Chemotherapy of Antibiotics (Part-11) Chloramphenicol Mechanism of Action | Chloramphenicol Spectrum

Download "Solution Pharmacy" Mobile App to Get All Uploaded Notes, Model Question Papers, Answer Papers, Online Test and other GPAT Materials - play.google.com/store/apps/de...
(1) Gram Staining techniques- • Gram Staining Techniqu... and Other staining techniques - • Microbial Staining | S...
(2) Microbial assay of antibiotics- • Microbial Assay of Ant...
(3) Route of Drug Administration- • Route of Drug Administ...
(4) Pharmacokinetic and Dynamics- • General Pharmacology C...
(5) Antibiotics Classifications- • Classification of Anti...
(6) Antiviral mechanism- • Antiviral Drugs | Clas...
(7) Factors Modifying drug action - • Factors Modifying Drug...
Antibiotics can be defined as pharmacological agents that selectively kill or inhibit the growth of bacterial cells while having little or no effect on the mammalian host. Bacteriostatic antibiotics prevent further replication of bacteria and therefore rely on an intact immune system to clear the infection, whereas bactericidal antibiotics kill the bacteria. Types of Antimicrobial therapy-
Selection of antibiotics depends on many factors such as-
1. Identity of microorganism = Sample of Body Fluid and Staining Techniques
2. Antimicrobial susceptibility = Bacteriostatic and bactericidal along with a minimum inhibitory concentration (MIC)
3. Site of Infection (BBB)= Lipid solubility along with molecular weight and plasma protein binding of drugs
4. Patient-related factors- Immune system, Renal dysfunction, Hepatic dysfunction along with poor perfusion and state of pregnancy and lactation
5. Safety of antimicrobial or antibiotics
6. Cost of antibiotic therapy
7. Route of drug administration- oral, topical, or parenteral
Basic Classification of antibiotics-
1. Chemical Structure- Sulphonamides, Diaminopyramidines, Quinolones, Beta-lactam antibiotics, tetracycline, nitrobenzene derivatives, aminoglycosides, macrolides, lincosamide antibiotics, Glycopeptide antibiotics, Oxazolidione antibiotics, polypeptide antibiotics, nicotinic acid derivatives, azole derivative, Other antibiotics
2. Types of the organism which they are used
A. Antibacterial chemotherapy, the use of antibacterial drugs to treat bacterial infections
B. Antifungal chemotherapy, the use of antifungal drugs to treat fungal infections
C. Anthelminthic chemotherapy, the use of anthelminthic drugs to treat worm infections
D. Antiprotozoal chemotherapy, the use of antiprotozoal drugs to treat protozoan infections
E. Antiviral chemotherapy, the use of antiviral drugs to treat viral infections
3. The spectrum of activity- Broad and narrow spectrum
4. Types of action- Bacteriostatic of bactericidal
5. Source of antibiotics- Fungal, bacteria, Actinomycetes
Get in touch with the solution by just clicking following links-
Facebook Group- / solutionpharamcy
Facebook Page- / pharmavideo
New channel (Pharmacy Dictionary) - / @pharmacydictionary
Instagram- / solutionpharmacy
E-Mail for official and other work - [e-mail]
LinkedIn- / pushpendrakpatel
#solutionpharmacy #Pharmacologyclass #GPATonlinetest

[@TheSilentStrum]

I related it with KD Tripathi and in your vedio it is exactly explained in much easy way you are amazing sir thanku so much

[@solutionpharmacy]

Suraj Panth Thank you so much

[@narinderthakur1912]

sir you are great! you are an inspiration to many people out there! you have helped us in this pandemic and that means a lot sir! !!! but sir its a mere request to make diagrams a little big in size to understand properly ! cause it makes us confuse as you have overlap some points to make us understand!!! but yeah wish you all the best and a great successs ahead.

[@solutionpharmacy]

Thank you so much for your suggestion. There are 02 points i would like to add (1) If you inctease the youtube video quality to HD then image will be more clear and (2) we have uploaded these images as animation in powerpoint which you can find in playlist

[@ajaysrivastava5963]

How to thank you sir! Iam watching your chemotherapy of antibiotics very attentively . I can say proudly that solution pharmacy is the best of all in India 🎉🎉🎉🎉

[@ajaysrivastava5963]

Sir publish your own books on pharmacology , , it will be boon for us 🎉🎉🎉

[@solutionpharmacy]

Thank you so much.

