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Hojlund had given United the lead after a strong run in the 10th minute, but shortly after was forced off injured holding his right hamstring.
As the clock struck 30 minutes, new United signing Yoro limped off with a potential ankle injury.
The Gunners won the game thanks to goals from Gabriel Jesus and Gabriel Martinelli, but United later won the pre-arranged penalty shootout 4-3 with Andre Onana the star of the show.
Result: Arsenal 2-1 Man Utd
Penalty shootout result: Arsenal 3-4 Man Utd
Arsenal XI: Hein, Timber, White, Heaven, Zinchenko, Jorginho, Nwaneri, Odegaard, Nelson, Trossard, Jesus
Man Utd XI: Onana, Wan-Bissaka, Maguire, Yoro, Amass, Casemiro, Collyer, Amad, Mount, Rashford, Hojlund