Argireline: Botox In A Bottle | Is Argireline Safe for the Eyes? | Is Argireline Harmful?

[@EyeSchoolwithDrD]

Lots of new views on this video, and I wanted to clarify my thoughts on Argirilene. It's a product that has NOT been extensively researched as it pertains to the eyes, I'm just sharing some concerns. More research absolutely needs to be done before definitively giving it a thumbs up/thumbs down for use around the eyes. Here is the good news about Argirilene: 30% reduction in depth of wrinkles with 10% argirilene with no adverse effects vs. placebo. Differences exist in younger thicker skin versus older thinner skin. Other studies mixed/did not show the effectivity of the above study. Here are my concerns (more research needed): It is a neurotoxic chemical, potential exists for it to weaken the orbicularis. Possibly can reduce blinking effect, leading to decreased surface wetting and mechanical expression of meibum (oil necessary for the tears) into tear film. As with many products I research on my channel, the impact on the eyes and ocular surface is just not well studied. I will always update you as I know more and I welcome you to do the same! Thanks for watching!

[@Lighttriumphs]

Thank you. Was concerned about holifrog eye cream which contains argeline. It sounds like a dream cream, butter texture, even if all i want is a cruelty free fragrance free hydrating eye cream.

[@suzeheidt8358]

I've been using it for 13 years and it completely got rid of my deep frown lines. It works for me and I highly recommend it! Doesn't affect my blink.

[@lisatucker3432]

What kind do you use ? I would love to try it

[@betterwiththeirish]

@@lisatucker3432 try the Ordinary. They are a very affordable brand.

[@aeducator1]

Wow. That's amazing. Wonder how it works since it doesn't penetrate the skin.

[@suzeheidt8358]

@@aeducator1 It does penetrate the skin.

[@Jessica-iq6kj]

Thank you for this comment!!

[@Christine-ry1qq]

Used it very successfully for years with no adverse effects It’s a must have in my skincare routine

[@aleydaespinoza4224]

It works!!! And, it does not negatively affect any eye muscle movements at all! Perfectly fine, it really works!!!

[@Herrera_70]

This product has a good reputation for a reason, if people were having issues with it they would bash it immediately. I have been using it for a while and I love the results.

[@roxyiconoclast]

I am 67 and have used an argireline product with hyaluronic acid for 2 weeks (Double Wood brand). It has been surprisingly effective, although of course not quite as much as Botox I tried 13 years ago. However, the argireline costs less than $20. I have noticed no side effects, even though I have pre-existing dry eyes. Maybe one reason is that I first use either petrolatum or castor oil on my brows and eyelids, so this probably prevents migration from the forehead and crows feet area. Regular eye cream may have the same protective effect. Another idea is to apply argireline/HA when lying down, to prevent migration before it dries. I appreciate the heads-up about potential issues, however! Thanks.

[@oliverkitkat6860]

Roxy hi thanks for your info i have alergies that make my eyes water best wishes kit ❤x

[@annpringle8219]

I use the Original products , the only thing I will use around my eyes is almond oil, vit E oil or vaseline. I am 60 with no wrinkles around my eyes. Either its been a blessing all these years or I'm just lucky. I think it's a blessing 😇

[@ql3670]

Argireline doesn't work like botox at all, people just thought it would work like that at first. It just increases the skin collagen production, instead of relaxing the muscles. Dr. Dray mentioned that in her review of argireline.

[@Rwissam1987]

From my understanding all the studies you talked about didn't cite any adverse effects. So what you talked about are "potential" side effects not proven side effects. Please correct me if I am wrong.

[@EyeSchoolwithDrD]

Correct. On the skincare side the studies suggest its effective (although how effective is mixed) and safe. I couldn't find any studies expressly concerning the eyes, so I am citing thoughts/concerns/potential pitfalls. Thanks for watching and commenting!

[@funlo8627]

Argirline doesn’t work on me. And the skin under my eyes are sagging after one month of using. Does anyone have the same experience? 😢

[@Basit759]

@@funlo8627 really

[@lisam2795]

I've been using it for less than a week, and somewhat recklessly around my eyes. I started having dry eyes for the first time in my life, and a stye for the second time in my life, so I googled 'dry eyes argireline' and your video came up! Thanks! I am just going to stick to using it on my forehead for now and see if the dry eyes go away. It makes sense that it could cause dry eyes, and I'd definitely rather get a few units of botox in my crowes feet (one of the cheapest areas to treat) as I have never had any issues with botox in the 10 years I've used it.

