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Cellular Adaptations -
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Cellular adaptations refer to the changes that cells undergo in response to various stimuli or stressors. These adaptations can be physiological (normal responses) or pathological (responses to disease). Understanding these adaptations is crucial in fields such as pathology, physiology, and medicine.
Types of Cellular Adaptations
1) Hypertrophy 💪 -
Definition: An increase in cell size, leading to an increase in the size of the organ.
Example: Cardiac hypertrophy due to high blood pressure, where heart muscle cells enlarge to manage increased workload.
Physiological Aspect: Muscle training can also cause hypertrophy in skeletal muscles.
2) Hyperplasia 📈
Definition: An increase in the number of cells in an organ or tissue.
Example: Endometrial hyperplasia due to hormonal stimulation, often seen in conditions like estrogen excess.
Physiological Aspect: Compensatory hyperplasia occurs in the liver after partial hepatectomy (removal of a part of the liver).
3) Atrophy 📉-
Definition: A decrease in cell size or number, leading to a reduction in the size of the organ.
Example: Muscle atrophy from disuse (e.g., immobilization) or from aging (senile atrophy).
Physiological Aspect: Normal aging processes can lead to atrophy in various tissues.
4) Metaplasia 🔄-
Definition: A reversible change where one type of mature cell is replaced by another type of mature cell.
Example: Squamous metaplasia in the respiratory tract of smokers, where normal columnar epithelial cells are replaced by squamous cells to better withstand irritation.
Physiological Aspect: This adaptation can help protect tissues from harmful stimuli.
5) Dysplasia ⚠️-
Definition: Abnormal development or growth of cells, often seen as a pre-cancerous condition.
Example: Cervical dysplasia detected during Pap smears, where abnormal squamous cells are observed.
Pathological Aspect: Dysplasia can lead to cancer if not resolved.
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