Biomimetic Nanoparticles for Personalized Medicine

Abstract: In the past decade, the development of biomimetic nanocarriers opened new scenarios in the field of nanotechnology related to the development of drug delivery systems. Particularly, we are witnessing the shift from the original concept of the nanocarrier as inert material with the only function of protection and delivery of the payload, to a more sophisticated entity that combines synthetic and biologic properties in the same nanoparticle. In this talk I will introduce the design and development of bio-hybrid liposome-like nanovesicles, called Leukosomes, by formulating the membrane proteins of circulating leukocytes with synthetic biocompatible lipids, of which we showed both their innate targeting and drug delivery properties in different mouse models, i.e., atherosclerosis and cancer. Besides the drug delivery activity typical of nanomedicines, interestingly we could observe also an intrinsic anti-inflammatory effect, which suggested us of their potential role in the treatment of inflammatory diseases like sepsis-like LPS-induced endotoxicosis and inflamed bowel disease.
Keywords: Nanomedicine; nanotechnology; biomimicry, inflammation, theranostics.
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