A Discussion On Over-The-Counter Cough Syrup Misuse

[@chubbyemu]

Thanks to Dr. Jagasia for the psychiatric perspective!

[@DavidBentley23]

Can you do one of these on Dimenhydrinate? (Aka Dramamine or Gravol)

[@MrChris7582]

I did all of them when I was i highschool nothing bad happened to me. I got the coridcedine pills did it multiple times with friends. took 6-8 each time. which was plenty. it was quiet enjoyable to be honest. codeine cough syrup I did too. it was even better. I also did benadryl which was the least enjoyable alls it did was give me audio hallucinations of my mom calling out for me. it was not fun at all. dramamine it makes you way more tired but if you can stay up I had the craziest hallucinations on that one. not psychedelic like lsd which I took or dmt mushrooms 2ci 2cb bromodragon fly 5meodmt 5meodipt maclaine ayahuasca ect which I also took before. nutmeg which I also did was its crazy own non psychedelic hallucinations. I did however never try hard drugs like meth crack or herion seems too risky and its not a hallucinogen. I smoked marijuana too before. the allure of tripping always interested me when I was a teenager to probably about 24 when I started having kids. ever wanna wounder what any of that stuff is like let me know.

[@MrChris7582]

@@DavidBentley23 I took it before it makes you super tired. its not psychedelic but its a hallucinogen. I saw a lot of bugs on it and most things looked realistic but mostly black in color. that stuff is crazy.

[@DavidBentley23]

@@MrChris7582 I abused it a lot. I see very few videos on the long-term effects. I could take 100 pills in 2 - 3 days too give you an idea of how insane my tolerance/abuse was. I thought it would be a good subject because of the lack of content and ease of access too it.

[@maryprantephd6736]

Yes! Enjoyed her contribution!

[@moosehead4497]

I had an addiction to dissociative drugs as a teenager, started with dextromethorphan, led to pcp, and eventually to opioids. I don't know why i enjoyed it so much, nearly destroyed my life. I just finished my my masters in synthetic organic chemistry, one good thing i can say from that experience i fell in love with chemistry

[@verybarebones]

Pro tip: if you develop deppression and/or anxiety you can dissociate for free Just kidding, it's just that, as someone w involuntary dissociation, the idea of causing that on purpose is pretty wild

[@Slodsworth]

@@verybarebones yh i agree iv been dissociated since i was 5 and im 28 now.... Why would anyone want to feel nothing. Barely even feel as if im living but not taking anything in. Do cannabis once in a while but no drugs to cause it xD

[@cjcummins519]

Amen!

[@TequitoClown]

Hey congrats on being clean! It's a hard habit to get out of.

[@DrymouthCWW]

Rock on. Not crack rock...but the normal kind. Like stones.

[@deusexmachinamotorsports]

I was on Robitussin for ten years. I have only 1.5 years sober. I can't go down that aisle in the store. It's crazy how much of a hold it had on me

[@opalfishsparklequasar8663]

You're doing it! Proud of you. God bless! 💕🏅🙂

[@Unbeniamhable]

Good job getting sober man

[@heyitsnasira]

Hell yeah! A year and half?! That's hard work put in

[@mothman4672]

@@davedave6577 This is why we can’t have nice things

[@Sonicsis]

Proud of you for taking your life back, keep up the good fight!

[@york-houngan7193]

Changed my life. Did dxm religiously from age 16 - 24. Took many different drugs in my life, including acid, 2cb, ketamine, mdma, etc. but went back to dxm. The long duration and serotonergic effect just kept me going back. I changed my life eventually and have a good life and stable job. I still feel permanently changed 4 years after stopping, though. Tripped so many times and ended up pushing myself into places I can never put into words. Almost didn't click on this video because I still have almost a ptsd effect from thinking about it now. Just too many powerful memories and I can't get back into that kind of thought. In fact, I'm going to have to click off of this now. It's almost like having been in a rock band and have traveled the world but had to leave that life. It's too hard to look back because of the powerful nostalgia / the feeling of nobody will ever understand the feeling or believe the stories. And it just consumes me. I'm already a fairly depressed person and it's easy for me to get carried away with things that take me out of reality. So with that, goodbye and good luck to everyone struggling with addiction or any issues.

[@AzraelFPV]

Dude I completely relate. I don't think I'm changed. I just feel older like I've seen life from a very different perspective and now I'm working with that knowledge. But I completely understand dude

[@djobe420]

Sounds like you just got shitty research chemical instead of acid then.....

[@AzraelFPV]

@@djobe420 yeah I don't like how people just buy whatever from people and take their word for it. They don't even know what they're selling you 99 percent of the time if they don't test it

[@loveistheanswer5924]

In wich way it changed your life?

[@loveistheanswer5924]

@@djobe420 acid is much better and saver for sure!

[@ZeddZeeee]

as someone who has been struggling with DXM abuse and not having enough information to 'convince myself its bad', this video sure changes my perspective

[@petergriffin680]

Lol, surprising. If you don’t quit your body will shut down if your mind doesn’t first.

[@jameson1465]

@@petergriffin680I appreciate trying to get people to quit but no, they could be drinking Robotussin everyday and I don’t think they would die

[@petergriffin680]

@@jameson1465 they definitely would. Stuff is not meant to be drank everyday. You’ll run into liver and kidney issues in no time

[@jameson1465]

@@petergriffin680 Maybe after 20 years? Or maybe if they’re drinking NyQuil? They’ll get stupid and have brain damage after a while but no

[@carlcarlson5553]

​@petergriffin680 yeah, that's why I used to get pure DXM powder, FAR better for your body but far worse for your mental. Good thing I'm clean now

[@arlineyoung1739]

This hit me. I was a chronic DXM user for many years. I became very dependent on it to just... function. I'm glad he explained somethings. My family didn't understand what and how DXM was abused. I felt alone and even my doctors didn't know what I was talking about. It's weird to have to educate your doctor on your what you are using. I did a urine test with my former doctor and, yes, it tested positive for PCP.

[@d1ssolv3r]

I once told a doctor I abused it and he almost laughed, like it wasn't something real or having any effect. I guess they assume I wouldn't have taken it dozens upon dozens of times. Probably have a hole in my brain now, lol.

[@vorpal22]

The fact that dextromethorphan can cause false positives for phencyclidine is quite interesting. After years of taking very high doses of hydromorphone for a chronic health condition and after recovering from surgery, no longer needing it, I switched to methadone to taper off such a high dose in a slow, controlled fashion over three years. I had to do weekly urine screenings, and during that time, I was using DXM at least twice a week at doses between 450 - 600 mg. The urine screenings specifically included testing for PCP, and I never tested positive for it. That being said, I'm a 2D6 poor metabolizer of DXM. Additionally, I was able to discontinue 20 mg / day of methadone cold turkey when many people say that even discontinuing 2-5 mg / day of methadone is incredibly painful. I suspect that the fact that DXM is an NMDA antagonist actually had to do with this, since NMDA antagonism is suspected to not only reduce tolerance building to opioids, but also mitigate opioid withdrawal. (For example, a single dose of ibogaine - which also demonstrates significant NMDA antagonism - has been shown not only anecdotally but scientifically to terminate heroin addiction and prevent withdrawal to the point where there are treatment centres in certain countries, e.g. Canada, where people can go to be administered ibogaine.) Note that ibogaine is illegal in many countries, and I don't recommend high-dose DXM use to prevent opioid tolerance building or terminate opioid withdrawal. (The last thing you need when in opioid withdrawal would be a difficult dissociative experience.) While there is some evidence regarding DXM and its effect on opioid use, it is far from conclusive and is still controversial, and anything I report here is purely anecdotal and should not be generalized: it could be attributed to my unique neurochemistry or even the fact that I metabolize DXM into dextrorphan poorly.

[@TheLokiBiz]

Even this vid has some misinfo - the part about most people not enjoying it cus they have to chug cough syrup made me laugh... most serious dxm users discover robotussin gel caps (or that they microwave Sucrets to extract the dxm) so they dont gotta drink the syrup. Drug users will always find ways to consume. This is way prohibition isnt the answer to anything, but thats another story entirely lol

[@Navi_xoo]

I used to be a drug addict, I would steal a lot of DXM for friends. Just walk in a store walk out, I was pretty unassuming and never got caught doing it. It's a strong semi-psychedelic experience. I have taken enough to where I blacked out deliriously and disassociated from my body lol. Wouldn't recommend it, there are better ways to recreationally have fun.

[@Joehtosis]

I recommend Battle Toads.

[@Navi_xoo]

@@Joehtosis Definitely a better option!

[@MrChris7582]

it makes hallucinations but not psychedelic. lsd is psychedelic. robo tripping in a dissociative and deliriant. more along the lines of pcp or ketamine. lsd dmt mushrooms are in technicolor lol there for are psychedelic. I have done a bunch of different drugs and figured out the differences between the types of hallucinogens and the differences between all of them. its different to be in a state of deliruim compaired to psychedelic hallucinations. alcohol with draw isnt very nice to go through but that will give you deliruim. they call that part of alcohol withdrawal the DT's. deliruim tremens. but robo trip is a dissociative first. a stronger delirium effect comes from dramamine. benadryl causes some small visual delirium but main effects audio hallucination.

[@Navi_xoo]

@@MrChris7582 I disagree, I think psychedelic in itself is more of a pseudo sciencey term but I do think DXM can cause psychedelic like effects ( hence why I said semi-psychedelic) just like it can cause time distortion and hallucinations like hallucinogens. I don't think it has the same benefits as LSD or Mushrooms, or the same enlightening experience, but some people would say the same thing about MDMA. A lot of it is just personal experience.

