Alpha-1 Antitrypsin Deficiency - causes, symptoms, diagnosis, treatment, pathology

[@Snowchris1]

Healthy my entire life. In 2018 I was at work and suddenly felt like I was shot in my stomach. Dr said, I had deep vein thrombosis, further test showed I had cirrhosis and A1AT. My heath diminished rapidly, it was horrible. I received a Liver Transplant, woke up and instantly felt better!!! I now feel great again

[@frisky6727]

god bless you

[@ChilupaKing]

Thank you for explaining. I'm about to be discharged from the military and just NOW got diagnosed with this. They just kept telling me I was being lazy, the same with some of my other airmen who had ACTUAL issues.

[@toddkeeton7450]

Hey there. Was this something that was an auto MEB and auto med discharge? I’ve been in 15 years and am being tested for this soon and am nervous.

[@1houndgal]

Thank you for your for service.

[@StephyGrowsWeed]

what’s been ur symptoms? I only got here because my sons a1-globulin came back decreased. 2,4 instead of 2,9 and read it’s mainly caused by this? 🤷🏻‍♀️

[@diegovarela2441]

I was just diagnosed with this and am separated from the Air Force as well. How much VA did you get from this?

[@cassieleedarlin]

Omg thank you for existing! I've been trying to understand this for days reading in text book and I have been so confused! You clarified EVERYTHING in 8 minutes! Wow! Thank you!!!

[@speachless5576]

hello

[@abdoufekroun4195]

Yes

[@amyboyd3535]

There is also a mutant S allele which is not as severe as Z but still problematic.

[@sameerapinky2995]

Every video made by u is extraodinary i note each and every word spoken in ur video its really helpful to grab entire concept on a specific topic....

[@alexjames1284]

I was born with this and i’m 15 now. I have been completely healthy my entire life tho and this hasn’t affected my life at all. I don’t even notice that I have it so i’m lucky.

[@dalamorshed5435]

this channel is the best thing that ever happened to me

[@osmosis]

Thanks for your comment, Dala! Glad to be of help! 😊

[@elizabethh560]

I'm asymptomatic so far, but I do have it. Whenever I get the flu it will almost always result in me getting bronchitis or pneumonia. I'm 22. My grandmother had it (and died of it), my aunt has it, and so does one of my cousins. My cousin and I also have IBS thanks to A1AT. None of us have liver problems thanks to us not having A1, but we are all monitored just in case.

[@nenadsima7105]

Ibs, depression, knuckles inflamation, foot in bruises. With years, weaker and weaker, lost 10kg of muscle

[@Omgitskrystal]

@@nenadsima7105 does the hands hurt and don’t draw up but hurts very bad when I write! I have A1AT and just found out last year , exactly 1 year and I’m on oxygen 24/7 and my genotype is ZZ

[@Omgitskrystal]

I understand I put my number out there. I’m desperate to learn more! Since they’re not really wanting to do anything here!!

[@alsson3137]

@@Omgitskrystal I'm just now learning about this disease and am also ZZ , tomorrow I begin my infusions . Fingers crossed for you .

[@Omgitskrystal]

@@alsson3137 if you don’t mind me asking how old are you? I haven’t had my infusions yet. I can’t wait until I do but I talk to someone I met on TikTok she’s in Florida. She does her infusions at home

[@oreskoul]

simply explained . great work . once again ! Thank you osmosis !

[@thingsthatgobumpinthenight6967]

Had a abnormallaity in a blood test a month ago, got a second blood test for this couple weeks ago. Dr called an I'm going in on Friday, I'm concerned there is a history of lung disease in my family. I dont know what this means long term. I dont expect any replys, just felt like a good place to vent.

[@brandongillette35]

Yo you dead yet

[@joycethorne3100]

I live in England I was diagnosed with alpha anitripsine deficiency and am waiting to hear back. Hope you are coping OK

[@xDougg]

@@joycethorne3100 I also was just diagnosed, I know it’s been 2 years since you posted this, any advice? Or updates jsut got diagnosed w this

[@firdausfarrah3223]

Any updates?

