PhD Explains: Alcohol’s SURPRISING Role in Your Health and Longevity

[@kraftwerk974]

My grandmother died totally autonomous at 104 yo in her bed in Barcelona drinking 400 mL of local cheap red wine everyday she bought by the pound. Followed a strict Mediterranean diet and never exercised. Lots of local olive oil and no process foods or seed oils whatsoever.

[@nsudatta-roy8154]

The one constant takeaway from your videos is that living optimally is complicated. Love your work, doc.

[@erikahuxley]

Not really, just be balanced and flexible, and not fundamentalists like half the people in this comment section.

[@shellderp]

@@erikahuxley balance is in all evidence not good lol. EG low fat or high fat is great but in between is the worst

[@larsnystrom6698]

Optimally is impossible! But who need optimal when we can easily get good enough! Looking for optimal is just a hobby of mine. I don't expect to get even close to it. Nutritional science really is sub-optimal!

[@SebastianStreicher-q5l]

Alcohol is not the problem, at least not in low or moderate doses. The problem is alcohol combined with smoking! This is the absolutely sickening connection!

[@warrengaskin3863]

100% agree. Almost all alcohol abusers are smokers

[@richardmalone3172]

I drink alcohol every day and have done all my life. I am 69 and very fit and have no health conditions. I drink about 4 standard drinks per day. Sometimes more and sometimes less. All my family drink. No has died under 90.

[@marianarebsawan8671]

Hello Richard!!! Nice to read your reply! A reply from someone who , trust what they are doing. I am a beer lover, and it makes me feel amazing, I was wondering what for drinks u mean and what the amounts would look like? For example,here in Brazil a stantard beer is about 350 mililiters. What is the dosage and what type of alcohol do you consume? Thanks!!!! And cheers 🍻

[@marianarebsawan8671]

Hello Richard!!! Nice to read your reply! A reply from someone who , trust what they are doing. I am a beer lover, and it makes me feel amazing, I was wondering what for drinks u mean and what the amounts would look like? For example,here in Brazil a stantard beer is about 350 mililiters. What is the dosage and what type of alcohol do you consume? Thanks!!!! And cheers 🍻

[@dexcortez7425]

Wise intake + geneticaLLy bLessed. The 1st miracLe by Jesus is to make heaLthy wine to xtend the merriment of a wedding; John chapter 2?

[@dexcortez7425]

Moderate drinkers tend to Live Longer Sir, just like yur case

[@larsnystrom6698]

@@marianarebsawan8671 Assuming that the beer is 3.5% alcohol, you would get 12.25 g alcohol from one beer. And about 30 - 40 g of alcohol is pretty acceptable, according to the video. So no more than 3 beers a day, perhaps.

[@JonathanOvnat]

Here's the thing about 0 drinks being associated with higher risk of disease: It's the sick people who never drink. They feel too bad when they drink so they quit. Interesting video though, thanks!

[@hyperTorless]

The large meta-analysis mentioned control for this.

[@JonathanOvnat]

@@hyperTorless In what way? I don't see how you could have a control to something like this.

[@hyperTorless]

@@JonathanOvnat Well they exclude what they call the "never drinkers" and the retired alcoholics. Just ask people.

[@JonathanOvnat]

@@hyperTorless Many people drink less than others because they are less durable. In other words, it should be one's ability to handle alcohol that is associated with better health. What we need is a randomized trial.

[@hyperTorless]

@@JonathanOvnat Then they should be in the "drink occasionally" category, which showed the best results with the "low-volume" drinkers. We've got rat, mice and even nematodes study confirming the benefits of low volume ethanol. We've got plenty of data. The mitochondria seems to like it.

[@hyperTorless]

I'm french and my grandmother drinks about a glass a day. She's 97. She has been living in a nursing home from the age of 93. They serve red wine everyday at lunch. She drinks it faster than water! I bet she'll make it until 100!

[@0626love]

for many of these stats, the natural molecules that come along with the ethanol may have been a confounding variable. As polyphenols like resveratrol and other stilbenes in wines, quercetin, etc. Still, hormesis makes sense - but this makes only sense while the body is under too little stress from similar toxins simultaneously :) - so some alco makes sense if you are in perfect health, while the hormesis cannot be created in the body that has already passed the threashold for stress with similar glyco-toxins in fried meats, fats, breads. In that case the extra stress just adds to the already excess ROS amount. This all also applies to all other hormeses that people are trying to create.

