Anna Marie Pyle (Yale U./HHMI) Part 1: RNA Structure

[@emlmm88]

You're a lifesaver. My engineering classes flushed me with so much work over the past few weeks that I haven't been able to get much biochemistry studying in and the test is tomorrow! Thank heavens for this explanation!

[@helmutzollner5496]

Amazing that RNA is so complex. At school i only learned about mRNA, not realizing that RNA can do so much more. Thank you for sharing.

[@rajanalexander4949]

This is fantastic. She clearly conveyed the complicated beauty of RNA!

[@FabianeAthayde]

Fantastic professor, perfect didactics ❤ I learned so much

[@leannalilienthal1966]

Thank you so much! I missed a couple of Biochemistry classes and now I feel like I'm all caught up. You are awesome.

[@monikasingha7495]

I've watched this a few times, this is so helpful. Thanks.

[@lucasqwert1]

Thank you so much for this video! It is a great introduction to RNA secondary structures.

[@KumarA1998]

it provided me a new dimension of thoughts, Thanks a lot iBio

[@michaelmacdonald2907]

I've been studying biochem & cellbio for, I don't know, 6 years now ( late bloomer, been busy ) and to me, it's become apparent, then obvious that DNA is a static library made from RNA by RNA from RNA. And that proteins are robots, made by RNA to help out with the 'mindless' repetitive work ( made by RNA on itself, with itself, by itself ; tRNA, mRNA, rRNA, self-splice, SRP, ect. ) . That's RNA IS life - the self replicating, metabolizing molecule wholly responsible for life !! But look who I'm telling. Thanks for knowing and breakin it down for us. ( exciting isn't it !! )

[@marrrtin]

I agree the role of RNA isn't well understood among the populace compared to DNA or proteins. This series of lectures has been revelatory to me about RNA that "does stuff" apart from the mere information library. I'm also boggled by the self referential aspect , as you say [proteins are] "made by RNA on itself, with itself, by itself". I'm also of the belief that life "bootstrapped" from random small molecules to self-replicating entities subject to evoluton via the multifunctional, shapeshfting molecule that is RNA.

[@KenJackson_US]

*Michael:* _"That's RNA IS life - the self replicating, metabolizing molecule wholly responsible for life !!"_ I don't understand this. Has RNA ever been found that's _"self replicating"_ *anywhere* in _any_ organism? What role does RNA play in _"metabolizing"_ anything? And how is the RNA component of life any more _"responsible for life"_ than the DNA and protein components?

[@nanotech_republika]

@@KenJackson_US : I think the idea is that originally it was all RNA, the robot, the material the robot works on, and the information coding the robot. Then at all these parts of the process improvement was evolved: the robot became a better robot (protein), the material became a better material (protein), the information storage coding the robot became better (DNA). And now most of the metabolism is DNA and protein, and the RNA plays the intermediate or somewhat supportive function to DNA and proteins.

[@KenJackson_US]

But @@nanotech_republika, the whole RNA World theory is just a wild theory, a wishful idea with no basis in science. And it has lots of holes in it, like transitioning from RNA to DNA one undirected mutation at a time, being living at each step and leaving no evidence. And where did the original code come from anyway?

[@nanotech_republika]

​@@KenJackson_US I am guessing that the proof will only happen when the molecular modeling be much easier. Unfortunately, we will have to wait for at least 10 years till we get strong enough quantum computers to show such systems and their evolution from based-on-RNA to based-on-DNA. And after that you might be able to go to the lab and repeat the computer model in a chemical flask. For now, you can always say "show me the proof" and I say "not enough computer power." So for not this is just a theory as a whole with some elements that can be shown in the lab or in the computer model.

[@ANamor...]

Very very usefull. A nace, clear and excelent presentación as well as the profesor! Tnks

[@jasmersingh6789]

Is there intermolecular Hydrogen bonding in secondary structure of RNA(single strand)?

[@kalpeshkumarnakrani1663]

Superb explanation .... tertiary str of RNA was just awsome. can you suggest me some good biochemistry textbooks.

[@rgudduu]

High quality material. Good teaching except some rapid jumps towards the end.

