Thanks for your suggestion, I'll keep this in mind. I'm moving through a lot of information quickly and I like to keep my conversations flowing in a way that feels natural to me. We all have our own style, and this is what works for me.

You can if you would like. Choose what works most conveniently for you.

@@peptidepodcast Thank you.

You are most welcome.

Let's unpack this. Poor eating or overeating is not always a behavioral problem. Many people are simply uneducated about proper nutrition (protein intake, sodium, fiber, hydration, and complex carbs vs. simple carbs). The list goes on and on. And let's not forget, some people overeat because they are stressed or bored or because they live with others who overeat. Others overeat because of a hormone imbalance, sleep deprivation, or because they've simply waited too long to eat. It's not always a behavioral problem as you stated. GLP-1 agonists suppress appetite, but they also stabilize blood sugar levels, preventing the spikes and crashes that can cause cravings and overeating. This helps reduce the emotional triggers that often lead to overeating, promoting a more balanced and controlled approach to eating. As a result, GLP-1 agonists support a healthier relationship with food and more sustainable weight loss compared to fad diets or extreme calorie restriction. It would be nice if weight loss were as simple as talking to a therapist and changing how you view food. Sometimes, people need that support in addition to medication to help them achieve their goals.

I have no desire to stop taking them, as I’m getting several benefits from them beyond weight loss. So, sure, I can stop but I like my BP being under control better than it’s been in decades (and this effect was experienced even before I lost much weight. Just one example. It’s also made it a breeze to quit drinking. So, this episode seems like it’s only taking weight loss into account as the only benefit and only thing one has to manage if they do choose to go off the drug.

Hello. There are a lot of things to consider. How many total mg or mcg are in the vial? What is your dose? Is the vial for multiple use or single use (reconstituted with BAC or sterile water for injection)?

No. BAC water allergic reactions are extremely rare. You may also want to keep in mind that a reaction can occur because of the added peptide or medication or the technique of reconstitution. Both bacteriostatic water and sterile water for injection can be used for subcutaneous injections. In a nutshell, if you’re using a single-dose peptide vial, either can be used. If you are using a multi-dose vial, you should use bacteriostatic water to dilute your peptide to help prevent bacteria from growing in your peptide vial. The added benzyl alcohol in the bacteriostatic water will prevent bacteria from growing in your peptide vial for up to 28 days. Because sterile water for injection doesn’t have anything added to prevent bacteria from growing, you should only use it to dilute single-dose vial peptides. It should be used completely at once and then thrown away. I hope this information helps!

@@peptidepodcast hey thanks for that information, i was prescribed cjc and ipa by a trt company and after long term usage i started to develop welts and bruising. I eventually ended up hospitalized with a rash/hive that spread from injection point to my feet and up to my neck and was causing breathing issues. Im still trying to figure out what might have caused with issue, needles were steriles. bottles wiped with alcohol wipes prior to each use. bactero added to correct dosage and stored peptides in the fridge which is roughly 35 degrees. What do you think may have caused such a reaction? or what typically can cause a reaction like that. (side note, when i originally started using it i had a slight itch to injection site which over times started to form a small hive and then evenutally into hospitalization i would say over 6 months)

So sorry you had to deal with that. I would think that you are allergic to one or both peptides.

Great question. TB-4 (Thymosin Beta-4) is a NATURALLY occurring peptide in the human body that plays a role in tissue repair and regeneration, promoting cell migration, and reducing inflammation. TB-500 is a SYNTHETIC version of a fragment of TB-4, designed to enhance its effects on healing and recovery by improving tissue repair and reducing inflammation more efficiently. Since TB-500 is a fragment of TB-4, it may not have all the same biological functions as the full-length peptide. However, both TB-4 and TB-500 have shown promise in promoting healing and reducing inflammation. When choosing between the two, it comes down to personal preference.

Tight junctions (TJs) are important for keeping our intestines healthy. These TJs are made of different molecules like claudin and occludin, and they control what can pass between the cells in our intestines. One of their main jobs is to act as a barrier to stop harmful substances from getting into our body. When TJs don't work properly, it can cause our immune system to overreact and lead to chronic inflammation. Recent studies suggest that TB4 and what we eat can help keep our TJs strong and reduce inflammation. TB4 is an immune modulator, anti-inflammatory and can be helpful when people are struggling with various sensitivities and intolerances. Because TB-4 helps heal and repair tight junctions in the GI tract and it may help reduce food reactivity. As for brand to recommend, I would suggest reaching out to a peptide therapy clinic near you. You'll want to make sure that get their peptides from uses peptides from a GMP-certified, FDA-registered, active pharmaceutical ingredient (API) manufacturer. This means they have quality and safe products free of unhealthy ingredients or dangerous contaminants.