[@solutionpharmacy]

We have MCQ book in HAP and pharmacology MCQ is about to come. Rest online MCQ are available in our app

[@ajaysrivastava5963]

Sir yadi kishi ko B pharmacy ka suru se dekhna ho to kaha se start kare ?

[@pratibhagupta4079]

Sir aapko bhagwaan sabase lambi umar de....thank you so muchhh so much!

[@solutionpharmacy]

Thank you so much. Aapke pyar aur shubhkamnaye ke liye

[@abhishekbehki15]

🙏🙏🙏🙏🙏🙏🙏thanx sir itni easy way mein samjhane ke liye agar aap na samjhate to pharmcology sabse tough subject tha

[@solutionpharmacy]

Thank you so much for feedback

[@drwahidhussain587]

I have no word to describe you.. Yours method of teachings are awesome.. Keep it up sir..

[@solutionpharmacy]

Thank you

[@GlobalSplendor-qx4vz]

Well explained 😊

[@sambitdas5065]

I always ever grateful to you sir 🙏🙏🙏🙏🙏

[@Jsp916]

Great lecture by great teacher👏👏

[@powerfulpawar05]

Thank you so much sir, your teaching style is unique and simple. ❤️🙏

[@solutionpharmacy]

My pleasure

[@vrijendra_maurya100]

Thank you sir ❤️❤️❤️

[@ShabirAhmed-ov3ql]

Thank you so much Sir ......🙏

[@daxhingfani3679]

One of the best teachers😍 thankyou so much sir

[@solutionpharmacy]

Thank you so much for your feedback

[@lofi_slowverbadsongs820]

Unbelievable teaching methodology God bless you sir🙏 Love from Pakistan ❤️

[@solutionpharmacy]

Thank you so much for your feedback and support.

[@mdnazirhussain7915]

Thanks you sir ap mahan hai sir

[@vishwanathajadhav5668]

Thanks alot sir

[@MANISHKUMAR-rz5fv]

thanku soo much sir

[@mohdshavez5123]

🙏 very very thank you sir God bless you and your family

[@solutionpharmacy]

Thanks alot

[@rajivdas8185]

Thanks, please help me to know about pharmacological properties of sparfloxacin,moxifloxacin,ofloxacin,ciprofloxacin,linezoid,levofloxacin

[@maheshrotepatil8007]

Thank u so much sir my all concepts are perfectly cleared👍🤟🤟😊

[@solutionpharmacy]

Thank you for feedback

[@Pharmacy3154]

Sir ji kya hmko yeh slides pdf ki form m mil skti hai please tell me 🙏🙏🙏sir ji about something

[@007.shailendrakaushik7]

Thanks Sir....help a lot

[@solutionpharmacy]

My pleasure

[@durgeshsingh6447]

Thanku sir

[@kissuchoudhary8722]

Sir I'm very very interesting for your class sir, mujhe bhot topic ki help mili h

[@solutionpharmacy]

Thank you

[@anafatma66]

Thanks a lot sir......your videos are really helpful

[@solutionpharmacy]

Thank you

[@tanmaygajbhiye6203]

As usual ur the best❣️❣️❣️

[@solutionpharmacy]

Thank you

[@lovely_Chauhan01]

Thank you so much sir u means a lot for us...

[@solutionpharmacy]

Thank you so much for your kind feedback and support

[@basirshaikh247]

Thank you sir splendid explanation

[@solutionpharmacy]

Thank you

[@chintuapintua9929]

Thank you so much sir...😊

[@solutionpharmacy]

My pleasure

[@soumyaagrawal2023]

Thankyou so much sir.

