Classical Pathway of Complement System

[@SuperTalvar]

Should be called the complicated system

[@suntrespasser9684]

Definitely.

[@arnobashtar6707]

Exactly what crossed my mind as I was watching this

[@Null257]

It's a homeostatic master mechanism too. The more we understand it, the more it becomes apparent that killing invaders is just what it does in its spare time.

[@laiaplaiap1688]

B zabet 😂 5osousan eza kent 3am te5od hede l mede b jem3a lebneniye 💔😂

[@stevencool9657]

🤣💀

[@soojinlee3527]

I got through Pre Med because of you. Sometimes your lectures were too advanced for me and I thought "I will probably need these when I'm in medical school." 5 years later and I will get through medical school because of you. Thanks man. I hope someone is paying you very well out there.

[@gggggggggg-uc3ss]

Fragment b is always kept and Fragment a is thrown into the plasma, but there is one exception, it's for C2. So instead of keeping C2b , you keep C2a instead.

[@LuciferMorningstar-dp7by]

Correct bro I also think that C3 convertase is C4bC2a

[@Srobvio85]

If you known so much why are you here¿¿ Just watch the damn video and then go to a book. Damn whites ruining everything

[@96butterfly95]

I think that this correction help lot of students......my opinion....

[@96butterfly95]

I think it s only C4b2b

[@lonelywanderer2467]

It's actually debatable, I observe, some of the older editions have it C4bC2b, even wikipedia says so. In my textbook it's C4bC2b.

[@nooshinmirzaee7008]

i love the way you stress on words it helps me stay focused.. ;) you are born a teacher ,keep up the good work

[@RaulGonzalez-oq5ei]

Yup! He kept my attention the entire time and I understood everything !

[@midnightsblaze27]

In respect to the C4bC2b complex, for about 5 years or so in the recent past, immunology textbook writers wanted to make the process more uniform since C2a is the only large factor which remains associated with the cell surface and renamed it C2b to be more inline with C4b. So C4bC2b was published for a couple of years but it never really stuck as C4bC2a was already widely accepted and established.

[@aslanr6]

clearest explanations on youtube. Much better than a certain "academy"

[@neslihangroll7597]

You helped me to pass the oral exam in Biochemistry in Step1. My professor asked me the questions you underlined in your videos and it would normally required me to read thick text books to understand. Now you are helping me to pass Immunology. I can't thank you enough.

[@Arthensolutions]

Hi! I'm from Brazil, I'm Pharmacy student, and I must say u r an incredible teacher! Your classes help me a lot! Thanks for Everything!

[@beckybrown4405]

hi Luiza Aguiar . am also a pharmacy student. hope it does help

[@leonidas2930]

This was SO helpful - You are making such a difference for me. I am almost crying of hapiness

[@ronettechojnacki232]

Thank you. You saved my life today!! I needed to teach the Complement System to my students and this explained it so well. THANK YOU!!!!

[@user-ms4sx6iy2f]

you made me understand in less than 15 minutes what my professor couldn't make me understand in more than 2 hours. thanks a lot :)

[@drsiddharthsaxena]

Shouldn't the C3 Convertase be C4b2a, instead of C4b2b?

[@AKLECTURES]

Siddharth Saxena Look it up and link me to your source. Ill take a look and let you know.

[@drsiddharthsaxena]

Hi AK. Could you please check out this source: www.complement-genetics.uni-mainz.de/cp.htm I was reading Kuby's Immunology 6th edition (internation).. And the lecture notes supplied by university in UK also say it should be C4b2a.. really confused now..

[@AKLECTURES]

en.wikipedia.org/wiki/C3-convertase#/media/File:Complement-pathways.png users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/Complement.html Here are two separate sources that describe the C3 convertase as having C4b-C2b structure.Your lecture notes are probably based on the book you're using. Perhaps its an error in the book. Double check with your professor and let me know what he or she tells you.

[@QueNhuPhamThi]

Siddharth Saxena Yep. My teacher also said "C3 convertase is C4b2a too"

[@AKLECTURES]

Phạm Thị Quế Như thanks for the feedback! I will look into it.