[@rockmove3547]

Took a lot of deugs and still dxm is really good reacreational drug but not for everyone

[@diyeana]

Born in 1974: I haven't felt this left out since all the young whippersnappers were Robo-trippin' and calling me a square.

[@beepbeepcasucha]

Born in 2001: hahaha can I join you

[@Airsoftforall]

Took care of 13 yom who drank 2 bottles of DM. He was difficult at best to treat. He finally fell and struck his head putting him out. His parents refused to allow us to use soft restraints. He was transferred to a children's acute psychiatric center and spent 2 weeks there. A month later I sat in on his organ harvest. He was a roller coaster, emotionally. Poor kid.

[@the_rachel_sam]

Well Jesus was it the dxm that killed him due to later organ damage? Or suicide? That’s just so heart breaking to hear. I’ve worked L&D and thinking about what that baby may grow up to be and do and feel and then learning about this would be shattering.

[@Airsoftforall]

@@the_rachel_sam suicide by overdose. Somehow he had came into possession of a half gallon bottle pharm bottle.

[@the_rachel_sam]

@@Airsoftforall that’s dreadful, what a lamentable death at that age.

[@Kitty-mb4hy]

@@Airsoftforall wow, half gallon bottle of cough syrup! 😮

[@manyshnooks]

A good candidate for the use of conscious sedation where soft restraints aren't going to be tolerated by family. A few mg/hr of lorazepam or a syringe driver of midazolam (or dexmedetomidine if BZDs are contra'd or discouraged, albeit with far more caution) isn't a bad idea. I've found that lorazepam just generally assists with alleviating the anxiogenic properties of these kind of agents in overdose, and has the added benefit of reducing tachycardia and heightens seizure threshold.

[@belmarduk]

A number of years ago I had a little too much cough syrup when I was sick - "I will take more; it will make being sick a little easier", was my thought process. I was expecting to feel a little loopy, but I ended up outside of my body for a couple of days, and literally spent the next two weeks afterwards dealing with intense, crushing depression and incredibly distressing episodes of depersonalization, a mental health problem I had previously heard of but hadn't experienced, and can report: really sucks. Turns out I experienced a common, and extremely dramatic drug reaction between my (taken as prescribed!) NDRI antidepressants and cough syrup, and in hindsight I probably shoulda gone to a hospital. Don't play games with your brain, kids.

[@chanelbrixx8987]

did u get seratonin syndrome?

[@DS-nf1mm]

Yeah that’s most likely what happened. Typically it wouldn’t occur from a a slight overdose of dxm combined with an antidepressant but it can

[@gts447]

They’ve now turned that combo into an fda approved antidepressant called auvelity, which is 45mg dextromethorphan to 105mg bupropion.

[@notyourgin]

my dad did the same thing 2years back and he started hallucinating , couldn’t even recognise use and now has nerve damage in his brain because of that and has trouble remembering certain things i.e partial memory loss

[@DS-nf1mm]

@@gts447 bupropion isnt an ssri tho its a ndri

[@W4t3rf1r3]

If someone is on an SSRI, it seems like it would be a good idea for them to consult their doctor or psychiatrist before taking this kind of cough medicine.

[@AuskaDezjArdamaath]

You can’t take cough medication when you’re on an SSRI. Probably for this reason.

[@acdfg56]

Yeah. It’s always a good idea to ask even like a pharmacist would know any interactions with SSRI/SNRI

[@Psychx_]

When the person has the intent to take the DXM as instructed (single 15mg dose every few hours), it might not even be dangerous as people who aren't used to ultra high Serotonin concentrations in the brain do usually react with intense nausea, which keeps them from taking more DXM.

[@johnlabonte5469]

@@foolishlyfoolhardy6004 In a perfect world, yes. As someone who's been prescribed antidepressants and has taken DXM I can tell you that the majority of psychiatrists/pharmacists just throw the medication at you with no warning or consultation.

[@lactofermentation]

@@AuskaDezjArdamaath Depends on the individual and the SSRI dose. Something to talk about with a doctor or pharmacist. I've never had a problem with taking dextromethorphan despite being on SSRIs, but I'm anal about taking the lowest effective dose of isolated OTCs as infrequently and for as short a time as possible, and high serotonin tolerance is a weird family quirk.

[@TairyHesticles]

I took DXM multiple times a week from about age 14 to around 25 years old. It didn't destroy my life or anything, but I missed out on a lot of relationships and experiences. I took the stuff to shut down and shut out everything around me. I'm glad I quit. It's taken me a long time to dig into why I always felt the need to block things out, and even longer to figure out how to stop living that way. Quitting DXM was the first step on a neverending journey of trying to be comfortable in an uncomfortable world.

[@jasongarcia2140]

Exercise will fully rehabilitate you especially if you enjoy yourself often while working off all that energy mr testies

[@Slayer-Knight]

This is the best medical content on KZbin. Hands down. I'm not even involved it the medical field, and I still find it really interesting and useful. I don't understand everything 100%, but I do feel I get a good sense of what is going on and take something useful from it.

[@arya7095]

Same I dont understand all if the things like the diagrams yet but I enjoy it a lot :) and it also let's me k ow new things and beware of things in other to stay safe :)

[@roberttrent4388]

This isnt accurate information to the core or even close, very biased and speaks down to the audience like we are a bunch of idiots. Some cool stuff sure but dont think you are gonna get spoonfed accurate information in a form you can understand without them trying to serve their own purposes

[@anitacigarette]

@@roberttrent4388 I don't get that impression at all... Actually, I get the impression you're the biased one. Just saying.

[@roberttrent4388]

@@anitacigarette Maybe, but My understanding of this particular subject is far broader than the studies listed. This is lie-to-children level consumer freindly info to rack up views because if it came to actually understanding this, then no one would watch a video that long nor complex

[@abox6989]

Based Opeth PFP

[@chincemagnet]

A friend of mine, my best friend actually, in high school (late 90’s), used to chug Tussin to get intoxicated. He ended up actually getting addicted to it, and the side effects of its use were SEVERE. I tried it, but it didn’t do anything to me except cause nausea. He died a few years later from a drug overdose. He was a great guy, but the Tussin literally destroyed his life. Actually his situation was very similar to GG from the other video. He was messed up in the head, and his parents were understandably scared, took him to see doctors and he kept his Tussin use secret as they did every test in the book on him. I remember him talking about getting a lumbar puncture and how painful it was. Actually I remember now they prescribed him Lithium. He said it helped. But this guy had a bizarre obsession with Nirvana, and I swear he liked taking it because Nirvana had a song about it. I remember at one point his skin started turning this weird yellowish color, idk if that was from liver damage or what. It was just a horrible situation that never should have occurred. He did enjoy it though, at least he seemed to. Maybe he was hiding things from me too, idk. I remember he was a smart kid, at least equally as intelligent as I was at the time, and after a period of prolonged, repeated use, it’s like his IQ had dropped 30 points. He did recover some of that, but it took years after he stopped abusing the Tussin. I actually carried him through high school for quite awhile, doing his homework for him and helping him with tests. But he literally did not care anymore and I got to the point I stopped caring too, because it was so much work and I got nothing in return and he wasn’t improving. He died of combination opiate and benzo IV injection overdose, he was maybe 21-23, it was a long time ago.

[@neurofiedyamato8763]

That's a very sad story :(

[@chincemagnet]

@@neurofiedyamato8763 I know, I still think about his parents occasionally, but haven’t seen them in several years.

[@guardianoftheduat]

@@chincemagnet have u thought about contacting them?

[@tasm9234]

@@chincemagnet i hope u can heal and recover from that traumatic situation

[@chincemagnet]

@@tasm9234 well that was at least 15 years ago so I’ve moved on

[@andreaclayton8914]

I was addicted to drugs as a teenager, DXM being one of them. Thank you for covering this and thanks to everyone in the comments who shared their story. Mental addictions are real and just as hard to break as physical ones. I really wonder how much damage I did to my brain with this shit.

[@sheeeitmayn4384]

I had a pretty bad DXM addiction myself, I just remember it being the only drug that was easy to get that made me feel actual happiness and bliss. I sort of miss a lot of the experiences I've had but know how hard DXM is in the mind and body now and just don't use drugs any more in general. Life is better now.

[@andreaclayton8914]

@@sheeeitmayn4384 thank you so much for sharing your story ❤ it means a lot to me. I honestly struggle with the same problem sometimes where i had so many fun experiences on it that part of my brain is like "go on do it a few times you'll be fine it'll be fun." But as I've gotten older ive really learned to respect my body and what i choose to put in it, i agree it really is so hard on your body and mind. I also dont want to risk going back to that place again where i lived in my own dxm world all the time.

[@bond6132]

My 3rd day on 400mg I was convinced I had died. Too worried of long term mental deterioration I quit and haven’t touched it since. I can’t believe how much of that crap I ingested… Memory and intelligence weren’t noticeably affected. I try to keep up with brain-healthy foods like omega3, mct oil etc. Meditation can put me in the same mindset I would take dxm for.

