Alternative Pathway of Complement System

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What a man you are!!! I really wasted my time while building up concepts from my tutor. I wish you would be my tutor. BTW thanksssssssssssssssssss aaaa looooooooottttttttttt.

[@beaniebaby_rei]

So concise and explains things in a way no textbook ever could! Why do we pay these schools to teach us???

[@369thegoose1]

I cried..when I finally got this and its because of you! THANK YOU TO INFINITY...... PLEASE keep making videos!!!!!

[@charllyparker9412]

This my wonderful LECTURER, I thank you immensely, you helped me to understand everything about immunity, may The Good GOD reward you a Million folds. Thank you once again.

[@giorgichaduneli585]

Well,here i am again.I have just finished watching and understanding this video for my studies and i have to write this.There are tons of videos about Complement System but i dont think anyone explains topics like this better than this man.I really appreciate this effort and thank you very much.

[@fahadabdulrazaq670]

I've listen these subtopic Alternative and Classical Pathways , truly and formidably with simple explanation any student can understand very easily !!!! Masha Allah !!!!

[@shivanshsurana3298]

Your lectures gives a new direction to learning life sciences. I have also tried to incorporate your way of teaching using only a single slide and that worked amazingly well.

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Thanks a lot,you always make me understand the task easily, and actually explain better than my PhD lector

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[@zackjohnson3662]

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[@titashchakraborty6532]

you explain so simply . I do loved to understand immunology portion.

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I am a french medicine student and your lectures are so helping me !! Thank you very much!!!

[@Everydayuseasitgoes]

Don't keep scrolling down and read comments. Go up and listen to the lecture. This guy is awesome:) Thank me for saving your time

[@KillingKunoichi]

What about the Lectin Pathway, though?

[@mydearestpotato]

Just in case anyone wanted a summary of the Lectin Pathway - A protease called MBL-associated serine protease (MASP) binds to the MBL (Mannose Binding Lectin). The complex of MBL and MASP cleaves C4 into C4a and C4b and C2 into C2a and C2b (like in the classical pathway). C3 convertase (C4b.C2b) is generated & cleaves C3 etc.

[@14zachay14]

mydearestpotato thank you!

[@stellayoss8316]

@@mydearestpotato thank you need it❤

[@MitoPagan]

Great videos and even better orthography! Thank you.

[@lucytravis9333]

thank you! i many videos dont fully explain how the alternative pathway is triggered, so now i understand!!

[@deemaaladhadh6306]

Thank you very much !!!, your videos saved my academic life * literally* !!!!

[@f_wardinawirasari8654]

THANK YOU SO MUCH FOR THIS VIDEO! YOU LITERALLY MAKE THINGS EASIER! THANK YOU FOR YOUR HELP!

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Amazing, please keep going. You have been a good source for my USMLE. Thanks!!

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Amazing revision on 2x speed. All your lectures really helped. Thank you!

[@johnkalule8382]

Your lectures a good but now l don't understand the meaning of c1,c2

[@thealgorithm3747]

Thanks, a lot. This really helped me .. literally, all the videos I've watched on your channel have helped me very much .. Great Respect and gratitude for your efforts =)

[@raanoooshh9296]

Thank you for doing a whole series for the Immunology course! Greetings from Sweden

[@Saraad94]

My exam is in a couple of hours This really helped Thank you!!

[@zgfddlm]

Thank you very much!!!! You are really clear in your explanations and I like how you summarize and emphasize the important concepts, very well done!

[@ahmedelkashory3389]

your way of explaining is so wonderful. thanks a lot.

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thank you so much. Your videos are so easy to understand

[@saurabhandurlekar8506]

you are awesome man.. every concept you teach is with ease. thankful to have such professor in this world.. keep it up!!

[@shibanithyagarajan7308]

Your videos really helped me alot in understanding this particular topic. Cheers to you!

[@TransportRoutine]

Insane explanation. Props to you and your presentation skills!

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[@ruhidyusifov2372]

1 billion times Thank you for easiest exlanation Ii have ever seen in youtube! Keep going I liked got susbcribed and I will follow always!

[@jenniferwiseman721]

thanks for explaining this... I get so much more out of your lectures

[@sakshisood7108]

Thank u. U didn't mentioned the role of Factor d as its binding results in cleavage of C3 protein.

[@CartesianFirstPrinciples]

Thank you so much! You are a great person for doing this and the recognition/compensation falls woefully short relative to other people.

[@aliharoon7189]

it's magically understandable...more power to you.

[@imtinan7136]

بيض الله وجهك ما قصرت

[@macsohk4171]

This is a very clear and easy to understand presentation...thanks for sharing!

[@AKLECTURES]

Mac Sohk you're welcome Mark :)

[@m.hennidi4547]

dude you are an amazing teacher keep up the good work.

[@عبيدةمازنشاكر]

U are perfect man i hope the success in your life !

[@nicodasm]

Really nice video. Great energy. Thanks!

[@kewlgurlrockz]

THANK YOU FOR THIS I FINALLY UNDERSTAND THIS CONCEPT

[@peterb1022]

you always deliver brother, thanks

[@TheVenusRising]

Thank you. Read it in my book, but it all came together here...

