This was an amazing presentation. This should have so many more views. Very informative.
@markb.87562 жыл бұрын
There is no drug without side effects or complications. The same drug that is a lifesaver for one may land another person in the hospital. Everything is a balance of risks and rewards. Tradeoffs are a given in this life.
@DanielSRosehill2 жыл бұрын
Excellent information. Thank you for publishing! (The binding profile in patients in remission provides a salutatory warning for medication compliance!)
@beta4474 жыл бұрын
New game: every time he clears his throat you have to take another hit of k.
@darkdogstudios3 жыл бұрын
It would helpful to have a better cursor that is more visible.
@axel95463 жыл бұрын
I have few questions: I) How does an SNRI differ from a SSRI? II) Could Gluten we eat be a problem on any of those arguments? III) If SSRI help reducing serotonin receptors, what would be the effect in the long-term, usage?
@ChadDidNothingWrong3 жыл бұрын
I) Noradrenalin vs Serotonin For a chart and explaination on difference, watch this video: kzbin.info/www/bejne/q5CafaqCaqqgd9U
@ajax7003 жыл бұрын
*"I have few questions:* *I) How does an SNRI differ from a SSRI?* II) Could Gluten we eat be a problem on any of those arguments? *III) If SSRI help reducing serotonin receptors, what would be the effect in the long-term, usage?"* Serotonin deficit theory was proved wrong many decades ago. Long term effect of supposed antidepressants is getting persistent non reversible neurological damage and worse depression. Hope this helps you get the answers, sources: ISSM Webinar on Post SSRI Sexual Dysfunction kzbin.info/www/bejne/r3fbfpillq6WacU PETER GØTZSCHE about many his studies on SSRIs/psychiatric drugs English Español kzbin.info/www/bejne/jKiZp2yXYtesosk David Healy, MD: Sex, SSRI's & Medical Groupthink kzbin.info/www/bejne/Y5q8ZGOprKmir9k The multiple damage these drugs cause is not reversible. So called antidepressants / SSRIs / SNRIs are very damaging, should be a very last resort on people with very acute problems (probably 0,01% of the people that get them now).
Very interesting findings! But what do we do from here on out? Will there be a change in the mode of treatment or medication?
@lebest84153 жыл бұрын
Focusing on the downstream effect of ssri (neuroplasticity) I believe they can find new ways to specifically target receptors (such as BDNF receptors) without causing too many side effects.
@No14me233 жыл бұрын
how can you get an order for a petscan. is hospital research dept best bet?
@danashannon82343 жыл бұрын
Research for clinical trials. They are the best tests / use specialized scans that show abnormalities that regular scans don't. I've been researching low dose naltrexone. So many studies are linking depression partly to neuroinflammation.
@duckwatching54293 жыл бұрын
Antidepredsants is like death sentence to me i wont be able to be happy anymore
@williamkreth3 жыл бұрын
Have you tried using Marijuana?
@donnakaz13783 жыл бұрын
Please watch Sadhguru iTunes videos I wish you all the best ❤️
@agceh3 жыл бұрын
Have u been happy with depression?
@tabioka18002 жыл бұрын
@@agceh Antidepressants are not prescribred only for depression but for other 100 problems and off label. Antidepressants induced anhedonia is more devastating than depression! I have it, it's terrible!
@Frobe82 жыл бұрын
@@tabioka1800 does it last even after you stop taking the meds
@hackthis17673 жыл бұрын
And the sad thing is i can make all the mental issues with transducer in a stomach lol thymus and aricualr lymph nodes
@cryptocomeback2 жыл бұрын
wuhhhhhhht
@danashannon82344 жыл бұрын
I don't understand. Am I supposed to take them or not?
@johanngotlub76624 жыл бұрын
Should You Take Antidepressants? I think you can put it this way: Depression itself damages the body. It is now known that depression leads to a higher risk of cardiovascular diseases and diabetes. Depression significantly shortens life expectancy. Depression also damages the brain. The brain volume decreases, the risk of dementia increases. Antidepressants can partially reduce the harmful effects of depression. On the other hand, they themselves increase the risk of dying earlier and can have many bad side effects. Some antidepressants lead to obesity, others increase the risk of bleeding etc. etc. In the end, one can say: With depression you will die earlier. In addition, the risk of numerous illnesses increases. With and through antidepressants you will also die earlier and risk numerous illnesses. So what's left for you? I think you should see if taking antidepressants improves quality of life. If antidepressants make you feel better, happier, and work better, then you should take them. You should also have a look at possible side effects and have yourself examined regularly. But always remember: Depression also has side effects. In addition, you should - generally - eat as healthy as possible and do a lot of sport. This also reduces the risk of gaining weight through antidepressants. All the best!
