Advancing bispecific discovery programs towards clinical success using GS Discovery® and bYlok®

In this webinar Dr. Jin Lu shows how Lonza’s novel GS Discovery® transient expression platform can boost transient titers by ~30-fold to enable rapid early material supply, and streamline the transition from discovery to stable production. Dr. Lu will also introduce bYlok® bispecific pairing technology - an innovative solution that drives correct heavy-light chain pairing rates in IgG-like bispecifics to greater than 95%. This improves yields of the correct species and streamlines downstream processing, without affecting key performance attributes of the molecule. Dr. Lu will present the latest case studies of bYlok® engineered bispecifics and explore how bYlok® compares to other established pairing solutions.
Key points:
- GS Discovery® supports high titer transient expression to rapidly generate material for early studies
- bYlok® bispecific pairing technology drives correct HC-LC pairing in bispecifics to greater than 95%
- This overcomes issues during downstream processing
- bYlok® and GS Discovery® are accessible via a license agreement
Speaker: Jin Lu, PhD, Senior Technical Support Manager, Licensing, Lonza
Dr. Jin Lu is a senior technical support manager for technology licensing at Lonza. She has over 13 years of experience in biotherapeutic protein characterisation, and a PhD in chemical biology from The University of Warwick, UK.