Acidity and Ionization States of Amino Acids

[@trayanc1496]

very useful, thank you so much

[@kal7708]

Great vid!

[@sabihakhan22]

how did he get the CO2 at the end in the histidine example

[@annaharshaw6211]

but how do we find At what pH would the structure be the predominant ionization state?

[@kmcel190]

For every acidic group in the amino acid, compare the pKa value to the given pH. If the pH is greater than the pKa value for that group, then it becomes deprotonated, (loses one positively charged hydrogen). If the species exists at a pH lower than a pKa of a group, that group remains, or becomes protonated.

[@annaharshaw6211]

@@kmcel190 Thank you so much!!!

[@firdaousf4291]

I wanna ask if someone could respond Why in histidine both nitrogen of immidazol couldn't be at an ionization state or why the N would be NH+ and NH would be NH2+

[@ritaakpokli2103]

Useful but the visuals are quite blurry