Beginning around minute 8 in the following video link there is a good discussion about paronychia, aka nail infection from the TKI. including prevention, management of mild, moderate, and severe cases. I hope this helps. kzbin.info/www/bejne/bIXWn3SFf7KCjrc

@CancergraceOrg thank you for all your answers.i am asking for my mother. she has exon19 and uses vizimpro.begin with 45mg after 3 months, and the tumor shrank by 1 cm. But side effects were too much, and she started 30mg. After another 3 months, it was not like the first one, but 1 mm smaller.we started with a 3.5x15 cm tumor, and now 24x15 cm. Do u think , Could the shrinkage has decreased due to lowering the dosage of the vizimpro?

Hi mrxxlll, These natural supplements are not able to kill or inhibit cancer like TKIs and chemo. Also speak to your onc before taking specific supplements because they can have effects that can counteract other meds or otherwise be harmful.

Dacomitinib has not been tested in this type of treatment (curative) so no one can say if it is as effective as osimertinib has shown to be. However if that is a drug that is available and osimert is not then it's worth a discussion with your onc. There is no telling it an insurance co or health system would approve of it either. Best of luck, Janine

I'm so sorry about your mother. Perhaps an unfortunate example of why it's so important to be an active participant in your own healthcare. Take care

@CancergraceOrg Unfortunately, many elderly people aren't capable due to diminished cognitive abilities.

I know, it's a broken system. I'm so sorry. Know that you do what you understand is the best for yourself and the ones you love. We can only do as much as we understand is necessary.

Lo siento por eso. Ver comentarios en el hilo de @joseluisriverap9659

Here's the video, kzbin.info/www/bejne/f4WapJ1_j7aprKs Our Spreaker posts are taken from our videos with the same name.

Best of luck onerider

There is much broken and unsustainable about our system.

Conversation is here, kzbin.info/www/bejne/mpnRfKyVmatoosU

Hi Rebecca, Let me check on this and I'll get back to you. What I can say is checkpoint inhibitors are relatively new and we know that potent drugs can cause weird and unusual side effects. With your hoshimoto's disease and keytruda I imagine you and your care team have been watching your levels closely. I will return with some info from an expert. Take care,

As you can see in the following links developing hypothyroidism or recurring hypothyroidism is common. These studies are small so they wouldn't be expected to capture the outliers like you with the onset being from days to 6 months. So a year may not be considered common but not out of the realm of possibility. BTW, most people find that their cancers and cancer management have some degree of rarity to them. I hope you are able to get the treatment you need. Take care, Janine pmc.ncbi.nlm.nih.gov/articles/PMC5546861/#t2n7 and ejim.springeropen.com/articles/10.1186/s43162-023-00210-7#Sec12

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Para más información, consulte los comentarios de @joseluisriverap9659. Gracias.

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¿Cual es su pregunta específica por favor?

Pues no sé ustedes ya no dijeron que hacer después de 48 a 72 hrs

Oh sí, ahora lo veo. Déjame comprobarlo.

A continuación se presentan algunos recursos relevantes que resultan útiles durante el tratamiento de quimioterapia. Quizás quieras traducirlos al español. Háganos saber si tiene más preguntas. www.mdanderson.org/cancerwise/10-things-to-avoid-while-receiving-chemotherapy.h00-159615489.html www.cancer.org/cancer/managing-cancer/treatment-types/chemotherapy/chemotherapy-safety.html

Hi, Front line treatment for unresectable is often systemic therapy of platinum, pemetrexed (alimta) (with or without Bevacizumab. See link, kzbin.info/www/bejne/jJPXYmybpshggdE&lc=Ugzq-NPbrXTt8yGj3B54AaABAg ) Addressing the needs of individual patients was at the forefront of Dr. West’s philosophy of care. “My primary goal was to provide optimal balance of appropriate, aggressive treatment and a good quality of life,” he said. “This requires individualized plans based on a patient’s particular goals and medical issues.” For many patients, Dr. West explains, a treatment plan will include a chemotherapy combination of cisplatin and Alimta®, but there are alternatives for patients who can’t tolerate that regimen, such as the often better-tolerated carboplatin." 2nd line options may include immunotherapies. This audio piece discusses some of the recent data collected in trials of immunotherapies in mesothelioma. kzbin.info/www/bejne/pnnEZoR9pNWWrsU kzbin.info/www/bejne/jJPXYmybpshggdE&lc=Ugzq-NPbrXTt8yGj3B54AaABAg Definitely not enough. Take care, Janine

