Controlling the Brain with Light (Karl Deisseroth, Stanford University)

Karl Deisseroth is pioneering bold new treatments for depression and other psychiatric diseases. By sending pulses of light into the brain, Deisseroth can control neural activity with remarkable precision. In this short talk, Deisseroth gives an thoughtful and awe-inspiring overview of his Stanford University lab's groundbreaking research in "optogenetics".
Prof. Karl Deisseroth's website:
www.stanford.edu/group/dlab/
Stanford University:
www.stanford.edu/
Stanford University Channel on KZbin:
/ stanford

[@VogelsongProductions]

His initial goal I agree with, treating depression, but it does have great ethical issues. It is a newly discovered power which can be used for the well-being of others or to be taken advantage of. Very interesting though.

[@lyrialzander]

Absolutely Fascinating Prof. Deisseroth, thank you for sharing. Narcolepsy has always intrigued me, you should add it to the search tags for this video. Very enlightening.

[@RafaKBLudo]

Thank you for the video.

[@lmlyon]

People and work like this gives me hope for future. Thank-you for sharing this with us.

[@AlexandreMagnoNeuro]

Although the original report of optogenetics used the light sensitive channels to evoke neuronal spikes, it is expected that other bioengineered recombinant proteins will be available soon. For example, recombinant adenylate cyclase light activated is already available.

[@jobirgheidi]

Very interesting and so very well presented. Thank you.

[@alienkishorekumar]

Great video.

[@whiff1962]

The existing problem is the continued maintenance of the idea of psychiatric labeling as disease.

[@AFunyun]

Nice presentation, you can tell he knows what he's talking about. Stanford rules

[@AlexandreMagnoNeuro]

Before trying that out, it should be crucial identifying which neuronal subpopulation encodes each aspects of which we call intelligence.

[@1811leah]

Dr. Karl Deisseroth and his whole team are absolutely genius. I have been researching this topic and the new field of optogenetics for about 2 months now. The application of this to human brains would be ground-breaking. A step closer to the cure of so many psychiatric diseases and understanding of the brain on another level. It's amazing how much progress this field has made since 2005. It's like it's not even taking steps but leaps. People admire celebrities, I admire people like this.

[@mrpregnant]

Light stimulates a powerful effect on the brains cognition according to Science Daily, recent discoveries of a light sensitive cell called “photoreceptor,” has been the central component in relating light information to the non-visual centers of the brain. During animal research non-visual functions were disrupted in the absence of the photoreceptors, meaning the behavioral variables deriving from our physiological mechanism is conducive to the non-visual robust effect of light, it reminds me of “Botany” (study of plants).

[@seanotube85]

Very interesting stuff! I wonder if you could make some really effective anti-psychotic medication from this sort of research too.

[@pokeshark]

great lecture

[@_StandardIssue]

Excellent video and an amazing technique. Although optogenetics could serve as a possible treatment option, it seems the potential for exploratory analysis of the brain is even more great. Imagine the potential to invoke neuronal change with such specificity - target only dopaminergic neurons in the basal ganglia, etc., etc. Great work.

[@emlmm88]

Yes you can cause action potential, but can you stimulate reuptake?

[@geezdude20]

This is the future.

[@Yurmomnsn]

He never mentioned it as a possible "cure" for developmental delay. I do not know where you got that from. Parkinson's and depression were the main focus. I did understand the lecture. I don't know what you are talking about. I am saying that somebody with parkinsons or depression will likely voluntarily undergo the procedure. I was countering Jack Napier's argument by saying that its not up to him what other people do if its not causing direct harm to himself or his property.

[@lostm0ments]

WOW!!!!!!

[@wullie1320]

I had a thought while watching this... I am short sighted, could this eye condition prevent or change the spectrum of light i receive, for example, blue light seems to be the "on" state for the brain, and I've been known to "not get it right away". fiber optics really interest me so, what if I stimulate by getting more blue light? what could the results be?

[@lostm0ments]

Then you see what I see. It's funny you mention that, because that is what I'm going into Neuroscience to research. Replication of all 5 senses in a virtual environment. And to my suprise, this is already being done to the extent that we have achieved sight, audio, relative touch, and even smell. Hopefully we will have made even more progress before I get a chance to work on the research with their teams. Search: The Cocoon Virtual Reality

[@djtoosh]

waaaay too few bioengineers do any work in cognition. kudos to karl disseroth, he's amazing

[@igotyoubeat]

wow its amazing how science has grown and its also scary when you see a rat being steered with light

[@projectmagnet]

When are you all in science going to try out torsion fields, and scalar cancelling coils. Vibration. True conscious energy.