[@solutionpharmacy]

My pleasure

[@vinitasolanki3627]

Thankuu sir 👍👍👍

[@solutionpharmacy]

My pleasure

[@uvsagu7]

Awesome

[@solutionpharmacy]

Thank you

[@Pharmacy3154]

Salute🙏 sir ji

[@solutionpharmacy]

Thank you

[@rashidulbsmmu]

thank you for nice and easy explanation

[@solutionpharmacy]

My pleasure

[@SAJIDKHAN-lt9iy]

Good Sir

[@navneetkumar5320]

So amazing

[@solutionpharmacy]

Thank you

[@chandrashekharkarhale2422]

Excellent 👌

[@solutionpharmacy]

Thank you so much

[@inchrist5570]

Thank you so much Sir 🤗🥰

[@solutionpharmacy]

My pleasure

[@mirhafeez3890]

Love you

[@AhsanKhan-ow9dz]

Sir mechanism of action samaj mein ayenehe raha hai,,,

[@gulamhussain8545]

Thank you

[@solutionpharmacy]

Welcome

[@divyathakur209]

Tqqq so much sir

[@solutionpharmacy]

Welcome

[@abdulhameedaryoubi808]

Sir.. Hope u will be fine and happy. I know i ask something that is not belongs to pharmacology subject but please Sir make an 3d or PowerPoint animation video on bacterial protein synthesis. I know you also explain it in video but i hope Can u understand me in animation PowerPoint or 3d video in sequence and step by step methods. I will be very thankful to u for this act of the kindness. Your sincerely student Abdul Hameed Aryoubi from Afghanistan

[@shwetadubey1546]

Mixed flora kya hota hai

[@akshaytambe3627]

Nice explain sir

[@solutionpharmacy]

Thank you

[@dhananjaysingh4133]

Thanks sir

[@solutionpharmacy]

Welcome

[@lovely_Chauhan01]

I have one doubt sir please clear.. bacteria resistance kaise karega khud ko antibiotic chloramphenicol se enzyme jo bacteria produce krta usako inactivate kr k??

[@solutionpharmacy]

Nahi koi alternative pathway bana kar jisse uska cell division aur separation ho sake. Resistance means usse bachne ke liye koi Naya rasta nikal lena.

[@lovely_Chauhan01]

@@solutionpharmacy thank you 😊

[@solutionpharmacy]

@lovely chauhan my pleasure

[@sohailmohiuddin7255]

Sir plz give an example of drugs which fall under this category

[@solutionpharmacy]

Chiramphenicol is example itself

[@aejazmahmood3012]

without source ko Jane hue ki yeh bacteria ya virus kis animal or birds me tha ! kya drugs or vaccine bnana possible hai ? if yes .. Toh please sir zaroor btaye ...

[@solutionpharmacy]

Vaccination depends on the nature of pathogens

[@thelearner1541]

This is not good to take drug own your own you can take otc drugs on the basis of appearance but for unknown symptoms laboratory test must be best to rely on to know the nature of organism and drug required to counter it, as sir explained some drugs may not work on particular person so at that time alternative drugs may be required this can be the another reason why we shouldn't take drugs by our own

[@solutionpharmacy]

Exactly. Thats the reasion we mostly (Untill necessory) dont explain the dose and brand name

[@drrkbhagat2869]

🙏 How will be decided drug doses and duration.

[@solutionpharmacy]

Please watch bioavailability topic

[@drrkbhagat2869]

Ok thank u sir 👍

[@FarhanKhan-ri6wh]

Inactivatimg enzyme lpx explain

[@mathstudy488]

Can I use in plants?

[@solutionpharmacy]

No

[@robstar2gaming424]

Sir I have been suffering from semisolid loose stool with mucus for more than 7 long years all my reports are fine but in my stool culture there is a Growth of Escherichia Coli ....I m dying for this ...in that culture report chloramphenicol has value 24 in the zone of inhibition and it is highly sensitive ..what to do ???

[@solutionpharmacy]

Nice

[@robstar2gaming424]

@Sreejita Sarkar ok sis

[@robstar2gaming424]

@Sreejita Sarkar nitrofurantoin has value 20 in my culture will it work ??

[@robstar2gaming424]

But Ciprofloxacin has value 19 only but highly sensitive in my culture there is no livofloxacin..😭

[@robstar2gaming424]

@Sreejita Sarkar sis my whatsapp number is .I want to show u my report of culture ...I mean there r three types in my culture 1 .highly sensitive 2.moderately sensitive 3..resistant ..which antibiotics should I take ??

