BRUGADA syndrome, from genetic mutation to sudden cardiac death, ESC 2022 guideline review

[@Andrew-ny1dl]

Bro this is amazing. I've been waiting for Phase 2 reentry and you didn't let down) Btw Brugada syndrome concealing was new for me, and tbh I feel sane when I start to understand why exactly something works as it does. Thanks for an amazing video. Keep it up

[@Foxterrier]

@Andrew-ny1dl glad to see that my video helps you, your comment really motivates me to keep doing, thanks)

[@krishvasa7644]

Great video! But why does further accentuation of the notch lead to a longer epicardial action potential?

[@Foxterrier]

Thank you for the question, it is challenging, concept that I represented in video called repolarization theory of brugada syndrome but unfortunately not all details are completely understood. Another theory that can explain the Brugada syndrome is depolarization theory which based on conduction delay in RVOT as a crutial part of pathogenesis.

[@krishvasa7644]

@@Foxterrier thanks a lot for the reply! Will check that out. This video was really excellent, made ECG translation from action potential more intuitive for me

[@Foxterrier]

@krishvasa7644 you welcome, this is exactly thing that I try to achieve go from mutation to ecg changes and symptoms, happy that you like it)