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in this video, I explained detail etiology and pathogenesis or pathophysiology of cancer.
the effective utelising of anticancer agent requires an uderstanding of the pathogenesis of cancer cells, cellula kinetics and pharmacology of the drugs. Cancer cells are generally characterized by their
• Uncontrolled proliferation (decreare apoptpsis, increase telomerase (RNA dependent DNA polymerase
expression).
• Uncontrolled differenciation and loss of the function
• Invasiveness - Tendency to spread over healthy cell
• Metastesis- Spead to different part of body
Normal cells are converted into cancer cells by mutation of the nomal base sequences of DNA which can be inherited or acquired and that lead to uncontrolled proliferation of the cells and become a tumor cells by inactivation oftumor suppression gene (Antioncogene) or convertion ofproto-oncogene (control normal cell devision, apoptosis and deffrentiation)to oncogene. Thus may lead to several changes in cellular system like:
• Over expression of growth fector receptor on the cells.
• Production of their own extracellular growth factor
• Production of cell cycle transducer e.g. cyclin-dependent kinases (cdks), cdk inhibitors and cyclins
• Inhibit apoptosis
• Tumor directed angeogenesis
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