Lovely talk, thank you for uploading it.

Lovely talk, very insightful.

Thank you very much for uploading this.

Sir John Burn's father Harry was my father's partner in the coach building building business between 1947 and 1964. The company built soft serve ice cream vans amongst other things. They also had a substantial vehicle repair business. The company was Burn and Slack Ltd. of St. Helens Auckland, County Durham. Outside of business our families were quite friendly. For many years, our parents and a couple of other families all went on holiday together. Congratulations to Sir John. He has worked hard and done well. Bryan M. Slack.

Prevention 101: don't take the sh0t.

Your content is very good. But there are some issues in your channel due to which your videos are not ranking well. If these issues can be resolved, hopefully the videos will rank, I can help with that if you want.

Is their limited penetrance because of evolutionary adaptation to that genetic variance? When referring to the genetic variant, how many of these variants are de novo? If it is high, then there might be evolutionary adaptation to the variant arising from de novo effects. It's not novel in evolution. Even if penetrance is low in any one generation, how about in subsequent generations? Is this all genetic load? If it is, you might really want to detect it in a generation when it is benign and look for it in their children, when it might not be. It would be an early warning across generations of a building genetic load. Again, it looks like evolutionary adaptation to the inevitable mutations occurring each generation, that inhibit normal functionality. A fault tolerance mechanism. If you were to compare the parent's and child's genome for de novo mutations, you would not be predicting disease so much as reduced functionality of the ... genome. The "polygenic score" even if there was no pathology... yet. Prediction about the future may be difficult, but it seems awfully likely that the removal of natural selection, what we call human progress, would lead to an increase in genetic load of de novo mutations, particularly ones that would be removed by the general stress of diseases. This might explain limited penetrance. It's just a normal evolutionary solution to a normal problem of heredity using DNA. @27:00 - Could the "polygenic score" represent the accumulation of de novo mutations, the genetic load? Apparently. @29:00 - They are birth defects, so to speak, but "late onset"... such as infertility or premature death. I wrote a book about all that, but if interested, try the old video about it at kzbin.info/www/bejne/rZu5mph8gMqpg80

Here we are three years later, and I'm still hearing how awesome CRISPR is gonna be!

Congrats for this extraordinary conference!🤔😀👏👏👏

Theirs is a True Love Story I pray she is still in great health and that either Them or Someone else Finds a Cure For this Devastating Disease God Bless Y'all and your Family

Hey, I want more on this!

Hello how are elizabeth it is chevelle

My 5 year old boy, has just had his bloods done for this sequencing

Needed that 🤟Thanks!!! Want more views? -> "Promosm"!!

very nice 👍👍👍

brava brava brava

all thanks to DR. harry herbs i contacted through KZbin for cuing me from type 2 diabetes with his herbs medicine, true natural medicine is powerful..

Fascinating to listen to you talk about your field of expertise. Can’t remember meeting anyone else at university who demonstrated as much passion for their studies, so no surprise! Best wishes, Paul A

You two are amazing, and I'm so thankful for you both and all you're doing!

Amazing stuff!

Go on you guys are the A-team!

The book he mentioned at the beginning is called "Rna, the Epicenter of Genetic Information: A New Understanding of Molecular Biology" (2022)

Thank u for uploading this video

The company behind this research and who has developed the POC test is Genedrive, based in Manchester.

Nice 👍

nice summation Q at the 1h7m mark that everyone should see, then review the presentation with fresh eyes. ultra processed foods should be outlawed, but until that happens the average consumer can achieve immediate results wielding their own forks. calories definitely are a useless metric leading the typical person astray. at FWC we have shown since 1990 that eliminating all refined sugars + carbs from the diet, and reintroducing healthy fats (with greens) is a very effective way to start to rebalance the microbes. rebuilding them post antibiotics .. figuring that out will be the next hurdle and a half. IF seems to be the only effective way to reduce excess weight gains due to how insulin locks the fat away. very thankful to see this in Canada.

Is this the reason for the quick development of the Corona virus vaccines? A RNA delivery system for spike proteins from Pfizer and joining an adenovirus with the Corona virus DNA for Johnson and Johnson.

Brilliant video

Incredible presentation. I especially appreciated the thoughtful questions submitted by the audience. I'll share notes I've created as a result of listening and preparing for a conversation I hope to have with Dr. Elinav and share on my channel soon. 00:00:00 - Introduction and Dr. Elinav's background 00:04:20 - Beginning of discussion 00:05:30 - Investigating non-gut related microbiota niches 00:07:00 - Microbiome as a signaling hub 00:09:40 - Limitations of one-size-fits-all treatments: fecal matter transplant, probiotics, prebiotics. 00:10:10 - Fecal matter transplants 00:10:30 - Probiotics 00:11:30 - The obesity epidemic 00:14:00 - Shortcomings of the glycemic index 00:17:00 - Predicting whether "carbohydrate-only restriction" will reduce glucose responses. 00:18:10 - The counterintuitiveness of diet predictions: "good diets" that improved diabetic control may include alcohol and chocolate, while a "bad diet" might be incorporating something like tomatoes. 00:19:40 - Microbiota driven: only the microbiome and the minor incorporation of very few other features provide a similar level of predictability. 00:20:00 - Trial under review: NCT03222791. Double blind diet randomizing to american diabetes association diet vs. algorithm diet. 00:21:10 - Vaginal microbiome transplantation (VMT) and treatment of intractable bacterial vaginosis. 00:26:20 - Postbiotics (metabolites) 00:27:00 - Amytrophic lateral sclerosis (ALS) 00:33:10 - Bacteriophage therapy 00:36:20 - Microbiome as a modulator of acute liver failure. 00:48:15 - Question: What role is the appendix in modulating microbioal communities? 00:49:20 - Question: What do we know about the microbiome in childhood vs. adulthood in shaping immune responses to pathogenic viral infections like COVID-19? 00:51:10 - Virome in human health 00:51:18 - Full sequencing of microbial data vs. analyzing key species 00:52:50 - Question: What role does microbiota transplantation play in mitigating the antibiotic resistance crisis? 00:54:26 - Question: Which model features were the most important in determining an individual's recommended diet? What were the particular food dimensions by which algorithm algorithm-prescribed diets differed across most individuals? 00:56:40 - Adverse effects of vaginal microbiome transplantation (for the treatment of bacterial vaginosis) 00:58:10 - Question: Could vaginal microbiota transplantation be more successful with multiple successive rounds of transplantation? 01:01:05 - Question: Is bacteriophage therapy susceptible to resistance in the same way that antibiotic resistance emerges? 01:02:50 - Question: Are there any adverse consequences to releasing bacteriophages in the gut, even though they don't affect host cells? History of phage therapy in Russia. 01:04:35 - Question: What do we know about the clinical relevance of the respiratory microbiome? Thanks again to Dr. Elinav, his colleagues, and CPM Oxford.

