WEHImovies

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@markmuller7962 3 сағат бұрын

I know it's a very human question but WHY?

@marcomonti5758 5 сағат бұрын

cool

@prototropo 9 сағат бұрын

I love this level of verisimilitude! But could someone with expertise please explain just how close to reality these videos come? The colors are artifice, of course, but how about the rest?

@WEHImovies 7 сағат бұрын

30 min presentation on wehi.tv animation, what is real science and what is art kzbin.info/www/bejne/p5Pcq3ifd9uVjtksi=itxbkKV5ELY2ua4j

@shirootaku6641 10 сағат бұрын

Nice movie

10 сағат бұрын

Looks a bit like a mermaid

@ultragames5663 13 сағат бұрын

those are amazing animations. Quite different to reading about this in a book. This must be very helpful for students and professionals trying to learn and understand the subject better.

@felipemorales5181 15 сағат бұрын

Imagine this but the proteins 100 × more jiggley and fluid

@joshroolf1966 17 сағат бұрын

Wow. By far one of the best molecular animations I've ever seen!!! I think you've really captured the frenetic grace of the processes in an aesthetically pleasant way, great job everybody.🌞💚🐾🐾🐾 I feel like a big squishy robot now..:::🛸🧬🌌🙉

@WeirdInfoTV 22 сағат бұрын

Can't believe that there are actually people that denies the existence of these beautiful molecular bio-machines

@iestynne Күн бұрын

I was wondering how these incredible animations were made - thank you so much for sharing! It would be amazing to see this running in VR. Unity has good VR support, so it would mostly depend on what kind of performance you get since VR generally requires more than 2x the compute for rendering than does a 'flat' game.

@iestynne Күн бұрын

Absolutely unbelievable. It's like magic. So hard to grasp that this evolved via stochastic processes. I do wonder if human technology will ever catch up. It's just so so far ahead of us, and took such a monumental optimization process to create.

@iestynne Күн бұрын

Amazing! I have 2 questions: 1 is this a simulation of the process or a 'representative' hand-made/procedural animation? 2 where does the proteasome get the energy for this process?

@iestynne Күн бұрын

Thought of 2 more questions: 3 what's the time slow-down factor for what we're seeing as compared to the real process? 4 how many of these proteasomes are active simultaneously in the typical human cell?

@iestynne Күн бұрын

This excellent talk on how the animations were produced answered two of my questions: m.kzbin.info/www/bejne/p5Pcq3ifd9uVjtk Time is slowed down by a factor of about a billion, and is derived from actual molecular simulations, however the animation is hand-tuned a fair bit to make it read more clearly for the viewer (reality would be way too messy to understand!)

@youtubeuser6067 Күн бұрын

As AI plays a greater role in clarifying movements and interactions of these molecular processes, it becomes more important to UPDATE previous depictions so that research can be further advanced. I hope there is one website with all of these previous videos (dated) that will soon indicate AI enhancements to them.

@pensularnaseeare9531 Күн бұрын

This is the craziest thing I watch today.

@nicopb4240 Күн бұрын

Omg this video is so good

@sonhuanson Күн бұрын

A real challenge for those who create molecules, in turn creating the pair that recycles it.

@donross7820 Күн бұрын

So beautifully crafted! Thank you

@rkgki Күн бұрын

Well done! I really like the chemical reality of constant motion, and bits bouncing all over the place.

@PatrickStaight Күн бұрын

I have a couple questions if anyone is up for them: • How efficient is the recycling system? Particularly, what percentage of damaged proteins fail to get recycled? • Are the number of Proteasomes in a cell comparable to the number of Ribosomes? • How accurate are the systems which attach the ubiquitin to proteins? • Do Proteasomes operate both inside and outside the nucleus?

@MichaelFlambe 13 сағат бұрын

I have some answers for you! a) The system is very efficient - all of those peptides will go on to be used within the cell. The raw matter is not lost, the only inefficiency is an energy one, I believe ATP is used to run the unfolding machinery of the proteasome, and more ATP will be needed to put new proteins back together, b) Yes, there are many ribosomes, and many proteasomes - although the exact numbers are not important, what is is that the proteasome is only one mechanism of many recycling mechanisms your cells have for facilitate resource turnover within your cell. Thus the ratio of proteasomes to ribosomes is not really important as your question presumes. Google Autophagy as that is the true cellular recycling boss, proteasomes are more "precision" recycling machines. c) They can be extremely perfectly accurate (dictated by the exact jigsaw fingerprint of ubiquitin binding of the target protein, and a facilitator signaling protein) but sometimes they are more relaxed, for example you may release a protein temporarily to attach ubiquitin to a lot of stuff as a stress response, and itll last a while then degrade after a time. d) Yes. Hope that helps, have a good day =)

@Gabriel-wq3lh Күн бұрын

This is mind blowing! Just wow.