[@r.girardi6253]

A dermatologist (or whatnot) wouldn't recommend a product that takes money out of their pocket.

[@bernardsadowski6812]

NEVER a problem, love it!

[@fellinloveinmaui]

Mahalo's! I have severe dry eye and I was about to purchase this product. How I ran across your channel and this particular video, must be a blessing for sure. ❤❤❤ New subscriber! 😊

[@GenXfrom75]

Just don't put it IN your eyes. This product is absolutely amazing.

[@PiggyLovesOllie]

Gee I wonder why derms dont like it😂🤣. Sure they dont want you to “waste” money. I bought some a month ago and it works amazing.

[@kallisteibeauty]

Thanks for this! I just started using an eye serum which has Acetyl Hexapeptide-8 because I can't use cosmetic neurotoxins anymore. I do not know if it is placebo or not however, today I noticed that my eyelids feel quite heavy or slow (I hope it's temporary) so I decided to do some research and came across this video! I wont be putting this ingredient on my eyelids anymore.

[@rhyothemisprinceps1617]

It does not make sense to say that argireline lacks effectiveness due to lack of skin penetration but then say that it can cause harm. My experience is that it is highly effective at reducing wrinkles as well as hyperpigmentation and telangiectasias. It also helps with blepharospasm without affecting voluntary muscle movement. I had pre-existing dry eye (dysautonomia) and have not noticed worsening since I started using it. It is possible it could affect dry eye since its main MOA seems to be reduction of sympathetic activity which could affect acinar cell function.

[@DC-wp8cr]

Which product/brand did you have success with? I'm considering trying it out.

[@rhyothemisprinceps1617]

@@DC-wp8cr Asterwood ; I also use Ordinary's caffeine + EGCG, which seems to boost it a bit. I don't use it with vit C, AHA or BHA. If it doesn't work or if you are concerned about side effects you could try Frownies or similar products for deep lines.

[@EyeSchoolwithDrD]

It seems to be safe on the skincare side of things. I am always hypercritical of potential problems any product can cause for the eyes or ocular surface, but we do not yet have studies to support those concerns. (See my pinned comment above for more)Thanks for commenting, you brought up great points and I appreciate it!

[@debee1544]

I have spiderveins on my cheeks...you have been using this and it helps?

[@rhyothemisprinceps1617]

@@debee1544 I think it helps a bit with spider veins. Eating blueberries & leafy greens seems to help also. I've tried things like hesperidin & citrus bioflavonoid supplements and they did not seem to do anything. I also take a lysine supplement which helps with pressure sores on my nose from my glasses - maybe a bit with the veins, but I'm not sure. I've also started using Eucerin Roughness Relief Lotion on my face, and overall it seems good - except perhaps a bit of acne as a side effect at first. It contains lysine plus a bunch of other stuff. It is meant for rough hands & feet so if your skin is very delicate it might not be a good idea.

[@anneo.896]

Thank you so much, I've been using Argireline around my eyes and I've noticed my vision is a bit blurry, I'm older and I think you have really helped me figuring it out. I'm going to throw it out!

[@SayuriYaki]

You could still use it on your forehead or around your mouth if you don't want to waste the product and money.

[@gloriald444]

Just don't put it around your eyes.

[@GenXfrom75]

Argireline isn't causing your blurred vision. I'm an optometrist assistant and you & I are at the age of worsening vision. Unless you're literally putting drops of Argireline INTO your eyes, it's not causing blurred vision. The Ordinary Argireline is amazing.

[@JaimeeLauren]

Presumably Botox could have a worse effect on the blink muscles? So for some people it might be a safer option than Botox?

[@jeanettedombroski3934]

So what if you just use on your 11 lines?

[@rhirai4024]

Thank you for the informative vlog but what are the alternatives, if any?

[@MsOliveLeaf]

Dr. D ........Please make a video about using coconut oil or other oils; vitamin E oil, grape seed oil, Jojoba oil etc. around the eye area.

[@jengus1951]

Yes I am one of those who purchased this...going in the garbage along with my tretinoin 😭. Dry eyes are a bummer!