[@bond6132]

@@s7r49 You’re speaking some truth brother I did not know that about omega 3. I’m in college, usually resort to supplements as they’re pretty cheap. All the other options excluding fish are a no go for me. I’ve gotta see if I have the stomach for sardines. Organ meats are definitely another thing we should be eating more of. Preach🙏🏻

[@beepbeepcasucha]

Congratulations on your recovery, I hope you're doing well now 🤍 one day at a time

[@Mishalalzahrani_]

Auvelity, a newly FDA approved rapid-acting antidepressant is a combination of Dextromethorphan and Bupropion It acts as an NMDA receptor antagonist like that of Esketamine (another FDA approved antidepressant for treatment-resistant depression)

[@greenbassboosts8872]

That sounds like a truly nightmarish drug

[@RandomChristianMusings]

Thank you for this information @Chubby Emu. I'm a grandparent and I've never heard of "Robo-tripping." I'm appreciative that you're educating others about the fact that even OTC meds can be abused and have catastrophic results. Peace

[@thakraken6995]

@hello because the flood of serotonin that rushes in your brain. Try to mimic that experience without the DXM

[@thakraken6995]

*"just because you know what neurotransmitter a drug involves doesn't mean you know Jack about what it's like."* You're right, it's the combination of my previous experiences with it and my research of it that allows me to know what it's like. *" Saying 'you feel good bc serotonin lol' is retarded"* I see you don't have an idea of how quotations were considering I never said that. Serotonin is literally what's involved in feeling pleasure and there is not another hormone primarily involved in giving you that experience than serotonin. Your personal argument from ignorance and incredulity is not valid. *''by that logic SSRIs would be the most sought after drug on Earth"* By what logic? Because it seems the logic you are attempting to discredit isn't what I actually acquire. Your argument is based on a strawman. *"Not to mention that DXM primary works on NDMA receptors and sigma1 receptors so you're just wrong too"* My statement wasn't based on what receptors are primarily activated with the use of dxm. I was referencing as to why people tend to develop mental dependency on it. All you presented was nothing but an ignoratio elenchi.

[@thakraken6995]

@hello *" Your research was 2 minutes of Wikipedia article reading"* You're projecting. It's evident in your ability to articulate an actual rebuttal. *"Stop being a pseud on the internet for imaginary points"* That's pretty specific considering nobody said anything about "earning" points. I think the actual condescending pseudo intellectual here is you. That's why your emotional instability prevents you from being able to give a legitimate response. Probably that DXM screwing up that dense brain of yours. Anything else my son?

[@thakraken6995]

@hello So in otherwords *" I still cannot articulate a logical rebutta".* Well then, class is dismissed.

[@peacefulcanadian3592]

@@thakraken6995 Off topic but it's kind of weird how obvious it is that you feel the need to come off as highly intellectual but go about it in a way that you kind of come off like a smug douche. I used to do that in the past too but I found that it was detrimental to my own well being and just all around kind of pointless

[@nmxsanchez]

This reminds me of my erowid days. Not that I'm proud of it. But I did learn a lot, both good and bad.

[@devinreed5725]

Yup.

[@BananaHelium]

you should be proud of it at least you were being somewhat responsible by instructing yourself.

[@quitoxictv8307]

That’s just the way it is. Things will never be the same for me ngl

[@BananaHelium]

@@quitoxictv8307 welcome to the cope. they definitely wont ever be with that kind of attitude.

[@shermsmoke]

Erowid was the shit

[@ZeludeRose]

Can confirm the dependence part, I had a huge mental dependency on DXM & DPH. You never know what your brain will latch on to.

[@daveb5041]

@@nullvoyent Is it like taking 15 dramamine? diphenhydramate I think its called. I heard it causes hallucinations not like LSD or mushrooms but seeing people objects that dont exist. I always wanted to try but was to scarred to. Stick to LSD way more fun and safer even though illegal.

[@daveb5041]

@@vitaeve Thats not how chemistry works. They dont cut or mix drugs they are two different but similar molecules. Caffeine is not structuly similar to either of those drugs. Look up the molecules shape on chem compare.

[@daveb5041]

@@nullvoyent Well thank you for not just making bs up and spouting it as fact.

[@jobis34]

@@daveb5041 no... @Vita Eve is completely correct. Try just googling something before claiming someone trying to help is wrong. DPH is the deliriant drug you are talking about. You said Dramamine which is different, and Vita eve explained with facts why.

[@daveb5041]

@@jobis34 I took pharmacology in college and I'm a 3rd year organic chemist. Go look up those drugs using chemcompare rather then random posts off google. I'm sure dr benard would agree.

[@michaelryanwildkardclark777]

I did it for many years, about everyday. I flooded my brain with serotonin when I was 23 due to a celexa overdose attempt, then I had a traumatic brain injury at 25, something in DXM altered my chemicals and it was a crazy journey and when I wasn't afraid I was dead or dying I will admit I loved it. The dissociative effects got me out of my PTSD-riddled mind and also away from my painful memories and existence at the time.

[@maryprantephd6736]

Thx, Dr Bernard! Always thorough! So well, extensively, explained! Always learn worthwhile information from your vids!💖

[@ojk14325b]

A lot of people in these comments had bad experiences and addictive experiences with DXM. I have used it a few times at modest doses and had some interesting trips. I wish that people who wanted to misuse it misused it more safely, but I guess given the nature of the substance it's usually desperate or bored people trying to find an escape. The DXM FAQ is a good resource on recreational use. Lays out the possible experiences but also the consequences of robotripping for the sake of harm reduction. Anyone curious should check it out.

[@mustangnawt1]

There is another person in these comments who feels like they caused irreversible harm from this. Nature of the beast is to take too much too often. Slippery slopes

[@Wolfgang_von_Caelid]

Yeah it was similar for me; I was a bored teen but was also fascinated by drugs, psychedelics specifically. I would spend hours just reading trip reports on erowid, and generally educating myself on random drugs that I would probably never get the chance to try. I think that's why I got lucky and never got addicted to anything/ generally used substances responsibly (outside of alcohol but that's a tangent). I tried DXM a handful of times, it can't be understated how horrible the syrup tastes. For me personally, I also consistently threw up around 1-2 hours after ingestion, at which point the trip began. I legitimately don't understand the appeal, the syrup is absolutely vile, and the trip, while interesting from a sort of "drug enthusiast" or intellectual point of view, had no euphoric or positive aspects for me, you just lose motor function (similar to alcohol) and get a severe case of double vision. I feel for people who are addicted to it, I've known of people who were addicted and it sounds like a nightmare. Dissociatives are no joke.

[@UrineDeity]

Exactly. Its honestly really sad but it makes me feel grateful for not being as shortsighted and wreckless as some of those people lol

[@vorpal22]

I think the term "misuse" should only really apply to people who use it naively and without preparation and research. I read the DXM FAQ three times before I decided to try DXM, and I would never consider my doses to be a "misuse." Certainly, they weren't in line with the indicated dosage for treatment of cough, but I wasn't using them to treat a cough.

[@vorpal22]

@@Wolfgang_von_Caelid Dissociatives are, IMO, the most challenging drugs. People shouldn't take them for fun, because they're really not that fun... they're going to take you to disturbing places that most people aren't prepared to go. Taking cough syrup (back when I used DXM) did the same thing for me: I would feel extreme nausea and often vomit just as I was coming up on it. I switched to cough caps or powder for that reason. The appeal to me over the two decades that I used DXM was not because it was recreational, but because I enjoyed how it challenged my entire worldview. I really don't get the addiction part. Sure, it can be psychologically addictive and a psychological addiction can be a pretty severe thing regardless of what it is you're addicted to (but TV and sex and overeating can be psychologically addictive), but I never had problems stopping DXM use, even after taking 600 mg daily for several months. I was just kind of bored and the world no longer had that "magical feeling" that DXM gives to reality. After a couple of days, I no longer missed it.

[@trevorprzepiora7926]

I've been too afraid of drugs from one bad experience in high school. Being in a college sport, I can't really afford to take anything anyways because we get random testing at tournaments. I've heard of this stuff. I appreciate raising awareness to this!

[@WeirdDuck781]

Bad experiences during that time are probably the best that can happen to you. I had a few but when I didn't, I didn't really feel well, always got too psychotic and afraid. I am really glad but unfortunately I am still addicted to tobacco nowadays with no plans to stop any time soon. I am also diagnosed with anxiety and I'm quite afraid of trying to stop. I don't wish this on anyone, high school is the worst place everywhere in the world.

[@neurofiedyamato8763]

@@WeirdDuck781 I wish you the best of luck. While what I say probably doesn't mean much but every attempt to quitting is a step forward even if it failed. You should try to remind yourself that the fear is often irrational. A good way I found to try and overcome irrational fears is to write down all possible outcomes and their likelihood. When you get to visualize these outcomes and their probability, you can make a more objective risk assessment and usually things don't seem as scary.

[@WeirdDuck781]

@@neurofiedyamato8763 thank you. Indeed you're right, even though I've mostly been a rational person and as a software developer I should be more of a logical person but ever since this started happening I cannot apply my rationale to these inner fears that I probably have yet to understand. Nevertheless I feel like I'm making good progress. I would wonder how would I be if my life was nearly as stressful as those in past generations when they indeed had far more concerns, it makes me feel so weak and I see our generation as so. It is a weird ass time where we have everything for granted yet we are getting mentally weaker. Maybe past generations just didn't talk as much about the issues. I really hope for the best for anyone with these troubles

[@SobrietyandSolace]

@@WeirdDuck781 Wait until you go to college

[@WeirdDuck781]

@@SobrietyandSolace I am a little bit past that but I was thinking about going to college to get an engineering degree. Pretty optional as I'm currently a Software Developer and pretty much well with my current education, but i still want that degree, might change my mind. I have plenty of friends in college at the moment and it seems rather chill. The more so since I will take post laboral classes instead of morning-afternoon ones, as I intend to keep working full time. We'll see if it's worth it tho

[@sheeeitmayn4384]

I used DXM to treat my own depression as well, but it just ended in addiction and serotonin syndrome over and over again but it really made me feel like, very happy for a long time I would sob at how much I suddenly loved and appreciated life. It was so strange. It also made me very manic and delusional towards the end of my addiction to it. Stuff is weird man.