[@StephyGrowsWeed]

any updates on anyone? Appreciated. My son (17) just had his bloodwork done… mainly because of hairloss…. bloodwork turned back normal except decreased DHT and decreased a1-globulin (which can be caused by AA? )

[@akhilka3582]

Amazing video. Helped alot in understanding AATD. Could you please provide the references you used in the video. Thank you

[@osmosis]

Hi! You may get in touch with our team at [e-mail] and they will be glad to assist you on this. 😊

[@skuaogaming2680]

Hay thanks i never really looked into it that much but im 15 and diagnosed. I was diagnosed 4 days after being born

[@skuaogaming2680]

@Internet Gangster add me on Instagram g id love to talk

[@makeupntipsbymmaritza1216]

How are you now ? My 5 yr old was diagnosed at birth . Always sick now my daughter always sick needs to be tested

[@skuaogaming2680]

@@makeupntipsbymmaritza1216 I'm 20 years old now, with very good health growing up I was often sick aswell. I get my lungs abs liver checked semi-frequently. I've never drank alcohol a day in my life, nor have I smoked or vaped nicotine or tobacco products. I was on a liquid medicine twice a day until 13 years old aswell for my alpha 1.

[@MohammedAlnaggar-b2b]

Thank you very much

[@osmosis]

Any time! 💖

[@michellegeist5421]

Thank you I am going to have my lung doctor check on this because I was just diagnosed with copd and asthma and I have been smoke free for 23 years. I understand the environment can cause copd

[@osmosis]

We hope this helped! 🙏🏼

[@joseph6948]

My Mom was diagnosed with Alpha-1 Antitrypsin Deficiency! At 47 years old she was on full-time oxygen and died at 52. I was tested for this deficiency and Thank God, I wasn't missing the Gene, I'm okay ( I do have mild COPD however, because of the environment)...It was hard to watch her suffer, not really being able to help. It was like she was drowning, no air over and over for years! Her lungs just didn't have the elasticity to function! R.I.P. Mom

[@osmosis]

Sorry for your loss, Joseph. 🙏🏼

[@anmoldhawan2671]

Neet aspirant here after biotech chapter to understand how alpha1 anti trypsinogen deficiency causes emphysema, got it , thx sir 👍

[@MariaReyes-jp4lb]

My father died of emphysema and blamed it on smoking. He also died at the age of 52 😢. Marine and stationed at call L in N Carolina. Mother also passed away young at age 62, sister conceived and died at 3 months there. Brother conceived there and passed at age 48. I wonder if they all had this deficiency?

[@ganchimeganjik9692]

thank youuuuuuuuuu love OSMOSIS. GOOD LUCK GUYS

[@JustWanaComment]

Love the channel. Life saver. PS. You sound like Morty

[@cloudqbaby-yx9eh]

Awesome! Thank you thank you thank you- I'm a nurse and I like to have a better understanding of the IV therapy I will be giving my patients. :0 :)

[@shirlvin777]

Your videos are so so helpful. Thank you so much.

[@castawayswearecastaways3670]

People in the comment section is studying this for school while I'm studying this for my book

[@tomato_6681]

Lmao me too. I started to be interested in diseases when I was writing the ‘sick kids’ story on Wattpad 5 years ago and now I incorporate diseases in every story I write

[@melaniefordham9142]

Some of us are here because we have A1AD. This is a difficult disease to understand, when you are just getting diagnosed, or were diagnosed before google/KZbin. I’m 47 and was born with A1AD but was adopted and it wasn’t explained well to my parents. I saw a dr 25 years ago who basically just told me not to smoke or drink and that I should be okay until I was into my 40s or 50s. 🥴 I’m the past 10 years, I’ve had additional medical problems arise and it all goes back to A1AD and fibromyalgia.

[@eucalyptus.sniffer]

4:53 for Symptoms. Timestamp for self😌

[@haseebakram2967]

The best channel I've seen after a long time ❤

[@osmosis]

Thanks! 💖

[@victoriawarren9526]

Thanks for this. I needed to clear this up in my head. Also, how about some NP merch! 🥰

[@mujeebjaffal433]

What is normal level of antirypsin Alfa-1 test????

[@_yeojo]

my family have history of lung, liver, and skin health problem.. should i be concerned about this disorder?

[@pamnewton2160]

YES

[@Dr.MatiasImfeld]

hola saludos desde argerntina!!! impecable como siempre!! you inspired me to start my own channel on youtube!! thannks !!