@@peptidepodcast Thank you so much for replying. 🙏🏻

No problem at all.

Let's discuss this. Many people believe that appetite suppressants are inherently harmful, often associating them with severe side effects and unhealthy weight loss methods. However, this perspective overlooks the fact that starvation diets and extreme exercise routines are not only hard to maintain but can also harm your health. Furthermore, the myth that all appetite suppressants are bad, fails to acknowledge their many health benefits and the individualized nature of medical treatments. What may not be suitable for one person could be life-changing for another. For example, there are certainly people who exercise daily, make positive changes to the way they eat, and practice good sleep hygeine and stress management, yet they're still overweight. These individuals could certainly benefit from an appetite suppressant like semaglutide. Let's also not forget to mention that weight loss in overweight individuals decreases the risk of cardiovascular disease (e.g., heart attack and stroke), type 2 diabetes, fatty liver, and certain cancers. It can help with joint pain and improve fertility, mood, and sleep. I would venture to say that these benefits outweigh the possible risks of taking an appetite suppressant. GLP-1 agonists suppress appetite, but they also stabilize blood sugar levels, preventing the spikes and crashes that can cause cravings and overeating. This helps reduce the emotional triggers that often lead to overeating, promoting a more balanced and controlled approach to eating. As a result, GLP-1 agonists support a healthier relationship with food and more sustainable weight loss compared to fad diets or extreme calorie restriction. I agree that changing how you "view food" is a must. With that being said, it's extremely important to work alongside a healthcare professional when using appetite suppressants or ANY weight loss strategy. They can help address nutritional and physical activity requirements needed to prevent lean muscle mass loss and nutritional deficiencies. They can also help manage possible side effects.

I would give it some more time. In clinical studies, people with long-term constipation had fewer episodes of constipation after about a week of starting Trulance. But keep in mind that everyone responds differently to medications. Your symptoms should improve over time with daily use.

You are most welcome!

Yes, it can.

Oh no! Typically the dose is 100 mcg or 0.1 mg SC daily into the abdomen.

@@peptidepodcast yeah. I can say I slept like a baby and had zero anxiety. I'm currently taking .250 mcg a day and it has changed my life for the better

.250 mg. Not .250 mcg lol

Depends on where you live. I would do a quick internet search for reputable peptide clinics or anti-aging/ wellness clinics. I would read reveiws on their social media websites and ask to speak to someone on the phone or via email that can explain where they source their peptides from to ensure that you're receiving safe peptides from a cGMP-certified, FDA-registered peptide API manufacturer.

Peptide science

@@ninodaghost😅 it says on the bottle, not used for human consumption. Have you tried it?

Great question. Not necessarily. Both oral and injectable BPC-157 work systemically. Injectable BPC-157 bypasses the digestive system, allowing for direct entry into the bloodstream. This means that the amount of a BPC-157 that enters the circulation and is able to have an active effect may be more significant versus the oral version. Oral peptides and medications may result in lower bioavailability due to the peptide being broken down by digestive enzymes and stomach acid. We know that oral BPC-157 works well for gut health and injuries. However, many users have reported better results with injectable BPC-157 for injuries.

Yes, you are correct. BPC-157 is available as a sublingual tablet. I like to think of BPC-157 sublingual vs oral tablet like this... Absorption and Bioavailability: Sublingual administration tends to offer higher bioavailability and quicker absorption since it bypasses the digestive system. Tablets, on the other hand, may have reduced bioavailability due to degradation in the stomach and intestines. Onset of Action: Sublingual forms generally have a faster onset of action compared to tablets. Convenience: Tablets are more convenient to take for those who prefer not to hold a substance under their tongue. Effectiveness: While both forms aim to deliver the same therapeutic benefits, the sublingual route MAY be more effective due to better absorption and higher bioavailability. Hope this helps!

BDNF- and IGF-1-derived peptides.

You're very welcome!