[@McFwoupson]

I think you're misinterpreting what serotonin syndrome is. Simply taking dxm in recreational doses isn't going to give you serotonin syndrome. It's from mixing it with other medications that work on serotonin.

[@devinreed5725]

"Stuff is weird" is an understatement.

[@trosktv]

⁠​⁠@@McFwoupson when I would take it everyday I could feel parts of my brain that felt sun Burnt but that sensation never lasted more than a day but I feel like I’ve lost memories from using dxm it has altered my mind I’m not so good of a way

[@McFwoupson]

@TroskTV I've only taken DXM once and it was awful. Felt like I was in menopause, sick and lots of heat flashes. Made my skin feel like it was on fire. Dissociatives are my favorite kind of drugs too, only one I haven't enjoyed was DXM. Also yea everyday use of dissociatives can mess with your memory. I used 3meopcp every other day for 2 weeks once and my short term memory was not up to par for a while.

[@UrineDeity]

How often were you doing it???

[@kodakitz1414]

When i was a kid i started to take cough syrups me often because my dad wouldn't take me to a doctor. I started to associate it with feeling better, like a comfort food. As a teen o would drink it to get high, and now a an adult i can't have any around because i can't really control my cravings for it. :/ I also easy halls like candy because i love the taste.

[@Razor-gx2dq]

so you're sober? did you ever get treatment?

[@afwaller]

Wow how can you love the taste, it is terrrrible

[@neurofiedyamato8763]

@@afwaller It's an addiction/dependency. The desire to feel better (or the association that it will) overrides the nasty taste. Addiction is a tough thing to deal with and sometimes never fully go away even with therapy, lifestyle changes and consultation. But all of these are still great methods in trying to overcome it.

[@necrobynerton7384]

@@afwaller It may taste terrible to you, but for someone else it may taste good. Of course, addiction as @Neurofied Yamato said overrides taste, but there are people who just like the taste, find comfort in it whereas others find discomfort so to speak.

[@APacifistAnarchist]

@@neurofiedyamato8763 Its not addictive, it's habit forming, there's a difference.

[@monsterinyourcloset7573]

My man ChubbyEmu trying to explain chirality at 3:52 but Hideo Kojima already made me an expert.

[@RhapsodicXStyle07]

Who would have thought that organic chemistry from scishow would come in so handy

[@caley.j.n]

When Dr. Bernard explained stereoisomers better than the ochem professor I paid thousands of dollars for this semester 😳

[@yannay4793]

walter white

[@veryfrozen3271]

You pay for the chance to get a piece of paper. Education is free and anyone can read a book, especially now with internet resources. Tho i admit hospitals are ran like the military so you need that piece of paper. Never confuse that paper for an education

[@nicolelebel1158]

Omg I thought the same thing. Years later have such nightmares of that class. Why the heck can’t professors explain it out like this.

[@Adamisgood24]

Very true

[@acmhfmggru]

If you never heard or read chirality being explained as handedness then you really should take up a different field of study... This is in every introductory organic chemistry text written in the last 200 years. This is fundamental. You can't really do or understand organic chemistry without a basic understanding of stereoisomers. Sorry if I seem terse about this, but it is like a carpenter who has never seen a saw or hammer, or a sailor who is unfamiliar with ships.

[@_Mr.Tuvok_]

This and the GG story just made me cry. About 2 years ago I went on a bender of Delsym after a bad breakup and move. I worked at a dollar store so it was easy to get. At one point I took a whole bottle each day. This lasted for about a month. I smoked weed with it and felt amazing. Until the diarrhea happened. And wouldn’t stop. I had to go to the ER and it all broke from there. I quit but nothing has ever felt the same since. Weed feels different. My head feels strange sometimes. My moods are always temporary-not extreme-but just fleeting. I usually feel an intense nothingness-as strange as that sounds. I know I could have seriously hurt or killed my self, hell I probably have irreparably damaged myself. Please please please do NOT do this. It’s not physically addictive maybe but psychologically absolutely. I am not the same person. I likely will never be. And I almost hate myself for it. It’s a great pain, wishing i were suicidal.

[@mustangnawt1]

I’m so sorry. Do u think there are doctors who can treat for this? You are really blaming you. Try to let that go. Move toward treatment. Maybe there was already something missing or something wrong before you even had a drop. Idk, but there have to be Dr’s out there to try to help. Know you probably want to keep it private. Good news is, it is. Have u researched any cases of another feeling a permanent change after cough meds? Hope you get better and feel better

[@X0X0LFertilizer]

Give it time my friend, our brains are capable of extraordinary things. . Take care of yourself and focus on your priorities. Stay away from dope, and drugs in general. I’m with you

[@catsara9114]

Yes, please give it time, and / or see a doctor. I know this is not the same, but when I experienced a "glorious" hypomanic episode (bipolar II) and then crashed into a mixed, then depressive episode, it was hell. When I talked to people who had experimented with drugs, I found so many similarities in my experience. Today I have recovered, the hypomania did not come back and I can cope well with depressive epidsodes. But it took time. So, I encourage you to not give up!

[@goldensloth7]

it gradually gets better... i was on it for years. don't beat yourself up. everyone's just trying to kill the pain.

[@jonathansmith7065]

Call on the Lord Jesus my friend! He is the only reason I am alive and have not suicided after 14+ years of addiction! God bless😁

[@sbocaj22]

The ironic thing is that the fda just approved dxm for psychiatric use in the combination pill Auvelity. For the treatment of depression. It includes welbutrin also but the welbutrin is only there to slow metabolism and how long the drug stays in the system

[@KelnelK]

I've done dxm a couple of times. The last time I did it, I made a dark and deeply disturbing abstract art piece on snapchat that was captioned "Do not do what I have done." When I woke up I listened to myself from the past and never did it again.

[@neurofiedyamato8763]

I'm kind of curious what that art piece is tbh...

[@KelnelK]

@@neurofiedyamato8763 It was made by applying a filter to amplify the sort of static you get by taking a picture in complete darkness and then basically just scribbling patterns over it in dark colors. Not really a drawing of anything in particular except my mental state at the time.

[@kevinmonaghan4678]

Yeah, I took DXM at a relatively high dose once. I don’t really think I want to experience that again. The come up made me think I was dying, it freaked me out.

[@UrineDeity]

i did about 2 bottles of the stuff and drew Danny devito and bjork

[@youngthug7815]

@@KelnelKthis is the most dxm shit ever 😭

[@asrielkekker]

As grateful as I am about you shedding light on dextromethorphan abuse, I feel you should go more in depth on anticholinergic abuse as it has for more devastating effects on the normal function of the brain. People literally develop major symptoms of dementia as young as 15 from taking benadryl recreationally. 14:33 Sources? Only hypothesized form of brain damage dxm can cause is olney's lesions and even then those were only recorded in rodents and not been able to have been replicated with humans

[@rdizzy1]

Reminds me of when I was taking care of my elderly grandmother with cancer and she kept being nauseous and vomiting and they prescribed her scopolomine patches, within hours of putting it on her, she completely lost her mind, went from practically zero dementia, to full blown dementia, within 4-6 hours.

[@andrewgarcia3136]

Benadryl should be a controlled substance. Or just not sold anymore since it's been usurped by better products with no side effects

[@asrielkekker]

@@andrewgarcia3136 tell that to the investors lol

[@genderlesswhale2868]

On his other channel, he's covered benadryl abuse and subsequent effects (Other channel is chubbyemu, if you don't know).

[@slopcrusher3482]

The studies on Olneys lesions also used what would be equal to an ungodly dosage of DXM. I also agree about Benadryl abuse. I would even argue that OTC “sleeping medication” causes long term negative effects.

[@Daggeira]

I see you talked Whang into more videos lol

[@austins.2495]

Whang is the man

[@JohnSmith-ox3gy]

Living that actor dream.

[@ricky-sanchez]

Looking for a whang! Comment. Found it.

[@dr.altoclef9255]

I notice he's in ones where he plays a patient getting royally trashed on something...whether booze or cough syrup. Is that typecasting?

[@Daggeira]

@@dr.altoclef9255 I doubt it; I don't think Dr. Bernard is the typecasting type.

[@shadowstar6692]

I used to use DXM once a month when I had depression for a year as a teenager. I would take a half a bottle of gel caps and wander around the city at night and cry. DXM made crying feel like the best thing in the world, and it helped me feel like I could be happy even when my world felt dead. As time passed, I really think it helped me get better, however, I have long stopped abusing it and wouldn’t recommend people use it until (if) it becomes an anti-depression drug after a LOT of research. The depression after using wasn’t worth the high and using the only “happy” time I had to cry while my brain exploded could be seen as a good thing or an awful thing depending on how you look at it.

[@ayyyd1n]

sorry i know your comment is 2 years old, but in case you are interested in it is actually in Auvelity today! (45mg dxm 105mg wellbutrin)

[@JackieOwl94]

This happened once on accident as a child when my mom gave me a little too much during a really bad cough. It was a terrifying trip as a child and I refuse to take delsym for the rest of my life. The patterns on my pillow kept flipping and my furniture was breathing. Luckily I didn’t need the ER. It was SO bad.