[@krutidesai18]

You have great videos!! Great work. Kudos

[@hanch96]

much appreciated, very clear and helpful

[@judahokonkwo3866]

Thanks a lot for this Video Osmosis

[@SanguinaryStrife]

I. LOVE! Yes! Thank you!!

[@michaelwoodward4094]

I worked for the Railroad for almost 20 years and was first diagnosed with pulmonary fibrosis then tested for Aat and I am zz. Now RR attorneys say my exposure has nothing to do with my Health problems and that it is all AAT. I was diagnosed at 52 and am now 55 . Any info or history of someone with zz and not having any symptoms till much later in life would be appreciated. Thanks

[@vuanhtuyen781]

Some segments in the video are stamped not adjacent to each other

[@Dr_Dubey]

Keep up the great work Osmosis ❤️

[@melaniefordham9142]

I have A1AD and my genotype is SZ 75. In 2022 my FEV1 was 87%, so normal. This past July my liver enzymes were concerning and my Rheumatologist is having me do bloodwork every 6 months now.

[@antonellalucero4919]

Please make one of hashimotos and hypothyroidism / herperthyroidism

[@osmosis]

Hi Antonella, we have those! www.osmosis.org/learn/Hashimoto's_thyroiditis www.osmosis.org/learn/Hypothyroidism www.osmosis.org/learn/Hyperthyroidism

[@millylovesyou7703]

great job!!

[@tallinhamda4741]

THANK YOU!!!!!!!!!!!!!!!!!!!!

[@amartyapaul8280]

Well explained 🔥

[@wardaarooj3928]

Great work... Keep it up 👍

[@vardaansinghmann3708]

Thank you doc

[@m.ichannel3248]

more gain in little time superb... no words thank you.

[@antonellalucero4919]

Thank you!!! Great video!

[@selvalakshmianand6800]

Your videos are the best..Thank you so much😁

[@bilelhamza114]

A great work , bravo

[@alevelsdemystified3410]

This was really helpful!

[@sarahfernandeswawginiaks5738]

Please, make a video about 17 Hidroxiprogesteron!! Love this channel!!

[@terkos3734]

Good idea 👍👍

[@speachless5576]

hiii

[@luisoctavio597]

love your videos :) thanks

[@abmsafiullah4014]

Fine,learn many thing from this youtube

[@jibrilmohamed9422]

Why do a1at blood test get requested with an aims test?

[@kadethayer3708]

Since less oxygen ia supplied due to the effects on the avioli, does the heart become more stressed as it attempts to move the lungs more? Can it cause side effects in the heart?

[@capedcod19]

why isn't a liver transplant in the treatment section?

[@__k9]

I'm 24yo and a chronic smoker. We (family) just found out my family has AATD running in it I'm really not feeling well guys.

[@melaniefordham9142]

You need to stop smoking immediately. Alcohol is also not suggested, as our liver is also affected.

[@lekimngan609]

the video image is too poor, you need to fix it more

[@osmosis]

Hi! Thanks for your feedback, if you have time, we'd love to hear more from you. Please reach out to our team at [e-mail] 😊

[@mariamemad8235]

good job❤

[@osmosis]

Thank you, Mariam! 💖

[@kavitakumari7180]

You are democratising education

[@selvalakshmianand6800]

Can u make a video on Grave's disease?

[@067girishramanan8]

Awesome👏

[@mickeysingh7443]

Can a prior liver disease cause at deficiency

[@قناةتجربتي-ش1ت]

Thank you

[@colleenmeyers3257]

What happens if you’re results are too high?

[@nishaniusmle4248]

Thank you so muchhhhhh

[@matchmedicines8209]

it was so useful, thanks a lot

[@khdr4165]

I don't know why the shit written in books can't be explained like you do in this video. Veeery clear explanation thanks alot 🔥❤

[@sarahgh4069]

Thank you thank you thank you

[@tinusftbl]

I have this

[@noorstudent331]

❤️❤️❤️❤️❤️❤️❤️❤️❤️ U people are amazing

[@hawaii3231]

My dna test says I have this…

[@tristanblack1920]

I have a 99 level but also have a vitamin d deficiency. Could that be the reason my level is slightly lower?

