2016 Roy Walford lecture: NAD, Sirtuins and Aging - Leonard P. Guarente, PhD

Leonard P. Guarente, PhD
Novartis, Professor of Biology
Massachusetts Institutes of Technology
Harvard University

[@Idahomie]

Amazing what has evolve d in biochemistry in the 47 years since my first biology class. Modern scientific miracles' of hope in these otherwise dark days.

[@scottwilliams2136]

For very different reasons, NAD+ has also attracted a wave of attention from cancer researchers. Recent studies suggest that cancer cells of many types depend on NAD+ to sustain their rapid growth and that cutting off the NAD+ supply could be an effective strategy for killing certain cancers. The data from these studies paint a more complicated picture of NAD+ and raise new questions about the diverse ways taking an NAD+-boosting supplement might influence health. “It might still slow down the aging part, but it might fuel the cancer part,” says Versha Banerji, a clinician-scientist at the University of Manitoba. “We just need to figure out more about the biology of both of those processes, to figure out how we can make people age well and also not get cancer.” This is just a fellow up to my previous post. Interesting that most sites are ignoring the possibilities of its effects on cancer.

[@catman4471]

This has been covered elsewhere but the bottom line is that there has been no studies that suggest that NAD+ pre-cursors cause cancer, but they can accellerate existing cancer. kzbin.info/www/bejne/Y2GXXmSFjZmFjK8

[@marionharris5952]

Good point. Analogous to photobiomodulation.

[@psiclops521]

What I get from this is that, at this point in human history, mice must be healthier than ever in their existence due to the massive number of medical breakthroughs.

[@markpatrick2735]

sliced and diced is rarely healthy or any lifeform

[@catman4471]

Yes, one day mice will rule the world.

[@antMight]

Super, thank you for a video. I’m passionate about aging and supplements to do it possible 🙂

[@abdullayt588]

wow

[@rezarabbi7419]

Nice

[@fondrees]

What does this have to do with roy walford?

[@rui-9-cs315]

💕

[@petercoderch589]

Audio so low couldn't understand anything.

[@biogerontology7646]

26:35 organoid colonies

[@biogerontology7646]

39:06 another organoid experiment

[@ganje3869]

Looks like it works hand is hand with the endocannabanoid system.

[@sheafisher3578]

So now the whole pro-SIRT/anti-mTOR view is complicated by the intervening deacetylation of S6K1.

[@fondrees]

Doris loh nade me aware of this connection. Brilliant woman.

[@fondrees]

Why doesnt David sinclair mention this. Surely he is aware. Sometimes i think he is nothing but a snake oil salesman.1st the resveratrol fiasco, which was his first miracke cure. Now NAD. It certainky does make sense that NAD WOULD PROMOTE CANCER AS WELL AS YOUTH.