028 - New findings: more evidence of poor oxygen perfusion in the brain.

[@youngerlab]

Erratum #1: It was noted in the comments below that it is inaccurate to say mitochondria need ATP to function. They have other sources, such as pyruvate, to perform their basic functions. It is instead correct to say that mitochondria produce ATP, which is then used by cells. Erratum #2: I misspoke and said "oxygen" instead of "lactate" at 5:59. Thanks! - Jarred Younger

[@tubejam3156]

Lol, now you are actually incorrect. If you read my replies to the comment you refer to you will see that mitochondria do indeed need ATP to function. Various transport mechanisms employed by the mitochondria require ATP, period. That ATP can be gotten from non oxidative phosphorylation sources like glycolysis, fermentation, phosphocreatine etc that then kickstart the production by the mitochondria, but the mitochondria absolutely need ATP to function.

[@youngerlab]

@@tubejam3156 Yes, since the mitochondria are in cells, they need the ATP support of those cells in order to function. Transport mechanisms being the best example. Though for this particular story, it would have made more sense for me to end with ATP in the pathway I described for aerobic metabolism. Thanks! - Jarred Younger

[@SamB79]

@youngerlab could the reason for low oxygen levels in the brain be due to a PFO which Dr Paul Cheney says that almost all the ME/CFS patients he tested had a PFO? It causes blood to be shunted from right to left and bypasses the lungs so de oxygenated blood is circulated?

[@isabellekeyzer]

where do carnivores get their glucose?

[@seanvogel8067]

@@isabellekeyzer, glucogenesis?

[@kikijewell2967]

Omg, I hang on every video! I kept going, "wait WUT?!?!" and rewinding! I feel like all the pieces are coming together in your work! I'm so grateful that you make these videos!

[@bradleyc6564]

Excellent update. Extremely excited for all the news to come!

[@bozobarr]

These tidbits are great. Everyone sideeyed me when I'd say my fatigue was mitochondrial-related. Too bad I have no interest in putting in the work to do research because if I did, I'd totally want to have you as a professor and look into such important topics that affect so many. I really appreciate how you aspire to actually help people with your research. You're awesome 😎

[@BryanKirch]

Thanks for everything you do

[@deel2435]

Gotta say I love seeing how excited you're becoming. With each successive video, you're becoming more and more energised. It's obvious that you love your job and it's a real joy to listen and learn along with these videos. Thanks for all you and your team do.

[@youngerlab]

Thanks - yes getting new data is my favorite part! And I just had another big batch given to me by the grad students yesterday. So I have new things to look at for next week! - Jarred Younger

[@michelleburstrom2548]

I am diagnosed with anklosing spondylitis and I test positive for the HLA-B27 antigen. I took several medications over the years to deal with it such as Humera,Methotrexate, etc. The meds did nothing but take the edge off. I entered a diet group that was headed by a doctor, dietician, and nurse. We did a strict ketogenic diet that consisted of eating meat,fat, some vegetables, and some low sugar fruit. I was completely and utterly free of all pain,inflammation, and brain fog. I lost 30 pounds and my blood pressure went down. All metabolic issues were resolved. I found out later that AS is triggered on by the klebsiella bacteria which mimics the HLA-B27 antigen. The klebsiella bacteria thrives on starch so when I cut out starch I starved the bacteria and all my inflammation was gone.

[@JeanPierreWhite]

Interesting. My wife just got blood tests back regarding HLA-B27 and she's positive unfortunately. Humira, Methotrexate do help as you say. She has Psoriatic Arthritis Who is your dietician who helps with the appropriate diet? Where is the study conducted you are in? My wife is addicted to sweet things. I'm sure that creates huge issues for her.

[@samhouston1483]

Everything revolves around cellular hypoxia. This is also shown on a 2 day CPET for ME. Many years ago Dr David Bell said ME is like a low level sepsis & cell hypoxia. This occurs in the brain and body wide. Definitely the crux of this whole problem & disease. The harder issue is what is the cause of this? What’s upstream of this? Is it an uptake issue via Mito probs or delivery prob (capillary issue?) or something else. Very complicated but the research should be focusing here. I had a 2 day cpet (I have severe ME) and was in an anaerobic state even at rest. Ty for your work here

[@dshepherd107]

Look up Dr Raymond Perrin and the Perrin Technique on KZbin. He appears to be onto something, & is having success treating patients with ME/CFS, and Long Covid.

[@Arkarian1987]

I recommend to look up IHT (Intermittent Hypoxia Therapy) or better IHHT (Intermittent Hypoxia Hyperoxia Therapy), that induces adaptations in mitocondria and gen expression to correct cellular hypoxia (and other things). It can be done with an altitude training machine (looks like an oxygen concentrator). IHT can also be done by free diving or breathwork (holding breath after exhale)

[@1truthseeking8]

​@@Arkarian1987that also restores CO2 LEVELS which are CRUCIAL for releasing oxygen from the globin of hemoglobin and myoglobin....

[@dr.nielsen9358]

What do you mean by day 2??

[@hawkarae]

THIS is the bottom line answer for the chronically unwell. Experiencing chronic illness and divine guidance with total resolve to be vital, functional, useful, FREE: oxygen loss/brain damage answers all. Thank you for your diligence and generosity ❤

[@maib1089]

I think the main cause is B1 thiamin difficiency which blocks pyruvate dehydrogenase complex so pyruvate accumulates and converted into lactate

[@1ere1]

As always, fascinating! Thank you! 😊

[@illuminationgoddess3]

Thank you Jarred, good information.

[@mukeshdesai2862]

7:25 choline 8:45. Rx choline? , HBOT , diet 9:48. French maritime pine bark

[@baileystruss7319]

Huperzine can boost the muscarinic aspect of choline and nicotine patch the nicotinic aspect of acetylcholine. Also acetyl L carnitine is a precursor to choline. Thanks for the update

[@fibromyalgianational]

I look forward to hearing more. Thank you! I was fascinated to learn recently that Michael Phelps is reported to produce the smallest amount of lactic build-up than other elite athletes. Has there been any studies with these elite athletes as healthy controls? It doesn't seem like it's training alone. There is a lot of discussion on choline in the Alzheimer's space. Really fascinating and intriguing!