[@szymonbaranowski8184]

isn't methyle blue cleaning up this ROS or is it about outside mitichondria too

[@KORTOKtheSTRONG]

i found that when i was a drinker i got virtually all my boron from wine lol

[@OrlandoAponte]

Very interesting video. As someone else briefly mentioned, alcohol consumption is so ubiquitous in western culture that voluntary abstinence (especially beginning at a young age) is likely exceedingly rare. Therefore, I would wager that a significant percentage of those who consume 0 drinks have some sort of preexisting health condition or disease that precludes them from drinking alcohol, thus skewing the data and explaining the higher incidence of some diseases in those who consume 0 drinks a day. I would like to add that people with rich social lives (clearly linked to greater overall health) are also more likely to drink some alcohol than completely abstain. With respect to alcohol's demonstrated hormetic benefits, is there any evidence that these benefits are unique and can't be obtained via other sources of hormesis, such as exercise? As far as "listening to your body" goes, any amount of alcohol makes me feel acutely crappy. On the other hand, other sources of hormetic stress, such as cardiovascular/resistance exercise or drinking green tea, do not. Therefore, I believe the burden alcohol places on my body likely outweighs any benefit, but I have not tracked health markers over a prolonged period of time in an experimental A/B fashion (as suggested in the video) to draw a conclusive verdict.

[@YaYippieYeah]

We can also metabolize more toxic substances into energy in an equivalent way, e.g. methanol. I cannot name any, but there are probably even more toxic ones (wild guess). So you could argue similiar about methanol ? This sounds like downplaying the negative effects. I don't see any benefits in "adapting" to alcohol metabolism and i cannot find any reason to consume alcohol in the video. This correlation with the lower risk can be explained by various co-founders (e.g. an active, positive social life is also strongly correlated with better health).

[@marius2447]

This! Quit alcohol a few years ago and never felt better. It really makes me wonder had they done some of these studies today if they would get the same/similar results to show?

[@dwaynemcallister7231]

I don't have answers but my father was a drinker the only one in his family, he out lived every other family member by a minimum of 5 years, a coincidence? I don't know.

[@larsnystrom6698]

I don't train every day, so maybe I shouldn't drink every day either. Actually, I don't drink at all, even though I do like red wine. It's just too bothersome to find a good wine at reasonable price here in Sweden. In France I can get it in every grocery store! Nice to know, though, that science allow me some red wine if I feel like it!

[@richieheetebrij8189]

I definitely have some issues with my energy metabolism. I a have to take about 1500mg of B1 daily to avoid feeling hypoxic. If not I have multiple systems dysfunction, or at least that’s what it feels like, non specific inflammation….. lack of nutrient rich, oxygenated blood flow to all tissues due to constructed vascular. This may be due to a lack of nitric oxide production for some reason or another…. High uric acid? Anyways some days I am so exhausted and have tried every supplement I have and still no energy and terrible brain fog, pain everywhere, tinnitus….. so I then have a few too many drinks and wake up feeling actually pretty good with all day energy, pain is significantly reduced. Acetaldehyde , is turned into acetate, acetate is a short chain fatty acid which is a good fuel for mitochondria I read. Something like a ketone????? There is something here that smart out of the box thinkers can figure out. It’s easy for a Doctor to say, “oh you drink, that is bad, you have to stop” Perhaps the drinker needs the acetate cause something in the energy metabolism is dysfunctional so the self medicate with acetate as a “fuel”?

[@airgetmar1928]

my grandfather was an obese alcoholic of 100% sicilian descent, was horribly out of shape and had an abysmal gmo diet loaded with tons of margarine for 65+ years and he died this past October at 89 years old. LITERALLY the only thing that stood out to me was his binge drinking of cheap paisano table wine and bud light. And, he had REALLY bad dementia too.

[@susanb3989]

I’m sorry for your loss. Sounds like his quality of life was limited by the dementia and obesity. It happens to many people.

[@szymonbaranowski8184]

but he had some fun and pleasure in life

[@janeslater8004]

Alcohol related dementia wernickes

[@kylemedia6113]

It's really about every day quality of life, not longevity. If alcohol is having a negative affect on your daily quality of life it's probably a good idea to let it go. If not and you enjoy it then by all means have a go. And some people with addictive tendencies should probably abstain. Alcohol definitely WILL damage internal organs, there is no question. But one drink a day is probably not going to have long-term negative affects. Be wary of studies and statistics. They can be interpreted and manipulated to fit the narrative. View each individually with a very objective and concerning eye.