[@EyeSchoolwithDrD]

Sorry to hear that. It's hard to keep track of which products are ok and which aren't!! I too keep learning and adjusting what I am telling my patients!

[@jengus1951]

@@EyeSchoolwithDrD thank you for your efforts!

[@Press2GetTheCookie]

After 3 months of using Argireline twice a day around the eyes, suddenly I started having eczema around eyes, blurred vision, eyes watering. Only stopped after using it and when I used it again that same issue returned. Now I only use it in my forehead but not in my eyes. At some point it was so painful and affected my vision so much I just wanted to cry but couldn’t because I knew it would make it worse. What a horrible experience.

[@eaglelensforemay7503]

Interesting, but I would assume if it affected your eyes and you had a bad reaction to it, then I personally wouldn't use it on the rest of my face.

[@kathleentinley7261]

Thank you for this video. I was going to order some but I have extremely dry eye syndrome and also have acute blipheritis. I am constantly cleaning my eyelids.

[@kathleenpignatari5306]

Thank you doctor-I was just about to purchase but I definitely won’t now!

[@GenXfrom75]

I've use The Ordinary Argireline for a few months, twice a day, and I will never stop! I'm 47 years old and it's virtually eliminated my 11s! I do use it around my eyes but I think my lack of crow's feet has more to do with great genes. But hey, it might be preventing new lines! 💞

[@Basit759]

U mean airgline can cause new line?

[@GenXfrom75]

@@Basit759 uh... 🤣 No.

[@Basit759]

@@GenXfrom75 ok

[@GenXfrom75]

@@Basit759 I don't understand your question. Argireline prevents deep creasing. And has made those little "11" lines between my eyes become very faint. No, it doesn't CAUSE lines.

[@GenXfrom75]

@@eaglelensforemay7503 thank you! I turned 48 on June 12! 💞

[@samanthathompson9812]

Been using this for almost 4 weeks and absolutely nothing.

[@vickim8710]

What about using it on the rest of the face?

[@Gingerella917]

I always wondered if this really worked, but never purchased (thankfully). Thanks for always looking out for us!

[@EyeSchoolwithDrD]

You are so welcome!

[@cathylaver4146]

They make money , not looking out for us !!

[@antonleuvenhok4722]

Mam do u also have eye floaters and if u have what colour is it and how do u ignore it please reply mam

[@melt7891]

Thanks so much Dr..are you aware of “Botox like” smoothing products that work temporarily? 🌷

[@EyeSchoolwithDrD]

You're welcome! Can you give an example?

[@melt7891]

Sure Dr..Plexaderm is one, or My Perfect Eye (which leaves white residue and you can’t wear makeup afterwards!)..After purchasing and being unable to use My Perfect Eyes, I’m worried about buying more products and wasting a lot of money

[@lkempin1]

@@melt7891 That's right, and the instructions also say no moisturiser prior to applying My Perfect Eyes or it won't work. No moisturiser is just way too dry all day for ageing skin in particular, surely?! So, no moisturiser allowed before & no foundation after application is a definite thumbs down for my skin at 57yo. Seems to me this product will do more harm than good by leaving skin insufficiently hydrated. Also it takes some practice getting correct quantity and application technique down, which inevitably means wasting quite a bit of product just practicing and redoing to get it right. They make it look so easy in the TV ads, which was not my experience at all (nor 3 of my friends who also tried My Perfect Eyes). That's 3 major negatives, so in my opinion don't buy into the the before & after images you see in the ad, 'cause with no moisturiser those women have all got dry skin under that film of "botox in a bottle" around their eyes, which is doing the delicate skin, crows feet/fine lines in that area no favours at all, save for a very short lived (4hrs max - don't believe the 6hrs they say in the ad!) effect.

[@consciouscrypto3090]

Well this oldy (but goodie) can vouch for the effectiveness of argireline on my 11s. I don't put it all the way across my forehead, because I don't want my outer forehead drooping the way people who use a lot of botox sometimes get. But it has eliminated my 11s in just a few months. My skin is thin enough on my forehead for it to work. Even on my crows feet I've seen an effect, but I don't regularly use it there because I don't have bad crows feet to begin with and would rather use less in my under eye than on my forehead.

