Chemotherapy of Antibiotics (Part-07) Penicillin (3)| Semisynthetic Penicillin | Chemotherapy

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(1) Gram Staining techniques- • Gram Staining Techniqu... and Other staining techniques - • Microbial Staining | S...
(2) Microbial assay of antibiotics- • Microbial Assay of Ant...
(3) Route of Drug Administration- • Route of Drug Administ...
(4) Pharmacokinetic and Dynamics- • General Pharmacology C...
(5) Antibiotics Classifications- • Classification of Anti...
(6) Antiviral mechanism- • Antiviral Drugs | Clas...
(7) Factors Modifying drug action - • Factors Modifying Drug...
Antibiotics can be defined as pharmacological agents that selectively kill or inhibit the growth of bacterial cells while having little or no effect on the mammalian host. Bacteriostatic antibiotics prevent further replication of bacteria and therefore rely on an intact immune system to clear the infection, whereas bactericidal antibiotics kill the bacteria. Types of Antimicrobial therapy-
Selection of antibiotics depends on many factors such as-
1. Identity of microorganism = Sample of Body Fluid and Staining Techniques
2. Antimicrobial susceptibility = Bacteriostatic and bactericidal along with a minimum inhibitory concentration (MIC)
3. Site of Infection (BBB)= Lipid solubility along with molecular weight and plasma protein binding of drugs
4. Patient-related factors- Immune system, Renal dysfunction, Hepatic dysfunction along with poor perfusion and state of pregnancy and lactation
5. Safety of antimicrobial or antibiotics
6. Cost of antibiotic therapy
7. Route of drug administration- oral, topical, or parenteral
Basic Classification of antibiotics-
1. Chemical Structure- Sulphonamides, Diaminopyramidines, Quinolones, Beta-lactam antibiotics, tetracycline, nitrobenzene derivatives, aminoglycosides, macrolides, lincosamide antibiotics, Glycopeptide antibiotics, Oxazolidione antibiotics, polypeptide antibiotics, nicotinic acid derivatives, azole derivative, Other antibiotics
2. Types of the organism which they are used
A. Antibacterial chemotherapy, the use of antibacterial drugs to treat bacterial infections
B. Antifungal chemotherapy, the use of antifungal drugs to treat fungal infections
C. Anthelminthic chemotherapy, the use of anthelminthic drugs to treat worm infections
D. Antiprotozoal chemotherapy, the use of antiprotozoal drugs to treat protozoan infections
E. Antiviral chemotherapy, the use of antiviral drugs to treat viral infections
3. The spectrum of activity- Broad and narrow spectrum
4. Types of action- Bacteriostatic of bactericidal
5. Source of antibiotics- Fungal, bacteria, Actinomycetes
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Sir im from Pakistan and I like your vedio very much sir please focus more on the uses of antibiotics there different type of ampicillin which are use for same bacteria if these are differentiate it will be very better thanks sir

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Sir Ampicillin and Aminopenicillin should be taken simultaneously? For better results

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[@drtarunkumarchaurasia1803]

explain sir please ,injectible suspension like 600000 units/1ml syringe 1.2 million units/2ml syringe. like in case of pneumonia 600000-1000000 units IM qDay.

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Naic information sir

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[@MANISHKUMAR-rz5fv]

Thanku soo much sir ✌️✌️🙏🙏💞💞💞 ,......sir penicillinase and beta lactamas both enzyme are same or not ? Plz explain.......I think beta lactamas and penicillinase both are same because beta lactam ring present in all type of penicillin and pencilline is work by attached beta lactama ring to the bacterial cell wall and inhibit synthesis of cell wall ........sir am I right? Plz explain. Thanku

[@solutionpharmacy]

Not same. Please ek baar aur parts ko dekhiye

[@MANISHKUMAR-rz5fv]

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[@solutionpharmacy]

Thank you. God bless you too

[@mdhurisingh6454]

Sir both ampicillin and amoxicillin come under aminopenicillin???

[@vishwanathajadhav5668]

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[@durgeshsingh6447]

Thanku sir

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Sir pls explain attained high blood level

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Where is your medical

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[@satyajitdas7079]

Why naficilin is given parenterally? Sorry sir Can you please explain it?

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[@mdhurisingh6454]

Sir acid resistance are acid stable?

[@saguftakhanam2356]

Sir why you not include carboxypenicillins as well ureidopenicillins as they are also extended spectrum penicillins and it is given in kd triphati 8th edition book???

[@solutionpharmacy]

I have given the reference

[@sakshibundake3299]

Hello Sir, why Methicillin is used in penicillinase producing Staphylococcal infection?

[@solutionpharmacy]

Because it prevent activity of degrading enzyme

[@iramsabaarab5223]

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[@solutionpharmacy]

Thank you

[@mdhurisingh6454]

Sir aminopenicillin are acid stable?