[@marlineemmal6458]

Studies on fibromyalgia in the 70's revealed that it cannot be induced in elite athletes, although it can be induced in normals and even cats by interrupting their slow wave sleep. Elite athletes have more mitochondria than people who are not as fit. The chronic trauma response associated with CSS leads many mitochondria to become dormant. Dr. Robert Naviaux calls this the Cell Danger Response.

[@hawkarae]

You are evidence for my faith in and devotion to humans at their humanest ❤

[@mars9953]

Thanks for all the work you do. 🫡

[@lsaltd8808]

Great video thank you. I've been testing my lactase at home over the last 18 months. It is often elevated and it relates to PEM (I have post viral me/cfs). Basically any small exertion leads to an increase in lactate and then post exertional malaise. I just have a finger prick blood test monitor. Very soon the are relasing 24 hour lactate monitors. I believe that lactate monitoring will perhaps do for me/cfs patients what glucose monitoring does for diabetics.

[@poppyseed6487]

I just fancy this guy so much!

[@scarredk0]

Haha easy there poppy you fox

[@ClaireCaoimheRaeMoonshadow]

We need to start a fan club. 😂

[@naomi5495]

This is such important work. Thank you for sharing. 🙏

[@Holy_ShihTzu]

Phosphadityl Choline and Citicoline have helped my partner and I who have chronic fatigue and cognitive dysfunction.

[@Holy_ShihTzu]

I also have fibromyalgia and chronic pain issues. Antioxidants and anti-inflammstories like high DHA fish oil also are helping. These were not all added in at once, due to risk of confounding variables, so we could assess changes in our bodies more accurately.

[@youngerlab]

Thanks for the info! - Jarred Younger

[@rhyothemisprinceps1617]

I have MCAS and my daughter has ME symptoms. My daughter and I both take ALCAR and in order to avoid getting a choline depletion headache I also take citicoline. I don't give my daughter citicoline since she eats ~ 4 whole eggs a week and also eats beans (I can't eat either). I've been thinking about giving her the supplement, though. I had been a bit concerned about TMAO, but I'm thinking the TMAO story is probably a red herring (see 'Microbial trimethylamine-N-oxide as a disease marker: something fishy?').

[@1truthseeking8]

​@@rhyothemisprinceps1617 try liver...

[@1truthseeking8]

​@@rhyothemisprinceps1617p.s. 4 egg yolks a DAY would be much better for her. But you need to begin eating liver. Kidney, and other organ meats high in Choline.... have ya heard of "proper Human Diet"?

[@tylerpelkey8958]

In case you aren’t aware, the University of Zürich is doing a Long Covid study with pycnogenol.

[@Rene-uz3eb]

It seems pycnogenol binds strongly to iron and due to its high bioavailability could be a strong iron chelator (as other tannins) Natural Iron Chelators: An Orthomolecular Approach to Treat Iron Overload and Its Related Diseases, 2020

[@youngerlab]

I didn't know! I will reach out to them and see how the study is going. Using pycnogenol for Long-COVID makes good sense. - Jarred Younger

[@brendabrenner2891]

Excellent! This explains how my long cov, past mold, celiac, sibo, gut dysbiosis, , sars in michchondria, stops energy production, + cause the multiple organs dysfunction I live w in daily agony.. this info needs to go to all Drs , interns, , re education, dr Paul. Anderson+ Dr David putrino, would concur with you, 🙏❤️

[@theancientsancients1769]

@@brendabrenner2891 I have long COVID with no longer issues..but during sleep my Whoop device shows oxygen dropping

[@dshepherd107]

Dr, have you heard of UK physician Raymond Perrin, & his thoughts on the lymphatic system m of ME/CFS, post viral syndrome?alfunctioning, as the origin? I have severe ME/CFS. I used to be a “junior” research scientist. I’ve been looking for answers for 10 years. I think he’s also onto something. There are peer reviewed papers supporting it. He has a technique called, The Perrin technique. Thank you for all you and your team, including Chloe for your dedication.

[@fibromyalgianational]

I've heard there is medical provider in the United States that uses this technique in her clinic - Dr Ruby Tam. It's something on my list to research more.

[@dshepherd107]

@@fibromyalgianational I know you’re very busy, but I think it may be worth your time. His initial theory over a decade ago, was lymphatic vessels (which it turns out, contain smooth muscle, like the heart & esophagus) actually reverse flow. More specifically, the glymphatic system. **For others reading this, “The glymphatic system is the analog of the lymphatic system in the CNS. As such, the glymphatic system plays a key role in regulating directional interstitial fluid movement, waste clearance, and, potentially, brain immunity.” NIH Instead of the vessels flushing cellular waste, etc out of the body, they reverse flow, carrying the toxins to the CNS. This may be at the root of why we see such broad, seemingly unrelated symptoms. Maybe this damages the mitochondria, or perhaps causes them to malfunction? He has had success using his lymphatic massage technique, in helping patients with long haulers Covid, and even with long time, severe sufferers of ME, either go into a remission of diets, or perhaps they’re fully recovered. There’s outside research that’s been published that appear to support Dr Perrin’s views. My brain is very tired tonight, but if you’d prefer I get the info/links for the information, please let me know. Ty for reading and responding to my first post. .

[@djVania08]

Have you done the technique on yourself?

[@dshepherd107]

@@djVania08 No but I’m planning on it, but I need some help. I’ve gotten worse, & am in the process of getting an aide. I also am scheduled to see a DO who I’m hoping will get on board.

[@KidCity1985]

I wake up some mornings with a mild headache, I can tell I didn't get enough oxygen during the night.

[@lucheeese]

There was a lady in a group who experienced drastic improvement of her ME after supplementing choline

[@Anikat]

Really fascinating findings. I don't know how I ended up at this channel, but I am glad I did 😂 Mind blown when you mentioned pycnogenol as a possibility. If anti-oxidants work as a treatment for your fatigue people, your findings might be worth mentioning to any colleagues who are working on ADHD. I wonder if there is a similar less-than-ideal-oxygen issue involved in both. There was a paper that suggested pycnogenol had effect for ADHD, and I've been self experimenting with it on and off for a couple years now. I find that pycnogenol + vigorous exercise gets me about 50% of the effect of the "real ADHD drugs" without the side effects. The effects seem to fade when I stop taking it. I have recently added in Ginkgo (also an anti-oxidant), but its too soon to comment on it's effects.