[@joenisnapje712]

If this opinion is based on evidence it would be ‘when in doubt, do not act’ at best. Botox is safe so Ageriline is even safer.

[@sarahlewis5005]

I just wanted to respectfully tell you that Botox is not safe...I almost lost my life to it and I know many others as well. I endured 10 years of incredible suffering in my body and there are countless others suffering too...seriously, thousands and thousands of people going through absolute hell from the neurotoxin and it's not just a "droopy eye." It can be a full on assault into your entire nervous system that makes you want to end your life...and people have. I have researched it to death after losing 10 years, my home, my career, my life savings and what hurts more than anything, I couldn't be the mom I so desired to be. I was lifeless in bed suffering minute by minute, hour by hour, month by month, year after year from a botox injection. I was busy drooling into cups from muscles not working, I had loss of muscle movement in arms/legs and had to be carried to bathroom/shower. I had seizures, the inability to breathe properly, migraines for days on end, hallucinations, extreme panic attacks...I could go on and on. They do have a black box warning. I never had a health issue or an allergy in my life. I was healthy girl one minute, then my life was snatched away the next from botox. Just wanted to share that. I never want anyone to go through. what so many are going through and it's rarely talked about. ❤

[@dawnwagnerprincesslgunab6476]

I'm a new subscriber and do use thus product by the Ordinary line. I don't use it around my Eyes. I do however use it on my Face. I'm 64 so what is your opinion on that? Tha k you for sharing this with all of us. ❤

[@analitycznie]

So nothing is good for the under eyes, retinoids are bad for eye glands, and botox doesn't work under eyes.

[@cjkfranco]

Great video!

[@conniemurphyover70stillgla47]

I remember VICTORIA PRINCILPES beauty line had that in it.

[@Thewayoflifeislamic]

Would argeline using it..... with microneedling on the rest of the face 🤔?

[@soniagold4771]

Thank you, great information

[@Ultimatecruegirl]

Is there an update on this?

[@EyeSchoolwithDrD]

No update, no peer reviewed studies have looked at it yet. I still have the same concerns, as do others @lauraperimanmd

[@lilpunk24]

Does it help with droopy eyelids ?

[@lindabell6954]

very informative. thank you.

[@possumpancakes1007]

Can Matrixyl used around the eye cause problems? thanks

[@EyeSchoolwithDrD]

Not sure, I will look into it!

[@KevinEvansFamily]

Interesting that you are worried the Botox-like actions will effect the blink, but at the same time say it doesn’t get deep enough to have an effect on skin. Basically, you have no idea if it works or not… making this video worthless.

[@morningglory4593]

🤣🤣

[@kevinhanley6462]

Well done on your extensive research! Maybe this product would be less wasted with microneedling, but there won't be enough data due to it being new.

[@amber_Forever16]

Yeah I haven’t even watched yet but I don’t even look at products that just go on the skin besides Tretinoin, nothing gets past the skin. Need to put it under the skin

[@Lisa-lo6yc]

I just saw this ingredient is not banned by FDA but certainly on the list of questionable regarding eyehealth. It just might get banned in future ..

[@240iBMW]

I tried the serum and was using it around my eyes and my forehead and I started to get headaches. Stopped it. Headaches stopped.

[@EyeSchoolwithDrD]

oh wow, thank you for sharing!

[@rhyothemisprinceps1617]

I've noticed a reduction in migraines since I started using it.

[@elenilachana1751]

Ive been using this serum for 1 year and never noticed headaches and negative but only positive to skins appearance..

[@laurieparis2203]

Sounds dangerous to me. Makes sense some of that getting into the eye would have greater influence on the eye muscles, because the aqueous environment and mucous membranes are easier to penetrate than the stratum corneum of the skin. My experience: tried some Asian made masks couple years ago. Did not check the ingredients because it was in some Asian writing. Left them on overnight because they had this wonderful gel that felt so relaxing on my face. I sleep on my back so there was no problem keeping them on. After a using them for a couple of nights in a row, I noticed that my face was starting to look saggy (-er) then normal. Checked the Amazon website where someone had asked about the ingredients lo and behold there was argireline. Would never have used it had I known, I've avoided it in all my products, after reading about it years ago. It seems to me that it works to relax the upper layer of skin but not the muscles beneath it, which for my older face, gave a very strange saggy look. But who knows? So much with appearance is subjective, particularly when you have no control subject and it's your own face.😆

[@jane9893]

That's interesting, I keep reading comments about sagging from Argireline. Some people swear by it though. I want to try it, but I've had negative results with other anti-aging products, so I don't want to risk it.