[@injest1928]

Oof. Just found today that 1. This genetic protein deficiency exists. 2. I have this protein deficiency, and 3. I have liver disease. Now i just have to wait to find out the next step. Probably biopsy. Fun times 😅

[@injest1928]

At least now I know why I feel like the walking dead 🫠

[@melaniefordham9142]

The liver biopsy for me, was an easy recovery. They do a small probe and it’s a punch biopsy that takes about the size of a pencil section out. A small stitch and steri stips to cover.

[@amtalali5529]

thnk u

[@DiamentyGrecji]

Szkoda, że nie ma tłumaczenia na język polski. Mam niedobór antytrypsyny i jest bardzo mało informacji na temat tej choroby w języku polskim.

[@osmosis]

Hi! Thanks for expressing your request for our content to be translated in other languages. We'll be sure to let you know once we have our content translated to other languages. 😊

[@DiamentyGrecji]

@@osmosisdziękuję i czekam na wiadomość 😅

[@rogerscottcathey]

I wouldn't begin with the wrong term. It is a historic footnote. Put it last.

[@markster8456]

Please make a video about Fetal Lung Maturity and Sperm Analysis. :)

[@rachaelweeks_84]

What if your results are 80 PI MM? On the lab report it says low, but the PI MM is normal..... I'm so confused.

[@tristanblack1920]

Hey did you ever figure it out. Mines at a 99 and the doctor I see acted like that was a big concern?

[@FrostVal-SZN]

Uhhh, am I the only one here because of a biology assignment?🤣😅

[@samruddhikale6763]

Osmosis is love life smile heart godddddddd i love u osmosis

[@stevenstephens8815]

I just want to say there’s 2 ways you can have this “alpha-1” can be a carrier or have it. My aunt died at age 42 bc the alpha one was effecting her after having a Brian angerizium-don’t quote me on how to spell that- and also my baby cousin just died at 3 months old due to fluid build up in her lungs “another act of this rare genetic disease” So my daughter was born today and since I’m a carrier and could easily pass it down to her... I’m making her get tested the doctors thinks it’s best to do a family tree but I don’t think that’s 110% accurate!! And I know the blood test are I just don’t think I need to waste time and see what my family trees gonna turn out to be. I wish everyone here with this rare disease good luck and wish everyone the best..!!!

[@melaniefordham9142]

I have it (SZ) and when my triplets were born, they tested them all in the neonatal unit in the hospital. Only one was a carrier and other two were not. I would HIGHLY suggest having your baby tested

[@AK-FITxPETS]

My baby is now one month old and she was born with jaundince her level was 17 by day 2 after that we did phototherpay so the indirect started to reduce but direct started to raise we were in concussion why it was rasing finally the direct was 5 and indirect was 7 doctor told my baby may have some liver disease did scan and took many test virus but everything was normal... We couldn't find why the direct is high last week we took the blood test again now the direct is 4.8 and indirect is 2.0 total 6.8 .. Direct was reducing slow... They they finally did nuclear scan it was also normal then they did ggt test it's normal.. At the end they did A1AD test the normal range was 145 to 270 it's mentioned but my baby is having 111 is it normal or not?? Doctor told it may be a problem of low level the jaundince was there still now.. Is it normal or not will it get cured plz help

[@madmemomemo]

What’s with the dump sound effects.. my ears

[@williamcase3994]

New here its obvious y

[@aeriozz7047]

I was born with this

[@shazzamyers]

Aeriozz me too

[@1houndgal]

Me too. I just found out. It explains a lot.

[@Nabilo8501]

❤❤

[@hiahlam8067]

هلا يا مستوى 5

[@aeriozz7047]

I was born with this and im scared now

[@shazzamyers]

Aeriozz i have this too

[@aeriozz7047]

Fudgenaya 13 but its not bad for me now but it can be if i dont treat myself good

[@dawntaylor4210]

Me too x

[@that2kguy924]

Aeriozz I have it to from birth but my numbers are good

[@067girishramanan8]

♥️♥️

[@shahbaz9231]

It's expensive.

[@katajoemama8934]

WHAT IS HIS BROTHERS NAME

[@fatmaelhadari2236]

❤😊

[@notella9213]

bestie im 14 i dont understand

[@ThePronounI]

Ugh I think I have this bs.

[@nadaadellefawzy9308]

Thank you

[@that2kguy924]

I have this

[@abdullakabdulla132]

❤❤❤❤❤

[@shazzamyers]

I was born with this

[@tamannaakter1649]

Thank you

[@abealpha4022]

Thank you.