I meant to add this witht he other post. Unfortunately not enough of a change in treatment options but more recent with more individual accounts and attitudes toward immunotherapy and combos, kzbin.info/www/bejne/h16oi3Z6r99qhs0

Tarceva works anywhere between a couple of months to a couple of years. Median time is about 8 months. There is no way of knowing who with an egfr mutation will respond best. There are newer drugs that have better efficacy and better side effect profile such as tagrisso and the newly approved combo discussed in the video in the link below kzbin.info/www/bejne/rpC2iIGpnNCZl8ksi=5OHTGAnZilrqfj5M

Hi. Radiation is often helpful in treating bone met pain. These drugs don't repair bone or shrink bone mets. They slow or stop the pace of bone mets, so while they won't reverse issues, they may stop them from getting worse. I'm not able to say how healthcare is accessed in Malaysia. In the US, these drugs are part of a standard of care as needed, so they would be covered (to whatever degree your insurance covers cancer management drugs). If considering them, get oral health taken care of beforehand to lessen the chance of necrosis in the jaw. Take care, Janine

@CancergraceOrg Thank you so much for your response. I did bring up about Denosumab however I was told that it can have a side in effect in terms of immunity of the body. I was told it is usually more for palliative care towards the end stage. Is this true that it can have adverse effect on the overall immune system of the body?

This from uptodate.com, "Parenteral administration of antiresorptive agents (bisphosphonates and denosumab, also referred to as osteoclast inhibitors, bone modifying agents, or bone targeting agents) reduces the frequency of skeletal-related events among patients with multiple myeloma and in those with bone metastases from a variety of solid tumors, including breast, lung, and prostate cancer. Prolonged therapy with these antiresorptive agents in patients with advanced malignancy is generally well tolerated, but some side effects are potentially serious and require periodic monitoring [1-3]. www.uptodate.com/contents/risks-of-therapy-with-bone-antiresorptive-agents-in-patients-with-advanced-malignancy?search=denosumab%20side%20effects&source=search_result&selectedTitle=3%7E150&usage_type=default&display_rank=3 This link is to Prolia's site and side effects, www.prolia.com/proven-results/safety-information Bisphosphonates and denosumab are often taken with anticancer drugs to help people live life with less pain and fewer bone mets. Unless there are other health reasons, like a compromised immune system, there's little reason not to try them.

yes, that wouldn't work.

@pujaiitbombay Hi, I'm sorry I don't have the answer but wanted to say hello. Truthreveal didn't comment on what the experiment was or how they were doing. If you have specific questions don't hesitate to ask. We have newer info on sclc though there hasn't been enough change in treatments immunotherapies do play a role for some. I wish you well. Here are a few of the more recent videos on SCLC, kzbin.info/aero/PLWsyUmdjLXhFNobkq9qpDQFcy4whIPSJY Take care, Janine

Hi and welcome. Radiation given with/concurrently with chemo of any type adds toxicity, often escalating the side effects of each. Cisplatin has a worse toxicity profile than carboplatin. Careful consideration needs to be discussed when choosing whether or not to use radiation concurrently or sequentially as well as whether to use cisplatin or carbo. The following posts are pretty old and written before immunotherapies and targeted therapies were developed. However the specific discussion about the difference between cisplatin and carbo remain relevant. cancergrace.org/search?keys=carboplatin+v+cisplatin&type=video_post&field_post_type_1=All&field_disease_learning=All&created%5Bmin%5D=&created%5Bmax%5D=

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Maybe

I am so sorry your mom is gone. Take care of one another

Quizás podamos responder una pregunta que tengas.