[@verykittypretty]

how tf did u get visuals on it

[@verticalyetti1266]

How did you accidentally get high on it? How many shots did you do of it

[@maxcharlsen3098]

That’s horrible I’m so sorry. Do mushrooms for therapy

[@JackieOwl94]

@@verticalyetti1266 my best guess was that I may have accidentally been doubled on cosine or some other cold medicine dose after coming home from my father’s house that evening while sick, plus I was on ADHD medications at the time as well. There was a lot of serotonin release at once, I would guess. But the event happened 15 years ago, so I’m only speculating. I’ve always been very careful about medication interactions and food interactions since then.

[@glitterbitesback]

I’m in the process of trying to get into rehab for DXM (I’ve noticed no one talks about getting help for their addiction and seem to just be able to go cold turkey but I can’t and I feel dumb because I can’t) I’ve been on it for years and it’s no fun anymore. I came out to my family and my doctor but, until now, have felt alone. My doctor, my psychiatrist and even the rehab place didn’t understand what dxm was or how I could possibly abuse it. They still don’t understand really. Like my doctor still gives my SSRI refills and now I’m scared I’m being set up for something tragic. It’s awful. That’s all I can say. Yes I’ve “tripped” and learned a lot about myself in the process but where I am now sucks and I wish I could go back in time and just stop myself. 31 and really just hanging on for dear life at times. It’s not where I saw myself being back in high school. I thought I’d be fully in a career and just be living…not getting rides from my mom to the drug store to get the daily cough syrup.

[@nickr688]

Daily… man. Hope you’ve quit by now. It is indeed hard to find support for this “niche” thing, because most people who try it do not go down this road with it, but I digress, recovery is possible for everyone, and looks different for everyone, too.

[@Male_Parent]

Woohoo new HR video. Also congrats on 100k subs here :)

[@KoltenTVC]

13:54 she saved me from relapse because she made me realize that dmx high always got worse and worse and worse and i was just chasing that first time feeling that i never got again

[@gamboodle]

I'm glad that there's information like this out there. Just saying "don't do drugs" causes more harm than good, actually learning about the drug and any interactions it may have leads to less harm compared to someone just taking and hoping for the best. It's like saying don't speed, sure it's easy to say not too, but people are going to speed no matter what, same with drugs.

[@CGoody564]

As someone who robo-tripped a few times when I was younger, it is one of the most intense disassociatives you can experience when you take a relatively large amount. It's definitely not something I'd recommend to even the most experienced psychonauts. During my last experience, I remember having an out of body experience to the point where I somehow was watching myself from a 3rd person point of view from above, and I needed two people on each side of me basically guiding me and helping me walk because I was practically incoherent and had very little conscious control over what I was doing. Thank God I had friends who were willing to baby sit me through that experience or I would have certainly been arrested or ended up getting physically hurt (It was at a public mall of all places) If you're going to do that kind of thing in general, always do extensive research and always be mindful of moderation; you can always take more of something, but you can't undo taking too much. At that point, you're just along for the ride, and it may not be a good one. But I still wouldn't recommend for anyone to use DXM in that manner. Word of warning; although the only active ingredient in the gel caps is DXM (as opposed to the liquid which has other things as well), the gel caps metabolize faster than the liquid, so the onset will likely be faster and the experience will likely be more intense than you're used to if you have only used the liquid... But seriously, you really shouldn't use it at all in this manner... But if you are going to make the informed decision to do it anyway, definitely don't use it anywhere near regularly.

[@jedimaster91]

I was born in 1987 and was today years old when I heard about robo-tripping. Must not have been hanging around the relevant circles and I’m ok with that.

[@TheConjurersTower]

Me too, I am also taking this as a win.

[@samiraperi467]

I know someone who did it semi-regularly and managed to stop it, but not before having seized herself to hospital at least once. Those circles are closer than you'd think. Also, I'm curious and did a ton of reading on shrooms, mezcal and other stuff in the 90s. Never used anything tho.

[@inuyasha13]

I wad born in 1995 and never heard of it, but I dont know about most drugs or their slang names. I have enough medical problems without adding to it so I stayed the hell away from drugs. I already have severe asthma, Hypothyroidism, depression, anxiety, etc. I dont need to make it worse lol. Seen doctors my whole life and have a variety of prescriptions that I take to make my life functional but I only ever take things as directed/per instructions.

[@christinesarkis4029]

I was born in 1988 but I knew about t because I hung around some pretty sketchy people in middle and high school.

[@opalfishsparklequasar8663]

@@inuyasha13 it's good you respect the health you have. 💕💐 It's difficult to understand those who cavalierly destroy their health, especially their brains. God bless.

[@pantherplatform]

I forgot it was called robotripping. I used to drink that a lot in high school. Didn't know it was a thing until I saw it on dateline nbc. Thanks nbc.

[@0xEmmy]

You've done drug abuse, now I think it's important to cover what happens when someone gets diagnosed as a drug-seeker or hypochondriac even though there's something actually, structurally or chemically wrong. (A lot of times, the patient has figured out the correct diagnosis themselves, but was dismissed as a hypochondriac. This is particularly common with Ehlers-Danlos syndrome, but it happens with other illnesses too.)

[@warbler1984]

He's a toxicologist hence why all his stories are about substance ingestion. Also Ehlers Dan lost comes with lots of obvious signs so your doctor should generally be able to diagnose it easily enough

[@SobrietyandSolace]

@@warbler1984 Um no, seems like at least half of doctors haven't even heard of it, it takes people up to a decade to get diagnosed and they're often refused diagnostic tests like genetic testing even if they have every symptom- that's because it systemically affects so many things at once so the doctor thinks you're making shit up to have so many things wrong with you or they're all all unrelated. They refuse to connect the dots and look at you as whole For some reason autoimmune disorders and such are nearly always diagnosed by the freaking patient then sheepishly confirmed by the doctor afterward...

[@rdizzy1]

@@warbler1984 This might be surprising, but in my own experience, most doctors do not keep up with modern medicine, especially older GP/PCPs, they are still practicing the medicine they learned in med school like 30-40 years ago

[@penelope-oe2vr]

Went through that myself from childhood to age 35. Diagnosed with two super rare diseases, genetic. Was called crazy and everything else. Wasn't asking for pain relief, was asking for answers. Never got any apologies either.

[@カスカディア国人]

I had hyperparathyroidism as a kid and because people thought I was faking it I almost died and it permanently fucked my body up to the point where I actually need drugs to function now. I just use edible weed at this point instead of the benzos and opioids I used to be prescribed for it after I was diagnosed and had surgery.

[@mjd3381]

Thanks!

[@HemeReview]

Thank you!

[@maenad1231]

As a reckless youth, i went robotripping a couple times. It was mind altering _(obviously)_ but it wasn’t really that euphoric nor depression-alleviating and it wasn’t even worth it because I was vomiting like crazy both times. It’s embarrassing to admit I even did it. I did it for dumbest reason too: a cute boy told me it was a good idea.

[@maenad1231]

@@s7r49 I knew all about the plateaus at the time. I did pleateau one and two _(dose adjusted for my low body weight)_ In my limited personal experience neither was that euphoric

[@iGame3D]

It's a dissociative/deleriant, not pleasurable at all. I've eaten a lot acid and I won't even touch this garbage when I'm coughing up a lung and my head is full of snot.

[@dykishandfriends]

@@iGame3D lol not even. It’s more relaxing than THC in some doses

[@evs6327]

@@iGame3D what? That's dph, different drug lol. Dex hits opiate receptors if you take enough and is one of the more itchy albeit euphoric dissos. Idk why people are shitting on it so much, just be smart with it and don't take it more than six times a year lol

[@mitchlamping530]

I would say the majority of millennials have went through a robo trip phase as a teenager it’s something most people grow out of but not everyone

[@stevenborgens4356]

Wang! getting up in that sizzzuurrp. Another fantastic video. Thank you for all your work. This knowledge transfer is priceless.

[@tricklebug]

im on the comedown of dxm right now and this was honestly the wake up call i needed

[@ethanrobideau4253]

I used to use this once in a while. I happen to have cystic fibrosis. It went from a break from the constant coughing. To once in a while for the high. It's scary to know about it's leading to serotonin syndrome. I recently had a bout with that in particular a while ago while being on a high dose of busporin and my trazadone for sleep reacting together. It's not fun. The only time I legitimately thought of killing myself. I have also realized that cy cystic fibrosis was probably safe gaurding me in a way. Because of my lack of digestive enzymes that come with my CF. I abused dxm to a point before where I legitimately heard things. I had a friend that also reported a "zipper" noise. Like someone zipping up a coat really fast. Just the sound out of nowhere. I've been waiting for a video like this to provide an inside. And to really learn myself what things it could have been causing. Thank you so much on the videos. I haven't used dxm since my early 20s. I'm almost 30 now. And I'm happy to report I will no longer be touching the stuff chasing the high :)

[@vorpal22]

I used it from about age 19 to age 39 intermittently, but usually in binges. Serotonin syndrome is horrific... I got a mild case of it when I used cyclobenzaprine and then a couple of days later, DXM... I suddenly felt this huge sense of dread and spent three days feeling unable to organize my thoughts enough to do almost anything. Really frightening. DXM is one of those drugs that people think is safe because it's pharmaceutical grade. It is relatively safe, but you can overdose on it, and it isn't what most people would think of as "fun," which is what they are often looking for. I'm in my mid-40s now and haven't used it for years, but I am incredibly thankful for my DXM experiences. They were severely challenging and often unpleasant, but overall, very formative to my worldview and spirituality.

[@the_rachel_sam]

Don’t use cough medicine when taking certain medications, like SSRI’s. Additionally don’t drink grapefruit juice while taking either of them.

[@drf0rk]

Or Buproprion

[@mihirpatil8843]

Grapefruit?

[@mihirpatil8843]

@@ShinyMcshine what's the mechanism? Do u know a good literature source on it?