[@abidurrahman3421]

Sir I can't found MONOBACTAMS AND CARBAPENEMS group of medicine Already i watched all videos from 1 to 10 number I need plz

[@solutionpharmacy]

These are not in our syllabus

[@abidurrahman3421]

@@solutionpharmacy ok sir

[@Anastesia2]

🌟🌟🌟🌟🌟

[@nikitaagarwal8355]

Sir plzz gpat k lia vdos bnaeaaa.....or guidance b chaea sir apkaaa

[@solutionpharmacy]

Actually we are theory based channel. Will start GPAT later

[@panuwatbill1956]

Can you put Eng subtitles plz 😢

[@suhanakhan4294]

Only one request hai ,sir ji please pathology k lecture provide kare

[@solutionpharmacy]

Jaldi aayega

[@suhanakhan4294]

@@solutionpharmacy thank you so much sir

[@shwetadubey1546]

Resistent na kre,aysa kyse hoskta hai

[@shwetadubey1546]

Kya sbhi antibiotics bure ke sath accche. Bacteria ko bhi khtm krdeta hai,to,kya koi aysa antibiotics nhi jo humanbeen. Ko nuksan bhi na phuchye or accche bacteria bache rhe,or accche bacteria kyse bdhye ja skte hai,card,ya kya khakr 🤪

[@poojabadve7777]

Thank you so much sir🙏🙏🙏 Sir,chloroamphinicol and erythromycin having same mechanism of action but only difference in transfer of peptide chain that is erythromycin inhit transfer of peptide chain from ASite to P site and chloramphenicol inhibiting transfer of peptide chain from P to A.. Is this right sir?

[@solutionpharmacy]

Yes. Exactly. You will get more MOA like these in upcoming vidoes.

[@solutionpharmacy]

You are learning very well.

[@poojabadve7777]

Ok sir .... Thank you sir...aapse hi sikha hai....

[@karanjaswal3543]

Nhi maam inka mechanism same nhi hai , i ll explain u , suppose kro ke jo P site hai udhar c3 mRNA codon hai aur jo A site hai udhar c4 mRNA codon hai to agar hum erythromycin nhi denge to jb peptide chain A site pe jayegi to Translocation hoga jisme jo c3 thaa vo nikal jaayega aur c4 P site pe aa jayega aur A site pe nya mRNA codon c5 aa kr lg jaayega , isi translocation ko inhibit krta hai erythromycin.

[@karanjaswal3543]

Jbki Chloramphenicol jo hai vo simply peptide chain ko A site pe transfer hone se rokta hai

[@we133]

Sir you teach very well but sir transfer ke spelling glt hai 😊

[@AmandeepKaur-jc7si]

Koi baat nhi sir bhi toh insaan hai or insaano se hi glti hoti hai

[@we133]

@@AmandeepKaur-jc7si yes

[@solutionpharmacy]

Sorry bhai kabhi kabhi ho jata hai

[@solutionpharmacy]

Thank you for understanding.

[@debashisnandi7395]

Sir please upload the previous year GPAT questions papers pdf on Facebook.

[@solutionpharmacy]

Sorry we are not related with GPAT

[@debashisnandi7395]

@@solutionpharmacy Ok sir Thank you ☺️

[@kissuchoudhary8722]

Sir sry but aapke whatsap number mil skte hai mujhe aapke nots chahiye sir please i request you sir

[@solutionpharmacy]

We dont have notes

[@kissuchoudhary8722]

Ok sir

[@shwetadubey1546]

Ye to D.N.A pr kaam kr khtm krta hai na ki groth rokta hai

[@shivampaswan5989]

Sir mechanism of action thik se smjh Mai nhi aaya hai🤔

[@solutionpharmacy]

Ha thoda tough hai. Maine kaha hi hai kinaap thoda dibara dekhiyega to samjh aayega. Aur baaki ki kami aane wale videos se puri ho jayegi

[@shortvideos9092]

Neet question

[@omkarsheelvanth8258]

Thank you so much Sir...🙏

[@solutionpharmacy]

Welcome

[@mohammadfarman8938]

Thank you so much sir 😊

[@solutionpharmacy]

Welcome

[@shwetadubey1546]

Sir urien culture report me Antibiotics ke sath ++++,++,++ ka kya mtlab hota hai

[@mirhafeez3890]

Thanks sir

[@surajverma2840]

Sir chemotherapy of leprosy

[@solutionpharmacy]

It will start after TB

[@bhagyashreekanani3802]

Thank you sir

[@solutionpharmacy]

My pleasure