@JoshWitte Күн бұрын

Looks like a woman in a green dress with a yellow flower in her pink hair

@paulferry7791 Күн бұрын

This would have made learning biochemistry so much easier back when I took it 30 years ago.

@donross7820 Күн бұрын

I love it! Thank you

@donross7820 Күн бұрын

I love it! This is so beautiful and creative. I do 3D animations and so I am doubly appreciative of your creativity.

@Falconer5752 Күн бұрын

So, has anyone yet thought about using or modifying these guys to fight Prions?

@Garyyost Күн бұрын

Wow, just wow so much... a thousand times WOW! To see all of this so clearly, what a miracle. The three chambers of the core? I had no idea that's how this worked. Thank you so much!!!!!

@carlosli7602 2 күн бұрын

Just so amazing, a full picture of the story.

@user-uo8yz1xy1h 2 күн бұрын

Thanks for vdo.❤❤❤

@Gelatinocyte2 2 күн бұрын

As always, the sound design is top notch!

@BlackLukeS 2 күн бұрын

KZbin compression algorithm hates this video

@rodrigomoreno11 2 күн бұрын

Amazing!

@koxafis 2 күн бұрын

Babe! Wake up! WEHI just uploaded another banger short film!

@agusavior_channel 2 күн бұрын

that is how a plumbus is made

@xfxox 2 күн бұрын

This animation is mind-blowing ! Thank you

@kongolandwalker 2 күн бұрын

Where does the motor take energy for its work? Does untangling protein take energy or release energy? Cutting stage looks like being powered by chaotic movement. Is it the same with motor: it works like a diod allowing chaotic movement down the pipe, but blocking reverse movement? (I think that explanation would delete the need in source of energy).

@Gelatinocyte2 2 күн бұрын

I think it uses ATP, it's just not shown in the video for clarity sake.

@fancytracy 3 күн бұрын

What program was used to create this animation

@WEHImovies 2 күн бұрын

wehi.tv animation pipeline kzbin.info/www/bejne/p5Pcq3ifd9uVjtksi=Xrr303O5T7OxrcRm

@kapkanal 3 күн бұрын

amazing, thanks a lot WEHImovies team! we love you.

@Melih_R_Calikoglu 3 күн бұрын

We are far away from processing molecular structures individually, yet it is happening inside of us billions of times a day, for hundreds of millions of years. Crazy stuff

@paulferry7791 Күн бұрын

It's estimated to be around 30 to 40 trillion times per SECOND in all our cells working in concert to give us this thing we call life.

@themushroominside6540 Күн бұрын

I find it so wonderful how all of this came about from random chaos, i find that the idea that there is some greater will or being some how brought about complexity to be rather boring, it really undermines the sheer scale of it all, with such few rules to follow, infinite possibilities come forth, complexity from the mundane, i find it all beautiful.

@iffyfox9749 17 сағат бұрын

@@themushroominside6540 We all came from a billions of years old microscopic 3D Tetris game, I enjoy describing it like that because it's not entirely correct nor is it entirely incorrect

@hydrochloricacid6731 16 сағат бұрын

I don't know what you mean by that, we can process individual molecules, just not with the same speed and efficiency.

@user-sj5lc3uw2i 3 күн бұрын

babe! wake up! new wehi video!!

@BrentLeVasseur 3 күн бұрын

Great job on the 3D animation for this video.

@anjotheweezky215 3 күн бұрын

Ultimate evil Malaria is

@Yoga_talk 3 күн бұрын

OMG!

@charlescabana7849 4 күн бұрын

Learned something. Makes my day.

@LiminalArcade1 4 күн бұрын

This apparently happened ”spontaneously” when life started on earth

@fr_rave 17 сағат бұрын

yes, after a long time

@igamerxd8450 4 күн бұрын

You are an amazing human, thank you for simplifying such a complex biological mechanical structures and mechanism to easily understandable chunks. Thank you for your work. Love your channel and your passion.

@TheHildegard01 4 күн бұрын

Great👀

@boringman6491 4 күн бұрын

Work, work, work.

@ks1v 4 күн бұрын

Wow, many thanks

@peters972 4 күн бұрын

Just when you thought you had seen it all, another fascinating machine you took for granted, who would have thought, specialized garbage collection and recycling of reusable parts. I thought stuff just dissolved or something, more like inorganic chemistry, but it’s all very specific machinery, built atom by atom.

@alecheesacker4460 4 күн бұрын

Mechanical Sounds of Machines?

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