[@youngerlab]

Thanks! I'm familiar with the limited earlier research on Pycnogenol for ADHD. I think your overview is accurate -- it is not as strong as prescription (psychostimulant) meds, but there are fewer side effects and adverse event concerns. I remember the improvement on standardized tests being around 10%, but that is quite a significant change for those tests. - Jarred Younger

[@oliverbird6914]

Thanks for working on this

[@twopointwow]

This is just FANTASTIC - THANK YOU!! I'm pulling the French maritime pine bark from my crowded supplement cupboard and adding it back in - thanks for giving me such a clear *why*! (Survivor of 2017 head on collision with unstable c2 break requiring anterior fusion, traumatic brain injury, dvt's, many other resulting conditions and injuries, as I now am coming way down on meds.)

[@youngerlab]

Thanks! I hope some of the many supplements you have are giving some relief from the symptoms. French maritime pine bark appears to require a few weeks before benefits are noted, especially the cognitive ones. - Jarred Younger

[@gregoryhatt6475]

New sub, thx for your work. Tremendous channel

[@guidodenbroeder935]

Acetylcholine deficit in ME has been known for decades.

[@baileystruss7319]

@@guidodenbroeder935 and I think its due to autoimmune response against acetylcholine receptors if I'm not mistaken?

[@guidodenbroeder935]

@@baileystruss7319 That sounds unlikely. ME is not an autoimmune disorder.

[@rdklkje13]

Thanks for this!

[@OceanBlue-l1u]

I read some research few years ago that poor oxygen perfusion in the brain is the cause of migraines too. 🤷🏻‍♀️

[@supersport22]

I think Covid, or EMF, is causing a stiffness in the smooth muscles that surround the blood vessels and arteries, causing restriction… This can ultimately put pressure on the portal vein and liver, which may increase ammonia levels in the body. Ammonia in the brain is neurotoxicand high levels could explain many of the symptoms. People are experiencing in regards to fatigue, malaise, brain fog etc

[@anontablet6304]

We have known for decades that M.E. patients have hypo perfusion issues, especially in temporal lobe. See Ismael Menna's SPECT studies.

[@AndrewNovitsky]

Hey, do you have breathing recommendation for ppl with chronic fatigue?

[@KarenParkerArtist]

I've had luck with methylene blue, which helps mitochondria produce energy and supposedly crosses the blood/brain barrier. It's inexpensive, low impact (compared to drugs) and works for a lot of people. I can testify. I hope it's on your list of substances to look at. Thanks for the tidbit on choline. Eggs it is then.

[@youngerlab]

Yep that is an interesting one to mention. It is in the top ten of treatments to test - it has been largely ignored. - Jarred Younger

[@nothere156]

Hey Dr. Younger I don't know if you read the blog by Cort Jhonson on the main page of Healthrising which is generally on developments in the ME/CFS and LC world, I figure you’re probably at least aware of it since there have been numerous blog posts on there about your work. In any case the blog posts frequently mention studies on blood vessels and blood flows as well as the thoughts of the involved researchers on possible implications and treatments By coincidence the blog entry today specifically involved possible low blood flows to the brain and other things related to the cardiovascular system, with the statement at the end of the entry saying the next post would be on blood vessels as well. If you look at todays blog entry, specifically all the tags right under the title of the entry, clicking the “Cardiovascular” tag should take you to all previous entries on the subject, might be something to consider if you’re ever looking for ideas

[@deel2435]

Cort has some great posts!

[@georgiecoghlan7128]

Health Rising has helped me get 80% of my symptoms under control. Love Cort!

[@deel2435]

@@georgiecoghlan7128 I'm so happy to read this! Are you happy to share any specifics?

[@youngerlab]

Oh thanks I will read it tonight. Cort's stuff is great. - Jarred Younger

[@EugeniaPortobello]

Thank you for your investigation and videos. This fits my own intuitive conclusion after decades of suffering ME, which is an oxygenation issue. I'm also autistic and have CPTSD, would you think that the ultra high requirements of ATP for sensory processing and for a nervous system always on alert would have to do with it? Thank you again, I'll keep an eye of your channel.

[@saoirse108]

Asd a senior survivor of TBI I deeply apprechiate this research and the way you present it - thank you. I also wonder of you have data that focused on breath work & oxygenation in combination with yoga? (aka stress reduction, leading to reduction of inflammation etc?)

[@PandaXEmily]

So, there are some doctors who use NAD shots to treat mitochondrial function in long covid. I've heard of a lot of success with this. The only down side is the only insurance company that will pay for it is medicare. What are your thoughts on NAD shots to treat this problem?

[@chrissowerby69]

Only about 20 to 30% of the brain requires glucose, and the rest can be run on fatty acids/ketones. this way of powering the mitochondria is more oxygen efficient. The rest of the brain can use glucose made via the gluconeogenesis pathway. To achieve this, the patient would need to be put on a strict low-carb diet (30 grams carbs a day) and would likely not be able to stick to it as the first few weeks you can expect worse symptoms during the transition, but this is mainly caused by electrolyte fluctuations until the body fully adapts to the low carb diet. You could run some tests by supplementing ketones as they have in dementia trials. Alpha GPC is a choline supplement that crosses the blood-brain barrier so that would be an easy win if you wanted to go down that route.

[@youngerlab]

Very interesting! My colleague Rob Sorge is just downstairs and is researching dietary interventions related to what you are noting here. I will run this by him and see what he is doing now. Thanks! - Jarred Younger

[@chrissowerby69]

@@youngerlab Sorry, I meant to say alpha GPC, not GCP. Edited my reply now.

[@fibromyalgianational]

@@chrissowerby69 I've done much better on a keto/low carb nutrition plan and have been experimenting with various exogenous ketones at different times of the day. It's helped my pain levels and improved some fatigue. Not perfect but it's helped.

[@chrissowerby69]

@@fibromyalgianational my partner has fibromyalgia. she's reluctant to try keto, which is a shame. Alpha gpc made her anxious. Have you got any other ideas? Will try buying some exogenous ketones for her thought.

