Introduction to glucogenic and ketogenic amino acids

[@chilldudemanguy]

I swear, every single time that I forget about this channel for a few courses and feel hopeless because I have no way of putting the information from lectures into context; I rediscover it and understand everything. Great job on this channel, you're a hero!!!

[@OhSoPeachyx]

Great video, they're perfect for reviewing and clarifying the mess of information thrown at us in lecture at school ahha. One thing though-- around 2:15 you mentioned that pyruvate -> acetyl coa is done by pyruvate decarboxylase, and correct me if I'm wrong, but I think that the pyruvate dehydrogenase complex does this conversion. I think pyruvate decarboxylase is involved in anaerobic breakdown of pyruvate

[@AKLECTURES]

if thats what I said, then you're absolutely right, I misspoke! thanks for taking note!

[@jamalamay]

Fantastic lecture

[@Habe111]

Pyruvate carboxylase not dehydrogenase

[@billypho1232]

So glad I read your comment cause I was bout to flip LOL

[@dipambitamoran2455]

Awesome explanation . Thank you.. Love from India🇮🇳

[@princesssaya2562]

2 years after graduation and you still my life saver ..thanks for your great efforts you are so helpful ❤️

[@dhirendrasinghpanwar8929]

Best and extremely comprehensive lecture on the subject 🎉🎉🎉

[@rosechemutaikoech8441]

all thanks to AK lectures I manage to improve my grades in biochemistry, looking forward to learn more,thank you very much

[@megm2253]

thank u very well explained ! u save lives

[@parri8486]

Best explaination so far !

[@heathermorrell2902]

Thank you this was so clear and concise!!!

[@wasifhsaeed]

Amazing Explanation! God Bless You!

[@atawahperry1852]

you are the best teacher in the world sir. how I which you were my teacher

[@selenepino7890]

God blessed me with this video

[@oceanneboisvert-lapierre4918]

Thank you for saving my ass for my exam! your explications is very clear and your scheme is so helpful to visualize. I just discover your chanel, wich is sad because the semester end soon, but at least I can understand before my final exam :)

[@Tuesday11]

Thanks alot sir ❤️❤️❤️... Very nice and clear method of teaching

[@farisalshboul998]

Absolutely genius , very clear presentation, thanks a lot bro

[@diegoortz8932]

Hey AK, Threonine is a both Keto/Glucogenic Amino Acid. Great Video anyways!

[@fireonyou4503]

he already said that

[@hektor6766]

@7:05 It depends on which definition of glucogenesis is used.

[@midhatomerovic8054]

Already passed this, but damn I missed those lectures...

[@tinayiu1273]

great video and many thanks. By the way, I learnt that Threonine is both glucogenic and ketogenic and would like to clarify with you? Many thanks.

[@Sheperdsdaughter]

Brilliant! Thank you!

[@sansonsanson476]

to day we had cholesterol synthesis in the class and we enjoyed...

[@noobbacon9801]

Thank you so so much!! Your videos are very helpful!!!!

[@zainabalkurdi6175]

Please can you prepare lectures about upper limb anatomy 🙏🏻 It will be so difficult to understand it from another else

[@krienbergproductions8844]

You're amazing !

[@amiraemam4802]

Thank you very much, your way of delivering information is very easy.

[@shinn-tyanwu4155]

Outstanding

[@avtawf]

But why aren't the amino acids that eventually form pyruvate also ketogenic? Pyruvate can also be converted to Acetyl-CoA, which leads to ketone bodies...?

[@dinesh760]

LiNingAir no there's a separate pathway pyruvate carboxylase which converts it to oxaloacetate which through gluconeogenesis forms glucose

[@kashafzulfiqar12]

excellent lecture....thankyou! so much

[@Ahmed_AboYounis]

You are Great!

[@biscentkapalasa8069]

U are so great sir Kip up

[@schrodingeru.k2795]

Thank you doctor so much .. You are the best teacher in this fucking planet

[@ELVINA0303]

what i can say is amazing. thanks soooooooo much

[@timmoers9718]

Is there a book you would recommend to learn all of this from scratch? I'm very interested!

[@hebashihab3766]

Waw waw waw thank you very very very much you are the best ever thank you so much.

[@ughsirius]

Thank you soo much!! I was so confused about why acetyl co A couldn't be fed into the cycle and produce glucose, and I had searched everywhere (and given up), so thank you soooo much

[@elizabethmyrus6813]

I freaking love you.

[@lamoush19]

Thank you! this is really helpful.

[@kailiu2428]

Thanks for this clear introduction to the glucogenic and ketogenic amino acids! I'm a newbie to biochemistry so sorry if my question sounds silly. You mentioned that tryptophan is both glucogenic and ketogenic as it can form pyruvate and then goes to acetyl-CoA to form ketone bodies. How come other amino acids listed in the same box that form pyruvate not both glucogenic and ketogenic? If alanine, cysteine, glycine and serine also form pyruvate, can't they go the other direction and form acetyl-CoA to generate ketone bodies?

[@chandanamalla709]

The structures of other amino acids doesn't support to form ketone bodies...so may be

[@sansonsanson476]

wooow this topic is next ahead

[@arjunbarman6509]

Thanks a lot.