[@clamum]

I think that whole grapefruit juice potentiation thing really depends on the individual. I've taken various kinds of opioids and drank probably 40 oz of grapefruit juice and could never tell the difference between that and not drinking it.

[@verykittypretty]

@@clamum it has to be white grapefruit juice

[@Smeggler]

I don’t leave comments on YT videos but I have to thank you because that was the best explanation for stereoisomers. I’ve known what they are but not how that works out physically but that honestly simplified it perfectly.

[@TravisCotter]

I have taken a boX of DXM over thirty times in my life. I always have this fear that something serious is going to happen to me when I take it. But then the euphoria kicks in and I wish I would have taken it much sooner. Mr. X

[@ChrisHowlandOfficial]

I was on Prozac (SSRI) as a teen and drank 2 bottles of Robitussin with some friends. I was high for like 5 days. I thought I was brain damaged after sleep didn’t remove the high. Was terrifying.

[@evonekky3672]

I was curious about how dmx would affect individuals taking ssris... with the risk of serotonin syndrome.... you felt impaired for 5 days ? Did it.get.gradually better ? Did you have any other side effects ?

[@Grgrqr]

I actually knew about cough robo-tripping because there’s a music video about “orphan tears” or, cough medicine.

[@jackaufenhand5710]

That song was about DXM?

[@pineappleactavis420]

orphan tears is absinthe

[@Grgrqr]

@@pineappleactavis420 isn’t that alcohol?

[@RagingInsomniac]

@@Grgrqr yes

[@fariesz6786]

i was treated with SSRIs for a long time and for at least five years i had serotonin syndrom that doctors unfortunately always wrote off as "just psychosomatic," with my resting heartrate at 100bpm, blood pressure getting to 180/140 after mild exercise, massive migraine-like symptoms, phases of hypomania etc. early 2020 i ran out of meds and due to the pandemic avoided riding the train to get a new prescription; after a few weeks all symptoms had disappeared. now learning that too much serotonin isn't only acutely dangerous but can cause permanent damage is heartbreaking for me.

[@lazuliwinters743]

Also when I come down from 3rd plat, the next day I have an afterglow, and my depression stays away for at least a week or two.

[@onebraincellarmy6972]

4:16 is probably one of the best visual explanations I’ve had of these. I usually just get shown a molecules that gets flipped on the next picture and it was kind of hard for me to imagine what the difference was.

[@quinton1661]

I hate the stuff and wrote it off years ago. Even a normal dose (8-12 mg) is enough to make me feel dissociated for 12+ hours. I've never taken much more than that, and once I realized it wasn't the cold making me feel 'in the clouds', I avoid it like the plague.

[@shanecoopershow]

I've been abusing DXM on and off for about 7 years, usually huge doses upwards of 1000mg+ (that's about 3 full bottles). I can verify that some level of brain damage has taken place, it's hard to define but I often just have this intuitive feeling that something is no longer there that should be. Amplified my dissociative episodes and general isolated loner lifestyle a lot, and I theorize that on a psychological level some of the strange experiences I've had have permanently changed my personality. I also found it has had a permanent impact on my creativity in a good way.. All of that being said the DXM void is a cold lonely realm of the weirdest shit imaginable. To enter this rabbit hole someone would literally have to be okay with the possibility of becoming the next Syd Barrett lol. Be safe everyone, open to questions too 🤠 Edit: I also have a strange reaction to the substance where the next day I become unfathomably sexually aroused. I seriously have spent literally all day going at it until I'm in aching in pain and it still feels incredible despite the pain.. Kind of reminds me of what people say what sex/porn is like on meth... DXM is the strongest aphrodisiac I've encountered. Anyone with any insight on this please share🙏

[@Liminal-Escalator]

The times you feel you truly know immortality and that your consciousness will never cease to exist changed me. And the times I started thinking I've died multiplayer times and slipped into more progressively chaotic parallel universes where I DIDN'T die each time... Entropy of the spirit. There's been a good few hellish experiences. The best experiences? A bit more than the worst. The few good can cause a person to go overboard to get there again but it seems like everything has a mind of its own and that it cant be forced by even logic, as forcing never seemed to work. Usually not trying. Interesting avenues and corridors of the consciousness and psyche

[@bociphous8094]

I have also permanently damaged my brain and no longer know who I am. And I am never going to recover.

[@mikeposner8563]

You probably don’t even remember writing this comment do you? You’re gonna get dementia so enjoy your brain functionality while you have it. The dextroverse is such a fascinating thing, it seems very real. I do believe it exists on some plain of existence. I haven’t even done dxm in over a decade and I still feel very connected with the places it took me while I was on it

[@tac6044]

You could quit and recover. You are just giving yourself the excuse you need to keep using it. " I've already caused permanent damage so what's the point in quitting". Bullshit! Just stop beeeatch.

[@shanecoopershow]

@@tac6044 The truth is I have a really weird masochistic relationship with the substance where part of what I enjoy about it is how hard it is on my body. What many would classify as "bad trips" I almost enjoy in a fucked up type of way. I also have a history of severe self harm that I got the same kind of depraved rush from... Soo what's really going on is probably a lack of self worth/self respect which is why it's so hard to really WANT to stop even though I should. I appreciate your intention to try and help a stranger🙏

[@Voidward]

I had an internet friend convince me to do this when I was a teenager. I took a lower dose than he was suggesting, and I mostly felt a bit drunk and saw some colors. Wasn't impressed enough to ever do it again. He was also very adamant that the syrup didn't have some specific ingredients, to the point where when I joked it did, he panicked and was contemplating calling my parents (he does not know them) to tell them I might die that night as a result. Not worth it kids.

[@neurofiedyamato8763]

I'm kind of happy that I don't think I get egged on easily. people has told me to do a bunch of stuff but I just don't since I don't want to. Even if they are otherwise close friends. But we all get influenced at a subconscious level

[@minhilg]

He wasnt wrong, it tends to also have ingredients like acetaminophen. If you drink enough to trip off DXM you'll drink enough tylenol to fuck your liver. Gotta make sure its the only active ingredient if someone's gonna do it.

[@spiritualau8263]

Research before you take any mind altering substances!!

[@medicine_abuser6969]

Well it's a good thing that your friend made sure it was Dxm only. My first time robotripping with my friends we were pourin' up nyquill and sprite into double cups (I know cringe xD).

[@mrdavman13]

@@minhilg sad thing is that much apap wouldn’t kill you but just basically destroy your liver and leave you alive

[@ulyssesm.daniels6927]

Love the guest appearance of muh boi Justin Whang. Love all your content too lol dont think ive commented on anything before. Long time fan, love the educational content.

[@Adamisgood24]

I used to take DXM, for the dissociative effects, and went to the hospital, several times, because it caused psychosis.

[@RomanoPRODUCTION]

be well

[@rockmove3547]

You stupid guy if it was once dangerous for you why did you try again xD

[@rockmove3547]

Psychosis is really rare for reacreatiomal use

[@chrisboelens2640]

@@rockmove3547 Addiction is a bitch, that doesn't make him stupid. And regarding your second comment, I wouldn't categorise psychosis as "really rare from recreational use",. in fact it's much higher in recreational use because high doses make it more likely.

[@rockmove3547]

@@chrisboelens2640 actualy if you do it in the right way chance it happens almost never. Set and settting + preparation. Know your body, know your substance. If you take to much for first time, without antyhistamine stuff, or in the place you are not safe, you have psychical problem or someone in your family ETC. Problem is that stupid people or kids take it, then it might be dangerous

[@RogueAstro85]

When I was in HS I robotripped quite a few times. The first time I experienced euphoria and had a great time and felt incredible the next day. After that I did it 7 or 8 more times and it never felt like that original trip. Luckily I didn't get addicted but around that time my ADHD symptoms were exacerbated even though I didn't know I had it at the time. I've also been mildly depressed since then and I've always wondered if the trips caused some sort of permenant damage that affects me to this day. A bunch of internet sources basically told me that it was harmless as long as it was DXM only and you didn't overdo it or take it too often. But who knows, I'm getting a little better over time so I hope it's just other parts of my life that I can control and not pernanent neurological problems. Great video!

[@COClimb6]

There’s an entire community that does dextromethorathan that call themselves dX, ran by channel called Ganval tv. Weird.

[@scordova98]

Just looked it up and it seems like a clusterfuck can you break down what this is about?

[@COClimb6]

@@scordova98 well doxxing is is their other hobby. They take dex and call them rubies due to the red capsules. They encourage people to take mass doses and have encouraged many autistic people to do it as well. There are lots of videos if you search Ganval and what his group does including calling people’s parents and harassing cancer patients. Mostly made up of middle aged women and ran by a 20 something guy with a BAD reputation.

[@wisconsinvoleyball]

yeah i had found and then looked into the community a while back, i do not do this stuff but somehow found out about it. for sure a really weird community

[@neurofiedyamato8763]

@@wisconsinvoleyball Sounds like a very horrible and toxic community rather than just weird.

[@wisconsinvoleyball]

@@neurofiedyamato8763 yeah for sure

[@oasntet]

The serotonin receptor down-regulation that can happen when you've got too much available for too long is the also the reason that you should avoid going off an SSRI suddenly. The rebound effects can be worse than the original depression.