[@bitegoatie]

@@chrissowerby69People tried putting me on a low-carb regime for ME/CFS during my first years-long episode of it. I was so desperate at the time, I did not (uncharacteristically) ask about the theory behind it. What I have seen since the regime was shelved after several months of at-best-no-improvement results on any symptoms (I was routinely sleeping 22 hours a day at this point and didn't do better than about 16 for more than a day at a time) related directly to ME - and certainly I had no help with my separate case of intractable pain - is that I don't see any coherent explanation in the literature on why we tried a low-carb diet in the first place. Why is this being recommended? What is the theory? I mean, profoundly inactive people would do best to moderate intake of calories generally and in particular to reduce intake of complex sugar-delivery molecules that rely on a working body to make good use of foods high in such resources. That is a simple, very-general dietary reason to reduce intake, but it is not a positive reason to use a "keto" diet in particular for this kind of autoimmunity problem. A well-thought-through approach to nutrition is a cornerstone of reaching remission in ME and of good health generally, but I have to say, "keto" diets, in most forms, are not that. More typically, they are means to an end for people looking for a short cut to weight loss, and they bring their own problems. But I understand there are people suggesting in some circles that some version of such diet may help this set of illnesses. I just have not found a convincing argument for it. If anyone has a good reference on this, I would be happy to read a detailed explanation of the idea. Thanks for any leads.

[@HerbQuest]

Would something like cordycep improve these conditions via its ability to improve O2 absorption?

[@stefanallard3084]

Yes. Peak02 is used by bodybuilders n they love it. A mushroom blend. But epo/itpp would be superior

[@Mattsnsjhdksjbs]

Thank you for the video!!! Amazing progress! - What about As an alternative treatment a cpap machine with a supplementary machine adding more oxygen at night? Both machine will cost 3k but still relatively affordable….

[@guidodenbroeder935]

The hyperbaric aspect is essential.

[@youngerlab]

Good question. The body-wide positive pressure is needed with the 100% oxygen. There has to be a chamber to hold the pressure. If an at-home unit is not available yet, it will be. I would be scared to see how much it costs. - Jarred Younger

[@GovilGirl]

The YT algorithm recently showed me a bunch of reports on studies on the use of vibration machines (in certain conditions) that seem to aid in generating bone growth and repair, increasing lymphatic drainage and (I think) reducing lactic acid after workouts - which was better compared to stretching. Some reports included a reduction in joint pain. I was unaware there was a way to see/measure oxygen flow to different parts of the brain! (Until the YT algorithm delivered your video to me!) Is there a study to see if the vibration boards actually help with brain oxygen use? I would love to sign up for one if so!

[@brobinson8614]

The only issue with choline is it can cause cardiovascular disease. Lots of studies on that. However if you are taking it for ME/CFS or Long Covid it may help, but be aware not to stay on it for years on end. I tried it for several months, unfortunately with no improvement whatsoever.

[@oliviajenkinson7281]

Oh no!! 😞

[@youngerlab]

Yes thanks for saying that. You probably noticed I wasn't too excited to pursue choline, and that is for the reason you noted -- there are downsides, some people who definitely should not take it, and the need to properly balance usage which can be difficult to track. So I am not recommending people try direct choline supplementation. - Jarred Younger

[@rhyothemisprinceps1617]

I have doubts about the TMAO story, mostly because fish is full of it and we don't see increased CVD risk with increased fish consumption. But OTOH, perhaps consuming TMAO orally is different from producing in the colon. There's an article that discusses this - 'Microbial trimethylamine-N-oxide as a disease marker: something fishy?'

[@brobinson8614]

​@@rhyothemisprinceps1617 TMAO hasn't been debunked like some claim. The only studies I can find countering the TMAO link to cardiovascular disease the authors conflict of interest were paid by the animal agriculture industry. We often find that. Also they intentionally mislead with the study design. Comparing unhealthy people to even more unhealthy people. Also comparing diets that both contained Choline and L-Carnitine (which is also linked to cardiovascular disease) Theres lots of good studies on it. It's not just TMAO and choline though. Animal protein too that also is linked to cardiovascular disease, via inflammation of the endothelial lining of the blood vessels. The reason is animal proteins have similar (antigenic) shapes to human proteins so the immune system sees them as foreign bodies, and reacts, unfortunately attacking the lining of our blood vessels, This inflammatory spike can be seen happening after every meal that contains animal protein. As for fish thats another false health myth spread by that industry. Most the fish oil studies are now debunked. Although DHA is good for us, its not a cognitive enhancer. but The problem is fish and its oil is highly contaminated. Much safer to get DHA at its source via the algae that makes it. Those that eat whole foods like all the vegetables, fruits nuts seeds berries, legumes, etc and fish, still aren't healthier than those that eat the same plant diet but no fish, as shown in this recent study (of many prior to it) I can't share the link but here's the title to search for >>>>> Cardiometabolic Effects of Omnivorous vs Vegan Diets in Identical Twins: A Randomized Clinical Trial | Nutrition, Obesity, Exercise | JAMA Network Open | JAMA Network.

[@1truthseeking8]

​@@brobinson8614tried raw high fat Carnivore yet? I have, never better, never going back to the plant based plantation and endless need for supplementation either.

[@r.1599]

French Maritime Pine Bark: For the sake of clarity, do you differentiate between French Maritime Pine Bark, and Pycnogenol? I can buy a supplement of either, but one may be cheaper than the other because of the name.

[@Unitedstatesian]

The story just keeps getting more exciting. Colleagues from Renegade Research have collected data on lactate. Especially post-prandial lactate. Blood lactate, staying below 2.0 is a good way to make sure you are pacing. Postprandial jumps in lactate jumps in lactate are interesting as well. In our nicotine patch research choline is often mentioned. I don't suggest too much choline supplementation... Anecdotally I see many mention it leading to depression. The low choline is probably downstream. Low-dose nicotine helps this issue upstream. However, we do suggest taking choline during breaks to reduce the cholinergic changes when nicotine is completely stopped. But this is not a big part of our protocol. French maritime pine bark looks promising. I wonder if there is an overlap with OPC (grape-seed extract) which happens to be antiviral?

[@1truthseeking8]

That IS A TOXIN *UNTIL* it is broken down by the liver ... You NEED to do more thorough research into biochemistry function of these toxins that have been and still are being pushed as utopian solutions that our ancestors nearly never had access to ... Choline IN LIVER. MEAT, EGGS, and other organs our ancestors DID HAVE ACCESS TO NEARLY every meal their entire lives... But not grains nor seed oils (all toxic and rapidly oxidized beyond a day or two after smashing them out of an olive even without industrial complex to preserve), nor any other year round sources of carboNhydrates... Stop eating plants and start a Carnivore diet (after doing some research). And see the difference...RAW CARNIVORE HIGH FAT is the solution.