[@driqra9016]

Sir cephalosporins along with penicillin. We can given both at a time??????

[@maruticlinicallab956]

Fane ho Gaya apde study me sir

[@solutionpharmacy]

Thank you so much

[@istiqbalkhan1292]

Sir you told us that Penicillin V is semisynthetic but in Lippincott it is placed in Natural p Sir G please comment

[@i_mermaid]

Sir please explain that point once. That ampicillins activity increases with beta lactamase inhibitors.

[@solutionpharmacy]

By typing it will be difficult to explain exactly. I tequest you to watch it again but if still not clear then i will type it for you

[@i_mermaid]

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@@i_mermaid Great. Happy to know that. All the best

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[@solutionpharmacy]

Thank you

[@manishmishra8486]

hello sir. You said penicillinase resistant penicillins are less effective to non-penicillinase producing microoraganism. Then why Nafcillin is given actively against non-penicillinase producing bacteria if it is highly resistant to penicillinase. Sir please clear this doubt of mine. Thank you

[@solutionpharmacy]

These are active against penicillinase-producing and non penicillinase-producing strains of Staphylococcus species.

[@manishmishra8486]

@@solutionpharmacy thank you so much sir for replying and clearing my doubt.

[@pravinpatel7657]

Sir, drug ka dose patient pr bhi dipant karta h kya? ki fever jadha hoga to dose bhi jadha denge adult dose ki tulna me

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Ha bilkul

[@anupverma6225]

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[@anjalipandey7292]

Sir I have a doubt if you could clear that would be really very much helpful.. Sir in some books like Prescott Penicillin V is placed under natural Penicillins. To Penicillin V natural Penicillin ka example hai ya semisynthetic I am confused

[@solutionpharmacy]

Its semisynthetic

[@majeedullahullah2243]

❤❤❤

[@shahzadalam8703]

Sir what is 'V' and 'G' in penicillin V and penicillin G ?

[@solutionpharmacy]

Just types

[@krishnachandra1766]

Allopurinol.?

[@yawarhayat4886]

Sir you are not write the recommended book in discreption. Sir please write on white board or in discreption thank you sir

[@solutionpharmacy]

Yawar Hayat why dont you see the video till last. I aways give reference. You can ask ys to do bur you should go through video

[@ruvayethussain1579]

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[@solutionpharmacy]

Hai na separate. Playlist to dekhiye

[@ruvayethussain1579]

firstly thank u thank u so much for reply Sir.... Sir edar unit wise hota tu bahut easy hota..anyway Sir..thank u...

[@ruvayethussain1579]

woh podhenge tu enough he na sir... passed korne ki liye

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Ruvayet Hussain unit wise aur sem wise sab hai

[@ruvayethussain1579]

thank you...thank you so much Sir..

[@nikitaagarwal8355]

Sir i m not able to understand the penicillinase resistant penicillin part....can you make me understand that plzzz

[@solutionpharmacy]

Nikita Agarwal please watch it again. Hope you will get. But for this you must watch all parts.

[@tanishajain7594]

Sir can uh please tell important ques from this chemotherapy chapter according to GTU ?

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Please check description box or download our app

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[@tanishajain7594]

Thank you sir🙏

[@user-hb3np6ym3k]

Sir, penicillinase and beta lactamase me kya diff. H

[@solutionpharmacy]

Difference in activity and responsible chemical. Please watch previous and further video

[@mudsairkhan9704]

SIR please give us Animation vedio also ,very helpfull for us

[@solutionpharmacy]

Already given

[@sadafskhan6381]

Sir synthesis of antibiotics topic pr video available ho jaaye to.

[@solutionpharmacy]

Sorry its not available

[@manishasisodia193]

Sir aapka carboxypenicillins aur ureidopenicillins का video नहीं मिला

[@solutionpharmacy]

Nahi hai

[@ashmitmehta7772]

Sir is the mode of action is same for all penicillin drugs?

[@solutionpharmacy]

Mode are same but mechanism is bit differ for other type like - penicillinase inhibitors

[@ashmitmehta7772]

@@solutionpharmacy all penicilin are cell wall inhibitor?

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[@Kavitapatel2002]

Agar ye penicillin acid resistance hai To phir kyu uski bioavailability low hai sir?🥲

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Uske aur kai factors hai

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Chemotherapy part 8 nahi mil raha sir

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Hai. Dekhiye

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[@sumanchoudhary5978]

Sir penicillin v me v ka matlb kaya h

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Its name only not full form

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[@urwa4954]

CORRECTION: penicillin v is a natural penicillin , NOT SEMI SYNTHETIC.

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Agree but few good book have this info

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Please sir i am waiting

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Thank you sir...

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My pleasure

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Thanks sir

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Thank you Sir......🙏