[@cj548]

Discerning*

[@johnconcannon3844]

That's it (green light), I'm having a hot whiskey.

[@ZZZZ-mkv]

I always assumed the benefits of alcohol were purely from the enhancement of social activity. It's well known that most people are healthier when they have a good social circle, and alcohol facilitates social interactions rather well.

[@jgilldrafting]

Not much social interaction from 1/2 a drink. In all my years of drinking I've never come across anyone that drinks just one drink a day.

[@erikgrafenschnell1036]

interesting content How come that the sound quality is so consistently low? Appears fairly distorted to me.

[@meggi8048]

same

[@truthpopup]

It could be Chris needs a new microphone.

[@cromyjr1592]

He prepares us for his next series, titled "The Booze Whisperer" :))

[@inittiela4934]

Can glycine inhibit histamine? I have symptoms of overmethylation on high methionine diet so i got collagen to balance it with glycine and it helped my mental status but i get problems with digestion after few days of taking it, and my problems looks like low stomacha acid because i get reflux and flat stomach.

[@ALFarrell-kv6ok]

Early in my seventh decade here. I do eat healthily and I have always exercised in one way or another. I am definitely fit. Furthermore, I still mountain bike up steep hills in tropical heat. Likewise, I also kayak for miles. And I've been frequently having moderate amounts of beer and red wine since I was 16. Cheers!🍻 PS. It has been conclusively proven that breathing earth's air for around 80 years is fatal🙂

[@andrijajanfranjcec6888]

Hello Chris, I have one question and would be very thankful if you took time to answer it. Today I have started taking a new multvitamin supplement and it has 12 mg of zinc oxide in it. I know you don't recommend zinc oxide but it's in the multi which is other than that very good. So, what do you think how much of zinc does my body actually usefully absorb from it? I used to take 22mg of zinc bisglycinate in the evening with 300 mg of magnesium supplement but since I also get some zinc from food and now I get 11 mg of zinc in the morning from multivitanin, I considered to replace that 22mg of evening zinc bisglycinate with 10mg of zinc gluconate. But, if I get nothing from that morning zinc maybe I shouldn't replace that evening 22mg, I don't know. (For tge record, I am a recreational bodybuilder and do not have vitamin/minersl deficiencies as far as I know, I take supplements for general health). What do you think doctor? Thank you.

[@monag.769]

You just saved Xmas🤩

[@qwertyqwertyqwerty4324]

😂

[@chris9559]

Q: Any thoughts on Bacterial prostatitis particularly common that it can become resistant to all antibiotic due to the anatomy of the prostate?

[@brendaalder1549]

Look up the study called nothing boring about boron.

[@s1p2a3r4]

I know that somethings not right with what we’re told about alcohol. Old days hot tauty before bed to ward of parasites. Thousands of tonics with herbs n spices to heal with alcohol. Then i was raise by sweet mom who was a bar maid in 1960’s n 1970’s and always had moonshine under sink. My parents ran bars and VFW’s and everyone who ever came into my home when I was a child, lived everyday with their drinks. But weirdly enough. When I got older or visited friends who went to church, they all had surgeries to take body parts like tonsels, hysterectomy, apendix, and lumps and thyroid issues and cancer, list went on and on they had to have so many body parts removed. So when I got into my 20’s in 1980’s, i tried to reason this out. Church people sick and my parents are just pickled. They don’t ever get sick and they drink everyday for 5-6 decades. Hmm. From what i can tell, stay away from beer due to yeast. Pick quality to avoid toxins and listen to your body, how do you feel when you wake up. Especially if you can make tonics with it! Or quality wine. Just my opinion when I saw the stark differences in my family verses mu friends parents who were religious about not drinking.

[@erikahuxley]

I can't drink wine sorry, not against it but it's too acidic for my taste and too high alcohol content. I'll stick with import beer. I do have to avoid typical american beer due to higher glyphosate. It's not everyday these days. I think yeast have to be put into perspective, I purposely ferment my vegetables, and wine also have their own yeast. There are lots of foods we eat regularly that have ethyl carbamate beside beer. If I drink more frequently, like 2 beers a day consecutively (which is too costly to do anymore), then I take milk thistle for liver protection. One thing you will notice about the comments in this video is the people who are against alcohol are very judgmental and absolute.