[@R0S3inC0NCR33T]

The most interesting effect of DXM, at least the two times I used it, was the time dilation effect. It felt like hours would pass and then you’d look at the clock and it’s been three minutes. When my partner and I were on it together at a party, we laughed to each other and talked about how it felt like we were in a pocket dimension and it was everyone around us who were on the wrong time frame. Made me feel too sick to keep doing it, unfortunately my partner has been addicted for years. Finally starting to recover, but still deals with chronic memory problems, visual snow, and brain fog. Google says those symptoms won’t last forever… probably. Also, if you’re gonna robotrip, please please please take the pills instead of the syrup. Robotripping is bad for you, but chugging an entire bottle of acetaminophen is worse.

[@BrickNewton]

I was able to try it in pure powder form and it was so strong compared to syrup. Yeah I remember as a teenager talking to someone at a party and it felt like hours and apologized for talking so long and the just looked confused as it was only like 5 minutes. Interesting stuff but a few times was enough

[@madeline569]

Your videos are making me take better care of my health and also respark my interest in chemistry and human biology. Thanks so much for your channel man

[@Psychx_]

Using regular HCl wouldn't have significantly increased the BOM for the producers of DXM, nor would it alter the effects; it is known that the stuff is getting misused and regulation is not going to change, so I think the manufacturers should really change their recipe; Converting between different halogen salts trivial anyway... Also, preventative work like you do is equally important - 99.9% of people who use don't know that bromide can even be an issue.

[@manyshnooks]

Agreed. Not even sure why they chose the HBr salt.

[@Psychx_]

@@manyshnooks It probably has to do with the synthesis. There are many reactions in organic chemistry that yield HBr as a side product.

[@manyshnooks]

@@Psychx_ convert to freebase with NaOH and then salt it out with HCl; I agree with you 100%; they know the product will likely be abused, and they should endeavor to make it as safe as possible. Edit: this does make me think of the bromide sedative/hypnotics used a century ago and the cases of bromism that followed widespread use & abuse

[@manyshnooks]

@@Psychx_ just had a look, it seems that dextromethorphan has been produced in a variety of differing salts incl hydrochloride and citrate going by a Google patents search. I agree that it probably boils down to cost and economies of scale.

[@k-isfor-kristina]

Wow the extensive metabolizer thing explains so much. I've taken dxm syrup to suppress dry coughs when sick but I when I take the recommended dose on the bottle, I end up pretty high and then when I take it for the second time later than day I end up high as a kite. I've always figured I was just "out of it" due to illness because I didn't know you could get high off OTC stuff, I only knew of people using the codeine syrup for that. That makes so much sense now. Also explains why it is more effective if I take a smaller dose than what the bottle recommends.

[@Hawkforstluver]

I used to experiment with this stuff. ugg, never again. I think it ruined my intestines. They haven't been the same since. I have to be careful what I eat. I'm lucky it wasn't worse.

[@timothylongblacksmithing6743]

I was once given Dextromethorphan when I was 5. All I remember is that I couldn't stop laughing and I couldn't get to sleep. I think I also had a fever, but that could've been because I was sick. I've avoided the stuff since then (I'm 23 now), up until February, and when I took it out of necessity, I was fortunate to not get hooked or get any of the side effects from when I was younger

[@edwardbutler9840]

😂taking it medically in normal doses is completely fine, glad you’re being cautious though.

[@based_mediumchungus1788]

"fortunate to not get hooked" lmao, you can't get hooked on dxm. this isn't oxycodone.

[@clownpocket]

I binged on these two channels, and was amazed to find out Dr Bernard was also a powerlifter. Do you still train?

[@mlgmcdonaldsland7063]

I love how we never talk about dosage

[@nathanharrower2778]

About the idea she expresses that an addict is trying to chase a high but never reaches it- Ok so yea you're trying to chase a high but dude, I hit it right on point just about every time. Just straight bliss, and that's the scary part

[@gavinm7851]

Fr bro, throw in some weed and as long as you can hold back the vomit for an hour you're golden

[@nathanharrower2778]

@@gavinm7851 couldn'ta said it better

[@TheCheemstar]

I used to chug a bottle of delsym before last period of highschool. I only did that a few times a week for about 6-9 months. 6 years later and I do feel that this changed something about how I think, I wish there were more studies on very long term side effects as I have heard anecdotally of this a few times but never have seen much in the way of official information on side effects years later.

[@indolealcohol8612]

controlled dxm use is one of the things that helped me quit smoking cigarettes' and vaping, which made it the best cough suppressant in a way

[@jmiod2819]

I mean you got a point hah, glad that it helped u

[@natalyawoop4263]

dxm in for the long con

[@rdizzy1]

Funny enough, the new drug that is bupropion/dextromethorphan was actually tested in stage 2 trials for smoking withdrawal symptoms.

[@tac6044]

Trade one addiction for another?

[@katieh9169]

A few years ago I went through a months long phase of drinking an entire bottle of delsym almost every day. Almost ruined my life and my brain still hasn’t recovered fully. It was a complete out of body experience in the worst way.

[@bridgetmoran7343]

Anyone EMS or otherwise want to tell me some visual cues that suggest involuntary ingestion of dextromethorphan?

[@daveb5041]

@Peter the NWO Rabbit I would say look at the eyes, huge pupils/mydriasis and the responses with the ankles. Also look to see if the patient is itching alot or signs of scratching. Should have weird HGS too

[@crystalpup97]

They walk like they're drunk and can't speak properly. The walking is the biggest indicator

[@deusexmachinamotorsports]

When I was robo tripping. I was hot but never itchy. Pour sweat that day and the next day. I liked to close my eyes alot and chill. My one buddy would get itchy. I'm pretty sure I could walk around and ppl just thought I have one too many beers.

[@carsonbrooks2102]

I believe what he may be talking about is the environment where the patient is picked up, empty bottles near by or lying on the ground next to the patient, other nearby medication, etc. All of the rest of these symptoms described by others below are things an ER doctor would be able to see just aswell as EMS. What is unique to EMS is they get to see the location the pt was picked up in. What I believe makes these clues necessary for an involuntary overdose is because there will be no social history from family or otherwise of the drug abuse, making the diagnosis less obvious to ER docs

[@joshuagavaghan224]

@@bigjohn4445 true. For someone who doses dxm regularly, with tolerance, they can more or less learn to mask the intoxication, and learn to override the gross motor impairment to a decent degree. Also, tolerance to the dissociative effects of DXM, (from its metabolite DXO) builds very rapidly, but the serotonergic activity of dxm remains strong, and stronger with increasing dosages over time. So the sweating, and large pupils can be indicative, as well as a general confusion of the patient, possibly just looking zoned out, but still sort of doing tasks and responding, like a robot. Another meaning of “robo” tripping. With chronic use, you kind of become “one with the DXM” and the patient will adapt to mask the obvious impairment, but over time, the impairments will be obvious in that the patient is always seeming tired, and kinda zoned out. It’s a very specific thing though that I’m finding hard to describe, but I’ve seen it many times where it was known, so I feel like I could guess, but it could easily be mistaken for other drug intoxication. But the combo of a weird gait, and the zoning out, staring thing, and large pupils would be some solid signs.

[@lissakaye610]

Very good episode! Thank you for all you do.

[@oloxhossono1956]

i used to drink this stuff in high school cuz my friends were doing it. i hated it. really hope i didnt get any permanent damage from it. think about it gives me anxiety

[@WorldOfWonder66]

I had no idea this was a thing. Thank you for this video

[@rogshotz]

7:25 thats wrong, or at least wrong in that its only for the initial euphoria. Theres an effect called an afterglow which is basically just a reverse hangover. I felt great and happy for days afterwards even after it was all metabolized. This is the reason I was mildly addicted to it. Not worth it.

[@your_stepdad]

used to mess with this stuff all the time in high school

[@anemoneyas]

I used DXM recreationally a few times back in college and enjoyed it but I never pushed it that far. I got it in gelcap form, was in these small allergy pill sized bottles and I'd just take a bottle of gelcaps at a time which ended up being around whatever my online "research" had determined was a mild to medium dosage. Made music more enjoyable so I'd kinda just veg out listening to albums for several hours. It seemed like taking more than that put you into the are where you had a more real risk of adverse effects either from the dxm or just nausea from all the inactive ingredients so I never went beyond that. After a few times I kind of lost interest and never used it again.

[@dj_laundry_list]

Did you notice different effects when socializing vs being alone?

[@badxradxandy]

You and I had the same experience. Now I enjoy edibles to get a similar experience with less problems.

[@badxradxandy]

@@dj_laundry_list I did, you really want to be alone for it because people will mess with you

[@anemoneyas]

@@dj_laundry_list never socialized on with it. taking it just made me want to chill alone.

[@nickr688]

@@dj_laundry_listI started using it alone and eventually socially. When people take this stuff together really weird things can happen. Everyone’s delusional, convinced they’re reading each other’s minds, convinced each other are planting thoughts in their minds, speaking in “tongues” is rare but a possibility (clang, aberrant salience). Gets cultish after a while. Can bring people closer in a toxic way and tear them apart from the world at large simultaneously. All identical stuff to what happens with PCP (commonly and erroneously referred to as embalming fluid) which many rappers have discussed, ghostface a prime example

[@grimreefer213]

It is not just the serotonergic activity that makes dxm so addictive, it’s also the NMDA antagonism and dissociation that makes it incredibly addictive psychologically. Similar to ketamine, pcp, or even nitrous oxide, drugs that have a dissociative effect can be very psychologically addictive for certain individuals. It allows you to retreat into your mind and be free or dissociated from whatever it is that ails you. For some people it’s depression and for others it’s even physical pain that dissociative drugs can help with, ketamine is used in some surgeries and medical procedures because it reduces pain in an indirect way

[@drakula420_]

Very interesting. I was a casual user when I was younger, I had one OD. Mixed DXM with other street drugs. Had a seizure & was walking around with a dislocated shoulder for days and didn't notice cause I was still so messed up. Still have issues with my shoulder to this day.