[@jonahhano4614]

great new informations; thank You!

[@MapacheOculto]

Thanks for all the updates! Could something like Chronic Myofascial Pain Syndrome involve similar process malfunctions as well? I know this syndrome involves muscles directly as well, but just wondering if you think it could be a component of the problem too. Asking for someone that has done about everything possible to relieve the pain.... (me S:)

[@Truerealism747]

Yes do you have hypomobility is it in just one area

[@MapacheOculto]

@@Truerealism747 I have full range of motion, but most of it is painful. It's the most noticeable on the left side of the back of my neck, but it's not just that area, it affects essentially all my left side from the scapula to the top of my head, front and back.

[@1truthseeking8]

​@@MapacheOcultolook for a Barral institute visceral manipulation/VM ""Instructor"" level ... And or craniosacral and or cranial osteopathy practitioner... Or if you're really lucky, someone advanced in ALL of those....

[@baileystruss7319]

Concerning the peripheral high lactate, are we assuming this also from low O2 from circulation or also the itaconate shunt and/or metabolic trap coming into play?

[@Db8it]

Thanks for another great video, Dr Younger! This one really resonates with me as someone with 30 years of chronic migraines and 2 1/2 years of severe ME/CFS. I am increasingly curious about whether there's a single point of origin (eg, an organ or gland) for these types of illnesses or whether we're looking at more of a self-reinforcing loop. Do you have any thoughts or theories on that point?

[@youngerlab]

Yes that is the big question. The work I have done so far (and my interpretation of the other groups' work) is that there are many origin points of ME/CFS. The pathological paths converge later to create common symptoms. I believe that solving ME/CFS will require identifying the critical subgroups and applying the appropriate treatments. I will be talking more about this in future videos, especially when I am able to talk about our recent genetics results. - Jarred Younger

[@Db8it]

Thanks! ​@@youngerlab

[@theancientsancients1769]

No surprise, this explains why when outdoors I feel better

[@Juxtapose76]

🙏💖🕊️

[@1truthseeking8]

Grounding/Earthing.

[@MegaLeoben]

Why is it so hard for national labs to do this basic research?

[@RagdollRocket]

exactly.

[@olivertruswell]

I thought the exact same thing. ME/CFS is supposed to be this 'labyrinth' of a disease, and yet Dr Younger finds all this clear evidence for something as basic as lactate that seems like it should have been performed decades ago.

[@1truthseeking8]

​@@olivertruswell BPD - Breathing Pattern Disorder. Butykeyo method, high fat RAW Carnivore diet, strict avoidance of supplements containing any and all fillers such as, but not limited to: microcrystalline cellulose vegetable Glycerin Glycerol, etc

[@timfrisch5694]

Ok so I had CFS for many years way back and started carefully Scuba Diving, probably 200 dives at average 15 to 20 metre over 12 months CFS left me. I always wondered if this was why. Same as Bara chamber in effect. 15 years on I now have FM unable to do pretty much anything. All Starting same time as Spike protein. Possibly I have issues with any virus with spike proteins. Starting with Epstein Bar virus starting in 1986.

[@xponen]

exposed to hyper-oxygenation, cold, and increase in respiratory load during diving, all alter breathing pattern.

[@youngerlab]

That would be an interesting clinical trial! I remember an observation about frequent divers having improved vascular health (but I can't remember if that was a proper study). Spending significant time at depth will certainly have durable impacts on the cardiovascular system. I can imagine some changes being good or bad depending on many specifics. It is a reasonable hypothesis that the diving improved your symptoms. - Jarred Younger

[@YinYang791]

Im just hypothesizing: Could it be that one common denominator is that most of those illnesses startet with some kind of symphatic overload and thus chronic overactivation. What could lead to a shallow and more frequent breathing. That is known for reducing blood co2, what is known to be a potent vasodilator. In that case it would mean that to much co2 is expelled from the body, leading the body to sense a o2 overload, by trying to protect the brain from Oxydation blood flow is limited. Leading to further metabolic disregulation etc.

[@marlineemmal6458]

Your hypothesis appears to be connected to the Cell Danger Response theory of Dr. Robert Naviaux.

[@YinYang791]

@@marlineemmal6458 Thank you, wasn’t aware of that gentleman.

[@1truthseeking8]

​@@YinYang791deep meditation is just one avenue towards reset....

[@JulieJensen-l9i]

You may want to consider breathing pattern disorders as being a cause for poor O2 perfusion in the brain. Low C02 levels preventing release of Oxygen from hemoglobin.

[@suzihazlove4979]

Omg i have always Said I breath funny.😢

[@DianaMarie23051]

Yes. People under stress or people with abusive back grounds breathe shallow & also breathe from the chest not the stomach. This can most certainly make a difference IMO.

[@suzihazlove4979]

@@DianaMarie23051 , I need to fix this. So hard. Ty

[@DianaMarie23051]

@@suzihazlove4979 You’re welcome. I’m sure you can find how to breathe properly on KZbin. Try it & let me know how you make out.

[@gidget711]

I have been a shallow breather for as long as I can remember. Isn't the autonomic system responsible for breathing? M.E. causes autonomic system dysfunction among other systems. Could this be at the core of breathing pattern issues?

[@georgiecoghlan7128]

Thanks for this week's update Dr. Younger. Very interesting that you bring up Choline as I have been looking into it lately. I have slow PEMT polymorphism and am trying to figure out how that might be impacting my symptoms. With no formal science training I'm finding it hard to understand the choline-acetylcholine pathways and to decide on the right supplement to try (Citicholine, Phosphatidylcholine or Alpha-GPC). Hearing that it impacts vascular health also makes me wonder if it is linked to the POTS and Orthostatic Intolerance that I experience. I came to understand some years ago that my mitochondria were likely not producing ATP optimally and I've worked hard to change my diet, lifestyle and add supplements to support them. I can now work out at the gym 4 times week without PEM or pain so it seems I'm slowly moving in the right direction. I've been considering HBOT for years and wonder if it would ramp up my healing but always put it off due to the cost. Look forward to the next update, and Chloe's thesis.

