Great video! Hard to find these types of pathology lectures, especially those for the pulmonary system and especiallyyy for medical school/USMLE prep. Thanks.
@FilipSokol5 жыл бұрын
Thank you for your comment. I am glad you find it helpful.
@maryammmm47396 жыл бұрын
thank you!
@braddavide3116 жыл бұрын
Good video, hyaline is still eluding my understanding. Can’t find any good info on HOW it’s formed. Is it a morphing of surfactant into a more fibrous material? Is it reversible? Also, is it’s formation what leads to ARDS related fibrosis? Anybody stumbles across a good video please share :)
@FilipSokol6 жыл бұрын
Richard L. Kradin M.D., D.T.M. & H., in Understanding Pulmonary Pathology, 2017: The pathologic changes may be divided into two phases. The exudative phase occurs within the first 72 h of the insult. It is characterized by a profound increase in capillary permeability (Fig. 6.23A). There is alveolar filling by proteinaceous edema as well as multifocal alveolar hemorrhage and neutrophil infiltration. The sine qua non of acute alveolar wall damage is the hyaline membrane (Fig. 6.23B). It is composed of necrotic alveolar lining cells and fibrin that remain tightly apposed to the injured alveolar surfaces.
@FilipSokol6 жыл бұрын
My understanding is that you have injury --> inflammation --> increased vascular permeability --> exudate --> fibrin rich fluid in the alveoli. fibrin + necrotic alveolar cells = hyaline membrane Surfactant depletion is responsible for colaps of the alveoli (or atelectasis in newborn RDS) but it is IMHO not part of the hyaline membrane. Mild cases of ALI/DAD/ARDS are reversible and some patients recover completely. More severe cases lead to fibrosis. Fibrosis is a healing process and the last part of the inflammatory response. It is caused primarily by injury and prolonged inflammation. Basically the whole process is very similar to injury, inflammation and healing elsewhere in the body. Unfortunately it is not very useful in the lungs and it does more harm than good.
@braddavide3116 жыл бұрын
Filip Sokol, Thanks man that helps a lot actually. I never really considered alveolar tissue dealing with the standard inflammation process. That’s a nasty domino effect, no wonder so many ARDS survivors end up with some level of fibrosis.
@Radar101music4 жыл бұрын
@@FilipSokol what an amazing explanation buddy. Bless you
@xavierellis26922 жыл бұрын
Thanks for the explanation! I am wondering what magnification this H&E stain is?
@FilipSokol2 жыл бұрын
Hi Xavier. It is a virtual slide so the magnification is variable (up to 40x as the slide was scanned with 40x objective).
@dralemsegedlecturessimplif48704 жыл бұрын
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