@SpaceNStuff4 жыл бұрын
@@johanngotlub7662 nice to see every piece of information summed up. Thank you!
@johanngotlub76624 жыл бұрын
@@SpaceNStuff welcome!
@okidoki32014 жыл бұрын
@@SpaceNStuff ssris destroy brain
@vincentbezares3 жыл бұрын
@@johanngotlub7662 But those drugs don't allow you to deal with the underlying trauma. They almost debilitate you. Agreed, if someone has to choose between life-threatening depression, then those medications might be a great idea. But if you don't cope with the underlying trauma, then how is it probable to really move forward?
@montesa91363 жыл бұрын
A lot of academic talk but no practical solutions
@lemonpie88193 жыл бұрын
Youre just plain ignorant
@margaretyiannopoulos59103 жыл бұрын
Pay attention dumbfuck
@user-yy8dh7bd4k3 жыл бұрын
for a ignorant with 0 knowledge, it won't mean anything
@camellia8625 Жыл бұрын
It basically explained how untreated depression can lead to neuronal death in some critical brain circuits resulting in treatment resistant depression and how such treatment resistant depression may amendable to treatment with ketamine which works by a different physiological mechanism. This knowledge is potentially very helpful to those reluctant to take antidepressants and those who have developed treatment resistant depression over the years.
@jdulast2 жыл бұрын
Please do research on PSSD and emotional numbness/ Anhedonia from antidepressants as well as other causes.
@l.n.9392 Жыл бұрын
An incredible piece of teaching. So consistent and clear. And it is also reassuring to see the coherency of the research that is being carried out. The mystery of depression - what it is and how the medication treats it - is receding nicely.
@renzagliarobb3 жыл бұрын
Could these results be drug damage? Was this researh done on people that were never drugged?
@rab-cnesbit41812 жыл бұрын
Hello from England UK I'm disabled and in chronic pain I also have suffered for over 25 years with chronic anxiety and reasurance seeking OCD about contamination which involves nearly touching everything without washing my hands , I'm obsessed with my clothes being contaminated with dirty toilet water backsplash on my butt getting on my trousers and bottom rear end of my jumper , and on and on . I'm taking 150mg sertraline and 100mg amitriptyline.
@juliawilkinson3 жыл бұрын
Great info! I learned a lot and I read a lot about depression. I had several ketamine infusions and they were wonderful and very helpful. The infusions are extremely expensive, tho. I am going to try the nasal spray but I have heard things that it’s not as effective. Thanks for your research and please update us if you can!
@acousticphilosopher64203 жыл бұрын
Buy it illegally off the darknet Much cheaper
@shahrock69693 жыл бұрын
Avoid ketamine, its addictive substance. Its an anaesthetic drug, not approved for psychiatric use.
@@shahrock6969 You are dumb and ignorant regarding pharmacology.
@Vectorman2X Жыл бұрын
I have tried 3 of the most terrifying drugs ever, finasteride destruction of hormones, then effexor destruction of my dopamine serotonin and norepinephrine receptors, then valium destruction of my gaba system.I am 3 years clean of all this,the withdrawal was hell. what it help me was cbd zinc vitamin c whatever reduce inflammation, i am not what used to be, but i can function, also my sexual life is back, not more errection problems from effexor usage and finasteride
@bobbyfischerwasright47873 жыл бұрын
Excellent study and detailed information about the topic... Greetings from Denmark
@catman13133 жыл бұрын
Knus
@Matthew84737 ай бұрын
This is a masterpiece. I recently read something similar, and it was a masterpiece in its own right. "Unlocking the Brain's Full Potential" by Alexander Sterling
@daveyork02 жыл бұрын
Fix my brain and outlook. I have been knowing depression over months and as a longer theme. Talking to you, God bro.
@akkaya80323 жыл бұрын
@ Brain & Behavior Research Foundation My question is that, if amount of 5-HT1a receptors are proportional to gray matter in various brain areas and it provides neurogenesis and synapsogenesis, does not taking SSRI's leads to reducing in gray matter and ability of synapsogenesis? Because doctor said that, SSRI reduces the 5-HT1a receptors. Does this means, SSRI antidepressants cause decrease in neuroplasticity and gray matter and even decline in intelligence? (since we are correlating intelligence with gray matter)
@zaheerahman72663 жыл бұрын
SSRI’s work because they downregulate the receptors. HT2a receptors are are implicated in plasticity and creativity. Unless you take a HT2a antagonist with the SSRI then other receptors can be affected by the increase in serotonin. Haha that’s all I know. Good question
@akkaya80323 жыл бұрын
@@zaheerahman7266 Thanks !