[@tartanhandbag]

can anyone explain if there is a reason for why dimensionality of nucleic acid structure is seemingly related to the addition of ions?

[@rgudduu]

Good question. Seemingly obvious answer is the K+ or Mg++ ions would try alter the position of the polar atoms namely H,O, N, so they would reorient. But we got to study some book to find the details

[@akayegeaydogan23]

Cations ‘neutralize’ the negatively charged oxygen in the phosphate backbone either direct or indirect interactions, making the structure more stabilized therefore more eager to form tertiary structures.

[@ericreiter1]

Well done, clear audio. I am guessing that most of this was devised from x-ray diffraction. Right? Thank you.

[@rgudduu]

Xray diffraction? What do u mean

[@rohaniesaalim5427]

One kiss is all it take (Shows the structure of RNA) fallin' love with me (Calculating RNA Duplex) * Throws away the headset* 😆

[@BlackHermit]

Great lecture! Greetings from Sweden!

[@IIrandhandleII]

Why does Jack Sztozak have comments disabled on his videos?

[@flymasterA]

Be careful.

[@flymasterA]

Great video - lots of work, polished delivery. QUESTION : Where and how in the cell are instinctual activities stored for male and females? Example: male Bird of Paradise dances. Just watched the 'Michael Jackson dance' by a Bird of Paradise. AWESOME! Why? And why do humans enjoy watching it? I'm a combination of the personality traits of my mom and dad, plus their abilities, tastes, dislikes, etc., all blended and programmed in. Where in the cell is this stored and kept organized until used in the future at the right time by the developed brain? I really hope you have some type of answer for me.

[@rgudduu]

Good question. The instinct (which includes all past behav of predecessors) is obviously stored in DNA. How brain works is not fully understood, as far as I hv seen

[@datadrivendev]

Just amazing

[@flymasterA]

Do you believe this is an accident of blind chance? She is barely scratching the surface of the cell's complexity.

[@rogerscottcathey]

The first enzyme.

[@inufuni]

thank you it is great

[@SidneyJill-w3u]

Corrine Point

[@madhabimadhusmita9377]

❤

[@ladypamela8269]

Anna Marie, I am asking a very serious question many want the answer to. I'm sure your aware they have spoken about this new vaccine as something that will reprogram the rna. What is your view and opinion on this?

[@KenJackson_US]

It doesn't _"reprogram the RNA"._ The vaccine contains mRNA. Usually mRNA is created in the cell nucleus, but this is injected. Your ribosomes translate that mRNA into the spike protein like those on the surface of the SARS-CoV-2 virus, which serves as the antigen for your immune system to develop antibodies against.

[@WindsorSwift-n7i]

Padberg Underpass

[@nanotech_republika]

A required watch for any alien technology conspiracy theorists.

[@flymasterA]

Why?

[@tartanhandbag]

nah, theyre never interested in crazy stuff that actually exists...

[@nanotech_republika]

​@@flymasterA If you want an alien technology, this is an alien technology. Complex systems with their emergence and the attractors at its finest. Far removed from the typical human-based engineering. ... Damn it! I thought my comment was funny. Why did I get why?

[@tomboland-u8c]

Pedro Heights

[@TobyHuxley-k9d]

Donnie Plaza

[@shoe_thompsano]

I love you

[@flymasterA]

Can you see any of this in a microscope? Why is it all graphics? Turner's rules?? How about God's rules?

[@marrrtin]

God's rules give you no idea how RNA will fold and react.

[@flymasterA]

marrrtin : Please explain. In God's rules, some things are partially random by design, but still controlled by overall design parameters. The spots on a dog are random, but flying is not an option on the window sticker.

[@KenJackson_US]

Visible wavelengths range from 4000 to 7000 Angstroms whereas some of the feature sizes she discussed were single digit Angstroms. So visible light is thousands of times too big to reveal fine RNA structure.

[@KenJackson_US]

I didn't detect anything antagonistic to creation in this video, @@flymasterA. She simply laid out some facts about RNA that have been observed. We can't learn of these wonders without gaping slack-jawed at God's glory. But there's no need to pick a fight about it.