Choosing efficacious treatment options for hepatocellular carcinoma

Laura Williams Goff, MD, MSCI, MMHC, Vanderbilt-Ingram Cancer Center, Nashville, TN, discusses how the multitude of treatment options for hepatocellular carcinoma (HCC) blurs the line regarding the optimal first-line treatment. While many patients are receiving immunotherapies, other regimens also demonstrate promising activity. For instance, the CheckMate 9DW trial (NCT04039607) revealed that therapeutics such as sorafenib and lenvatinib achieved the highest-ever recorded median overall survival (OS). Atezolizumab plus bevacizumab is preferred in the first-line setting due to slightly better hazard ratios and statistically significant progression-free survival (PFS). However, immunotherapies may be chosen for patients with varices or other conditions. This interview took place during the 2024 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.
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