An Overview of Cutaneous Fibrohistiocytic & (Myo)fibroblastic tumors

[@madhuk5449]

Your videos are an eye opener. Teaches us to update. On Tuesday, in dermpedia session, you showed ALK rearranged granular cell tumour. This was awesome.

[@madhuk5449]

You are a good soul.

[@madhuk5449]

Too good, thanks

[@madhuk5449]

DF with monster cells. Is it same as Atypical dermatofibroma. Bernie called them as DF with monster cells.

[@ΘεόδωροςΤζιγκαλίδης]

Thank you for yet another remarkable and extremely useful lesson. I would like to make a question. Is diffuse positivity for p53 diagnostically helpful for the fibrosarcomatous transformation of a DFSP ? Thank you in advance.

[@klinos]

I do not usually use it. I believe the interpretation of fibrosarcomatous transformation is a morphological one. Colleagues have described p53 diffuse positivity in FS-DFSP. Everytime I used it was not helpful. I suspect if there is a diffuse positivity you should scrutinize the tumor but I would not rely on this one way or the other. I don't think you need any IHC for the interpretation of FS-DFSP and if you rely on IHC it is almost certain that eventually a mistake will happen.

[@ΘεόδωροςΤζιγκαλίδης]

@@klinos thank you for the advice.

[@madhuk5449]

Bernie always considered DFSP as benign not sarcoma

[@madhuk5449]

With molecular classification, morphological interpretation is getting ambiguous / not apt.