Sir came to our school tonight. A big honour for us

I appreciate that you say they "could" be helpful. Since they currently have a massive asterisk.

SBMA. ?

Can Crispr be used to add girth to my penis?

This is brilliant. We are just at the beginning of understanding the microbiome. Thank you Tim Spector.

To me, the amazing thing is not the technology. My belief is that this technology will become common for a number of reasons including that much of what we call Human Progress is the removal of natural selection. To survive, we will have to replace the natural selection that we have removed and pre-implantation artificial selection offers potentials that natural selection cannot. Natural selection cannot select for "good" genes, only against "bad" genes. It is incredibly inefficient and brutal. No, the amazing thing about this video is the date, the number of views, and the comments... This man is talking about husbanding the greatest wealth in human existence and the only chance for long term human survival... yet in over 4 years it has only been viewed less than 700 times. That could be shocking but I guess it just illustrates how people think. For decades I've examined the need for and the potentials of pre-implantation artificial selection from an ecological perspective. It's quite different than Dr. Wells' view but you might find it interesting because it not only describes why what he is doing will be necessary to human survival, but also it illustrates the weakness of natural selection, the genetic strategy given to us by nature. That principle even extends to show the problem of other strategies nature has given us. I wrote a book about it called Genetics For A New Human Ecology. If you are interested, the genetic part is a KZbin video at kzbin.info/www/bejne/rZu5mph8gMqpg80 (Dr. Wells' work is mentioned at 16:00). The video is a bit older. The more updated book is at www.amazon.com/dp/1544900996

It could be used in eugenics she said. No shit sherlock, come and get your jab....

Bravo Docteur Inès :)

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My chronic fatigue was caused by Antibiotics I think. Sines working on gut health I’m almost back to normal but it’s took 2 years. Could Antibiotics be a feature in causing long Covid ?

Can you add to your stock gut bugs. My gut biome got damaged by antibiotics I have a couple of bad bugs E Coli and Ergettella can you restore the gut bugs that have been wiped out by Antibiotics ? And can you get rid of Bad Bugs ?

Tool of human. Blessing or pandoras box? Huge money finds its way to super solider programs China, Isreal , Russia, Germany, biggest user America. Exciting, dangerous new worlds ahead. P.s. I suspect this is 60 year old science. Think president designed from birth..think Obama

I bet no one can answer these questions: 1. What does CRISPR do? 2. What part allows the CRISPR-Cas9 protein to interact with DNA? 3. What class of species uses the programmable adaptive immune system? 4. According to the narrator, if you are a bacterium, what is the “big enemy”? 5. Alternatively to bacteria, how do eukaryotic cells deal with a double-stranded DNA breaks? 6. How can a CRISPR protein be easily reprogrammed? 7. What kind of mutation is illustrated in the sickle cell disease? 8. What is something the narrator mentions as a blocking point in making the CRISPR technology readily available? 9. What is the cost per patient? 10. What is the ethical concern of using CRISPR? 11. What does chemical editing by engineered CRISPR-Cas9 do? 12. What was the fastest purified editing protein? 13. What technology developed the 3D structure of the CRISRP-Cas9 + editing complex? 14. Why does the editing TadA-8e still need more research and refinement? What are the challenges? 15. Do alternatives to CRISPR-Cas9 occur in nature? 16. What kind of approach is used to identify a mixed sample of many different bacteria? 17. What is the big bottleneck in the CRISPR editing field? 18. What are the current ways of delivering a CRISPR- engineering complex into a patient? 19. What class of diseases were illustrated to benefit from the targeted protein RNA delivery? 20. How was cell penetration achieved? 21. What was the proof that the delivery worked? 22. How does CRISRP tackle the COVID pandemic? In what way? 23. Look up how accurate are CRISPR-Cas9 technologies? 24. Did you enjoy learning about this gene editing approach? What strikes you the most?

Data is definitely morally neutral. Four apples, three bananas and two pears; this is a data set and it contains no morality. Data can be used for moral or immoral purposes, but the data itself cannot have any morality attributed to it any more than any other inanimate object. Give printed data to a five-year-old, no matter how horrific it is, and the child will probably use the paper to draw on or make a paper aeroplane. It is the uses that humans make of the data that can be ascribed the label of moral or immoral.

DIRTY ROTTEN

I want to ask you is there a technology that change many cells??

Can genome editing help in our fight against future super bacteria?