Great questions. In short, yes. The benefits last for several months. Typically, people get 2-4 cycles of Cerebrolysin per year. Keep in mind, clinical studies indicate that the best treatment effects are seen when Cerebrolysin is administered as soon as it is possible after TBI and continued during the rehabilitation phase. Clinical studies and evidence report the following: Short to Medium-Term Benefits Cognitive Function: Studies have shown that Cerebrolysin can improve cognitive functions in TBI patients during the acute and subacute phases of recovery. Improvements in memory, attention, and executive functions have been reported. Functional Recovery: Patients receiving Cerebrolysin tend to exhibit better functional recovery, including motor and daily living activities, compared to those receiving placebo or standard care. Long-Term Benefits Sustained Improvement: Some studies suggest that the benefits observed in the short term can be sustained in the long term. Patients treated with Cerebrolysin may show continued improvement or stabilization in cognitive and functional outcomes for several months post-treatment. Neuroplasticity: Cerebrolysin is thought to support neuroplasticity, which is crucial for long-term recovery and adaptation following TBI. This includes the formation of new synaptic connections and the repair of neural networks. Unfortunately, Cerebrolysin isn't approved for use in the U.S. It's available in more than 50 countries worldwide. I suggest speaking to your neurologist about its availability. They may be able to direct you to a peptide compounding pharmacy or clinic that can provide Cerebrolysin.

@thepeptidepodcast Wow, sounds like I need a great source... sounds like it really would help someone like myself

You're welcome!

Thank you for listening!

Great question. It depends. Storage requirements for lyophilized tablets and reconstituted thymosin alpha 1 differ. Also, will you have access to a travel cooler and refrigerator? First, the lyophilized tablets will last for up to 3 weeks at room temperature (prior to reconstitution). Reconstituted thymosin alpha 1 should be placed in a travel cooler during travel and in the refrigerator when you arrive at your destination. However, once it's reconstituted, it only lasts one week in the refrigerator. Hope this helps.

Finding the right prescription medication often involves trial and error, as everyone’s response to medication can vary based on individual differences.

Great question! Cerebrolysin is a mixture of enzymatically treated peptides derived from pig brain.

Bump

Great question. No you cannot use normal saline. Using normal saline vs SWFI may cause poor dissolution of the powder, precipitation, or deactivation of the active pharmaceutical ingredient (peptide) before further dilution or administration.

It's recommended that PPIs be used short term (4 weeks duration, followed by 1 to 2 weeks dosage tapering if needed).

Glad it helped!

Great question. We aren’t exactly sure. Most of the research on BPC-157 has focused on its effects on gastrointestinal healing, muscle and tendon injuries, and corneal injuries. Some individuals and practitioners may speculate about potential benefits of BPC-157 for eye floaters due to its anti-inflammatory and tissue repair properties, but to my knowledge, as of today, this has not been studied in animal models or clinical trials. Keep in mind that eye floaters are typically caused by age-related changes to the vitreous inside your eye, not injury. Tiny clumps of collagen fibers form inside the vitreous, and these can cast tiny shadows (floaters) on your retina.

@@peptidepodcast ok cool thankyou for the reply. I’m only 30 years old never had an eye floater my entire life . I know it’s usually from age related problems . But i think in my case it was do to injury cuz i had a pretty severe blood infection when I was 28 . And ever since then i have had the floater in my left eye. And yea it seems bpc-157 helps the cornea but not the vitreous ? But since mine seemed to be caused by injury. I guess theoretically it may help cuz it was caused by that and not by aging I think .. ? Thanks .

Yes to do mass scale production they do that . Only peptides like thymosin beta-4 are not. Tb-500 is the spps version of it for example.

Great info. Thank you

Jay, this is a great question. Your healthcare provider should provide you with the bacteriostatic water necessary to reconstitute your prescribed peptides. I do not recommend purchasing bacteriostatic water from Amazon. You may end up with a product that isn't safe to take.

Doesn‘t sound good

Unfortunately, heart palpitations have been reported as a side effect in persons using VIP. Other potential side effects may include low blood pressure, rash, dizziness, irritability, and headaches. Make sure to seek medical attention if you have palpitations lasting longer than a few minutes. Or if you have chest pain/tightness, pain in the neck or jaw, shortness of breath, or dizziness.

The typical dose is 100mcg-300mcg Sub Q daily. But remember, more than this maximum dosage can lead to desensitization.

You said nasal spray and now you’re saying SUB Q.

You are so welcome!

