Prions and Protein Misfolding

[@esan120au]

You are a natural born lecturer. Thank you very much

[@jamalkaka5201]

RESPECTED SIR YOU ARE GREAT WITH SMART PERSONALITY

[@Hegeleze]

Spongiform encepalopathy for those wanting to know... man I love your lectures.

[@ayeshasalah6079]

i love the explanation method. and the way he ends the video stashing on the last few words

[@Rosey7teen]

This was such a helpful video. Thank you!

[@MichaelHarrisIreland]

Prions turn us back into bricks.

[@Dr_smit_patel]

hats off sir 👍👍👍 love from INDIA best expained sir god bless you.....lot of love from me ❤❤❤❤❤😍😍😍

[@Waeyonim]

your spirit is totally awesome! thank you sir!

[@LukeChavers]

Excellent lecture, thank you

[@christopherleubner6633]

Hydrogen bonding occurs between the far beta sheet and the first alpha helix. It causes the binding energy to shift forming and expanding the beta subunit. Next the hydrogen bonding becomes far stronger than normal within the molecule and part of the final helical linkage becomes a beta sheet. The solution would be to change an amino acid on the end of the first helical subassembly that is one with less energy of attraction. Im not sure what the precise function of PRp is, so that must be explored to make sure the transformation is not going to cause deleterious effects. Misfolded protiens can possibly be cleaved by a special antibody bound protease enzyme trained to attack the beta sheet at the end of the molecule.

[@farahhammoud4477]

Excellent video, thank you AK!

[@KH-cs7sj]

This video demystifies the whole prion thing for me. They are no longer as terrifying to me as before. As for why they can transform normal prion protein to deformed one, my guess is that the beta sheet can attract the beta sheet in the normal protein and form larger polymers. I also have a question, why this only happens to the prion protein but not on all other type of proteins?

[@irinabains4300]

Amazing videos, just have a doubt: Are prions formed only when beta-sheets are folded instead of alpha sheets or the other way around also or is it when beta-sheets are misfolded?

[@BrettHoustonTube]

Thanks for the info. I am wondering why everyone is using illustrations to explain this. Are there no sufficient images of misfolded proteins?

[@tessamarie8698]

You can probably find some better examples in other videos such as animations etc. it’s hard to really depict its image but there’s bound to be one that sticks as a reference.

[@mohammadhalabi6743]

Loved your excitement

[@Letik3x]

Absolutely amazing!!!

[@mleoq]

It's actually PrPC > PrPSC. Your labels are incorrect, which causes confusion that leads to false information. PrP stands for prion protein, both PrPC and PrPSC are prion proteins except one is infectious. Your diagrams are correctly drawn, but they're not labeled correctly. It's supposed to be PrPC. It's not that it's a picky thing, it's just that prions are already misunderstood enough and we need to be precise when it's about teaching it to other people.

[@furqankhan3741]

Saying prion proteins are infectious is wrong. Because it is not precise. It should be like special form of prions are infectious. Right? I got so confused.

[@Calebisaturtle]

PrP and PrPc are the same thing the only one that is pathogenic is PrPSc

[@蛋子-l3y]

Clear explanations! Thank you so much!!!

[@AymanSmairat]

thank you very much .. thats very very useful 🎉

[@akmaralassylbekova688]

The confusion here is because actually it is not the beef which comes from a cow with mad cow disease, but it is the brains of those cows. There are certain types of food called haggies and brawn which are made of cows’ brains and these can cause prion disease in humans...

[@credterfe]

Some questions . Did the alpha helices transform or unwind into beta sheets or did the amino acid polypeptide chain undergo denovo transformation into beta sheets without going through the alpha helice form ?

[@bilalkhalil2795]

Hi Sr! Hope so you are doing well video was fantastic. Kindly tell me about the name of biology you are following for lectures.

[@cn4140]

We are currently having an out break of prions In 2020 in the 24 of our states here in the US. In the deer and Elk populations. To my understanding it "MAD COW" disease. No cure and deadly. Am I correct?

[@estevanpakozdi1346]

Christina Nelson it’s called chronic wasting disease, but yes it’s pretty much the same as mad cow.

[@mllakml155]

I need help with other stuff in protein folding . can you help with that ?

[@Alaa-cv8pj]

Thank you so much 😊

[@edlemillion8238]

You are the best

[@ameenamer4782]

Whats the relation between prions and diabetes (T2D)

[@MissNebulosity]

Great lecture!

[@Procrastinerd]

So is a prion the result of a genetic mutation, whether in a cow or a human. In other words, does the prion originate as a mismatched mutation and then begins to aggregate, functioning as a disease?

[@Procrastinerd]

Cognitive Philosophy I know it was just an example with the mad cow but still

[@erickishel7417]

No, not necessarily. We do not fully understand the origin of prion proteins.

[@afthabmadavoor9473]

Thank you. This was helpful.

[@irinabains4300]

so a prion is a group of misfolded proteins? Also, what sets prions apart from the other misfolded proteins that can be denatured or refolded by the body cells?

[@soylentgreenb]

They can somehow catalyse healthy proteins into misfolding and adding themselves to the stack of misfolded prions. A protein that is misfolded/denatured in another way is just junk that gets cleaned up.

[@ShivaniSharma-bn5ce]

Best explaination😇

[@stayingsimple9072]

Why don't you talk about charperones ?

[@greenzebra97]

agreed

[@shahzaibsohail7265]

Good Content Sir'.....

[@goldon5909]

Thank you 🙏

[@SultanKhan-ng6ng]

sir please add videos of plant physiology ...espclly abt secndry metabolites and plant hormones plzzzzz

[@Gk-ni8vn]

Thank you!!

[@muhammadaliaslam4023]

Hats off 💜❤️

[@massimoazzano]

Please could you give a feedback about spike combining with heparin generate prions?

[@raghadhammami5364]

Thanks a lot 💙

[@afc90501]

thank you so much!

[@lujainaa6086]

What written in the board scares me

[@1MoreStep1]

Saving me yet again from unclear university lecture.

[@anteater2536]

thank you sir

[@irem9955]

THANK YOU SO MUCH

[@drabdullahzulfiqarch1898]

Helpful

[@noelychonya5148]

thank you so much

[@r3dm4il]

thank you,

[@vickyaustin7548]

Beta pleated sheets

[@Paranoidhuman]

Linear should be replaced by planar in the video

[@emilyc8958]

Pronounced 'pree-on', not 'pry-on'

[@deodex2067]

beta pleated sheets

[@WutLawl]

swag

[@medizzyie]

🧃

[@GGANA19]

it's pronounced PREE-ons

[@Wes8761]

Its pronounced Pre ons you nit wit PrI ons are birds

[@arunkumars6257]

Thank you so much!

[@katielui131]

thank you very much!