[@MrShitConnection]

Hey, Chris. About your recent video on seed oils, you mentioned nice and shiny mechanistic data, but Dr. Layne Norton has also recently done a video on seed oils, and he cites a load of OUTCOME data that flies in the face of your mechanistic data. Could you find the time to hash that one out? Thanks!

[@delinquents212]

Spits in its face? I second this as a request, but friend, you know there's a nicer way to ask, don't you?

[@MrShitConnection]

@@delinquents212 Yes, you’re right. My bad. I’ll alter the wording.

[@LukePranay]

❗The subtle effects over cognition and all other parameters of consciousness of alcohol, can be too subtle to be measured as such - and in moderate to large quantities is a clear: attention, precision, intelligence and empathy powerful reducer and a consciousness compartmentalizer (makes one unable to think systemically / 'big picture'). The same hormetic benefits can certainly be obtained in numerous other ways, through numerous other compounds and plant extracts 😉

[@darkfieldcarnivore3928]

The ability to process alcohol is left over from when we had a large function caecum for fermentation. Nothing more.

[@marketlider2811]

Say this bullshit to people who lost family members and friends to alcohol. My grandfather died because of alcohol.

[@robthevampireslayer3211]

I don't recall him saying that people should become alcoholics. Moron.

[@gordonsmith5589]

Excellent video Sir! 👊🏻💥👊🏻

[@JohnSmith-tx3ys]

I’m going to send this video to everyone. It’s going to ruffle some feathers. 😂

[@fadiyt8816]

Waiting for hermetic effect of smoking tobacco: the benefits of smoking one sigerate a day

[@protoplast.youtube]

i heard that study of 1 cigarette daily ca. 15 years ago…, could be possible!…. but later no one discussed it any more…

[@FaCiSmFTW]

Dont listen to the haters who say buy a new mic. Best lofi nutritionist in the game

[@ahnehtub2]

Theory sounds good but alcohol is highly addictive so it becomes easy overtime to ,,overdose" and so you got neuronal problems and other problems associated with alcoholism! Also sugar addictiond and other :))))

[@mitunknowngirl]

cooking wine is enough. LOL

[@Sakaripeltola]

The ability to not mix your morality or your subconscious fears with facts is one of the most important features of a scientific mind. Chris is great at this. Many "longevity experts" are probably just really scared of dying and this affects negatively their objectivity.

[@erikahuxley]

Partly, the other part is they want to sell you their supplement, in the case of Sinclair, patented supplement.

[@edsuttmann7889]

Is this also true for paint thinner!?

[@j.fitness5701]

Yes after 5000 years in the future maybe if mankind start consuming Paint Thinner now ? After all Paint Thinner been around for like 150 years maybe ? You see, alcohol has always been consumed by mankind mainly as in the form of beer and wine since the dawn of civilization and altough I am also very skeptic about some claims in this video, I don't have a strict mentality like "There is no safe dosage for alcohol for health and longevity" Alcohols effect on "hormesis" mechanism on body mentioned in this video is in fact quite reasonable. And in fact it's true that some chemicals produced when breaking down the alcohol by the liver which is acetaldehyde is indeed found in fruits also.

[@MC-op6gb]

Could chatgpt be used to analyse your whole genome to look for errors of metabolism?

[@jimhuerta9038]

Is this what the medical profession has come down to 😂😂😂

[@SGBoffice]

If you already have cancer does that necessarily mean you have to be alcohol free ?

[@ashypharaoh8407]

Cheers Chris! 🥂

[@robmcguckin7605]

As much as people here in the comments may have a problem with this video, it makes sense.

[@cosmicgreen]

If you guys want to use these info for an excuse for your drinking, go on.

[@robmcguckin7605]

Thanks!

[@tonycrouse6544]

Remember kids start drinking young and drink often. You too can live to be 150!!

[@priapsus]

150, here I come!

[@JonathanOvnat]

Numbers are fun!@@priapsus

[@Julio-l4y7u]

Drink up 🍷🥃🍺🖖😋😛

[@jhshett]

What about the paper that put into question the j-curve. It’s criticism focused on never drinkers being in the same no alcohol group as people who had quit drinking alcohol, saying that people probably quit because they were sick so it skewed all the data to favor low-moderate drinkers.