Es normal el dolor en el pecho mientras estas en este tratamiento?

@linethpopoca9303 Es importante informar a su equipo de atención médica sobre síntomas nuevos o síntomas que empeoren, como dolor en el pecho. Podría ser una inflamación grave, un efecto secundario poco común pero conocido del tagrisso que necesitaría atención inmediata."

Hi, I'm so sorry about your diagnosis. If the lymph node dissection caused nerve damage perhaps a consult with a neurologist who specializes in nerve damage. I'm curious if your tumor was resected. From www.cancerresearchuk.org/about-cancer/breast-cancer/treatment/surgery/remove-lymph-nodes , "Nerve pain-You might have numbness, tingling or a shooting pain in your armpit, upper arm, shoulder or chest wall. This is due to damage to the nerves during surgery. The nerves usually repair themselves, but it can take many weeks or months. Your doctor or nurse can give you medicines to help with nerve pain." Gabapentin is often helpful for nerve pain. Also topical (put on the skin) creams, physical therapy (PT), and massage and desensitization can be helpful. How did your appointment go with your oncologist?

@@CancergraceOrg I am scheduled for CT of the Neck...since I have Small Cell my oncologist feels that it is radiating from my spine. He ordered two Scans 2-weeks apart so they can compare them. I was prescribed Dexamethasone to help me. Thank you for responding...I get hit with Attacks with pain beyond the scale, and it lasts about 45-minutes, afterwards I am exhausted and very sore, like I am right now. I have had a few days with up to 4 attacks...what a mess. I know of the numbness and tingling (sunburn feeling) because of the dissection, but that was done in April, and it never caused such pain before now. I can only guess at what the real issue is, but todays x-rays did not reveal anything, sadly!

Geez, I'm so sorry. A CT will give a much better view than the xray. If there is progression in the spine there are several options that might help. Radiation for one thing can give quick relief and neurosurgeons have many tricks up their sleeve that might help. If the dex doesn't give relief call your onc office to let them know and ask about gabapentin and lyrica. Don't think you're being too pushy. Back pain from cancer is no joke. Let the office know you need help. I've never dealt with health professionals as kind and helpful as those in oncology.

Glad it was helpful! Let us know if you have questions.

Hi. I'm sorry to know about your diagnosis and that it's not obvious from where it came. PET scans can see if there are any places that suggest a tumor (or inflammation or infection) is present. I assume you've had one? There are usual suspects for malignant ascites. If the fluid hasn't returned perhaps you'll not need another paracentesis as early as Friday. However until the culprit is found and dealt with it is likely to return. From jamanetwork.com/journals/jamaoncology/fullarticle/2757397 , "Certain cancers, such as ovarian, pancreatic, liver, and colon cancers, are more likely to cause ascites." Best of luck and don't hesitate to ask if you have questions, Janine

Hey how are you have you found out what is the cancer?

I'm so sorry about your diagnosis. I hope you are getting what you need. Please let us know if you have questions. Ask here or on our forums, cancergrace.org/forum/active Take care, Janine

Hi studiohost, I'm sorry. That is troublesome. Have you spoken to your oncologist/hematologist or you primary doc about what can be done to coax the levels to normal again? These problems can last. There are survivor groups online that are surely to have tips on what has been helpful. I'm not familiar with these groups other than knowing they exist but I do know that this type of crowd sourcing can be life changing. Best of luck, Janine

You're welcome and welcome. Any questions you have we can try to answer. Take care

Very easy to follow and correlate with labs. Thanks

Yes, I agree. We encourage our faculty to use both generic and brand names which is a pretty easy thing to miss in a live webinar for our faculty who are accustom to using just one term. I'll pass your note along to our program manager and she may be able to correct this type of oversight in edit. Thanks for the input.

I'm sorry you're having this issue and if it's causing problems I hope you are able to have it resolved. Don't apologize for having good luck with lung cancer. I know how troublesome problems from cured lung cancer can be. Best of luck.

@@CancergraceOrg Thank you and the best of luck to you as well