[@codyrussell5885]

I just want to say ive watched this guys videos since grad school immunology. I am now in medical school, and still use his videos on all go his topics. 10/10 would reccomend AK Lectures!!

[@ameeralbaghdadi9798]

You are the best and i guess the only one on youtube who really deeply understand the scientific material and introduce it with no side talk and in a very simple and informative method Best regards to your efforts

[@lujainaa6086]

He’s so good at explaining. I can’t do this even if I have perfect understanding of something.

[@edessatanafranca1380]

Hi I noticed that the C3 convertase should be C4bC2a ☺️ I looked it up in Immunology 7th Ed David Male page 90 fig. 4.4 ☺️

[@alnahi999]

I think he did great explanation for classical but he missed to explain more how C3 convertase formed instead to explain formation of C4bC2b complex

[@harrishussain8926]

Yes me too

[@melisengin9268]

Actually, it was historically called C4bC2a. These days, scientists call it C4bC2b for the sake of uniformity. AK lectures is right.

[@sonamraghav5830]

love your accent 😍😍😍 ,the way you speak 😘😘 understandable

[@htetlin2449]

Hello AK lecture, according to my professor, C4bC2a is the C3 convertase that cleaves C3 to C3a and C3b. And also C4bC2aC3b is the C5 convertase and C3 convertase cannot cleave C5. Please keep on making video. thank you very much.

[@ethelswale259]

Your lectures are worth to be acknowledged on my final dessertation

[@Sunshine-zi7oy]

i hope you know that till this time while im in training for speciality i still return to your videos to remember things 🙏 may God bless you wherever you are 🙏

[@kayamanesh3294]

I love this man so much right now

[@apricotpomegranate]

I like how you started with the big picture first and then went into the nitty gritty details. My immunology prof doesn't do that enough, hence why I'm here. She will drill the process steps, but doesn't really get at the purpose of why these things happen. Thanks for this. :)

[@eugeniomtz5484]

You helped me a lot. Inmunology final tomorrow. Wish me luck.

[@AKLECTURES]

Good luck!

[@user-bk5jr5kw8u]

I love u man u are the best lecturer i have seen ❤️❤️❤️❤️❤️

[@marinapapuashvili1393]

Everything is simplified and understandable. I am so thankful for your style and form of lectures.

[@fahimzubair3766]

Amazing summarized lecture on the classical complement pathway and its significant immunological functions! Thank you so much for this, sir!

[@buixuanbaodanh5203]

Your lectures are amazingly easy to understand. I'm so grateful for your effort.

[@abulfazalwashim5117]

Master of all, i almost use half of time before exam watching your so organized precise articulately presented lectures. Love and pray for you from bangladesh.

[@cincrlatko]

quality of this video cured my cancer via my innate immunity boost

[@israelojo6875]

Hats off sir, you are better than my lecturer. Remain blessed.

[@arvanaseer7699]

your youtube channel is the 1st one that helps me a lot in my studies....solute you

[@kelvinbrown6795]

Excellent Video! Clarity is second to none. Brilliant

[@competitiveminds1264]

Love from Indian occupied kashmir..... awesome way of reaching

[@kakinda1984]

More thanks again for your help sir keep it up ,by abel kakinda from Tanzania at CUHAS.

[@carmelokm]

What a Man,Good stuff..Life saver

[@elliegarcia4706]

this was honestly so helpful! thank you for being so clear in you explanation

[@mjeed4205]

I am really grateful for these lessons that you are lecturing, but I've got a small note which I hope you will consider, you're speaking with such loud tone and keep speaking without any pause to take a breath. anyway your lectures are very useful for me, thanks

[@Sunny0894336431]

"Clocked" couldn't figure this shit out for months!

[@Quztuk]

10:03 shows just the info. Fairly simple to follow what he's written. Much better explanation than my books.