[@TominationTime]

Are you referring to the study Zhao 2023 - "Association Between Daily Alcohol Intake and Risk of All-Cause Mortality"? That study takes into account the never drinkers. If yes, the numbers do not look very convincing. I've seen this study paraded around in the media as the counter to alcohol's health benefits. However, if you read the RR's and P values, the data does not look very convincing. Remember that 1 drink = 14g ethanol, so the low-volume drinkers are drinking Around 1-2 drinks per day. From the study: "the meta-analysis of all 107 included studies found no significantly reduced risk of all-cause mortality among occasional (>0 to

[@Santa-ny1yp]

@@TominationTime well done, regardless if it's the correct study.

[@protoplast.youtube]

thanxxx a lot!

[@Hornet135]

@@TominationTime The trends don’t matter with p values like these. Alcohol does not have a health protective effect. This is pseudo science masquerading as science.

[@hyperTorless]

@@TominationTime I mean yes, even ignoring the p values, the RR values are telling a whole other story that the accompanying text. There's a lot of studies like this in nutrition, when the forced narrative is contrary to the data when you look. Baffles me each time, crazy stuff.

[@BrunoCrocco]

Amazing video! Just one thing yo note: Seed oils should be considered as a hidden culprit, since it exacerbates Oxidative Stress depleting aldehyde dehydrogenase and glutathione in parallel to alcohol. The benefit of moderate alcohol consumption is that it upregulates the omega6 detox pathway, clearing those toxic aldehydes.

[@erikahuxley]

I have looked a bit into aldehyde, it is particularly a problem with cooked seed oils as they create more aldehydes as a result (compared to evoo and coconut oil). People with genetic variation of ALDH2, particular Asian, are worse at detoxifying aldehydes. This ALDH2 is also related to various neurological disorders. Due to this they require more molybdenum, which is not just important for aldehyde oxidase, but also sulfite and xanthine. The average consensus is molybdenum deficiency is rare, but now I question this because there aren't enough research, we probably need slightly more, also because sulfite is in everything now.

[@KORTOKtheSTRONG]

neato

[@vanessac1965]

You didn't discuss effect on gut. You can't just look at longevity data to decide whether to drink or not.

[@hyperTorless]

Yes you can?

[@larsnystrom6698]

It's probably healthy not to make a fuss about a minor alcohol use. Those not worrying about that sort of things might simply live better than those with more rigid personalities. That's a confounder, I guess!

[@aarondirnfeld9949]

Hi doc, you need a better recording device...

[@hyperTorless]

People are not ready for this: "Long-term low-dose ethanol intake improves healthspan and resists high-fat diet-induced obesity in mice" "The long-term ethanol-intake mice showed improved thermogenic activity, physical performance, and mitochondrial function, as well as resistance against the high-fat diet-induced obesity with elevated insulin sensitivity and subdued inflammation. Our results suggest that long-term low-dose ethanol intake can improve healthspan and resist high-fat diet-induced obesity in mice. It may provide new insight into understanding the protective effects of moderate alcohol drinking." Drinking a low-dose of alcohol everyday makes mice resistant to obesity, better at sports and make them live longer. Remember: our ancestors rarely drank clean water, especially in the cities as it was unpractical because you had to go fetch it or the network would get soiled by human activity. 2 liters of 3% wine daily was very common in 12th century France. American pioneers didn't have clean water for more than 2 centuries, they drank low-ethanol beer. Fermenting liquid is a good way to get rid of pathogens, thanks to CO2, low pH and low oxygen levels -- it's the traditional way!

[@bmelvin1234]

Personally, alcohol does not serve me. I’d rather get better REM sleep.

[@robthevampireslayer3211]

Don't drink it 2 hours before bed.

[@MarkIron]

How does one drink a day impact the gut micobiome?

[@brendaalder1549]

Alcohol made from moldy grains (beer) would be worse

[@urtyp6596]

it doesnt matter bc we dont know if that even is a thing

[@Sabrina.LC17]

European's will agree with you! Thank you!

[@hexchad765]

The increased risk of esophageal cancer might be related to silent acid reflux and famotidine

[@meggi8048]

what has famotidine to do with it?