[@SSJfraz]

Serotonin Syndrome generally occurs when a Serotonin precursor is combined with an SSRI. It's one thing to increase the amount of Serotonin availability in the pre-synaptic vesicles, but if you block the reuptake of Serotonin from the Synaptic cleft on top of that, then the concentration build up of Serotonin in the cleft will inevitably be too high resulting in the over activation of the 5-HT receptor sites leading to Serotonin Syndrome.

[@Anne_Onymous]

I personally never saw anyone get hurt by robotripping... But it was always like rolling dice. Trips would be fun for some, scary for others, even sometimes miserable (hallucinating while vomiting is not fun lol). And if you _did_ luck out; you're sucking it up for hooooours due to the long trip length. So it's just not worth it impo. =)

[@jonshannon6252]

Thank you for making these videos man, they’re the best! 👍🏼🥳

[@ModernParadigm]

Aside from some people having slow metabolization of certain liver pathways (like CYP2D6 you mentioned here), some people have genetic mutations on their serotonin transporter gene (SERT / SLC6A4) directly. I have a mutation on this gene (s/s). It's given me serotonin syndrome multiple times, and was only discovered when I had a near fatal case of it in the ICU. It did give me permanent brain damage, and took far too long to diagnose (with some of my cases being more mild before severe.) I can get SS from SSRI monotherapy. I think serotonin syndrome is less rare than we think, especially people with slow metabolization genetics thrown in the mix. I don't think it always takes a high dosage or mixing of typical serotonergic medications. Also as noted in your video, serotonergic OTC medications or herbal MAOIs are on the rise in popularity. There are many herbal supplements I cannot take that people think are otherwise benign (for example turmeric is an herbal MAOI.) In the future, before we give people psychotropic medications (even for something like migraine), I hope it becomes normalized to test these genetics. I know in the future personalized medicine will likely take this into account.

[@Matricias]

Robo-tripping refers to the misuse of dextromethorphan, an active ingredient in Robitussin. 00:00 Misuse of dextromethorphan has been talked about since the 1990s. 00:27 Dextromethorphan comes in both syrup and powder form and can be taken orally. 01:15 Dextromethorphan does not fit into the opioid receptor site to produce analgesia because it is flipped. 05:06 Dextromethorphan and PCP can be dissociative agents which could explain the feeling when someone robodoses. 06:31 Over-the-counter cough medicines may contain other medicines like Tylenol or guaifenesin, which may cause liver damage or have other effects in overdose. 10:30 Misusing cough syrups containing dextromethorphan hydrobromide, which has a long half-life in the body, can result in too much bromide in the body and cause hyperchloremic non-gap acidosis or a negative anion gap due to increased negative charge, leading to falsely elevated chloride levels. 11:13

[@stockstreamtwitch]

When I was younger I messed around a bit with codeine. I never did feel any effects from it. I suppose I'm a poor metabolizer. That's a good thing in my case 👍

[@xiangyu1579]

Good and bad tbh I tried getting high with codeine too and didn’t have much luck so I also lack the gene I assume. The problem is tho I hurt my back the next month and my GP prescribed me strong codeine pills and they didn’t work. This means I’d have to start with morphine or oxycontin which is far more addictive and would’ve been overkill for back pain so my gp could only prescribe me naproxen (which is a slightly stronger version of ibuprofen). It’s good from the perspective of recreational abuse-as in it can’t happen, but it’s bad from a legitimate medical point of view

[@SobrietyandSolace]

I suffer with chronic pain and allergies. I am prescribed promethazine and codeine but the way they affect me scares the shit out of me. When I had aspiration pneumonia (I have crowded teeth and struggle to chew tough vegetables sometimes so inhaled a pea skin). I was given syrup as I could not stop coughing to the point of vomiting and my lung were full of sold jelly bloody mucus. Even feeling that ill and it easing the cough a bit it freaked me out how messed up I felt. My dad has an addiction to painkillers and my uncle went from prescription painkillers to crack. Morphine makes me panic and throw up, tramadol makes me panic and have trouble breathing. Given the amount of alcoholics and addicts in my family I'm glad the only substance I fuck with is cannabis (and my asthma control is excellent even after the pneumonia related lung damage)

[@ajxhfdcdx]

I love this stuff. I haven’t taken it in years, but I messed with it in my early 20s. I smoked a bunch of pot and drank a lot, and I would get drunk/high, but generally I just became a sloppy careless person and it kind of felt good, or at least better. First time I tried DXM was with Coricidin HBP Cough and Cold. I took 4 tablets and all I can say is I felt amazing. I didn’t feel high. I felt happy and sharp. All of the sudden I became the life of the party and I started making a bunch of friends and having a really rewarding social life. I took it on and off for years with each time being of similar gain. I stopped when hearing it can mess up your kidneys. I had no idea how it worked, and watching your video and understanding the chemistry leads me to wonder if I am just a depressed person. Also, I don’t know why, but when some of my friends would take it with me, on a similar dose, they would get super sick upon feeling the effects. They hated it, it seems that it has very polarizing effects on people who take it, why is that?

[@gionatavassena801]

Most people don't enjoy dissociation, it can be a very overwhelming feeling.

[@4k-os]

I also started with Coricidin HBP. But it has Tylenol in it and I was concerned about my organs. When I got more serious about I was ordering Dexalone gelcaps because they were the "dex", alone, with nothing else. Swalling 8 or more gelcaps at a time eventually got to be too nauseating though.

[@godfilth]

could you make a video about the long-term effects of mdma on the brain?

[@earlgrey2130]

Yes please!

[@asrielkekker]

the long term effects dont start to manifest until you start binging it or taking it more than once every 2 months.

[@hartincmajor202]

@@asrielkekker this statement isnt backed by hard science. Be careful of what folks say on the internet y'all. Statements like this made people believe, in mass, that marijuana was a non-addictive drug or that fiberglass was a safe alternative to asbestos etc etc

[@PeppermintSwirl]

HartInCmajor of course it’s addictive, practically anything can be if you do it long enough or if you’re massively depressed and looking for an escape. The key, like with anything, is moderation.

[@hartincmajor202]

@@PeppermintSwirl if this is about marijuana I'll just add that it is a physically addictive substance and that addiction is not exclusive to any single or type of psychotic state. The CDC finds that about 1 in 10 users are dependent, 1 in 6 users that used underage (during brain development, not just legally underaged) are dependent. As it is currently the withdrawal period from the physical addiction is viewed on average 2 weeks, but as thc potency rises and higher potency tests conclude, we may see shifts in some if those metrics. And before I get the "ha who trusts the CDC?" Comment I will say that when I did a paper on this subject I used credible sources that were both supported by the government and sources that were trusted independent.

[@beaus123]

In Ireland, you can get codeine cough syrup OTC. In the pharmacy I work in, if we don’t know the person, we don’t have it in stock. I have no clue why it’s still licensed for OTC use.

[@rdizzy1]

Codeine is weak, and not very dangerous. Actually quite difficult to OD on, even if you wanted to, let alone accidentally. Especially at dosages found in OTC cough syrup. It works better than alternatives, that is why many countries have it otc. Countries that don't have it OTC have people abusing far more dangerous substances like DXM instead of abusing codeine. DXM is far more likely to kill you from long term abuse than codeine is.

[@beaus123]

@@rdizzy1 I have patients who are on methadone due to codeine misuse. While it's difficult to OD on - that's not the point of opiate misuse. It is a really effective antitussive but if a cough really is that bad I'd be referring to a GP long before I sell codeine - it would be bad on me if it turns out the PT has stage 4 lung cancer which was overlooked.

[@maxwell_edison]

*Says 40 things in a row* "Also, keep in mind," Me: "No, I don't think I will."

[@stonedyeet2675]

Dextromethorphan is similar to ketamine as both of them are dissociative type drugs. I for one enjoyed my DXM trips. I do intend on doing this again as well. Although I have done many low dose tests and a large amount of research on the effects and doses.

[@Sammysapphira]

Cough syrup needs to be sold in smaller quantities. Nobody needs a massive XL sized bottle of cough syrup. In all my times being sick as a kid I'd maybe have a couple tablespoons maybe 2 to 4 times maximum per year. Buying a jumbo XL bottle doesn't raise any flags to anybody when a teenager is buying it, but if a teenager is buying eight small bottles those flags could be pretty easy to see. Especially on receipts if the parents see them.

[@mandakhbaatar]

@@s7r49 That's quite retarded. Bigger or smaller knives serve different purposes, they aren't smaller because you need "less knife". The only realistic drawback to selling smaller medicinal bottles is more frequent purchases, which depending on how you see it, could even not be a drawback since it's not an essential-for-life medicine and could provide some good tax revenue in the large scale.

[@featurebreaker]

Nowadays, there are dextromethorphan combination medicines like Auvelity, which is the brand name for a medicine combination for bupropion (wellbutrin), and dextromethorphan, which can be used for anxiety and MDD (major depressive disorder)

[@florenceforbush63]

You mentioned this non specifically, one of the interactions with DXM and other meds is a crucial one between Wellbutrin (Buproprion I think?) it’s the most prescribed anti depressant in the US and will potentiate DXM It was not a fun moment when I took a normal dose and realized I was tripping. It was a low trip but 15mg shouldn’t cause that,

[@AlysaDunn-r6o]

I know this vid is 3 years old now, but interesting the mention of anti-depressant effect around 7:30. Since this vid was released the FDA approved a combination drug of dextromethorphan and bupropion for major depressive disorder.