Older people say they feel great on the lion diet People lose muscle when getting and become flabby, no muscle strength

Wow

Thanks for sharing this lecture recording. Dr. Leena's step by step explanation makes the lecture easy to understand.

WE ARE NOT RODENTS!!

5:45 It seems like they lose weight with the isoleucine restriction initially but they all go up in weight over time. Maybe the effect of cutting this specific protein doesn’t last for a long period of time?

1:40 Protein restriction reduces body weight gain? It also increases energy expenditure? This is quite the opposite of all the common nutritional wisdom even given by doctors. Mainly that protein is the most satiating macronutrient, and that you need protein in order to maintain muscle mass.

Increased HSC number? What about endogenous stem cells?

Ultimately... it seems that survival of the species figures in to just about everything diet related. When food of all types is plentiful lifespan might be shorter, when only certain foods are available lifespan often increases. It appears we've been through countless of thousands of rough and good times in order to get our bodies to this point. What other secrets lie within?

She’s so good at explaining things

Secularism: denial of God and the Bible

Dear Professor, please excuse me if my comment merely shows my ignorance on the subject. The position of seniority in evolutionary age of the mitochondrial system along with it's being incorporated into and acceptance by so many different organisms tells a story of ubiquitous success. Its a well established, a settled in, a widely accepted, very old system that has stood up to all the evolutionary challenges so far. I acknowledge it's capable of getting sick and developing nasty mutations. Besides when such things might affect it, I can't see a reason to suspect that it plays a major role in aging, but who knows, it might. Genetics is definitely the right field to be in, but there's more than one tree to be barked up. Take for instance the bristlecone pine (Pinus longaeva) and a regular pine. The only thing that sets them apart from each other is the difference that exists in their genetics. Somewhere within that bulk of different code, are held the recipes / keys to its extraordinary longevity as compared with more regular pines. I suppose since you are looking at mitochondria, you might do well to compare the mitochondrial sequences so to capture the differences between that of Pinus longaeva and the other shorter lived pine species. That might provide interesting results much sooner than the ROS hypothesis. I'm not sure which if any may have been sequenced to date. If none have, then I guess it would be a good place to start trying to uncover new information. I hope you make lots more interesting discoveries. Wishing you the best of luck!

Hmmm

May be high mtor related to fungus growth.. rapamycine may stop that .

Where on earth do you find anyone in the developed world that eats too little protein? Youcan get enough protein if you only eat fruit.

Your host is terrible she sounds like a sixth grader

How many exogenous ketones to get to 1 mM ketones in the blood?

How did you prevent the mice from overeating like they did in the verdin study?

Does color scheme in 11:37 match up with the 2022 paper? Green yellow is gonna become canonical sometime

Wonderful - thank you

What would you recommend for a teenager who is trying to build muscle? Large amounts of protein (and calories) can really help.

Thanks for this very informative lecture. This should have far more views given the popularity of the longevity subject.

if only the intro music could be louder, include electric guitars and maybe a screaming goat... then i would be properly motivated for protein restriction to try to preserve the health of my ears

Man GH is anabolic to the connective tissue’s not skeletal muscles. 29:46 even testosterone doesn t impact muscle growth when he is in normal range

I was really interested in this topic but I agree that the audio was extremely difficult to understand and the video was also fuzzy and functionally unviewable. Dang!

Thank you for this interesting talk. Is it possible to avoid protein deficiencies on low protein diet if one eats enough cellulose fiber? I ask because of this update by Suzanne Devkota: The gut microbiome as biosensors of host nutritional deficiencies kzbin.info/www/bejne/i3bKmX1undNqjLM

Suh

In my case, doing 16/8 TRE and eating a whole food plant based diet I am able to routinely elevate my ketones to clinical levels (0.5 mmol/L) plus or minus a bit for last few hours of fasting window. I also take this as a good marker for low insulin, which is desirable. If I restrict my calories for a few days, addition, similar to the Longo FMD, ketone levels will go up to 1.5 to 2.5 mmol/L which may be a good marker for increased autophagy, probably a good thing to do every month or two if you're older like me.

Great information but the audio and video quality could be better

With so much discussion about rapamycin being the gold standard drug for aging, I wonder if modulating BCAA might be a good way to accomplish this as they are both accomplishing aging increases by reducing mTORC1 activity?

Good talk. This video had some annoying noises in the background.

Very helpful video. Would be possible to get some references?Especially for the Phenotypic Age?Thank you very much

Would love to know which plants, when eaten, slows down the epigenetic aging the most.

Thank you

thank you that was a very interesting presentation

This is among the best I've ever seen

There is a new quantum microscope that is 30% higher resolution. Any chance of getting some time-lapse of the processes using the new microscope. Paper is titled: Quantum-enhanced nonlinear microscopy.

Prof Kaeberlein is a legend in this space - keep up the great work!

Awesome talk, thanks!