[@hexchad765]

@@meggi8048 h2 blocker, acid reducer

[@nikolastsatsaronis5544]

THANKYOU!!! I am 69 years old! I have been drunk once in my life! That was enough! I really enjoy a glass of dry, red wine with a meal! I really enjoy a bitter. hoppy craft beer. Either on its own or with a meal! I really enjoy a single malt! Dark honey tones! This in particular is a ritual! I’ll pour myself a shot! I will look at the colour! I will nose the glass for an extended period to pick up the nuances! I will take my time in sipping it! One shot is enough! I might have another the next day! Maybe another on the following! Then again, I might not have another for a month! Or Two! I know persons who, on having one drink will have to finish the bottle! If I had that problem, I would be a teetotaller! So much bad publicity on alcohol for years now! My health is important to me! I have contemplated becoming a teetotaller! No! I decided it would be my one bad habit! Your video informs me that I haven’t given up a bad habit! I have maintained a healthful one! My other vice is an early bitter black coffee every day It’s also had some bad press! I was delighted with a sixty minutes story into healthy 90 year olds that they drank coffee and alcohol in moderation! One last thought! I like the people I drink with! I enjoy their conversation! The benefits of social connection and the inherent pleasure on your health should never be underestimated!

[@StevenOrland]

Excellent, critical review of the literature. This is why you're my primary source for understanding nutritional science and how I make dietary decisions.

[@YaYippieYeah]

Critical review? Did we watch the same video? Where did he discuss the strengths and weaknesses of the studies from which he took the graphs? He just tells people want they want to hear. He is a stoy-teller.

[@StevenOrland]

ok

[@Hornet135]

If his videos are your primary source for understanding nutritional science, you’re screwed.

[@Steve.Orland]

Then why do you visit these videos and leave comments? Foolish.

[@1aliveandwell]

0.3-.5 drinks of what ???? you give lots of #'s and diseases, but do you mean 3% , 14% or higher alcohol , or is beer ? What if the drinker doesnt have enuf vite A (you said the pos. health may be from). How would we know which person could drink what amount.

[@Jowls16]

If I remember correctly isn't there data showing that over 30 years 1 to 2 drinks tripled brain matter loss? Also what about mendelian randomization is nonsensical?

[@TotallyVeracious]

I've been drinking two 16 oz IPAs for years, I'm 65, lean and fit. I had an extensive Boston Heart panel recently and my liver enzymes are fine and my inflammation is very low. I've been taking asparagus extract prior to drinking and surely it's helping metabolize the alcohol dehydrogenase.

[@solideomusical]

Asparagus extract?

[@VanillaAttila]

How many drinks are you having ser?

[@Jowls16]

It's not hard to reconcile the differences the study using mendelian randomization and earlier studies if take into account the limitations of those earlier studies. They controlled for lifestyle factors ,but there are alot of factors to consider. For example people who are sick and stop drinking because there health got worse, they would go into the non drinker groups. Someone who drank there whole lives and then recently went sober would go into the non drinker group.

[@matthewhansen93]

Alcohol is the lowest vibrational substance humans consume. But let’s not discuss that!

[@Guidosvinos]

Link to the vibrational test please. And also which vibration. Then we won’t discuss “that”.

[@matthewhansen93]

@@Guidosvinos oh you want to justify your addiction huh? I see this from all people who can’t over come the urge to drink.

[@Guidosvinos]

@@matthewhansen93 What!!! Are you serious, you made a claim about the vibrational characteristics of a substance with nothing to back it up. You seem to find it unreasonable that someone would question that statement and then also go on to claim they are addicted, once again without proof. Unusual.

[@matthewhansen93]

@@Guidosvinos so it’s just one of those things you should instinctively know. Alcohol kills all microbes. It’s utilized as a disinfectant. Is that not proof enough? I could go find the exact source of this but I have seen it multiple times on Gaia shows. I believe this to be true. I know my personal habits and patterns have raised in vibration since I stopped drinking. If you want the scientific results to prove something I don’t care to do that. Do you really need it?

[@kerrmcclure5787]

Chris you look so healthy compared to even 6 months ago, 1)Do you wear make-up for you videos?

[@BiZii1024]

I also notice it but it might be just diffrent camera or camera setting or a lot of beta carotene ;)

[@erikahuxley]

No.

[@samgravell3180]

Hey Chris, Any idea what might suddenly cause a couple of drinks well before bed at dinner time to lead to insomnia all night? I drank moderately for years and then all of a sudden, BOOM, 2 drinks and I can forget about sleep. Wondering if there is a supplement or something that might help. Everything else (nutrition, exercise, stress, light hygeine) is in order .

[@isardamov]

"Healthy"? Am I the only one who perceives an "altered state" here?

[@marketmonster6055]

soo for methylation which would you say is more important daily choline or daily creatine?

