Computational Investigation of Underlying Disease Mechanisms and in Silico Drug Repurposing

Abstract
Network science, together with machine learning and computational modeling, lays out a roadmap for the further development of bioinformatics towards a more efficient exploitation of single-level as well as multi-omics. Network-based inference and integration provide great opportunities to develop innovative methodologies that lead to new insights into candidate biomarkers, repurposed drugs, and disease-related mechanisms, supporting and enhancing the vision of Network Medicine.
Network-based methods and tools for mechanism understanding, drug repurposing and biomarker discovery, developed by the Bioinformatics Department at CING will be presented.
About the speaker
mcusercontent..... George M. Spyrou is the Bioinformatics European Research Area Chair Holder and the Head of the Bioinformatics Department (C-BIG) at the Cyprus Institute of Neurology and Genetics (CING). He is the Bioinformatics Course Coordinator at the Postgraduate School of CING where he has been elected as full Professor. He is a Senior IEEE Member and he serves as member of the Editorial Board in well-known bioinformatics-related journals.
His work is focusing on the design and development of computational methods for the discovery of complex patterns of biomarkers, the understanding of underlying molecular mechanisms and drug repurposing though network-based analytics and systems bioinformatics.