Algorithm-assisted assement of HER2 ISH to reduce interobserver variability

As a regional leader in advanced and integrated solutions in pathology and diagnostic testing, Roche Diagnostics Australia joined the XXXIV International Congress of the International Academy of Pathology as a platinum sponsor.
Contributing to the scientific program of the event held in Sydney in October 2022, Roche sponsored a symposium by Australian pathologists, Dr. Cameron Snell and Madeline Gough, on their study "Improved concordance of challenging human epidermal growth factor receptor 2 dual in-situ hybridization cases with the use of a digital image analysis algorithm in breast cancer."
Previous 'manual' approaches to pathology, involving microscopes and handling glass slides, are being improved by integrating vastly more efficient means of diagnosing cases as high-resolution digital images. The symposium presents the findings of an Australian study into applying digital pathology techniques to breast cancer tissue samples (algorithm-assisted assessment of HER2 ISH samples), which reported an effective reduction in the difference in measurement between different pathologists for the same sample(s) (interobserver variability).
In the study, it was found that digital pathology had the "potential to improve therapy selection and outcomes for patients with HER2-low and borderline HER2-amplified breast cancers".
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