Antigen antibody reaction overview

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This video focuses on discussing various types of antigen antibody reactions and their clinical importance.
The word affinity is used to describe the strength of binding between one antibody binding site and an antigenic determinant (epitope or hapten). The association constant is the mathematical value that is the measure of the strength of binding.
Anibody molecules are multivalent and antigens are also often multivalent. This multivalency tends to increase the strength of the interaction, and this really represents the true state of affairs. This overall binding energy that results in the binding of a multivalent antibody with a multivalent antigen is called the functional affinity or the avidity.

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Teacher plays your video in online classes sir. Respect.

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Same in our University

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I saw this video in 2017 during my mbbs study,and this concept help till now while neet pg preparation.

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Hats off to you sir... Thanks for clearing my concept of this topic in just 15 minutes. And it'll help me in my final exams.

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Glad to hear that you're getting benefit from my lectures

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[@shomusbiologyofficial]

Thank you for watching the lecture

[@documentarychannel8947]

Hi. Valency for your antibody is 2 not 4. Besides, the affinity is not 4, affinity is the strength of binding of the antigen to its antibody.

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You're welcome

[@aj-uo3uh]

From somewher on the net: Antibody affinity is defined as strength of the binding interaction between antigen and antibody. It depends on the closeness of the stereochemical fit between antibody sites and antigen determinants, the size of the area of contact between them, and the distribution of charged and hydrophobic groups.

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your efforts are helpful to me even after 7 years....

[@shomusbiologyofficial]

Thank you. Glad you liked my lectures

[@stattaffefuchs6285]

Thanks for the Video, its a great summary. But I think you made a mistake: You say the valency of one antibody is 4, but each antibody (as the one you drew) has 2 paratopes and thus a valency of 2, right? "Each tip of the "Y" of an antibody contains a paratope (a structure analogous to a lock) that is specific for one particular epitope" Source: Wikipedia ("Antibody")

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Stattaffe Fuchs ya you are right man

[@prajaktasarwade8801]

U r right

[@dr.nareshkshirasagar5694]

Somu sir valency is 2 But for IgM it is 6-7 that is due to steric hinderance

[@i.g9110]

Very good method of explaining the topic with fully preparation.

[@shomusbiologyofficial]

+Ishvinder Singh you're welcome. Glad to hear that

[@chetanmasram2837]

Tysm sir your teaching skills are really awesome.😍😍☺

[@shomusbiologyofficial]

Thank you

[@Pushkarajify]

Plz make some of corrections about the valency u said is 4 instead of 2

[@tejaswishenoy3786]

Yeah it has to be 2

[@shafikahomayara4372]

Perfectly explained 💜😊

[@shomusbiologyofficial]

Thank you

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Thank you so much sir nice explaination

[@shomusbiologyofficial]

You're welcome

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It would be better if u make a short summary after a lecturing ❤

[@christiandiormanea4317]

Hi Suman! This was really helpful! Thanks very much! P.S: Hope this doesn't upset you but sometimes you tend to hurry up with the explanations and it becomes a bit difficult to understand Thx again! :)

[@SKA12206]

Sir valence of monomeric is 2 and divalent is 4 but you say 4 and 8 plz explain it 🙏

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Great video, I love the line, "Don't try to forget this". HAHAHA sadly, i forget stuff without trying :(

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This video was really helpful Sir.

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You're welcome

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Thank you so much sir 😊

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You're welcome

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Thanq so much sir.. I reffered my material but i cant clarify in that.. But in just 15 mins you clarified it.. Means a lot sir ♥ . Tomorrow is my board exam.. Tanq♥

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it helped me a lot for immunology paper.thank you. keep going.

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i came to learn from video...but comments taught me better

[@shomusbiologyofficial]

+Doorgesh Kafle great

[@bidishasethy8063]

Very good explanation sir.. bt i hv a confusion between affinity & avidity .. could u plz explain it once again.. & sir plz upload some mathematical problems related to antigen-antibody complex actually i found vry hard to solve those questions..

[@anitasubba9894]

mistake can be corrected but i like the way of explanation. thank you so much sir

[@allstatus2551]

What is prozone phenomenon.......? Ple ....Make a video about it.......

[@aakibkhan4772]

Is valency of all antibodies fixed or it varies with type of antibody?

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Following him since 2015🥹

[@shomusbiologyofficial]

Thank you so much

[@sajidmicrobiology]

14:40 antibodies binds form different directions ????? brother.... lattice is formed... LATTICE..... one antibody binds to two antigens and one antigen binds to two antibodies... then it agglutinates .. correct me if i am wrong....

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[@shomusbiologyofficial]

Thank you

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Sir I am preparing for IIT JAM . I motivate myself to study everyday . I study and take breaks . Should I take a gap after my sixth semester ? please help me on this sir . I want to join IISER Kolkata after graduation .

