Antiplatelets and Anticoagulants | Dental Pharmacology | Full Lecure 2024

Hey my Tooth Doctors and Doctresses!
Here is the Antiplatelets and Anticoagulants Lecture!
Enjoy the Lecture and please share your feedback in the comments below!
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Content Creator: Dr. Kanan Shah
Content Presenter: Dr. Rishi Shah
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@TheToothFactory

[@UNKNOWN-un6nz]

Love it

[@drparadox7833]

Great video!

[@TheToothFactory]

Thank you so much doctor :)

[@gurpreetkaur-p3c]

Doc at 29.00 you said to increase platelet activity we need decrease prostacyclin and decrease thrombin thromboxaneA2 . Won’t the thrombin will be increased in injury and increased platelet activity ?

[@TheToothFactory]

Hello doctor, a very good question. So I apologise, I should have been more clear. At 29:00, I displayed a “Resting Platelet” stage where when there is a vessel injury, at that moment there is a decreased state of all clotting relatives including THXA2 and THRMBN. However, eventually in order to activate those platelets something will need to change that. Decreasing prostacyclin will trigger that. Therefore, in a state where there is decreased Prostacyclin C becomes an indication for the liver begin the clotting cascade and for the hypothalamus to begin the arachidonic cascade. Eventually the Thrombin is formed in the liver and transported to the sight of injury, and theomboxane A 2 is formed and done the same. Those resting platelets are now woken and platelets increase. Hence at the beginning of that pathway, there was decreased everything which is odd and the. Body needs to figure out how to fix it and later it is fixed by keeping prostacyclins low and thxnbs go up in number. Hope this helps doctor. Again apologies during the video I should have been more clear.

[@UNKNOWN-un6nz]

Vitamin k deficiency you said increases clot? Error?

[@TheToothFactory]

So at timer 13:40 we discuss vitamin K deficiency and I mentioned that vitamin K causes clots then I mistakenly said deficiency increases clots. You are absolutely correct. It is my error and I will correct it within. Great catch!👍

[@UNKNOWN-un6nz]

Near 29: 30 plus. Did you say high dose of aspirin can cause blockage of prostacyclin then said therefore will increase bleeding? Thanks.love the videos

[@TheToothFactory]

Yes doctor so we mentioned some basic prostaglandins and cyclins however, studies have shown that high doses such as 1000 mg and above can lead to ambiguity in blockage which leads to blockage of pgi2 and still cause bleeding and clotting ambiguity.