Applying Expert Knowledge for ICH M7 Impurity Classification - Session 1

[@yomudon2]

46:36 "API or related compounds to the API" may be better, because Ames test data of some related compounds to the API (e.g. process intermediate) are usually collected for manufacturing.

[@yomudon2]

It's fun. I enjoyed it. Was 2-amino-1,3,4-thiazoles recognized as deactivating/ mitigating feature in GT_BMUT? I'm interested in how to review compounds with deactivating/ mitigating features. I'm looking forward to the part 2!!

[@MultiCASEinc]

Glad you enjoyed! Yes, the GT1_BMUT picks up 4 analogs which is not enough to produce an alert however GT_EXPERT picks up the alert. Part 2 next week...July 7th!

[@yomudon2]

@@MultiCASEinc However statistical-based is likely to be positive prediction in case study4.