@user-yy8dh7bd4k3 жыл бұрын
@@zaheerahman7266 Actually, the 5HT1a receptor that provides therapeutic benefits when downregulated is the pre-synaptic one (the autoreceptor one), not the post synaptic). Subtype and location in the synapse will make it have different functions. Even though, not only the pre synaptic one is down regulated. The post synaptic one is too, alongside with the other 5HT receptors. The down regulation of the 5HT3 receptor, the only ionotropic sertoninergic receptor, also provides clinical benefits because it stops the dopaminergic signaling, and this receptor is a very unique one because it actually interfere with the signaling even when not bound to serotonin, therefore, the downregulation of this subtype will actually lead to substantial decrease on it's activity (thus, an increase in dopaminergic signaling).
@user-yy8dh7bd4k3 жыл бұрын
They actually lead to a downstream effect that increases BDNF, reduces cortisol effect, has anti inflammatory activity, removes cytokines from the membranes and some other features that will result in neuroprotection and actually increase synaptogenesis. Even with the post synaptic receptors being downregulated, the SSRIs won't cause a reduced serotoninergic activity. The receptor is downregulated as a response to the increased serotoninergic signaling.
@gr8dvd2 жыл бұрын
@@user-yy8dh7bd4k In short, "[SSRIs] result in neuroprotection and actually increase synaptogenesis." So NO the opposite (positive) affect on gray-matter & neuroplasticity. Correct?
@tabioka18002 жыл бұрын
Antidepressants can cause permanent damages
@kyounginkim-r4z5 ай бұрын
Ketamin Anesthetics might make a ViVid dream ( Night mere?)
@thinkify682 жыл бұрын
Great talk, thank you very much. Was amazed to see the proliferation of serotonin autoreceptor 5-HT1A on one of the slides. Big question for me is - is that proliferation caused by stress, or was it pre-existing?
@thinkify682 жыл бұрын
After a brief article review. Not much that looks at adverse childhood events related to 5-HT1A expression
@janicefreedom86655 жыл бұрын
What was the human dose for Ketamine?
@Anderassser2 жыл бұрын
What about drugs like Wellbutrin? Does this still give brain damage?
@moodybugg-20982 жыл бұрын
Hell yes
@Anderassser2 жыл бұрын
@@moodybugg-2098 Source?
@moodybugg-20982 жыл бұрын
@@Anderassser my father in law! No better source than real life experience.
@chickoohitch89762 жыл бұрын
Then whats the way out ......
@adventureguy41192 жыл бұрын
I took 2 pills and ended up having serotonin syndrome. Stuff is nasty in the end no pills few years later anxiety is minimal as normal background from work deadlines and court
@studentaccount43542 жыл бұрын
This is nuts. Mice are not humans. Correlation is pseudoscience.
@MusicPLUSBusiness2 жыл бұрын
Interesting! Insightful. Forward thinking. Love it! Thank you!!
@lui8885 Жыл бұрын
i don't get it how atypical antidepressants like mirtazapine or antipsychotic (that block 5 HT) work then
@louisejessup39942 жыл бұрын
The biggest joke of all is if the suicides were known to be depressed were they taking the depression medication? Because if they were then that leads to increase serotonin and receptors that's the whole point of what they are supposed to do. Also these drugs actually cause increased number of relapses. Quite frankly anyone who can hold a mouse by the tail and when it stops struggling shows its depression really needs some urgent psychiatric help himself. Does it not occur to him maybe the mouse is simply tired?? Also it is shown that these drugs increase suicidality, cause agitation etc. Such a dangerous talk, plus the withdrawal problems are horrendous, but also what is happening in someone's life in the first place, ie not what's wrong with you but what's happened to you? But oh yes that won't need drugs but you will need to talk to them, maybe un dealt with trauma? Oh but then big pharma? Yes of course, money the root of all evil
@beta4472 жыл бұрын
Wow, an intelligent comment! This guy is basically getting paid to characterize depression as a disease, and to then describe any brain difference he can find as a defect. In reality, there is no disease and there is no medical treatment, only synthetic drug consumption with increased dysfunction and disability. The drugs don't work anyway, whether or not you think it's a disease.
@jdulast2 жыл бұрын
I agree. These drugs gave me PSSD and anhedonia/ emotional numbness and also I believe they did increase agitation.
@jdulast2 жыл бұрын
Oh yes and last but not least suicidal ideation
@ASMR-XI-ZUI2 жыл бұрын
Quetiapine make me overdose on 80 paracetamols . I'm still on it with conjuction of venlafaxine. I'm addicted to these medicines and struggling to reduce .
