Bone Homeostasis (Calcium and Phosphate) Hormones

armandoh.org/
Part III

[@1102sn]

there is a special place in heaven for armando hasudungan. life savior of thousands med studs

[@armandohasudungan]

@gentletribe gomen, Im not really a chemistry guy. But I will upload some biochem on macromolecules, DNA and its chemical constituents. Not on other topics, mainly concentrating on cells, I hope that is good?

[@lrbolotin1227]

People telling to slow down... you can stop and listen again, it's KZbin, not live TV.

[@lengsenghong9591]

I listened at 1.5 speed hmm

[@areebajameel2907]

Well said 🤭😂

[@baudrey15]

Tip for people saying he talks too fast : you can lower the speed to 0,75, or even 0,50 in the settings if you want

[@armandohasudungan]

Yes, that was a mistake I said, but couldnt correct, cause I was recording and nearly finished (and had to many attempts). Good you brought it up though. Thank you~

[@ShiraRachlin]

Hey! I just wanted to thank Armando (and if anyone else is behind this channel) for all your help over the years. I found your videos when I was studying for AP Biology in high school and they’re just as helpful now as I prep for interviews for my masters. Learning how to make my notes more like your videos is honestly a huge part of why I’m still in life sciences today!!

[@theadrinka86]

I noticed 2 mistakes in the video, PTH enhances uptake of phosphate in BONE and GI tract. He said twice that PO4 is not reabsorbed in the bone, but it is!

[@Brahminix]

Dear Armando Im seriously in love.... With your videos... They're so amazing. Your video on beta oxidation of fatty acids actually gave me an A++ on my seminar... Thanks... Byt the way.. I dont remember which video exactly, but it was something from endocrinology.. You said you didnt know about the function of one of the two hormones- calcitonin or calcitrol... I dont remember, sorry... But i do know they both are antagonistic hormones i guess.. Work in the regulation ofcalcium level in bone and blood...... Please do post some more endocrinology videos... We'll love it.. Thanks Armando.

[@Fuskobot]

Youve come a long way armando, comparing this to your newer videos you sure have improved :D Thanks for the videos and please never stop ;)

[@ViHoney]

Brilliant. This helps tremendously!! Thank you so much.

[@giraffeting]

This is really clear and helpful! One little thing though: Phosphate has 3 negative charges, not one

[@RahulSharma-bj7bl]

Hi Armando, your videos are really great. You mentioned in your drawing Pharynx to adam's apple, did you mean Larynx?

[@lielenetsanet7919]

the lecture is so great tnks aramndo...but i noticed a mistake in osteoclast the bone release both po4 and calcium so the action of pth on osteoclast increase both po4 and ca unlike the action of pth on the kidney cos in the renal system pth favours the excreation of po4 and reabsorption of ca.

[@armandohasudungan]

Cheers!

[@rockymountainwoman2618]

At 8:16 you stated that if the body senses "low plasma calcium" it will stimulate the thyroid to secrete calcitonin. Did you mean "high calcium levels?" I am confused. Is this a verbal error? I thought calcitonin had an opposite role of parathyroid hormone and 1,25 vitamin D OH?? On the chart you have a drawing of plasma calcium in relationship to calcitonin with an arrow pointing up. At 2:45 you say the body senses high concentrations of calcium in the plasma so the thyroid gland secretes calcitonin which helps lower calcium concentrations in the body.

[@BlueSky-lc4gx]

You are right there was a mistake the correct is that when the plasma calcium is high thyroid gland will release calcitonin to decrease it but when calcium level is low in plasma there will be secretion off parathyroid hormons .

[@jakeperry7719]

I like the drawing on your hand

[@negvpay]

oh god you are AMAZING i am 1st semester PA student and they cant explain these but you saved my life :)

[@Zen00neZ]

Great stuff man! One comment though: PTH in small concentrations will stimulate bone turnover continuous concentration of PTH will put Ca++ out the bone In the short run Vit D will stimulate PTH, in the long run it will decrease PTH production... Love your videos!

[@bitsandpieces5953]

what would i do without armando :')

[@mrarvayoachtinstructor8717]

fix the audio i hear static and its distracting, very good discussion, intelligently done.

[@darshandcoolest]

There is one mistake.... at 8:12 - 8:16 , you said If the body senses low amount of calcium, then it secretes Calcitonin.... Actually its opposite.. Though the arrows which you hav drawn are correct....