[@LouisDallara]

What about the French paradox? Basically, Alcohol combined with food is different, especially wine that has been fermented in an oak barrel. Look at the studies in the rabbit hole.

[@BossHogg805]

I'm a huge fan of C. Masterjohn PhD's work. That being said, personally I don't like drinking alcohol and I'm not an anti-alcohol or pro-alcohol zealot. I just can't imagine this is going to result in worse overall health outcomes if my health and fitness are as optimized as mine are. I'm certainly not going to start drinking because of statistical relationships between two variables as indicated in the meta-analysis of these studies. Even though Chris repeatedly reminds us that most of these studies were associative, I see a lot of commenters here taking this presentation as a means of posting warm and fuzzy anecdotal family stories and as a justification to continue with a habit they likely enjoy in excess of the noted quantities. Based on the general population, I'd speculate most of these same commenters are likely metabolically and generally unfit and drinking alcohol is not going to make you live longer.

[@inittiela4934]

Do anyone know what to do if someone is undermethylating glycine and overmethylating dopamine and histamine? I heard few times about overmethylating glycine but never oposit.

[@dwaynemcallister7231]

It's interesting, my father drank sometimes way too much, he quit in his mid 60's but his siblings didn't drink ever nor did his parents, he lived longer than all of them by at least 5 years.

[@patcusack6252]

I do like my beer. But the research in this video reminds me of all the research that said smoking was good for you.

[@kit888]

Love your videos. Could you upgrade your microphone?

[@technofeeling2462]

I am histamine intolerant and alc is the worst whereas thc is a mast cell stabilizer and helps.

[@monag.769]

What is thc?

[@technofeeling2462]

@@monag.769 the most famouse ingredient of cannabis. It works like a wonder. I was unable to exist 2 hours ago and smoked a small amount and feel like a human again

[@protoplast.youtube]

@@monag.769the hallucinogene „drug“ ingredient

[@chronicallyalive]

@@monag.769 thats the main psychoactive compound in weed

[@Jimmy-ln2kw]

What is the name of the study are you are referencing at 6:24?

[@LouisDallara]

All alcohol is not the same!

[@nieuweabnormaal5869]

I am happy I already stopped totally alcohol drinking for 1.5 years. Thanks to the Sinclair method by late Dr. David Sinclair. The only thing to do is take a Naltrexone pill one hour for drinking, and repeat this. Process took one year to finish.

[@ballinout92]

One hour before drinking?

[@questionauthority-f6i]

Late Dr. David Sinclair? Last I checked, he's still alive...

[@nieuweabnormaal5869]

No his full name is John David Sinclair (March 28, 1943 - April 6, 2015) . There is indeed another one called David Sinclair.

[@nieuweabnormaal5869]

en.wikipedia.org/wiki/John_David_Sinclair

[@questionauthority-f6i]

@@nieuweabnormaal5869 I thought you were talking about the Harvard Scientist known to the longevity community. My mistake.

[@xwsftassell]

Nonsense. It's good for you in large doses. Why do you think Europeans have been drinking beer for literally thousands of years?

[@typtyp1992]

Interesting video, however, I'm surprised that you don't mention the sick-quitter bias. Studies that adjust for the sick-quitter bias often show detrimental effects of alcohol at any level. The Umbrella Review of Meta-Analyses you cite, for example, doesn't seem to adjust for it. What about the other studies, did you take this bias into account for selecting studies for this video?

[@freeyoga]

I wonder as l try to understand your speech about booze and no booze what exactly your point is. Are you recommending booze? For health? Where is your funding coming from? I will,watch to the end of this but something seems off. But open mind and willing to explore other peoples idea of “good science”.

[@busyrand]

This is the first channel that actually address alcohol making testosterone spike... The day after I drink, my testosterone is sky high. My musculature is erect, I feel more aggressive, I have vivid dreams, and sometimes remain rock hard for 8-12 hours... The effect has gotten more mild over the years, but I can always tell when I've had something to drink the previous day...

[@pauljmey]

Well anything Peter Attia says has to be taken with a grain of salt

[@Bubbagump871]

No alcohol for me, thanks. I prefer the occasional psychedelic trip 1x or 2x per year. Keep your liver clean, folks.

[@harmankardon478]

I'm all about hormesis and this is certainly possible but there are other reasons that may cause people who don't drink to have higher rates of disease.