@babelbabel2298 Жыл бұрын
that doesn't lead to increased but decreased receptors
@time_g_space3 жыл бұрын
i am doing deep brain massage, trans cranial magnetic stimulation for the treatment of MDD :)
@time_g_space3 жыл бұрын
Fuck pharma!!
@bonbon78813 жыл бұрын
Tried it. Doesn't work save your money. Even the clinical trials done for TMS & RTMS show it to be effective at about the same rate as placebo... So, don't make the same mistake I did save your money.,
@Srose21312 жыл бұрын
Is it helpful?
@TheMarcusrobbins2 жыл бұрын
Fantastic that we seem to be making excellent progress at last.
@kuhajeyangunaratnam8652 Жыл бұрын
great presentation. Hopefully these findings lead to main stream effective treatment.
@_._._._._._._._4 жыл бұрын
Very informative and mind boggling at the same time.
@policeluber67203 жыл бұрын
Where is ketamine ?
@dr.sudarsanraymentalhealthdoc Жыл бұрын
Thank you John for an enriching presentation.
@jamesstevenson60862 жыл бұрын
Fantastic and brilliant information. Thank You
@mickbowe4252 Жыл бұрын
And once again trauma is missed.
@sivasankarnallapati3 жыл бұрын
Ok I
@esindirik44473 жыл бұрын
So am I saved now or what?
@bobparquet4 жыл бұрын
I see that there has been a great following, well 5 comments uahooo !!! I wonder if it is because of the great trust that people have towards psychotherapy or because they have broken their balls to get themselves fucked. Then I'd like to know if with all this funding they have taken into consideration, even minimally, the natural active ingredients, those not monopolized, because they seem to work quite well, aside from LSD, but which is already your patent. Then I'd like to know why the ketamine molecules, which are of two different types, have been chosen the most harmful one. Thanks.....
@redencionjimenez11114 жыл бұрын
:-)
@TheDarknight70003 жыл бұрын
anti psicotics are pretty dangerous dont use that shit
@trololopeth3 жыл бұрын
Depression is pretty dangerous.
@tabioka18002 жыл бұрын
Yes,and anthypsicotics destroy dopamine and cause depression,avolition, anhedonia, emotional numbness etc.
@belugabath3 жыл бұрын
Good job
@hoivanbanla15713 жыл бұрын
The yummy hen unfortunatly cry because cemetery rhetorically obey pro a lavish cougar. courageous, unsuitable modem
@hailstrom97803 жыл бұрын
....what
@emmaayla58893 жыл бұрын
@@hailstrom9780 Lmfao 😂
@reflection_8_5 жыл бұрын
Does all of this apply to anxiety disorder as well
@Robin-di4gq3 жыл бұрын
Yes
@Sk0lzky3 жыл бұрын
No
@MusicPLUSBusiness2 жыл бұрын
Depends on origin
@hypolaristic5 жыл бұрын
now: effects of CBD on serotonin/glutamate please
@t.n.38194 жыл бұрын
A systematic review of the available literature was published in arguably the most prestigious medical journal (the Lancet) just last month (October 2019). The authors concluded that there is a lack of quality evidence (especially clinical evidence) to support the efficacy of CBD as an antidepressant. So there's not really much to discuss. There are anecdotes abound, but that doesn't mean anything... CBD is being aggressively marketed as a magical panacea, but in many cases this is unwarranted. Here's a link to the Lancet review (sadly it's behind a paywall but you can find it for free elsewhere): www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(19)30401-8/fulltext
@Vectorman2X Жыл бұрын
it works great, also you can try palmitothelamide that enchance the action of endogenouns cbd production
@allthewayfrom2 жыл бұрын
Thank you, Angie and Dr. Kirsch! After watching this fascinating interview, I’m wondering about a few things. If SSRI’s are basically placebos... 1. How do you explain the positive neuroplastic changes in folks with MDD who’ve been on SSRIs vs. those with MDD who have not taken SSRIs? PET scans prove that positive structural changes occur with SSRIs vs no SSRIs. Granted, they don’t have PET scans of people who were given a placebo, so maybe they’d have neuroplastic changes, too. 2. How do you explain the positive neuroplastic (and behavioral) changes in mice that are given an SSRI? 3. Would SSRIs show a more significant effect (vs. placebo) the longer folks take them? It seems that most studies aren’t long enough. Here’s an example of the neuroplasticity I mentioned: kzbin.info/www/bejne/oWOklZiYfsera7s
@elle45203 жыл бұрын
13:21 but was suicider depressed? maybe not at all or wrongfully ruled suicide.. just devils advocate because exponential variables in every study make me have these intrusive room for error thoughts
@DrZhivago-l2b3 жыл бұрын
I imagine they studied the brains of more than one person who has committed suicide.