This is great! I'm so glad that BPC-157 has helped with your fibromyalgia pain and gut health. Typically most people take BPC-157 for 6 to 12 weeks with one month off. I hope this helps!

Great question. In short, yes. Firstly, one of the primary expenses is the procurement of high-quality amino acids, the building blocks of peptides. These amino acids must meet stringent purity standards to ensure the successful synthesis of the desired peptide sequence. Additionally, the cost of reagents and solvents required for peptide synthesis can be significant. Reagents such as coupling agents, protecting groups, and activating agents are essential for linking amino acids together in the desired sequence, while solvents provide the medium for these reactions to occur. The purity and quality of these reagents directly impact the efficiency and success rate of peptide synthesis, thereby influencing overall costs. Furthermore, equipment costs represent a substantial portion of the expenses associated with peptide synthesis. Specialized synthesis instruments such as peptide synthesizers, HPLC (High-Performance Liquid Chromatography) systems for purification, and analytical instruments for characterization are necessary for efficient peptide production and quality control. Maintenance, calibration, and occasional upgrades of these instruments also contribute to the overall expenditure. Additionally, labor costs must be factored in, including the salaries of skilled personnel responsible for designing peptide sequences, performing synthesis reactions, purifying peptides, and conducting analytical tests to assess purity and identity. The complexity of peptide synthesis often requires highly trained chemists or biochemists, whose expertise commands a premium in the job market.

@@peptidepodcast Very interesting, if there an online course I can take to gain these skills? I love learning from home

Great question Patrick. Adderall is a stimulant medication that works by increasing levels of 2 chemicals; dopamine and norepinephrine. Both of which are believed to play an important role in attention and mood. DIHEXA on the other hand works primarily by interacting with the angiotensin IV receptor (AT4 receptor) in the brain. This receptor is involved in various cognitive functions, including memory formation and learning. When it binds to the AT4 receptor, it triggers a cascade of intracellular signaling pathways, ultimately leading to the release of neurotrophic factors, such as brain-derived neurotrophic factor (BDNF). BDNF is essential for the growth, survival, and function of neurons. By enhancing BDNF signaling, DIHEXA promotes the growth of new neurons, strengthens existing neuronal connections, and enhances synaptic plasticity-the ability of synapses to adapt and change in response to experience. These neurotrophic effects contribute to dihexa's ability to improve cognitive function, including memory, learning, and executive function. Overall, dihexa works by promoting neuronal growth, synaptic plasticity, and neurotransmitter function in the brain, leading to improvements in cognitive function.

Thanks for sharing!

Thymosin alpha-1 is primarily known for its immunomodulatory effects and its role in enhancing the immune system. It does this by modulating cytokines, regulating T Cells, and inhibiting pro-inflammatory mediators such as prostaglandins and leukotrienes. It's not typically associated with direct effects on clotting factors or the coagulation cascade. However, it's important to note that research on thymosin alpha-1 is ongoing, and new findings may emerge. As you may know, rivaroxaban has a predictable anticoagulant effect, eliminating the need for routine coagulation monitoring. But there may be instances where your physician may monitor your hemoglobin, platelet count, aPTT, and PT. Usually this is necessary when breakthrough trombosis or bleeding occurs. Hope this helps!

@@peptidepodcast IT ODES ! THANK YOU SO MUCH. HIGHLY APPRECIATED.

The answer to this is complicated. The relationship between kisspeptin and DHT levels might indirectly occur through their interaction within the endocrine system. Changes in reproductive hormone levels, influenced by kisspeptin, might affect the production or balance of testosterone, which, in turn, could impact DHT levels. However, the direct effect of kisspeptin on DHT levels is not well-documented or understood in scientific literature. Keep in mind, that kisspeptin doesn’t directly affect testosterone levels but influences the hypothalamic-pituitary-gonadal axis, a complex system involving interactions between the hypothalamus, pituitary gland, and gonads (testes in males, ovaries in females). Through this axis, kisspeptin stimulates the secretion of gonadotropin-releasing hormone (GnRH), which triggers the release of LH and FSH. LH then stimulates the Leydig cells in the testes to produce testosterone. Therefore, while kisspeptin itself doesn’t directly impact testosterone levels, its role in stimulating the release of hormones like LH indirectly influences testosterone production by affecting the signals that regulate its synthesis in the testes.

Great question. You cannot mix the two together in the same syringe/vial. You can, however, take both peptides at the same time as two separate injections. I hope this helps!