[@AKLECTURES]

+TheVenusRising awesome! :)

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Thank you mr.AK You are the best ever thanks thanks thanks alot.

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Only guy I can count on when in finals , thanks a million

[@zahrinamardina9200]

Thanks! your explanation and the handwriting are awesome!! It is so clearrrrr

[@juliaburdo1898]

Thank you sooo much for your lectures! U are amazing :)

[@gutlessband5825]

Sweet video. Really dig this kind of thing. Would love to see more. Keep it up.

[@mutaiezrakibet2935]

this is a very nice presentatio i wonder even why are there only 172 views?

[@AKLECTURES]

Mutai Ezra Kibet thanks! :)

[@rosekagwima1444]

Prepare for the formation of c5 convertase through lectin pathway of the complement system

[@mydearestpotato]

Thanks for your help, I sent a donation.

[@AKLECTURES]

Thanks! I saw it, appreciate it! :)

[@vipulpatil1846]

You r really best thanks for the explanation

[@dajanayash1608]

Thank you.Great video, helped a lot! I'm a little confused on what exactly the outcome of the alternative pathway is.

[@drlrmathias]

Excellent. Great job. Tx

[@princessoftheshire236]

thank you sir for this amazing explanation

[@bibooo7191]

I am really thankful...keep on!

[@chioffilm]

Thank you for your excellent presentation. I am wondering if someone knows what happens to C3a portion when C3 molecule spontaneously splits into C3b and C3a?

[@o-o3116]

Thank you please keep making videos God bless you

[@ayatahmed8120]

شكرا لك 💜

[@anjalishalajan7718]

Well understood, Thank u🥰🥰🥰

[@BhawnaSharma95]

What is the inhibitory protein which keeps the C3b inactive in case of healthy cells??

[@LuciferMorningstar-dp7by]

Your lecture was great but I have a question. If C3 can spontaneously convert into C3a and C3b then why do we need the classical pathway in the first place since C4bC2a does the same thing?

[@jeanbelanger1467]

Your the best!

[@KingSlimjeezy]

I'm so fucked Whyyy did i take immunology my final semester. I couldve taken nutrition!!! WHYYYY

[@NURSEKARMA]

Love these videos!

[@johnkalule8382]

Thank a bunch

[@MsCleibson]

You sir, are awesome.

[@lanaabourafeh6987]

This is great but there is no mention of LPS ( bacterial lipopolysaccharide) and I was just wondering at what point it binds to any of these, if at all? Can anyone clarify the role of LPS here?

[@nuhuibrahimmusa292]

I think the c3bBb isn’t stable so it binds properdin p to form c3bBbP which is the c5 convertase

[@abdelkrimboukhari3931]

great video.....

[@NateandNach]

So helpful.,thank you.

[@BhawnaSharma95]

So the C3b is inactivated in case of healthy cells and what about C3a whose function is to bind mast cells to release histamine?

[@rimodotika4123]

thx for the video plz where can i find the lectin pathway video

[@jawharrebai6764]

nice thank you but where is factor D that protelyse B on Bb and Ba??

[@Samsta36]

Please do a video on the lectin pathway

[@fleralovella9821]

thank you so much for this video, its very helpful and i learned a lot. :)

[@giorgiakhvlediani4478]

you helped me a lot !!! Thank you so much !!!

[@MrSuperAlive]

Great!!!!! Thank you very much!!!!!

[@meganmcnally9699]

hey can you do videos on muscle physiology by any chance?

[@spikeglad]

Oh, thank you so much!

[@srikarsharma633]

sir, but how is C3 lysed in the absence of C3 convertase at the beginning?

[@azalzuheir1462]

really really thank you

[@kristijan67]

Awesome!!

[@noufm5108]

i love this man

[@-mix3065]

Great ! 👏🏻❤️

[@ahlbiurgaid61]

What induces the formation of Bb?

[@thuladumalinga1719]

Thank you, this was really helpful :-)

[@yevgenyjejamejekiri8364]

Thank you!

[@AKLECTURES]

+Yevgenyj Jejame Jekiri welcome!

[@brightmwape5119]

what about factor D is not mentioned in the alternative path way

[@mobbenart]

Beautiful

[@lamaaldosari7835]

If C3 can activate itself then why do we need c3 convertase in classical pathway??

[@positivevibes7425]

-Alternate pathway of complement system can be activated by A) drugs B) endotoxin C) dextran please tell me the correct answer

[@chavviattri7204]

Hatts off to u sir 😊😊

[@vktscience8351]

brother what is differences between factor D and factor B in this video

[@bharat.tiwari6361]

You didn't mention about factor D and propridin

[@aidenpantaleon8540]

Thank you :)

[@jamesrichard1140]

IS there a video the the lectin pathway?

[@AKLECTURES]

+james fancourt There is not.

[@jamesrichard1140]

Okay. Thanks for the response! Really enjoying these videos, especially the electron transport ones :)

[@AKLECTURES]

Thanks! :-)

[@martinaradwanski4169]

What about soluble C3 convertase producing C3 convertase... :/ other than that good vid

[@hamza-yb3yz]

and i thought it couldnt get more confusing than the classical pathway...

[@saharbayat5816]

thaaaaank you!