[@jungshrimp998]

you're absolutely great and talented, thank you for these insightful videos, really help me to understand the materials in my college :) may God bless and keep you

[@zainababdulkareem7746]

I had difficulty in understanding complement system but with this video I will teach complement system to my friends. thanks as much as sea :-)

[@ashleywarren8181]

AMAZING!!!!! You are the best explainer

[@arriettae8291]

C4b2b is correct and it's the new form of formerly known C4b2a complex aka C3 convertase. Anyways, the name changed cause of some wrong nomenclature of complement proteins. The 'b' in these complexes stand for binding and 'a' stands for anaphylotoxins, so that should be it.

[@77daud45]

This guy helped me pass my doctoral exams 🤲🤲

[@heysselg.3993]

There is Super man, there is Batman, there are the X man, there are all kind of super heroes and then there is you... the one who saves me every single time since I started Biomedical sciences.

[@sophiapauling6677]

best video ive ever seen on this

[@halaalabboud480]

Love how you make everything easy, you’re the best 👌🏻keep up the good work.

[@carmelokm]

Many Thanks from the UK🎖️🎖️🎖️

[@nurulbalqis2348]

glad that many realise whats in c3. overall, this video is helpful in my Immunology subject. worth the subscription.

[@enoacres9592]

i love this man makes every make sense

[@annes5279]

You're helping me so much in my Immunology and Clinical Chemistry subjects. Thanks a lot! :)

[@nkosinomusazulu9414]

classical pathway made simple and sweet..... great video

[@DoctorOzair]

Although it’s good but Instead of Giving Compliments about the lecturer, i would rather encourage everyone to comment about the video like some more information or things that needs to be kept in head. Thank You✨

[@MA-dd9dd]

Somehow you can make me understand those topics so easily. Thank you

[@Chemistry-r3f]

Hey guys It all begins with the combination of antibody circulating to an antigen This complex attract C1 to bind here is the story. This complex will activate C4 and C2 to cleave into there( b) ones and( a )ones . Note any (a) constituent will initiate immune response . Any (b) constituent will bind to membrane, or to activate the others complements (only for c4 and c2) This complex after combination will give an activation for c3 to be (a) &(b) .any (a) will go to initiate immune response and for (b) will (b)ed on membrane. And so for C5

[@NURSEKARMA]

Thank you for this video! You explained this way better than my patho book.

[@Andr295]

I love your recaps at the end of your videos. Great video!

[@AKLECTURES]

+Andres De Avila Thanks Andres!

[@hilarykayeocaba4898]

Thank you so much! This video really helped me understand the classical pathway of the complement system.

[@mohd_athar123]

it will be C4b-C2a complx. because of historical reason here C2a is larger fragment which is an exception.

[@katherineRAWAR]

Great video! Very clear, thank you so much for posting. I do have one question though. When mentioning the C3 convertase you said that it is formed by a C4b and C2b molecule. However, in my text, as well as from my professor, I have been told that it is composed of a C4b and C2a, instead of C2b, molecule. I was wondering if there are any discrepancies in naming of the subpart of complement molecules after they are cleaved, or if this was just a small mistake? I apologize for the specificity and detail of my question, I just want to ensure I am understanding this process correctly. Thank you kindly, Kat

[@niiinjaaa3241]

+Katherine Williams I confirm, it's a small mistake that I didn't even notice before I read your question ^^ It's indeed C4b and C2a, well spotted ;)

[@AKLECTURES]

+Niiinjaaa Its not a mistake. As I said in a comment below this one, its currently known as C4bC2a but for a while people were pushing to change it to the C4bC2b to make it more logical. But people were simply not using it enough so I guess were stuck with C4bC2a for now.

[@Micro-life]

Great one👌👌👌...n thanks to A K Lecturers fo adding new stuff in C3 convertase part(c2b c4b)...it is nt at all mentiond in books till now, thnks again...😊😊😊

[@ashri234]

Woowoo.. you make it so easy and helped me with my exam..thank you alot.