[@CarmenMinguez]

Hi. I need help. I got toxic taking too much sam-e. My body can't flush It out. Will be It link with GNMT enzime? Thanks

[@د.محمدنصير]

How about smoking one sigarate a day? This is serious question because I crave smoking but only few per week.

[@livingsmart]

APOE4 probably plays a huge role when it comes to the alcohol and brain health. Also it's not very clean where actual hormetic effect and reducing stress/socializing benefits cross. I wish there was an intervention study looking at biomarkers and aging clocks.

[@cromyjr1592]

What about artificial self selection effect ? (not sure if there is a more scientific name for it). Those with better genes will prefer drinking, because they can stand the unpleasant effects better than those with worse genes. We need to know more mechanisms of action for those J-curves, if any other then vitamin A pathway "training". The rest is just statistical artifacts.

[@Artman1]

Alcohol is a crime against humanity.

[@KORTOKtheSTRONG]

TIL alcohol has a bell curve, wild

[@SladkaPritomnost]

I always wonder how heavy drinkers can last drinking so excessively for so long. The only drug giving (relatively) long life for its users.

[@jalbhagwagar3353]

🤸

[@hexchad765]

So two drinks a day?

[@chrismasterjohn]

Keep watching.

[@monag.769]

Rather 1 drink every other day😉

[@hexchad765]

@@monag.769 that's where I landed after watching in full. Cheers to CM 🍻 for pulling this together 😁

[@robthevampireslayer3211]

Depends on bodyweight.

[@TheMaui2020]

Yes, alcohol is just another nutrient. Good thing this guy does treat drug addicts or any patients.

[@npkfm]

The chart at 4:32 says I can drink 4 beers per day. Total nonsense so I’m not watching the rest.

[@okamsug]

Total nonsense.

[@7CAJONEZ]

Nikolaa Tesla said vodka is the elixiir of life. In his seventies he said it ruined his life. But he was loony and a vegetarian. As far as fruits giving similar results, we now know that fructose is bad. Avoid both, consume what your body was designed for, not plants but meat.

[@thiagop3519]

EXCELENT!

[@duckduckgo1755]

Great analysis! The data seems highly suspect for almost all of these because the only people who drink zero drinks per day in modern society are either people so sick that they don’t feel great on a single drink, or religious radicals. There are very few teetotalers, so it stands to reason that a meaningful portion of them are teetotalers because alcohol is exceptionally bad for them.

[@MonSamDan]

There are many of us who drink zero drinks per day simply because we don't like the taste of alcohol or the feeling that comes after such beverage. I am a healthy woman in my forties living in modern society, not religious and the 3 or 4 cocktails I have PER YEAR are more than enough for me, I don't crave more. Shockingly, I don't drink coffee either, just because I don't like the taste 🙂

[@tohopes]

​@@MonSamDanhave you tried mixing liquid milk into coffee? milk protein neutralizes the tannic acid in coffee.

[@susanb3989]

There are many teetotalers. You might not hang out with them so you don’t know many? But believe me, entire cultures don’t drink.

[@Santa-ny1yp]

Or they've had bad life experiences with alcoholics. I drink an average of 1 to 2 drinks a month. I enjoy what I drink when I drink it and stop when I've had enough.

[@MonSamDan]

@@tohopes Yes, I used to drink coffee all through my twenties and with milk was the only way. Then I stopped and don't miss it. I love all kinds of tea, black, green and herbal. I know the herbal ones are technically not teas, I think they're called infusiones or tisanes.

[@kjr8660]

Well, there gotta be gender differentiation. I’d argue that in females 0 alcohol is a safe limit due to alcohol interfering with clearing out estrogen, and in the case of COMT mutation, alcohol use is detrimental. But men are more likely to get addicted, due to stronger dopamine induction. So, all in all, there’re other,better ways to reap the benefits of 0,3-0,5 drinks per day.

[@newdata]

the liver make igf 1, a well known aging accelerator. so 1 drink a day likely KO or slow this process , leading to lower mortality in the stats.

[@VanillaAttila]

How did Huberman miss all this?

[@3dstaco]

Fad masculinity guru

[@robmcguckin7605]

Stanford doesn't allow the truth just like Harvard, Cambridge and U of P.

[@RealitikDaily]

He is a j3w clown that's why.

[@robthevampireslayer3211]

Jewberman is a fraud, he looks depressed and very unhealthy considering the thousands of dollars he spends on supplements and steroids.

[@billbucktube]

My doctor said my EGFR results indicate that I need to drink more…. Hmmm…