[@teresalavigne5555]

My daughter has POTS and I was wondering too if this would help her.

[@youngerlab]

I've seen some small scraps of evidence suggesting choline can help POTS. I think they were case studies on patients, and not experimental studies. So, there isn't enough support for me to recommend looking into choline. But you might want to look at the case reports and see if your primary care provider is willing to test it out. There may be a protocol that can be done in a hosptial/clinic enviroinment. - Jarred Younger

[@everywherenowhere6901]

POTS is a classic symptom of thiamine deficiency Quote The initial symptoms of thiamine deficiency beriberi are those of dysautonomia [1], a broad term that describes any disease or malfunction of the autonomic nervous system. This includes postural orthostatic tachycardia syndrome (POTS), inappropriate sinus tachycardia (IST), vasovagal syncope, mitral valve prolapse dysautonomia, pure autonomic failure, neurocardiogenic syncope (NCS), neurally mediated hypotension (NMH), autonomic instability and a number of lesser-known disorders such as cerebral salt-wasting syndrome. Dysautonomia is associated with Lyme disease, primary biliary cirrhosis, multiple system atrophy (Shy-Drager syndrome) Ehlers-Danlos syndrome and Marfan syndrome for reasons that are not fully understood [2]. It has been hypothesized that the association of dysautonomia with so many different diagnoses is because a common form of dysautonomia originates from high calorie malnutrition. This leads to loss of oxidative efficiency (pseudo hypoxia) and subsequent disorganization of ANS controls that are mediated through the limbic system and brainstem. Unquote From the paper: Thiamine and magnesium deficiencies: Keys to disease On the Sciencedirect website

[@1truthseeking8]

​@@everywherenowhere6901do you follow Elliot Overton?

[@Someone-cr8cj]

I heard somewhere that erythropoietin (EPO), the banned drug used by some endurance athletes improves cognitive performance in healthy human subjects. I wonder if you have any insights on that.

[@meeerdock]

Is there a way for a lay person without the super high tech maschines to find out if they have low oxygen perfusion in the brain?

[@1truthseeking8]

When sitting SAFELY: Hold your breath for as long as you can, thrn a little more until you can't anymore, then hold for just a little more, then FINALLY: breathe.... This is justvone way to INCREASE C02 sufficiently to activate oxygen exchange at the hemoglobin & myoglobin etc sovthat oxygen will release and perfuse. Yes. a LACK OF CO2 WILL REDUCE the amount & rate of oxygen being released from red blood cells!!! You can have a 100% O2 saturation of red blood cells and your tissues can be dying of oxygen deprivation for anyone of a dozen conditions ....this is why having a DEEPER understanding than simply a pulse oximeter reading is CRUCIAL for surviving doctors and researchers like the one in the video. Learn about meditation breathing practices as well. Nasal breathing is a must in general. But "how" we breathe WHEN nasal breathing is crucial... much of our posture and unnatural plant based diets lead to shallow chest breathing which REDUCES/offgases CO2.... CO2 is extremely important --- it's THE solution to people who are hyperventilating....and many are subclinical forms of chronic malbreathing/hyperventilating.

[@ethereumrise7860]

What about ingesting methylene blue?

[@orion9k]

Is this why my fatique comes back when I run out of vitamin c powder that i use for high daily doses? As i understand vitamin c increases your blood plasma and volume 🤷‍♂️

[@orion9k]

I am currently taking choline, it does nothing for my breathing issues and fatique.

[@AliasTekTV]

Vitamin C is also an antihistamine. Maybe look in that direction to see if that might be an issue.

[@Edward-q2q]

I have very bad cognitive conditions through lack of oxygen as I have lung issues so as you know lack of oxygen the brain will shut down some times quickly or slowly

[@YinYang791]

Thank you a lot, for your effort! Is the lack of oxygen also showing up on an oxygen meter?

[@agnetalindstrom7405]

Maby not if measured on the finger (close to heart) but maby on the toe?

[@dshepherd107]

Yes it absolutely can. Mine has dropped to as low as 84%. I have severe ME.

[@Truerealism747]

​@@dshepherd107mine does but ime doing sleep apnea test now this is in alot with me fybromyalgia

[@liliha986]

My personal experience… Oxygen saturation measures 97-99% on oximeter. But my symptoms of fatigue and brain fog are drastically improved with supplemental oxygen. I use it for 20-30 minutes twice daily.

[@ednauseum3060]

@@liliha986 Hello...could you let me know, please: 20-30 minutes at what concentration?

[@Rene-uz3eb]

Gulf veterans now have 3x hypertension and cvd vs non veterans, so they would be taking a lot of bp meds at this point.

[@youngerlab]

Yes that is a very important point -- most of the participants have high blood pressure, among other things. Part of high blood pressue is loss of vessel elasticity. The control group also had many individuals taking antihypertensive meds. It isn't really possible to find a truly healthy group of Veternas who are in late 50's and still perfectly healthy. One of the biggest obstacles to GWI research now is all the other conditions that are hitting the participants now. It means we have limited time to come up with the truly impactful treatments. - Jarred Younger

[@bhavom4037]

Thank you, how does breathing exercise from India that is referred to as Pranayama help by alternating breath and detoxing and helping force oxygenated breathing.

[@danben8432]

Is Methylene Blue at the top of your list to try.

[@bobmciver6437]

Confused...shouldn't higher lactic acid stimulate hemoglobin to release more O2? (Bohr effect)....or is this a chronically high lactate level different from a high acute CO2 gradient response?

[@TheNicgannon]

Would Hyperbaric oxygen therapy help with the oxygen levels until you find the root cause and hopefully a solution.

[@albineg]

Yes

[@alanx4121]

what could be easily applied at home? i think a nanobubble faucet or hydrogen bottle may do the trick.

[@ronrice1931]

5:59 "Why is there a lot of oxygen." You meant to say "why is there a lot of lactate," yes?

[@youngerlab]

Yep! I wish I had time to write out a transcript in advance. I'm going to make a note of that error in a pinned comment. Thanks! - Jarred Younger

[@furiousdoe7779]

I am using pine bark …. and if i use …brain works better.