[@simransharma1967]

Thanks a lot for this lecture sir..... Your notes and explaining is legendary..... Keep up the good work sir

[@AllahuAk113]

There are 2 groups of people. Those who call the larger active C2 fragment C3a and those who call it C2b. The larger active fragment of C2 was originally called C2a for some god awful reason and now there are people who want to switch around the names to go in line with the other complement proteins. Which makes sense, but it kinda just causes confusion.

[@gigglefeather]

Amazing, very easy to follow. Thank you for sharing

[@tkanes17]

My textbook describes the C3 convertase as C4b2a not C4b2b. it mentions when C2 is cleaved, fragment C2b leaves into the fluid phase and C2a joins with fragment C4b to form the C4b2a complex.

[@katherineRAWAR]

+tkanes17 You are correct the C3 convertase is composed of C4b and C2a, not C2b. I think this was a small mistake in the video as C2 is an exception to the general rule that the b fragment always is kept.

[@romainkamba969]

Really, I appreciate these courses

[@samyavellani6111]

Thank you so much for making this video, I found your explanations really clear and helpful!

[@AdesanoyeOluwafemiibukun-yl5ku]

Thanks so much for this... You are appreciated.

[@kayodetolulopeadeyemi2286]

Hi, This is amazing! Great Job! I use this to teach my students and it is really really really good!

[@ivailopavlov5138]

Great teacher, great explanations!

[@malikbasharat7119]

What a way of teaching.. Superb #AK

[@mohammadhalabi6743]

Couln't help my self to finish the video ... I had to pause and put like and comment first ... Thank you so much 😊

[@ayushkatare8080]

C4b-C2a is the C3 convertase.

[@tamerawado4933]

beautifully explained 👌

[@isisrateb]

Thanks a lot for your explanation

[@newworldorderordis-order6803]

thank you for teaching online

[@tiffanywyatt7591]

C3 convertase is made up of C4b and C2a. The portion of this video where c1 binds to IgM should result in C2aC4b complex instead of C4bC2b complex.

[@HussainBlogs19]

I'm so thankful for your efforts ☺️☺️☺️

[@amangartia8415]

Thank you sir it was very helpful.

[@beautykayb.b1047]

I'm so greatful for ur lectures I was abt to complain the same thing abt c3 convertase but I can see that it has already been done.I'm ur big fan... I appreciate ur metabolism videos on biochemistry.I'm hoping that immunology videos will help too. Pls prepare lectin pathway and also transplantation. If possible also prepare lectures on the other types of immunoglobins. I sincerely hope u would consider my pleas cos my exams is soon approaching... Thanks in anticipation.keep up with the good work AK..

[@muhammadhanif4777]

C4b combine with C2a both are large fragments

[@vascaino946]

Thanks for the video....greetings from Brazil

[@hebashihab3766]

Dr.c4b with c2a make the complex not c2b Make sure

[@kelvinmagava444]

these notes are wonderful

[@serratumer7805]

Sir, great explanation, I'm grateful 👏

[@Rebecca-op7id]

Very helpful!

[@Roseenmarie]

Very well explained! thank you very much 😊

[@mariabernadettedevera7856]

you got me confused there for a moment. But thanks, you helped me out a lot;)

[@jenniferpaddack6467]

Ok, but you just saved my life

[@parasverma7320]

God's work it is😢, so clear. I got this on 1.25x ,tysm

[@muhammadhanif4777]

Larger fragments combine and smaller diffuse

[@leanswagger5822]

Holy fuck you are so good man, sorry for swearing, but you are amazing.

[@ngqabuthobhebhe1171]

good explanation

[@besherkhattab3340]

U r so one kind keep going

[@pfln]

DISCLAIMER: from first aid USMLE 2018 pg 106 "*Historically, the larger fragment of C2 was called C2a but is now referred to as C2b."

[@topalaluiza9647]

Thank you so much 🙏🙏🙏

[@Be1smaht]

Med students love and thank you so much

[@jurksid]

Just wanted to say that I passed immunology due to this video 🤩🤩🤩

[@thabisonyawo500]

thank your sir very informative lecture ,immunology section be giving me headache for days...