[@janme936]

Sir, Help me please.. I'm conffuced.. are all essential amino acids transaminated and deaminated? in some books, it was explained that the carbon skeleton of transaminated amino acids would be used as an intermediate in the citric acid cycle, glucose synthesis, and the manufacture of fatty acids. then whether essential amino acids that enter the body cannot be directly used for protein synthesis? must be remodeled again ... if it becomes glucose ... what's the point of consuming essential amino acids from protein in food while glucose can be obtained from carbohydrates for amino acid synthesis?

[@goodnessadeosun3768]

wow, wow, you have just saved me!!

[@Osama-le1zx]

Unbelievable ❤

[@25chrishall]

If you need Oxaloacetate in addition to Acetyl CoA in order to form Citrate, then you had Oxaloacetate from the get go. That is, you have the molecule you need for gluconeogenesis. So what's the point of the citric acid cycle? Am I missing something?

[@doraarbanas6791]

production of electrons for electron transport chain

[@amyknodel143]

bless your heart oh my god

[@syifaothman4372]

great great video

[@jananirajasri_06]

thanks sir

[@greggasco2153]

So the amino acid Leucine doesn't spike your glucose?

[@angieleung4481]

I can’t understand T-T why can’t alanine be converted to pyruvate, then acetyl CoA and then to acetoacetyl CoA?

[@adernain]

Why do we use these Amino acids to produce Glucose through the citric acid cycle for Energy production? I mean, Citric acid cycle is used to produce intermediates for Energy production, isnt this quicker and more effective? Or am I missing something

[@dinosaurcolour850]

It's because this all happens in tissues that aren't in the CNS. The CNS requires that we keep blood glucose levels up to feed neuronal tissues. When we're starving, we break down amino acids and convert them to glucose through gluconeogenesis or to ketone bodies that feed into the Kreb's cycle. This is more of a last resort for the body, as it's using proteins and muscle tissue to feed the CNS. Typically, we use glycogen or fatty acid oxidation to feed the brain instead of amino acids.

[@Tuesday11]

It was a really helpful video

[@thanhbinhphamthi7078]

woaaaa, amazinggggg!!!!

[@alexbarajas317]

If a molecule of histidine gone through deamination and the carbon skeleton of that histidine enters the Citric acid cycle during the fed state, would there be a net production of ATP?

[@dinosaurcolour850]

The histidine's carbons are converted into alpha-ketoglutarate, so there should be a net production of ATP. Catabolism of amino acids shouldn't require any energy input, since the point of amino acid catabolism is to gain energy. Because it's filtering into the Kreb's cycle at the alpha-ketoglutarate step, which is before the ATP-producing succinyl-CoA --> succinate reaction, it should net some ATP.

[@amitcarbyne3635]

So does one amino acid molecule form one glucose molecule?

[@pemasangay]

I read in first aid that only methionine, valine and histidine are purely glucogenic. Is it wrong?

[@dinosaurcolour850]

Maybe it was saying that Met, Val, and His are all only glucogenic, not that they are the only purely glucogenic amino acids? If not, then yes, it is wrong. Most amino acids are purely glucogenic.

[@sylvano2010]

Sylvano Anselmo 1 second ago Has anyone studied ketogenic diet for Ornithine transcarbamylase deficiency?

[@WutLawl]

ak can you please get a nice collared shirt with a small logo on it. haha I'll wear it to pharmacy school. your videos are amazing, the grad level videos are spot on jkeep up the good work!

[@AKLECTURES]

I'll look into it but for now I only sell regular t-shirts! :)

[@WutLawl]

Woop woop.AK LECTURES

[@thefaltus3933]

u had not provided all videos of fatty acid nd amino acid metabolism.. plzz make video of further topics..

[@아카시아나무-c6j]

TNX so much :)

[@manal3767]

so, its the ketogenic amino acid are converted to acetyl coA and acetoacetyle coA ???

[@joellunzaga8611]

Manal yes to produce ketone bodies. and it depends what kind of pyruvate pathway...

[@patient3841]

Thx

[@ran9628]

thanks!!!!

[@TheHeninhardenne]

The muscles are quite distracting.

[@progressmarange1783]

nic

[@edifrcovski2282]

Isn't threonine ketogenic too?

[@dinosaurcolour850]

In my textbook, it has threonine as being both ketogenic and glucogenic, and isoleucine as being strictly glucogenic.

[@JasonVaysberg]

He talked about this at the very end. He said, depending on how you define it threonine can be considered just glucogenic or both.

[@عبدالرحيمصالح-م1ظ]

اظبط زول⁦❤️⁩🔥

[@MohammedAli-ih5jx]

The pyruvate dehydrogenase babe

[@emchoolio5682]

Is that a Russian accent? It’s fun :)

[@MAYIK-rt2fz]

you look like Diego Ruzzarin

[@Textbook000]

De bestest

[@lynnndhlovu8338]

wow.....

[@alinitwematia6038]

Hahahah Hannah Jeter

[@Bactino]

First comment haha!

[@AKLECTURES]

:)

[@jesscaruana8040]

[@biscentkapalasa8069]

U are so great sir Kip up