[@suzihazlove4979]

Is that pygynogenol

[@awaken69]

great video! the problem with pycnogenol is that it is not immunologically "inert". meaning, it acts as an immune booster as well. i took it for over 10 years with great success (btw, its also one of the most powerful and impressive "skin antiaging" compounds), but then had to stop after i found out that it suddenly was triggering my autoimmune-symptoms. this especially can happen when regularly having leaky gut (which pretty much all with CFS have). my new "weapons" for protecting the vessels are currently a combination of Diosmin, Rutin and Hespedrin. these seem to help as well and are all proven remedies for vasculitis etc. Not to mention Astaxanthin, which is known to supress inflammation and cytokines like IL-6 etc.

[@1truthseeking8]

*Plant free* and eating "RAW High fat Carnivore" *since November of 2023* ... No longer need all but two of the 72 supplements that were keeping me barely alive before that. EDIT: see playlist for video of the same by "Excellent Health" ... finally broke the myths & fears & bad information about such diet .. amazing health rebounding now.

[@andreasstuermer4946]

Hyperbaric oxygen? Wouldn't that just be a temporal fix because you have the amount of erythrocytes that you have. I don't think you can saturate your blood beyond 100% ?

[@madmax-bu6wh]

You can saturate 96% max. However Hyperbaric oxygen increase plasma dissolved oxygen and is helpful in select situations

[@liam.4454]

I agree with what you say, but is all this not just caused by stress?

[@poppyseed6487]

Maybe hyperventilation contributes to the problem

[@NickBoileau]

Not strictly the right video, but have you ever studied sleep, specifically the chronic severe insomnia and non-restorative? I'm very much wondering about the mechanisms of sleep and what treatments might be useful beyond standard sedatives. It also seems to be that these medications are not formally tested on people with neuro induced sleep disturbance such that the side effects may be bad on ME patients. I could really use any help.

[@drscott1]

Wim Hof style of breathing has immediate effects

[@alanx4121]

or buteyko, or ozone water, or hydrogen water.

[@michael-bell]

​@@alanx4121Are any of these available on the shelf at common grocery stores and markets?

[@ethereumrise7860]

@@alanx4121what about EZ water (4th state)?

[@sfn-life]

Have you looked into microclots too? I had a transcranial doppler...low flow at both ica terminus bilaterally...on right side at p1 pca spevifically...

[@JeanPierreWhite]

Hey doc. I read about French Maritime Pine Bark on WebMD and one of the warnings regarding this is as follows. ""Auto-immune diseases" such as multiple sclerosis (MS), lupus (systemic lupus erythematosus, SLE), rheumatoid arthritis (RA), or other conditions: Maritime pine might cause the immune system to become more active, and this could increase the symptoms of auto-immune diseases. If you have one of these conditions, it's best to avoid using maritime pine." This seems to say the opposite of what you're suggesting. Thoughts?

[@angelbryan98]

Hello. I was injured by the HPV vaccine and have been feeling bad for 8 months already, same symptoms as Long Covid; Brain fog, blurred vision, anxiety and panic attacks, fatigue, fasciculations, palpitations, shortness of breath, food malabsorption and more that I am forgetting. Do you know anything about this or heard something similar? It's been hell for me and nobody has been able to help. I am desperated, sad and scared.

[@Spartanbeast1]

Look into high dose thiamine or benfotiamine or tfdd.

[@GDe-gi1kz]

Time will heal

[@angelbryan98]

@@Spartanbeast1 Have you experienced the same?

[@angelbryan98]

@@GDe-gi1kz Have you experienced the same?

[@Spartanbeast1]

@@angelbryan98 not exactly - CIRS (mold reactivity). Thiamine is one of many things Im doing. It just best fits what he's talking about.

[@guysoleil9672]

Question about treatment ?? What about cranial release therapy

[@guidodenbroeder935]

Do neck stretches once a day.

[@1truthseeking8]

​@@guidodenbroeder935 Butykeyo breathing.

[@TheSadieFables]

Very exciting. Is there anything that might be a good alternative to French maritime Pine bark? I and others I know have had intolerable GI symptoms from it which is disappointing as it sounds very promising

[@nancienordwick4169]

Like sleep apnea rather than a metabolic issue could too.

[@gerardburns2500]

I used to get bottles of some kind choline made up at a chemist about 25 years ago for M.E. , prescribed by an M.E. Dr but it didn't help me unfortunately.

[@guidodenbroeder935]

Acetylcholine will get broken down almost immediately. You need inhibitors against that.

[@baileystruss7319]

Is the low O2 from repurfussion injury (vasospasms) or from poor blood circulation delivery?

[@youngerlab]

It is a great question. The scan doesn't differentiate the two possibilities. My default position would be reperfusion issues are unlikely the culprit because we are testing chronic conditions without any known recent brain event (TBI or stroke). I don't think we would capture vasospasms, especially on a group level. We exclude individuals with known strokes or brain damage in the past few years. - Jarred Younger

[@SamB79]

@youngerlab could the reason for low oxygen levels in the brain be due to a PFO which Dr Paul Cheney says that almost all the ME/CFS patients he tested had a PFO? It causes blood to be shunted from right to left and bypasses the lungs so de oxygenated blood is circulated?

[@rdan721]

Dr Younger, could red light therapy be used to increase brain oxygenation? It has been used to treat neurodegenerative disease with success. If i understand correctly it works by increasing nitric oxide and thereby increasing oxygen, enhacing the krebs cycle.

[@GDe-gi1kz]

No

[@rdan721]

@GDe-gi1kz Wow! Thanks Dr Younger!!

[@KH-sd8kr]

TY for the video. I wondered if the high lactate is definitely a sign of low oxygen levels in the brain vs low oxygen utilization? Meaning, the oxygen is there is adequate supply, but the mitochondria can’t use it for some reason? I ask because ME is a widespread disease with effects well beyond the brain on immune cells, muscle cells, gastrointestinal microbiome, etc. a common link seems to be mitochondrial dysfunction, but clearly immune cells floating in the blood stream wouldn’t be in an oxygen deprived environment. Also, the recent muscle biopsy studies by Dr Wust didn’t show any decreased vessels into the muscles of people experiencing PEM.

[@DrewSchibsted]

Nice, it only took 30 years.

[@stefanallard3084]

And another 30 years before they will even do anything about it, mainstream healthcare

[@RinTexas]

Thanks for the video. Very interesting.

[@themilkman7367]

Did you by chance look at adenosine levels?