[@toni5133]

Hello, did your skin return to normal after discontinuing use?

[@laurieparis2203]

@@toni5133 hi Toni. I'd say it took about six to eight months before my face started to improve. I began using Retin-A and also taking a collagen peptide supplement powder, so I think that helped undo some of the damage.

[@jflo2012]

Could using it on 11s and forehead potentially affect the blink muscles? Or is the concern strictly the crow’s feet area? Thank you.

[@rhyothemisprinceps1617]

She says it probably doesn't penetrate the skin enough to help with wrinkles - but then says it might affect muscles involved in blinking. Makes no sense.

[@jflo2012]

@@rhyothemisprinceps1617 I know. "Don't use it because it doesn't work" and "Don't use it because it might work". LOL I think she was trying to say that at this point in time it isn't proven to do anything to relax the muscles; however, if studies find that it does affect the muscles, then those with dry eye should beware. I'm just wondering if using it on the forehead (11s) is far enough away from the blink muscles to not (potentially) cause a problem. Also, if we follow the blink muscle logic, then wouldn't injected Botox affect the blink muscles too? I hope the Dr. responds to clear some of this up.

[@rhyothemisprinceps1617]

@@jflo2012 I think it could be a problem if when applying or washing one is not careful to make sure it does not get into the eyes. It would be simple enough to do a study to see if use affects blink rate (if funding could be found), but there may be something else going on with decreasing sympathetic nerve activity - which could affect the cells that produce tears, should it get into the eyes. Botox has been implicated in dry eye, but proponents say this does not happen if properly placed (but of course they will say that if they are selling it). Interestingly, Botox has also been used to treat dry eye. If you are concerned about dry eye from either Botox or argireline, you could try 'Frownies' or similar product for 11's. Sounds silly, but many people say they work. If the argireline (Asterwood) and Ordinary EGCG + caffeine stops working for me I will try Frownies. I wish I had not bought such a big bottle of the argireline since apparently it can become oxidized over time (the expiration date on the bottle is pretty far out, though).

[@neva5326]

@@rhyothemisprinceps1617 what does the egcg stand for, or mean? Do you use this instead of the Argireline? Tyia

[@rhyothemisprinceps1617]

@@neva5326 Epigallocatechin gallate - key component of green tea extract. I still use argireline & have not used the Ordinary serum for a while. Not sure why I stopped - maybe started reacting to it (my skin tends to become sensitized to stuff). Will have to try it again - thx for reminder. I've been neglecting my skin (& the rest of me) lately.

[@rickyn1135]

If someone could come up with a topical super anti under eye depuffer,thus be Wealthy. Surgery is just not an option & $$$$$

[@brendamoote7304]

What is your verdict on Botox which is much more expensive and does a lot more damage to the nerves let me see yes go get it

[@Iquey]

Nah she's an opthomologist, not a dermatologist or med spa owner. She has nothing to gain by promoting injected Botox either. You can still get droopy eye as a Botox side effect.

[@DCARA06]

Great video!! Ha I have been going through these little bottles of Argireline 10% (The Ordinary) and I love the stuff but I had no idea that it was related to the botox toxin. I typically am so careful knowing everything that I put on my skin. Anyway, I do love the stuff and I have not had any side affects at all, no dry eyes or any eye issue. It does sting if you get some in your eye and I am now going to be extra careful not to do that. I use the dropper and let it drizzle down my elevens and my frown lines then use my fingers to massage it in, after I put my (homemade) moisturizer on.

[@cathycathy6170]

Hi there👋it has to be used before moisturiser on a clean surface😊

[@DCARA06]

@@cathycathy6170 yes, that's why I put it on the way I described.

[@brendamoote7304]

Maybe people with center older skin. Unlike yours have weighed the pros and cons and if you're not putting it on your eyelids where you're blinking. Eye Suggest no pun intended get some thinner older skin women's opinions

[@jennifermcmillan2588]

Supposedly they have fixed the skin barrier issues ..