[@AlexandreMagnoNeuro]

Not hard to believe. Check this recent paper from Deisseroth: Temporally precise in vivo control of intracellular signalling You should also read this paper for a update of the optogenetic toolbox: Molecular Tools and Approaches for Optogenetics Both paper are open access.

[@bboymarcel]

be aware of it...!

[@gallardo228]

My Name is Stanford

[@NexusARC]

I need help.

[@nicoleta498]

Scusate si può tradure in italiano..Grazie

[@AlexandreMagnoNeuro]

Optogenetics is awesome.

[@131kimber]

Delgado - alive in 2020

[@HowToMakeFriendsX]

Wow, he is very intelligent.

[@rajus0]

its a kl area of science but in my opinion from a ethical point of view it might not all be gravy

[@bigsky780]

Come on Karl lets not get testy

[@Yurmomnsn]

Somebody has to bridge the frontier. For example the discovery of the small pox vaccine. I am sure there will be people willing to undergo the procedure and what one chooses to do to their body is not my concern.

[@JohnLambrechts]

3:49

[@AineWolberg]

Light work and justice for all psychiatric patients!!! no more electroshocks!!! tell me what to drink and what color to look at :) im ready for the future thanks for this investigation hope the best for you and your team!

[@createwitheachbreath4597]

I wonder if sam harris has seen this

[@sarbruis]

They use adeno-associated virus to introduce the genes into the cells (a virus commonly used in gene therapy). Specific promoters are attached to the genes so that they are only expressed in a certain cell type.

[@Unclevertitle]

@skb0rzn Currently, this kind of control requires a specialized surgical implant, so chances are that you don't have one. The control in terms of TV that you're referring to is more a result of the media (with the tendency of people to accept what they encounter as truth) and advertising (with inherrent emotional messages and insinuations of a person's personal worth in relation to a product). A surgical implant like this could one day be used for advertising that's impossible to ignore.

[@stevenunua2118]

Will you be able to turn on 100% of the brain?

[@Guilopes99]

+steve nunua if there were areas of the brain that werent used they would atrophy over time. 100% of the brain is used, the "we only use 10% of our brain" is a common myth that derivated from a marketing campaign.

[@MikeM8891]

this is the same way the aliens are controlling me. can you imagine what we are to those rats we do tests on. we are the aliens butt probing them. if only the rats could make their own tin foil hats like i can to protect myself.

[@roq99]

matrix science coupled with computer science...

[@TaureDawn]

Light/Photons? -- More sunlight then without all the technology???

[@moreausisland]

I am saddened by this video and the comments that are pro-what-this-guy-is-doing. Psychiatrists (pseudo-scientists) should not be meddling with other people's minds (and no, I'm not a Scientologist.) Please leave neurology to qualified neurologists.

[@lightmobile]

Wait a second. So all we have to do is insert pond algae genes into all the relevant brain cells? Is that easy?

[@TheNataliaRR]

Every person can make own invisible quantum machine alive, Otti Dracul will reset your data with new young generation for example and its fashion quantum machine.

[@TheGreatDeciever55]

Ironic--- because judging a person so harshly is a grotesque form of arrogance

[@eigilmus]

scary shit

[@whiff1962]

Hum, paradigmatic shift, from a neuro-chemical, to an electrical mode of explaining (mis)behaviour. Hypnosis alters consciousness, so, should this be proof that there is curative affect to hypnosis? Is this researcher actually a neurologist, or just a shrink?

[@whiff1962]

Deep brain stimulation, as a treatment for depression, is fraught with considerable risk to the patient, and does not obviate the need for continued maintenance of psychiatric poisons prescribed before the procedure. It is, however, a rather costly procedure, and surgeons(notably vascular surgeons, given the major arteries and veins exposed during the surgery) love to get paid for this procedure.

[@TheNataliaRR]

They dont understand TIME and with LIE you cant fly.

[@drdeee5]

yeah.. in 2020 there will prob be human robots

[@bboymarcel]

Karl Deisseroth...this doctor should be crossed up and judged by god....! psychiatrists are the worst psycho criminals in the world...!