[@Frunobulax53]

Is it known which medications the patients were on? Plenty of drugs have anticholinergic effects, like opioids, antidepressants and sleep inducing drugs. My ME/CFS started just a few months after the start of my opioid treatment (30mg Oxycodone/day as Restless Legs treatment).

[@youngerlab]

Excellent point - and one of the hardest parts of interpreting the study (and most Gulf War Illness studies). Almost everyone was on several medications. Not so much opioids, but a good number of anti-depressants. Unfortunately, the sample size is too small to try to examine subgroups on different medications. So that will have to be a clearly stated caveat in the scientific publication. - Jarred Younger

[@everywherenowhere6901]

Just out of interest, I get severe restless legs if my ferritin gets low. It goes completely when I get levels back to the normal range. Have you ever had your ferritin levels checked? Restless legs are a classic symptom of low ferritin levels

[@Frunobulax53]

@@everywherenowhere6901 My ferritin is high, and I even got the big iron IV -- no change.

[@kikijewell2967]

I'm curious about low doses of food grade hydrogen peroxide. (Eg 1-10 drops of (very strong!) 30% food grade H2O2.) I tried this as a treatment decades ago, and it made me feel noticably energetic and happy. So much so, every day, I'd increase the dose. Until I'd get to the point I couldn't tolerate it. I cycled like this a few times over the years, then gave it up entirely. I'm ready to try again, now with understanding that I need to keep things sustainable. But I'm curious what the mechanism is for such a small amount of extra oxygen.

[@ollewernersson3837]

Could buteyko breathing improve the oxygen uptake in the brain by increasing CO2 using the Bhor effect?

[@mariannegiblin1328]

Would hyperbaric oxygen therapy help this?

[@youngerlab]

I haven't studied that treatment, but the literature suggests the long-term effects of hyperbaric oxygen is improved vessel dilation and oxygen perfusion. But I don't think it has been trialed in GWI specfically. So I think it is a logical hypothesis and worth attention in a proper clinical trial. - Jarred Younger

[@nancyharkness5999]

I tried non hospital grade hyperbaric soft chambers for a several sessions at a few different locations but didn’t feel that they were consistant. If this is trialed it should be in hospital settings please. Also I’d love a non hyperbaric option.

[@rhyothemisprinceps1617]

​@@youngerlab It's worth looking into the proposed mechanism of action of the Aviv Clinics HBOT protocol - it is designed to mimic hypoxic stress w/o the damage. There's a good Pop Sci article on it 'Inhaling pure oxygen could keep your brain younger for longer'.

[@stuartwakefield1657]

Thank you for this information. A question for you! Is there a way to clean out the spike protein in my body.

[@brobinson8614]

Depends what variant you got. As some patients (3 or 4) who had one on the earliest strains were given monoclonal antibodies (from Dr Nancy Klimas’s team) all those patients were cured. So now they need to find out if everyone with Long Covid has viral debris causing the issues (chances are it won’t be, because many people develop ME/CFS from all sorts of viruses and bacteria. Even accidents. So even if a broad spectrum monoclonal antibody can recognise epitopes off all the SARS-CoV-2 variants and rid the body of them, we will see some people get cured, but also still see a lot of people with Long Covid left realising they have ME/CFS instead Although ME/CFS could also be caused by a viral reservoir but would be difficult to know what one is causing the disease because we all have some viruses from certain past infections in us. Some researchers believe ME/CFS is a disease of a failed ‘Cell Danger Response’ (CDR) switch that normally turns on when sickness or injury occurs, but fails to turn off when the virus is under control or gone, or body has healed. Meaning the patient is stuck in an energy conserving and sickly state. We need to find a way to turn that switch off. Professor Robert Naviaux has researched this area. Have a read what he has published. He believes it has something to do with a problem of ATP signalling outside of cells

[@youngerlab]

Good question. It is outside of my area, so I don't have a good answer. As mentioned by the response by brobinson8614, Nancy Klimas is the go-to person for those questions. She has done much more COVID-related researcher than I have. - Jarred Younger

[@rhyothemisprinceps1617]

It binds to albumin, so plasma donation might do it - but the problem with that is plasma donation temporarily depresses immune response. Some clinics offer therapeutic plasma exchange with albumin replacement, but it's extremely expensive and not yet proven safe / effective for LC, AFAIK. Recombinant albumin (lab made) seems like it might be more reliable than donor albumin (which would depend on quality of donor pool), but again, no studies AFAIK.

[@suzihazlove4979]

Crazy question, would getting sculptra, lactic acid, in face cause issues for CFS Patients?

[@zaeliris5053]

I wonder if this relates to how crappy people feel on Acetazolamide, especially long term

[@sfn-life]

Pycnogenol is helping me some.

[@julie-artfullyopen5860]

Fluoroquinolone Toxicity - How many of you have taken Ciprofloxacin or Levaquin and have these problems ? t me ciprodamage

[@JackR772]

Peter Rogers MD speaks about reduced blood flow being caused by excess fat and salt in the diet. The fat causes red blood cells to stick together.

[@youngerlab]

Yikes. I'm not familiar with his work, but I'm betting this is when excess adipose tissue becomes inflammatory and increases fibrinogen, and could be measured with erythrocyte sedimentation rate (ESR). I'll see what he says. Thanks - Jarred Younger

[@dawseyboy1]

i was about to make this comment as well, so i shall like yours instead

[@michael-bell]

So then what diet does Peter Rogers recommend?

[@dawseyboy1]

@@michael-bell very low fat

[@michael-bell]

@@dawseyboy1 So just any and all fat from any source whatsoever? No healthy fats like avocado, olive oil, etc? He makes no differentiation between animal fats, seed oil fats, and plant-based fats? Just all fats are evil, period?

[@monicali2608]

Did Rhizoles Zeta and chronic fatigue was gone. Possible EBV. Later Iver., methylene blue and fenbendazole, teasle tinkture. Same time VitD and K, magnesiums and zink. Another person did the minerals plus selenium and biofilm cleanse from unaya and was better to 70 percent after it. Disease eats up a lot VitD and minerals so more has to be supplemented for a time. Also natural sun needed. Several roads to Rome.

[@youngerlab]

Thanks for the notes. I was not familiar with teasle. - Jarred Younger

[@1truthseeking8]

Are you into Dr Jack Kruse?