[@Viktir123]

Nice explanation. And I can understand your accent perfectly too.

[@juanmiguelreyes8502]

came here to learn about the things that our professor was supposed to teach

[@vaisakh3462]

Aye another recent viewer. Howdy! :)

[@KatieFerraro1]

This is fantastic.

[@DailyDoctor1]

U r doing gr8 work Sir. I highly appreciate ur work. Hats off to u 4 ur gr8 deeds.

[@dornsapothecary]

Really enjoyed this. Appealed to my inner visual learner!

[@oliviac8838]

Hi there, Just noticed some incorrect information- The C cells in the thyroid produce calcitonin, not PTH. PTH comes from the parathyroid glands embedded in the posterior thyroid tissue

[@syndihardja6359]

It's not C cells but Chief Cells. Totally different.

[@TheJace504]

Olivia C C cells are also called Parafollicular cells which were mentioned in the video btw. Chiefs cells are different.

[@rachaelbetancourt9225]

Can you please make a fluid and electrolyte balance tutorial? Your drawings are very helpful!

[@cormacdoyle3435]

Really good. Love the style.

[@brijsharma7778]

What can you advise on calcium deficiency in lumber bones, diet and calcium content in tablets and vitamin D? BBSharma

[@vwziful]

This is not quite correct .PTH effect on Git is only indirect thru bit D and calcitonin has no effect on kidneys or Git .only osteoclasts have receptors for calcitonin and thru its receptors calcitonin inhibits osteoclasts activation and and stops new formation ( Guyton and katzung)

[@tsunaguichikawa5531]

Question: Why do we need sufficient Ca ions and phosphate ions in the blood? What functions do they serve?

[@simpl6775]

Ca : 1 nerve conduction 2 cardiac pacemaker 3 muscle contraction P : 1 phospholipids 2 ATP 3 various cell metabolism

[@vrennelligailpueblo6933]

I hope u will do electrolytes this topic is very confusing specially with each function of ions so like ur videos and dont rush ur videos next time thnx

[@sudhirchaudhary5080]

always go for naturaly made products . brands like earthyboon & patanjali deliver best results

[@edris.alkozi]

There is one using wrong word and should be high level of calcium not low level of calcium cause as you know in high level of calcium calcitonin has to be secrets. If you take look in video in 8:11 you will notes it instead of low calcium should be high level of calcium just friendly amendment. the rest is very good explanation.

[@yazann4886]

1:04 the drawings are already there and he repeats on them ;) even before check it every time the page is empty also in 8:11 increased calcium not decreased... that was a mistake

[@Emmathe12th]

nice! in the beginning, the pharynx, is actually the larynx :)

[@drdineshkarma7579]

Thanks sir

[@itsisraLy]

Think you so much

[@laragharzeddin3977]

genius

[@HamidHamid-vj3um]

Which is bone remodeling hormone Calcitonin or parathyroid hormone

[@kevinmoll-llobell5151]

Good Job, after immuno, endocrino system could be a good idea. Thanks a lot Armando ;)

[@aaronli1042]

very talented

[@stelioskolomvounis]

Amazing work!!! One question: osteoclasts activity on the bone tissue does increase serum phosphate level as well? How is phosphate regulated? Isn't it like calcium regulation?

[@brittanyrouse2859]

I know you asked this a year ago, but I can answer this! So osteoclasts make FGF-23 which is what regulates phosphate. FGF-23 is a hormone that acts on the kidneys to decrease NPT2 (sodium phosphate cotransporter 2). When you decrease this transporter the only place phosphate has to go, is into the collecting duct to be excreted! Hope that helped!

[@isoldesolange1739]

@@brittanyrouse2859 How can the phosphate be reabsorbed by the bone ? Is calcitonin helping to deposit back the calcium and phosphate? Thanks

[@MssMystery]

Thanx. Great job, very helpful.

[@constantion305]

DUDE YOU MAKE AMAZING VIDEOS THANK YOU!!

[@ravikumarmeshram8882]

thanks..!!! it is very nice explanation..!!!

