CheckMate 9DW: the future of checkpoint inhibitors in advanced HCC

Laura Williams Goff, MD, MSCI, MMHC, Vanderbilt-Ingram Cancer Center, Nashville, TN, provides insight on the CheckMate 9DW trial (NCT04039607) of nivolumab plus ipilimumab versus sorafenib or lenvatinib in patients with advanced hepatocellular carcinoma (HCC). The results demonstrated a statistically significant improvement in overall survival (OS) rates for patients receiving nivolumab plus ipilimumab. Additionally, nivolumab plus ipilimumab outperformed both atezolizumab plus bevacizumab, as reported in the IMbrave150 trial (NCT03434379), and durvalumab plus tremelimumab, as seen in the HIMALAYA trial (NCT03298451). This interview took place during the 2024 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.
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