming out please help me
@eujebenqo6159 Жыл бұрын
Bioinformatics is soo cool.
@kajalpanchal8239 Жыл бұрын
loved the vedio, Artistic!
@edwardsedwards796 Жыл бұрын
Epidemics? So you are part of this scam as well? Shame on you.
@CMunsk 2 жыл бұрын
Thank you very much for the excellent and informative video
@HadasAshkenazi-eg9mn 2 жыл бұрын
Thank you! Very informative
@ShakespeareCafe 2 жыл бұрын
Invest in some better audio equipment
@naromsky Жыл бұрын
The audio quality is poor, but it could be improved with an AI enhancement (post factum).
@sanashaheen6864 2 жыл бұрын
plz explain the repository portion in swiss model
@AnimeshSharma1977 2 жыл бұрын
Double descent discussed at kzbin.info/www/bejne/oXTSlYGwaK57nrc is enlightening and scary at the same time!
@langleywright2647 3 жыл бұрын
hahahaaha
@jovialcs-it1387 3 жыл бұрын
Kudos keep doing👍