[@OJASVIVYAS]

thank you sir..really helpful..could you plzzzzzzzzzzzzz upload more videos on physiology..CVS.RESPI..etcc plzzzzzzzzzzz

[@alsh123am3]

Sry but Calcitonin and PTH are both having the same influence on the kidneys... they lead to a decrease of Phosphatresorption and an increase of Calciumabsorption. Indeed they are antagonists in the bones but NOT in the kidneys... in the kidneys they work as synergists.

[@sbubearcat]

Even tho this is a year old... PTH increases Phosphate excretion, Increases Calcium Reabsorption. Has always been that way. He had it right.

[@jayshreedey7571]

Is Vitamin D a hormone?

[@RobWalker1]

superb

[@MrManpower99]

electrolytes plz.. and neurosciences...and amyloidosis..plz live up to my expectations for upcuming videos too.. u r very fast, more than my adaptation power..plz be slower in the nxt time..

[@cuteXpuffy]

that was great, but I wish you were slower. thank you

[@mna3694]

thank you so much

[@areebajameel2907]

Thank you soooo much

[@vrennelligailpueblo6933]

Nice way of illustrating but its just so fast i mean the discussion is like in a hurry no time to digest all the info needed to remember but its okay though, myt as well pause and rewind

[@Viktir123]

What can you do to lower your parathyroid count?

[@rapaceable]

good job men that's great

[@giraffeting]

Sorry...since plama has a pH of around 7.4, HPO4(2-) dominates. All my professors just use PO4(-) for short, like what you did in the video.

[@belbenanel5566]

I think its the stomach that releases gastrin not the duodenum.

[@ELFCloudGamer]

Bel Villanil Yes you're right, but gastrin is also produced by the duodenum and pancreas :)

[@anasamer7223]

+Bel Villanil Gastrin is secreted form G cells in the pyloric antrum in stomach, and from TG cells in the duodenum.

[@Teresahorner]

So what do you do if phosphate level to high sir?

[@vrennelligailpueblo6933]

Nice

[@iulyci]

Thanks dude!

[@chonalynmagtoto5520]

U talked cery fast. Vid is good though and helpful

[@vrennelligailpueblo6933]

I hope u will do

[@Ahoywhore]

Wow thank you!!!

[@JP-rz2vt]

you are pretty awesome!!

[@lupineous]

Muffled Sound.

[@twright4650]

I love that Vitamin is discussed (D3). But what of Vitamin K2 ? D3 should never be supplemented without its cousin helper Vitamin - K2. This Fat Soluble Vitamin (as I understand it) is essential. AND, without it Calcitonin related calcium activation proteins do not get "Activated" essentially gumming up the metabolic works blocking proper metabolism of calcium (from blood to bones, teeth etc) The chronic lack of Vitamin K2 (true in western diets) is now being thought to be associated with ALL the Calcium related metabolism issues and show up today as very familiar modern ailments (e.g., calcification of arteries, osteoporosis etc...) I do love all your videos. Very, very informative. Thanks!

[@flightsimusman]

Yes you are correct. Lack of vitamin D3, K2, magnesium and/or bile production is responsible for many calcium related issues such as soft tissue calcification, kidney stones, atherosclerosis, etc.

[@daydecz673]

Good Video, but you draw the Larynx and called it the Pharynx... which made me question if the rest of the info was fully accurate.

[@Interactivemedicine]

YOU ARE GOD!

[@vwziful]

Stops new osteoclasts formation

[@ElinoraFrench]

Awesomeeeee!! :)

[@annychen5194]

who's Bob in the video🤣

[@achiriu1987]

too fast

[@marcbernier7185]

Chief not Cheif (Minor mistake)

[@Sujjaad]

Nice, no google docs jpeg for this tho?

[@abdoukamal7736]

uhkk

[@anttt7993]

Great video...but really man, SLOW DOWN

[@Kmfash]

you are way too fast when talking

[@mattkneale2785]

He's fine, I watch his stuff on x2 speed

[@Baharaakbari]

may be he is not native speaker like me and your words are more exaggeration than what you really are , its so high speed for one who want to understand especially in medical .

[@zhuzhuyu8356]

Rosa poya mehr I think his English is pretty good. Try listening to Polish people speak English 😵

[@hikaruwerasombati3786]

Matt Kneale ?

[@thetoothfixer8509]

You are too slow when trying to comprehend. just lower the speed.

[@vyshakgowda6034]

you are tooooo fast