[@bindushajan5078]

Really helpful . thanks

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You're welcome

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Why all of commenters only finding his mistake?? Mistakes can occur. Do you all forgot his explanations.... Everyone telling mistakes not this good lecture...😡😡

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It's mistake is dangerous

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Thank you so much for helping us to understand 😊

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You're welcome

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sir i want to know what is radio immunology. sir aapne immunology study karaya hai per kya aapki koi tutorial me radiology per bhi hai.

[@aakibkhan4772]

The Keq you have shown in the video, is that the concentration of products and reactants at equilibrium when both Ag and Ab are in equal amount?

[@biologyblooming2287]

ur videos r helping us a lot.......

[@doraemonindiavideo405]

Very nice but at last I was feeling sleepy 😴

[@pannagaprasadg3957]

4:05 does the valency of monomer antibody is 2 or 4?

[@lunareclipse-pc3xd]

Sir jodi kono antigen r akadhik epitop thake .....kintu prottek to epitopi nirdisto antibody r sathe add hoi !! Tahole ei ghotona ke ki amra specificity r modhhee bolte pari?????? Sir pls bolben...

[@shomusbiologyofficial]

Different antigenic determinants bind with different antibodies

[@kaustuvdas129]

good(bhalo bole6n). would be helpful if MHC is discussed!!

[@patelshru1]

Wrong concept, is not 4 valancy, plz read thoroughly before uploading here, many people will get wrong by this.. plz dont put wrong data.

[@shomusbiologyofficial]

Thank you for pointing that out.

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you need to relax lady, he has put up countless hours of flawless material that has helped thousands of people. a tiny mistake is not at all an issue

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Man, we r dealing with students where tiny mistakes may create issue, u better calm and let others do their work, even shomu accepted and we communicated about this. Be happy

[@lathanglemponye8429]

If its not 4 "valancy" what is it mam?

[@allstatus2551]

Then what is the answer...?

[@govindtomar5024]

Valence means simply number of antigen binding site, one antibody in Monomeric form has valence 2 not 4,u mentioned 4 here which is wrong

[@shomusbiologyofficial]

For one antibody it's 2. If an antibody is present in pair, the valency becomes 4

[@ratnamanjari3925]

Thank you sir

[@shomusbiologyofficial]

You're welcome

[@ratnamanjari3925]

Your teaching style is awesome and it is very helpful for me.Again thanks a lot for your learning videos

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we all make mistakes, and must learn from mistakes, thats not a huge matter to criticize...

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Is Specific Resistance and Specificity the same?

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In cell serum testing why we put cell first den serum

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shomu you are explained serotyp ?

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Sir plz aap Hindi videos bhi bnye na

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Explain floculation types sir...

[@FarhanAhmed-tr2es]

Thanks sir , but valency isn't 4 . Its 2 check and repeat again

[@marvisharma9346]

Sir plzz tell me the answer of avidity ....

[@pujakapoor5401]

Ag-Ab reaction are reversible or irreversible or both ?

[@nitinmishra7286]

Reversible

[@siham290]

Thank you

[@shomusbiologyofficial]

You're welcome

[@sarikavishwakarma2235]

thanks sir

[@shomusbiologyofficial]

You're welcome

[@jessielee9395]

great explanation =) thank you !

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Please explain about FY2 or Yz2

[@kondwamwafulilwa4613]

Thanks

[@mahimasrivastava1420]

Hello sir plz explain tumor immunology... its important sir.plzzz

[@shomusbiologyofficial]

Okay. Will make a video on that too

[@subhechhaghosh5993]

I am not understand the counting of valency...

[@shomusbiologyofficial]

Number of fab region is counted as valency

[@subhechhaghosh5993]

2 variable region is present.... So valency is 2?

[@vinayvarma2891]

thank u sir helped me alot....

[@akashkumarbal3705]

upload a video about hematopoiesis....

[@maramkiwan5201]

please correct your valency , it's 2 not 4 .

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sir blood of human ag ya ab

[@bhartimanjhi6073]

Thanx a lot

[@shomusbiologyofficial]

You're welcome

[@jasmint7822]

difficult to see ,,,but teaching nice

[@pratikshyame4585]

yes... no precipitation takes place here. what occurs here flocculation.

[@surjyaroy1496]

Sir please clarify the sound.

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How much clearance you require more, stfu

[@ashutoshgoyal6832]

Valency should be maximum of two

[@heeralalsaini2260]

Thanks skr

[@Shuborna112]

it would have been better if you have mentioned the forces of interaction

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thanks man

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Why are you wearing a helmet tho ? 😂

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Bz this videos are tooo old type, so advanced techniques areas not avilable in that time,so he weare this headset, its not a funny element okey🙏this is also help for this videos sound quality 🙏

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Super but I am Hindi student

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good

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tqvm.!!!

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Master g vdo check kr liya kro then upload...

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Check my website

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this is completely wrong concept... plz don't create misconception among students...

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For anti globulin Fy2

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No. Only 50%

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Thank you sir

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good