Bone Growth and Remodeling: Appositional and Interstitial Growth

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Prof Knoppy

Күн бұрын

Whitespace lecture capture on the processes of Appositional and Interstitial growth influences on bone remodeling.

Пікірлер: 26

@ProfKnoppy 10 жыл бұрын

Thanks so much for watching and posting!! This is somewhat gender and individual specific....but in general, a person begins having reduced ability to build bones around this age. However, it is different based on an individuals genetic history as well as gender. A female has a higher incidence of osteoperosis due to the effects of estrogen on osteoclast activity.

@rachelmcadamslover 10 жыл бұрын

Extremely helpful! Thanks a lot !

@tmsact8577 8 жыл бұрын

Awesome video!!

@hiranyasankarroychowdhury1547 10 жыл бұрын

Just one comment. Osteoclasts are derived from monocytes, which in turn are derived from myeloid cell line.

@ProfKnoppy 10 жыл бұрын

Hiranya, Thank you for commenting. That is correct. The osteoclasts are derived from the myeloid cell line enabling phagocytosis for bone degradation.

@rachelmcadamslover 10 жыл бұрын

Ps: my teacher said that bone peaks in mass at 30 years old. If this true? So after thirty, our bones cannot get any thicker? Thanks once again

@ProfKnoppy 10 жыл бұрын

You are welcome!!! I hope it helped you... please like and subscribe if you would...

@mehrnooshvalipour7970 7 жыл бұрын

What about zone of reserved cartilage ?

@JF-dx5wl 10 жыл бұрын

Thanks you

@YousifAli-hy4sh 10 жыл бұрын

Thanks so much..i want to ask you....after appositional growth of cartilage the triggering of calcification and destruction of chondrocytes will occur directly that is true or wrong????

@ProfKnoppy 10 жыл бұрын

Yousif, The calcification process can be triggered by several factors. I will give two major ones here. (1) The deposition of cartilage in bone is the body's response to stress on that bone (Wolffs law of bone). The osteocytes will trigger the process of appositional growth where osteoblasts lay down bone. As the bone is deposited, the chondrocytes have reduced diffusion of nutrients thus dying. (2) Hormones, such as growth hormone, can trigger bone growth as well. The cells of bone growth (chondroblasts and osteoblasts) are affected by this hormone causing them to multiply and deposit bone. In addition, growth hormone causes the production of IGF-1 (insulin like growth factor) increasing the activity of these cells.

@YousifAli-hy4sh 10 жыл бұрын

Thank you prof .......you helped me :)

@MysticMD 8 жыл бұрын

thank you so much ! :)

@ProfKnoppy 8 жыл бұрын

You are very welcome! I am so glad that it helped you.

@MegaTylerDavis 10 жыл бұрын

What about the zone of lacroix and the growth plate progenitor cells? Please check out NaturalHeightGrowth and Height Quest to share your thoughts.

@syednaseemshah7102 8 жыл бұрын

sir. wt is appositional growth or surface accretion

@ProfKnoppy 8 жыл бұрын

appositional growth is growth that increases the circumference of the bone to help resist stress that is placed on it. This growth is not from epiphyseal plates (growth plates) but rather the combined action of osteocytes and osteoblasts to deposit both the inorganic and organic components of the bone matrix.

@MegaTylerDavis 7 жыл бұрын

A couple of things. Wolf's law really is just the bone adapts in a manner specific to the stresses placed upon it. Now this tends to be more deposition in response to the load placed upon but it doesn't have to be. Bone adapts to the stresses placed upon it and in a manner specific to the stresses placed upon it but there's no guarantee that adaptation will be the best, most logical manner relative to the stimulus. Also, you saw that appositional growth is growth of the diameter but that is not strictly true as well. Appositional growth can theoretically occur on the longitudinal ends of the bones as well. But where would you get the osteoblasts to deposit the bone in those cases? The articular chondrocytes I have seen evidence can differentiate into bone cells though.

@ProfKnoppy 7 жыл бұрын

+MegaTylerDavis fair points... please keep in mind that these videos are made for beginning A&P students... they are meant to streamline and simplify the complexities of bone growth and repair... Thanks so much for posting!

@ProfKnoppy 7 жыл бұрын

+MegaTylerDavis those are all good points...please keep in mind that these videos are made for beginning A&P students.. in that sense some generalizations are made to prevent the student from being overwhelmed in the topic... In addition, the information is presented in a general way to draw on the "average" person's general knowledge... Thanks for the input!